检索结果-南通市图书馆

White matter changes in 80 mild cognitive impairment patients using magnetic resonance imaging

Neural Regeneration Research 2009年第9期4卷 654-658页

作者： Hyun cho Jee-Hyun Kwon Sun-young Kim Department of Neurology Ulsan University Hospital

BACKGROUND： Many studies have suggested that one possible etiology of mild cognitive impairment is small vessel cerebrovascular disease, which is associated with small subcortical infarcts and white matter abnormalities. These white matter changes have been detected as white matter hyperintensity （WMH） using magnetic resonance imaging. WMH may be associated with frontal lobe dysfunction. OBJECTIVE： To examine white matter changes in mild cognitive impairment patients of different subtypes, and to evaluate the correlation between white matter changes and neuropsychological characteristics, demographic information, vascular risk factors, and mild cognitive impairment subtypes. DESIGN, TIME AND SETTING： The neurophysiological, comparison study was performed at the Department of Neurology Memory Clinic, Ulsan University Hospital, South Korea, between March 2007 and March 2008. PARTICIPANTS： Out of a total of 83 subjects with clinically diagnosed mild cognitive impairment at the out-patient clinic, 3 subjects with severe WMH were excluded. A total of 80 subjects were included in this study. No patients suffered from cognitive impairment induced by neurological diseases, mental disorders, or somatic diseases. In accordance with magnetic resonance imaging results, the patients were assigned to two subtypes： 56 subjects without WMH and 24 subjects with WMH. METHODS： All patients were subjected to a standard neuropsychological battery using the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating, and comprehensive Seoul Neuropsychological Screening Battery. The Clinical Dementia Rating reflected general cognitive function of patients. Results from the Seoul Neuropsychological Screening Battery reflected attention, language function, visuospatial function, verbal memory, nonverbal memory, long-term memory, and frontal/executive function. Magnetic resonance imaging was used to map changes in the brain. MAIN OUTCOME MEASURES： The association between va

关键词： mild cognitive impairment cerebrovascular disease white matter hyperintensity frontal/executive dysfunction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Uhwang Chungsim Won Decreases Blood Oxygen Level-Dependent fMRI Signal Response to A Motor Stimulation Task

引用

Chinese Journal of Integrative Medicine 2015年第7期21卷 493-499页

作者： Woo-Sang Jung Jong-Man Ryu young-Jee Kim Seong-Uk Park Geon-Ho Jahng Jung-Mi Park Sang-kwan Moon Chang-Nam Ko Ki-Ho cho Department of Cardiovascular&Neurologic Diseases(Stroke Center) College of Oriental MedicineKyung Hee University Department of Radiology College of MedicineKyung Hee University

Objectives： TO evaluate the effect of Uhwang Chungsim Won [UC, Niuhuang Qingxin Pill （牛黄清心丸] on the blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） signal response to a motor stimulation task using a hand grasping paradigm. Methods： Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. Results： With the administration of UC, BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen, right and left medial frontal gyrus, right parahippocampal gyrus, right and left sublobar insula, right and left posterior cingulate, left precuneus, and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus, right cerebellar culmen, left superior temporal gyrus, right and left middle frontal gyrus, and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate, while there was no increased response to the right hand motor task after UC administration. Conclusions： UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex, but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.

关键词： Uhwang Chungsim Won Niuhuang Qingxin Pfll pharmacological fMRI cerebral blood flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Security Analysis of Smart Speaker: Security Attacks and Mitigation

引用

Computers, Materials & Continua 2019年第9期61卷 1075-1090页

作者： youngseok Park Hyunsang choi Sanghyun cho young-Gab Kim Naver Corp. 6 Buljeong-roJeongja-dongBundang-guGyeonggi-doKorea Sejong University 209Neungdong-roGwangjin-guSeoul05006Korea

The speech recognition technology has been increasingly common in our ***,a number of commercial smart speakers containing the personal assistant system using speech recognition came *** the smart speaker vendors have been concerned about the intelligence and the convenience of their assistants,but there have been little mentions of the smart speakers in security *** the smart speakers are becoming the hub for home automation,its security vulnerabilities can cause critical *** this paper,we categorize attack vectors and classify them into hardware-based,network-based,and *** the attack vectors,we describe the detail attack scenarios and show the result of tests on several commercial smart *** addition,we suggest guidelines to mitigate various attacks against smart speaker ecosystem.

