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Molecular engineering of antibodies for site-specific conjugation to lipid polydopamine hybrid nanoparticles

Acta Pharmaceutica Sinica B 2020年第11期10卷 2212-2226页

作者： Hobin Yang Quoc-Viet Le Gayong Shim Yu-Kyoung Oh young kee shin Laboratory of Molecular Pathology and Cancer Genomics College of Pharmacy and Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea Bio-MAX Seoul National UniversitySeoul 08826Republic of Korea

Conjugation of antibodies to nanoparticles allows specific cancer targeting,but conventional conjugation methods generate heterogeneous conjugations that cannot guarantee the optimal orientation and functionality of the conjugated ***,a molecular engineering technique was used for sitespecific conjugation of antibodies to *** designed an anti-claudin 3(CLDN3)antibody containing a single cysteine residue,h4 G3 cys,then linked it to the maleimide group of lipid polydopamine hybrid nanoparticles(LPNs).Because of their negatively charged lipid coating,LPNs showed high colloidal stability and provided a functional surface for site-specific conjugation of h4 G3 *** activity of h4 G3 cys was tested by measuring the binding of h4 G3 cys-conjugated LPNs(C-LPNs)to CLDN3-positive tumor cells and assessing its subsequent photothermal effects.C-LPNsspecifically recognized CLDN3-overexpressing T47 D breast cancer cells but not CLDN3-negative Hs578 T breast cancer *** binding of C-LPNs to CLDN3-overexpressing T47 D cells resulted in significantly higher temperature generation upon NIR irradiation and potent anticancer photothermal *** with this,intravenous injection of C-LPNsin a T47 D xenograft mouse model followed by NIR irradiation caused remarkable tumor ablation compared with other treatments through high temperature *** results establish an accurate antibody-linking method and demonstrate the possibility of developing therapeutics using antibody-guided nanoparticles.

关键词： Molecular engineering Site-specific conjugation Lipid polydopamine hybrid nanoparticles Claudin 3 Photothermal therapy

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Advanced polymer materials-based electronic skins for tactile and non-contact sensing applications

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InfoMat 2023年第7期5卷 1-42页

作者： Feifei Yin Hongsen Niu Eun-Seong Kim young kee shin Yang Li Nam-young Kim Department of Electronics Engineering Kwangwoon UniversitySeoulRepublic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Information Science and Engineering University of JinanJinanthe People's Republic of China

Recently,polymer materials have been at the forefront of other materials in building high-performance flexible electronic skin(e-skin)devices due to con-spicuous advantages including excellent mechanical flexibility,good compatibil-ity,and high ***,most research works just paid considerable attention and effort to the design,construction,and possible application of e-skins that reproduce the tactile perception of the human skin sensory *** with tactile sensing devices,e-skins that aim to imitate the non-contact sensing features in the sensory system of human skin tend to avoid undesired issues such as bacteria spreading and mechanical *** further promote the development of e-skins to the human skin sensory system where tactile perception and non-contact sensing complement each other,significant progress and advances have been achieved in the field of polymer materials enabled e-skins for both tactile perception and non-contact sensing *** this review,the latest progress in polymer material-based e-skins with regard to tactile,non-contact sensing capabilities and their practical applications are *** fabrication strategies of polymer materials and their role in building high-performance e-skins for tactile and non-contact sensing are ***,we also review the research works that integrated the polymer-based tactile and non-contact e-skins into robots and prostheses,smart gloves,and VR/AR devices and addressed some representative problems to dem-onstrate their suitability in practical applications in human–machine ***,the current challenges in the construction of high-performance tactile and non-contact e-skins are highlighted and promising properties in this direction,by taking advantage of the polymer materials,are outlined.

关键词： electronic skins human-machine interaction non-contact sensing polymer materials tactile sensing

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Advances in advanced solution-synthesis-based structural materials for tactile sensors and their intelligent applications

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InfoMat 2024年第1期6卷 31-64页

作者： Hongsen Niu Ning Li Eun-Seoung Kim young kee shin Nam-young Kim Guozhen Shen Yang Li School of Information Science and Engineering University of JinanJinanthe People's Republic of China RFIC Centre Department of Electronics EngineeringKwangwoon UniversitySeoulRepublic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijingthe People's Republic of China School of Microelectronics Shandong UniversityJinanthe People's Republic of China

