检索结果-南通市图书馆

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Neuroendocrine carcinoma of the stomach:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2014年第4期6卷 77-79页

作者： Sang hyun Kang Kwang hee Kim Sang hyuk Seo Min Sung An Tae Kwun ha ha Kyung Park Ki Beom Bae Chang Soo choi Sang hun Oh young kil choi Department of Surgery Busan Paik HospitalInje University College of Medicine

Neuroendocrine carcinoma(NEC)is a rare tumor,comprising<1%of stomach cancers.A 55-year-old woman was referred to our hospital with biopsy-proven gastric cancer.A shallow ulcerative lesion was detected in the lesser curvature of the lower *** was suspected to be early gastric cancerⅡA+ⅡC ***,endoscopic submucosal dissection was *** was subsequently diagnosed with NEC,which is aggressive and carries a poor *** conducted a radical resection and a laparoscopic-assisted distal *** tumor had infiltrated the subserosal layer and6/42 lymph nodes were *** mitotic index was16/10 high power fields and the Ki-67 labeling index was 26%-50%.The final diagnosis of NEC was made according to the World health Organization 2010 *** was suspected of having jumping metastasis to the proximal *** patient was treated with an oral anticancer drug(5-flurouracil based drug)for2 *** patient has been followed up for 3 years without recurrence.

关键词： Neuroendocrine carcinoma Mitosis Ki-67 Gastrectomy Prognosis

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Virtual Mold Technique in Thermal Stress Analysis during Casting Process

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第3期24卷 359-363页

作者： Si-young Kwak Jae-Wook Baek Jeong-Ho Nam Jeong-kil choi E-Design Center Korea Institute of Industrial Technology Department of Virtual Engineering Korea University of Science & Technology

It is important to analyse the casting product and the mold at the same time considering thermal contraction of the casting and thermal expansion of the mold. The analysis considering contact of the casting and the mold induces the precise prediction of stress distribution and the defect such as hot tearing. But it is difficult to generate FEM mesh for the interface of the casting and the mold. Moreover the mesh for the mold domain spends lots of computational time and memory for the analysis due to a number of meshes. Consequently we proposed the virtual mold technique which only uses mesh of the casting part for thermal stress analysis in casting process. The spring bar element in virtual mold technique is used to consider the contact of the casting and the mold. In general, a volume of the mold is much bigger than that of casting part, so the proposed technique decreases the number of mesh and saves the computational memory and time greatly. In this study, the proposed technique was verified by the comparison with the traditional contact technique on a specimen. And the proposed technique gave satisfactory results.

关键词： Casting process Thermal stress analysis Virtual mold

Impact analysis of casting parts considering shrinkage cavity defect

在线全文

学校读者我要写书评

暂无评论

China Foundry 2011年第1期8卷 112-116页

作者： Si-young Kwak Jie Cheng Jeong-kil choi Center for e-Design Korea Institute of lndustrial Technology Incheon 406-800 Korea Department of Virtual Engineering School of Engineering Korea University of Science ＆ Technology Daejeon Korea

Shrinkage cavity may be detrimental to mechanical performances of casting *** a consequence,design engineers often use overly large safety factors in many designs due to insufficient understanding of quantitative effects of shrinkage cavity *** this paper,process of Al alloy wheel impact test was computationally analyzed for both the wheel models with and without shrinkage cavity *** on shrinkage cavity data obtained from industrial CT (Computerized Tomography),the shrinkage cavity defects were modeled with SSM (Shape Simplification Method),which reconstructs shrinkage cavity defects to hollow spheroid *** the impact simulation was conducted,the results show that under impact test condition,the wheel considering shrinkage cavity defects may fracture while the sound-assumed wheel may not.

关键词： casting shrinkage cavity defect impact computational analysis Al alloy wheel

Development of Ubiquitous Simulation Service Structure Based on High Performance Computing Technologies

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第3期24卷 374-378页

作者： Sang-Hyun CHO Jeong-kil choi Center For e-Design KITECH7-47Songdo-DongYeonsu-Ku

The simulation field became essential in designing or developing new casting products and in improving manufacturing processes within limited time, because it can help us to simulate the nature of processing, so that developers can make ideal casting designs. To take the prior occupation at commercial simulation market, so many development groups in the world are doing their every effort. They already reported successful stories in manufacturing fields by developing and providing the high performance simulation technologies for multipurpose. But they all run at powerful desk-side computers by well-trained experts mainly, so that it is hard to diffuse the scientific designing concept to newcomers in casting field. To overcome upcoming problems in scientific casting designs, we utilized information technologies and full-matured hardware backbones to spread out the effective and scientific casting design mind, and they all were integrated into Simulation Portal on the web. It professes scientific casting design on the NET including ubiquitous access way represented by ＂Anyone, Anytime, Anywhere＂ concept for casting designs.