关键词： Smart speaker personal assistant system IoT security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermoelectric Transport Properties of R_yFe_3NiSb_(12)(R=Ba,Nd and Yb)

引用

Journal of Materials Science & Technology 2014年第11期30卷 1134-1140页

作者： Ruiheng Liu Jung young cho Jiong Yang Wenqing Zhang Lidong Chen CAS Key Laboratory for Energy-conversion Materials Shanghai Institute of CeramicsChinese Academy of Sciences Materials and Processes Laboratory GM R&D CenterWarrenMI 48090USA Department of Materials Science & Engineering University of Washington

To evaluate the influence of Ni substitution on electrical transport properties, the thermoelectric transport properties of the p-type skutterudites RyFe3NiSb12 （R = Ba, Nd and Yb） are systematically investigated from 2.5 K to 800 K. By carefully modifying the filling fractions of the three fillers, Ba, Nd and Yb, the carrier concentration is precisely adjusted, which changes proportionally to the nominal value calculated by valence counting rule. The carrier concentration dependences of mobility and Seebeck coefficient represent two band contribution in the valence band, and the optimized carrier concentration for thermoelectric performance is between （5-9） × 10^20 cm^-3. The lattice thermal conductivity of samples filled with rare-earth elements （Nd and Yb） are significantly lower as compared to Ba-filled, due to the lower resonant frequency and partial filling. Compared with Co substitution, Ni substitution tends to close the band gap, which results in heavier bipolar diffusion at high temperature for RyFe3NiSb12. However, due to state, when the carrier concentrations are similar, RyFe3NiSb12 possess higher thermal power and thus higher power factor than RyFe2Co2Sb12 in the lower temperature range. A ZT value of 0.73 is obtained for Yb0.77Fe3NiSb12 at 660 K.

关键词： Thermoelectric Skutterudites Band structure Bipolar diffusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of potassium pyrophosphate in electrolyte on coated layer of AZ91 Mg alloy formed by plasma electrolytic oxidation

引用

中国有色金属学会会刊：英文版 2009年第4期19卷 824-828页

作者： Jin-young cho Duck-young HWANG Dong-H eon LEE Bongyoung YOO Dong-Hyuk SHIN Department of Metallurgy and Materials Scienc e Hanyang University

The effect of potassium pyrophosphate in the electrolyte on plasma electrolytic oxidation(PEO) process for AZ91 Mg alloy was *** morphologies and chemical compositions of the coating layer on the AZ91 Mg alloy were evaluated and corrosion resistance was also estimated by potentiodynamic polarization *** coating layer on AZ91 Mg alloy coated from the Bath 2 containing 0.03 mol/L of potassium pyrophosphate for 360 s exhibited considerably dense structure and contained 11%-18%(mass fraction) of *** higher content of phosphorous of coating layer coated from Bath 2 could be detected at the bottom of oxide layer,which strongly implied that the phosphorous ion might be concentrated at the barrier *** potential of coating layer of AZ91 Mg alloy increased and corrosion current density decreased with increasing the concentration of potassium *** polarization resistance(Rp) of coating layer of AZ91 Mg alloy coated from Bath 2 was 4.65×107 Ω/cm2,which was higher than that(Rp=3.56×104 Ω/cm2) of the sample coated from electrolyte without potassium *** coating layer coated from Bath 2 containing 0.03 mol/L potassium pyrophosphate exhibited the best corrosion resistance.