Intelligent applications,with tactile sensors at their core,represent significant advancement in the field of artificial ***,achieving perception abilities in tactile sensors that match or exceed human skin remains a formidable ***,the design and implementation of hierarchical structural materials are considered the optimal solution to this *** contrast to conventional methods,such as complicated lithography and three-dimensional printing,the cost-effective and scalable nature of advanced solution-synthesis methods makes them ideal for preparing diverse tactile sensors with hierarchical structural ***,the process and applicability of advanced solution synthesis methods have yet to form a seamless ***,the development and intellectualization of tactile sensors based on advanced solution synthesis methods are still in their early stages,and require a comprehensive and systematic review to usher in *** study delves into the advantages and disadvantages of various advanced solution synthesis methods,providing detailed ***,the positive effects of hierarchical structural materials constructed using these methods in tactile sensors and their intelligent applications are also discussed in ***,the challenges and future opportunities faced by this emerging field are summarized.

关键词： aqueous phase reduction artificial intelligence hydrothermal growth in situ polymerization tactile sensor

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Tailoring Classical Conditioning Behavior in TiO_(2) Nanowires:ZnO QDs-Based Optoelectronic Memristors for Neuromorphic Hardware

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Nano-Micro Letters 2024年第7期16卷 265-280页

作者： Wenxiao Wang Yaqi Wang Feifei Yin Hongsen Niu young-kee shin Yang Li Eun-Seong Kim Nam-young Kim School of Information Science and Engineering University of JinanJinan 250022People’s Republic of China RFIC Centre NDAC CentreKwangwoon UniversityNowon-guSeoul 139-701South Korea Department of Electronics Engineering Kwangwoon UniversityNowon-GuSeoul 139-701South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoul 08826South Korea

Neuromorphic hardware equipped with associative learn-ing capabilities presents fascinating applications in the next generation of artificial ***,research into synaptic devices exhibiting complex associative learning behaviors is still ***,an optoelec-tronic memristor based on Ag/TiO_(2) Nanowires:ZnO Quantum dots/FTO was proposed and constructed to emulate the biological associative learning *** implementation of synaptic behaviors,including long and short-term plasticity,and learning-forgetting-relearning behaviors,were achieved in the device through the application of light and electrical *** the optoelectronic co-modulated characteristics,a simulation of neuromorphic computing was conducted,resulting in a handwriting digit recognition accuracy of 88.9%.Furthermore,a 3×7 memristor array was constructed,confirming its application in artificial visual *** importantly,complex biological associative learning behaviors were emulated by mapping the light and electrical stimuli into conditioned and unconditioned stimuli,*** training through associative pairs,reflexes could be triggered solely using light ***-sively,under specific optoelectronic signal applications,the four features of classical conditioning,namely acquisition,extinction,recovery,and generalization,were elegantly *** work provides an optoelectronic memristor with associative behavior capabilities,offering a pathway for advancing brain-machine interfaces,autonomous robots,and machine self-learning in the future.

关键词： Artificial intelligence Classical conditioning Neuromorphic computing Artificial visual memory Optoelectronic memristors ZnO Quantum dots

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Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing

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Science Bulletin 2019年第4期64卷 236-244页

作者： Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim young kee shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu BGI-Shenzhen China National GeneBank-Shenzhen BGI-Shenzhen Laboratory of Molecular Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Institute Department of Drug Design and Pharmacology University of Copenhagen Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Department of Histology and Embryology Inner Mongolia Medical University Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease Institute of Digestive Disease and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Department of Pharmacy College of Pharmacy Seoul National University James D. Watson Institute of Genome Sciences Micro Pharmatech Ltd Department of Biology University of Copenhagen

Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor ***, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease.

关键词： Gastric cancer Single-cell whole exome sequencing SNV Signi-cell mutated gene Heterogeneity

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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin shin Sun-young Kwon Sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

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Stabilized sub-grain and nano carbides-driven 1.2 GPa grade ultra-strong CrMnFeCoNi high-entropy alloy additively manufactured by laser powder bed fusion

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Journal of Materials Science & Technology 2022年第22期117卷 8-22页

作者： young-Kyun Kim kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea Korea Institute of Materials Science(KIMS) Changwon 51508Republic of Korea