关键词： Parallel computation Message passing interface (MPI) Shared memory processing (SMP) Clustering Ubiquitous

Critical cooling rate on carbide precipitation during quenching of austenitic manganese steel

在线全文

学校读者我要写书评

暂无评论

China Foundry 2010年第2期7卷 178-182页

作者： Youn-Soo Ham Jeong-Tae Kim Si-young Kwak Jeong-kil choi Woo-young Yoon Daeyang R-Tech.Co. Ltd290-28Daehwa-DongDaeduk-GuDaejeonKorea e-Design Center KITECH7-47Songdo-DongYeonsu-GuIncheon 406-800Korea Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul 136-701Korea

Critical cooling rate to avoid carbide precipitation during quenching of austenitic manganese steel was investigated by means of optical microscopy,image analyzer and numerical *** efficient heat treatment analysis program including temperature-dependent material properties was developed for the prediction of cooling rate and probability of carbide precipitation during quenching by finite difference ***-dependent heat transfer coefficient was adopted to achieve more precise *** ratio of carbide precipitation was measured by image analyzer to determine the critical point of carbide ***-dependent critical cooling rate at that point was calculated by the developed numerical ***,the probability of carbide precipitation on the whole area of specimen can be predicted by the proposed numerical program and the numerical result of a specimen was compared with the experimental result.

关键词： austenitic manganese steel carbide precipitation quenching critical cooling rate

Die Casting Mold Design of the Thin-walled Aluminum Case by Computational Solidification Simulation

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第3期24卷 383-388页

作者： young-Chan Kim Chang-Seog Kang Jae-Ik Cho Chang-Yeol Jeong Se-Weon choi Sung-kil Hong Korea Institute of Industrial Technology Chonnam National University

Recently, demand for the lightweight alloy in electric/electronic housings has been greatly increased. However, among the lightweight alloys, aluminum alloy thin-walled die casting is problematic because it is quite difficult to achieve sufficient fluidity and feedability to fill the thin cavity as the wall thickness becomes less than 1mm. Therefore, in this study, thin-walled die casting of aluminum （Al-Si-Cu alloy： ALDC 12） in size of notebook computer housing and thickness of 0.8 mm was investigated by solidification simulation （MAGMA soft） and actual casting experiment （Buhler Evolution B 53D）. Three different types of gating design, finger, tangential and split type with 6 vertical runners, were simulated and the results showed that sound thin-walled die casting was possible with tangential and split type gating design because those gates allowed aluminum melt to flow into the thin cavity uniformly and split type gating system was preferable gating design comparing to tangential type gating system at the point of view of soundness of casting and distortion generated after solidification. Also, the solidification simulation agreed well with the actual die-casting and the casting showed no casting defects and distortion.

关键词： Aluminum casting alloy Thin-wall die casting Solidification simulation

Heat Transfer between Casting and Die during High Pressure Die Casting Process of AM50 Alloy-Modeling and Experimental Results

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第1期24卷 131-135页

作者： Zhipeng GUO Shoumei XIONG Sang-Hyun Cho Jeong-kil choi Key Laboratory for Advanced Manufacturing by Materials Processing Technology Department of Mechanical Engineering Tsinghua University Beijing 100084 China Advanced Material R＆D Center Korean Institute of Industrial Technology 994-32 Dongchun-Dong Yonsu-Ku Inchon Korea

A method based on die casting experiments and mathematic modeling is presented for the determination of the heat flow density （HFD） and interfacial heat transfer coefficient （IHTC） during the high pressure die casting （HPDC） *** were carried out using step shape casting and a commercial magnesium alloy,*** profiles were measured and recorded using thermocouples embedded inside the die. Based on these temperature readings,the HFD and IHTC were successfully determined and the calculation results show that the HFD and IHTC at the metal-die interface increases sharply right after the fast phase injection process until approaching their maximum values,after which their values decrease to a much lower level until the dies are *** patterns of heat transfer behavior were found between the die and the casting at different *** thinner the casting was,the more quickly the HFD and IHTC reached their steady ***,the values for both the HFD and IHTC values were different between die and casting at different thicknesses.

关键词： : Interfacial heat transfer coefficient High pressure die casting process AM50 Magnesium alloy