关键词： AZ91镁合金合金涂层焦磷酸钾电解氧化等离子体电解质腐蚀电流密度耐腐蚀性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An herbal formula,CGX,exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats

引用

World Journal of Gastroenterology 2006年第38期12卷 6142-6148页

作者： Jang-Woo Shin Jin-young Son Se-Mi Oh Seung-Hyun Han Jing-Hua Wang Jung-Hyo cho chong-kwan cho Hwa-Seung Yoo Yeon-Weol Lee Myong-Min Lee Xiao Ping Hu Chang-Gue Son East-West Cancer Center Dunsan Oriental Hospitalof Orientai medical College of Daejeon University 1136 Dunsan-dong Seo-gu Daejeon 302-122 South Korea Department of Oromaxillofacial Infection and Immunity and Dental Research Institute School of Dentistry Seoul National University 28 Yongon-Dong Chongno-Gu Seoul 110-749 South Korea

AIM： To evaluate the therapeutic effect of Chunggan extract （CGX）, a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine （DMN）-induced chronic liver injury model in rats. METHODS： Liver injuries were induced in Wistar rats by injection of DMN （ip, 10 mg/mL per kg） for 3 consecutive days per week for 4 wk. The rats were administered with CGX Coo, 100 or 200 mg/kg per day） or distilled water as a control daily for 4 wk starting from the 15^th d of the DMN treatment. Biochemical parameters （serum albumin, bilirubin, ALP, AST and ALT）, lipid peroxides, hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-β, TIMP-1, TIMP-2, PDGF-β, and MMP-2, all of which are known to be associated with liver fibrosis, were analyzed using real-time PCR. RESULTS： CGX administration restored the spleen weight to normal alter having been increased by DMN treatment. Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP （P 〈 0.05）, ALT （P 〈 0.02）, and AST （P 〈 0.02） that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly upregulated expression of TNF-α, TGF-β,TIMP-1, TIMP-2, PDGF-β, and MMP-2. Of these, the gene expression encoding PDGF-β and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration. CONCLUSION： CGX exhibits hepatotherapeutic properties against chronic hepatocellular destruction and consequential liver fibrosis.

关键词： Dimethylnitrosamine Hepatotherapeutic Herbal medicine PDGF-β Chunggan extract

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxicological study of the hepatotherapeutic herbal formula,Chunggan extract,in beagle dogs

引用

World Journal of Gastroenterology 2006年第46期12卷 7497-7502页

作者： Woo-Jin choi Jang-Woo Shin Jin-young Son Dong-Seok Seo Hark-Soo Park Seung-Hyun Han Ha-lung Sung Jung-Hyo cho chong-kwan cho Hwa-Seung Yoo Yeon-Weol Lee Chang-Gue Son East-West Cancer Center Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University 1136Dunsan-dong Seo-gu Daejeon 302-122 South Korea Safety Assess-ment Center Korea Testing and Research Institute for Chemical Industry 7-6 Gomak-ri Wolgot-myeon Gimpo-si Kyonggi-doKorea Department of Oromaxillofacial Infection & Immunity and Dental Research Institute School of DentistrySeoul National University 28 Yongon-Dong Chongno-Gu Seoul110-749 South Korea

AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis. RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopa- thology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug. CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

关键词： Hepatotherapeutics Herbal remedy Chung-gan extract Safety Toxicological study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pulmonary metastasectomy for colorectal cancer: How many nodules, how many times?