High-entropy alloys(HEAs)with interstitial atoms that are produced by additive manufacturing have gained intensive interest in the materials science community because of their suitability for constructing high-strength net-shape ***,a strategy to additionally enhance the strength of selective laser melted carbon-containing HEAs was *** as-built carbon-containing HEAs(C_(x)(Cr_(20)Mn_(20)Fe_(20)Co_(20)Ni_(20))_(100-x)(x=0.5 at.%,1.0 at.%,and 1.5 at.%))contain supersaturated carbon,and the extent of supersaturation increases as the carbon content *** subjected to aging treatment at 650°C for 1 h,the microstructure of the three alloys did not change at the grain ***,the microstructure at the sub-grain scale changed markedly,and these changes influenced the tensile properties and deformation *** particular,the tensile strength of aged 1.5C-HEA at 650°C was∼1.2 GPa at room temperature,which is higher than those reported for CrMnFeCoNi ***,the main deformation mechanism changed from deformation twinning to dislocation-mediated slip,resulting in much higher strain hardening capacity after the aging *** work led to the development of an alternative promising method that involves tailoring the microstructure,to enhance the mechanical properties of additively manufactured metallic materials that contain interstitial atoms.

关键词： Selective laser melting High-entropy alloy Carbon contents Aging Microstructure evolution Tensile property Deformation mechanism

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Effect of carrier gas species on the microstructure and compressive deformation behaviors of ultra-strong pure copper manufactured by cold spray additive manufacturing

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Journal of Materials Science & Technology 2022年第2期97卷 264-271页

作者： young-Kyun Kim kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea

Cold spray(CS)which has recently become a promising additive manufacturing(AM)technology,was used to fabricate ultra-strong pure *** addition,the effects of carrier gas species on the microstructural characteristics,mechanical properties and deformation mechanisms were systemically *** CSAM copper manufactured with N_(2) carrier gas reveals a heterogeneous bimodal microstructure consisting of ultra-fine grains at the particle interface and relatively coarse grains in inner *** He carrier gas,a homogeneous grain structure consisting of ultra-fine grains in most areas was *** tests showed that N_(2) and He carrier gasses enabled ultra-high yield strengths of 340 and415 MPa,*** values are comparable to severely plastic deformed copper,which has extremely low ductility and shape *** the other hand,both samples showed a strain-softening phenomenon that does not commonly occur at room *** deformation microstructures revealed that dynamic recovery(DRV)and dynamic recrystallization(DRX)phenomena were generated despite being deformed at room *** on the above findings,the overall deformation mechanisms according to the carrier gas species in the CSAM copper manufacturing process were ***,the work hardening and softening behaviors of CSAM Cu are predicted by using a constitutive equation.

关键词： Cold spray additive manufacturing Carrier gas Pure Cu Mechanical properties Deformation behavior

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Effect of asymmetrical channel chirping on field intensity patterns of supermodes and modal discrimination in index guided laser arrays

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Journal of Central South University 2014年第9期21卷 3513-3517页

作者： kee-young Kwon College of Engineering Kongju National University

The effect of channel-width chirping on near- and far-field intensity patterns of the six supermodes was investigated. The supermode discrimination was evaluated in various channel-chirped index guided laser arrays. The results show that the linearly channel-chirped laser array has very good supermode discrimination which is better than that of a uniform laser array, the V channel-chirped laser array has the smallest radiation angle of the fundamental supermode among the calculated arrays, and the asymmetrically V channel-chirped array has a very small radiation angle of the fundamental supermode, which is smaller than that of the uniform array and also allows for very good fundamental supermode discrimination against the higher-order supermodes, which is better than that of the V channel-chirped laser array.

关键词： laser array channel-width chirping field pattern modal gain

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Facial Expression Recognition of Various Internal States via Manifold Learning

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Journal of Computer Science & Technology 2009年第4期24卷 745-752页

作者： young-Suk shin IEEE Department of Information and Communication Engineering Chosun University

Emotions are becoming increasingly important in human-centered interaction architectures. Recognition of facial expressions, which are central to human-computer interactions, seems natural and desirable. However, facial expressions include mixed emotions, continuous rather than discrete, which vary from moment to moment. This paper represents a novel method of recognizing facial expressions of various internal states via manifold learning, to achieve the aim of humancentered interaction studies. A critical review of widely used emotion models is described, then, facial expression features of various internal states via the locally linear embedding （LLE） are extracted. The recognition of facial expressions is created with the pleasure-displeasure and arousal-sleep dimensions in a two-dimensional model of emotion. The recognition result of various internal state expressions that mapped to the embedding space via the LLE algorithm can effectively represent the structural nature of the two-dimensional model of emotion. Therefore our research has established that the relationship between facial expressions of various internal states can be elaborated in the two-dimensional model of emotion, via the locally linear embedding algorithm.

关键词： manifold learning locally linear embedding dimension model pleasure-displeasure dimension arousal-sleep dimension

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