引用

World Journal of Gastroenterology 2014年第20期20卷 6133-6145页

作者： Hong kwan Kim Jong Ho cho Ho Yun Lee Jeeyun Lee Jhingook Kim Department of Thoracic and Cardiovascular Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea Department of Radiology and Center for Imaging Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea Department of Hematology and Oncology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea

Colorectal cancer(CRC)is one of the most common cancers worldwide,with 5%-15%of CRC patients eventually developing lung metastasis(LM).Despite doubts about the role of locoregional therapy in the management of systemic disease,many surgeons have performed pulmonary metastasectomy(PM)for CRC in properly selected ***,the use of pulmonary metastasectomy remains controversial due to the lack of randomized controlled *** article reviews the results of surgical treatment of pulmonary metastases for CRC,focusing on(1)current treatment guidelines and surgical techniques of PM in patients with LM from CRC;(2)outcomes of PM and its prognostic factors;and(3)controversial issues in PM,focusing on repeated metastasectomy,bilateral multiple metas-tases,and combined liver and lung metastasectomy.

关键词： Colorectal cancer Pulmonary metastasectomy Surgery Metastases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anti-angiogenic effects of the water extract of HangAmDan(WEHAD),a Korean traditional medicine

引用

Science China(Life Sciences) 2011年第3期54卷 248-254页

作者： BANG Ji-young KIM Kyung-Soon KIM Eung-Yoon YOO Hwa-Seung LEE Yeon-Weol cho chong-kwan choI youngJin JEONG Hyun-Ja KANG In-Cheol InnoPharmasceen Inc. Hoseo UniversityAsan 336-795Republic of Korea East-West Cancer Center Dunsan Oriental Medical Hospital of Daejeon UniversityDaejeon 302-122Republic of Korea BioChip Research Center Hoseo UniversityAsan 336-795Republic of Korea Department of Biological Science College of Natural ScienceHoseo UniversityAsan 336-795Republic of Korea

We investigated the anti-angiogenic effects of the water extract of HangAmDan (WEHAD),which is a crude extract of nine Korean medicinal substances of animal and plant *** human umbilical vein endothelial cells,WEHAD significantly inhibited bFGF-induced proliferation,adhesion,migration,and capillary tube *** used an antibody array to perform an analysis of signaling proteins,which showed up-regulated expression of various proteins including RAD51,RAD52,and p73,and down-regulated expression of *** vessel formation in a chick chorioallantoic membrane (CAM) treated with WEHAD was markedly reduced in length compared with a PBS-treated control *** results suggest that inhibition of angiogenesis by WEHAD may be the mechanism of action for the anti-cancer effects of HAD.

关键词： angiogenesis HangAmDan WEHAD antibody array HUVEC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sorption enhanced catalytic CF4 hydrolysis with a three-stage catalyst-adsorbent reactor

引用

Frontiers of Chemical Science and Engineering 2017年第4期11卷 537-544页

作者： Jae-Yun Han Chang-Hyun Kim Boreum Lee Sung-Chan Nam Ho-young Jung Hankwon Lim kwan-young Lee Shin-Kun Ryi . Advanced Materials and Devices Laboratory Korea Institute of Energy Research (KIER) Daejeon 34129 Korea.. Department of Advanced Materials and Chemical Engineering Catholic University of Daegu Gyeongbuk 38430 Korea.. Department of Environment and Energy Engineering Chonnam National University Gwangju 61186 Korea.. Department of Chemical and Biological Engineering Korea University Seoul 136-701 Korea

In this study, we developed a three-stage catalyst-adsorbent reactor for the catalytic hydrolysis of CF4. Each stage is composed of a catalyst bed followed by an adsorbent bed using Ca（OH）2 to remove HF. The three stages are connected in series to enhance the hydrolysis of CF4 and eliminate a scrubber to dissolve HF in water at the same time. With a 10 wt-% Ce/AlaO3 catalyst prepared by the incipient wetness method using boehmite and a granular calcium hydroxide as an adsorbent, the CF4 conversion in our proposed reactor was 7%-23% higher than that in a conventional single-bed catalytic reactor in the temperature range of 923-1023 K. In addition, experimental and numerical simulation （Aspen HYSYS） results showed a reasonable trend of increased CF4 conversion with the adsorbent added and these results can be used as a useful design guideline for our newly proposed multistage reactor system.

关键词： PFCs catalytic hydrolysis calcium hydro-xide sorption enhanced process simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：