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Systematic study of(MoTa)_(x)NbTiZr medium-and high-entropy alloys for biomedical implants-In vivo biocompatibility examination

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Journal of Materials Science & Technology 2021年第19期78卷 183-191页

作者： Muhammad Akmal Ahtesham Hussain Muhammad Afzal young ik lee Ho Jin Ryu Department of Materials Science and Engineering KAISTYuseongDaejeon 34141South Korea lee's Biotech Co. Ltd.#415C-Dong13 Techno-4-roYuseong-guDaejeon34013South Korea Department of Mechanical Engineering KAISTYuseongDaejeon34141South Korea Department of Nuclear and Quantum Engineering KAISTYuseongDaejeon 34141South Korea

In this study,the application of medium-and high-entropy(Mo Ta)_(x)Nb Ti Zr alloys in biomedical implants was systematically *** alloy with the best combination of mechanical properties was selected and characterized for in vitro and in vivo response for the first time to examine its biomedical properties.A logarithmic increase in the hardness and the yield strength was observed as a function of the Mo and Ta *** with up to 0.4 mol fraction of Mo and Ta showed a plastic strain of more than 30%under *** nanoindentation results showed that the addition of Mo and Ta increased the elastic modulus of the system *** was surmised that the addition of Ta and Mo above a critical concentration(mole fraction=0.4)was unfavorable from a biomedical perspective as it increased the brittleness and elastic modulus and decreased the ductility of the ***,the(Mo Ta)_(0.2)Nb Ti Zr alloy is a potential structural material for biomedical implants because of its excellent strength and *** developed alloy was investigated for its corrosion properties and compared with commercial biomedical ***,the biocompatibility of the alloy was examined using an in vivo *** alloy was implanted in the skeletal muscles of mice for four weeks and the histology of the surrounding tissue was *** alloy exhibited strong passive behavior in a phosphate buffer solution and non-toxic soft tissue response.

关键词： High-entropy alloys Medium-entropy alloys Biomedical applications In vivo Biocompatibility

Analysis of expanded criteria to select candidates for active surveillance of low-risk prostate cancer

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Asian Journal of Andrology 2015年第2期17卷 248-252,I0008,I0009页

作者： Jung Ki Jo Hart Sol lee young ik lee Sang Eun lee Sung Kyu Hong Department of Urology Seoul National University Bundang Hospital Seongnam Korea.

We aimed to analyze the value of each criterion for clinically insignificant prostate cancer （PCa） in the selection of men for active surveillance （AS） of low-risk PCa. We identified 532 men who were treated with radical prostatectomy from 2006 to 2013 who met 4 or all 5 of the criteria for clinically insignificant PCa （clinical stage 〈 T1, prostate specific antigen [PSA] density 0.15, biopsy Gleason score 〈 6, number of positive biopsy cores 〈 2, and no core with 〉 50% involvement） and analyzed their pathologic and biochemical outcomes. Patients who met all 5 criteria for clinically insignificant PCa were designated as group A （n -- 172）, and those who met 4 of 5 criteria were designated as group B （n = 360）. The association of each criterion with adverse pathologic features was assessed via logistic regression analyses. Comparison of group A and B and also logistic regression analyses showed that PSA density 0.15 ng ml-1 and high （〉7） biopsy Gleason score were associated with adverse pathologic features. Higher （〉 Tlc） clinical stage was not associated with any adverse pathologic features. Although 〈 3 positive cores were not associated with any adverse pathology, 〉4 positive cores were associated with higher risk of extracapsular extension. Among potential candidates for AS, PSA density ~ 0.15 ng ml-~ and biopsy Gleason score ~ 6 pose significantly higher risks of harboring more aggressive disease. The eligibility criteria for AS may be expanded to include men with clinical stage T2 tumor and 3 positive cores.

关键词： prediction prostate prostatectomy prostatic neoplasms risk

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑young Kim Yang Li Guozhen Shen Jong‑Chul lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee lee Yu-Ra Jeon Changmin Shin Sun-young Kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Usefulness of magnifying endoscopy for iodine-unstained lesions in a high-risk esophageal cancer population

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World Journal of Gastroenterology 2010年第37期16卷 4709-4715页

作者： ik Seong Choi Jae young Jang Won young Cho Tae Hee lee Hyun Gun Kim Bo young lee Soung Won Jeong Joo young Cho Joon Seong lee So young Jin Institute for Digestive Research SoonChunHyang University College of Medicine

AIM: To investigate the usefulness of magnified observations of iodine-unstained esophageal lesions in the histological diagnosis of esophageal mucosa abnormalities, in high-risk esophageal cancer groups. METHODS: The subjects included 38 patients who had at least one of the four criteria known to be highrisk factors for esophageal cancer. Following endoscopic observation, magnified observations were performed on iodine-unstained lesions of the esophagus. The total number of lesions was 43. These lesions were classified as type A (clear papilla), type B (fused papilla), and type C (non-visible papilla) according to the findings. Tissue biopsy was then carried out. Finally the histological findings were graded in terms of histological factors, and their relationships were compared. RESULTS: Of the 43 lesions, 11 were type A, 17 were type B, and 15 were type C under magnifying endoscopy. Histological findings such as inflammatory cell infiltration and basal cell hyperplasia were significantly increased in type B and type C lesions compared with type A lesions (P < 0.05). Low-grade esophageal dysplasia was apparent in 1 (9%) of 11 type A lesions, in 3 (18%) of 17 type B lesions, and in 6 (40%) of 15 type C lesions, with the highest rate in type C. CONCLUSION: Magnified observations of the esophagus, classified by papillary aspects using magnifying endoscopy of iodine-unstained lesions in high-risk esophageal cancer groups, are considered useful in estimating dysplasia and inflammation of esophageal mucosa.

关键词： Esophageal cancer Iodine Magnifying endoscopy

Cutaneous metastasis as an initial presentation of a non-functioning pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2015年第33期21卷 9822-9826页

作者： Woo young Shin Keon young lee Seung ik Ahn Shin-young Park Keun-Myoung Park Department of Surgery Inha University HospitalInha University College of Medicine

Non-functioning pancreatic neuroendocrine tumors(NF-PNETs) are rare tumors that account for 2% of all pancreatic *** 60% of NF-PNETs present distant metastases and usually hepatic ***,cutaneous metastases are very ***,we report our experience with a 60-yearold male who visited our outpatient clinic with a mass on his left *** abdominal computerized tomography scan demonstrated not only a left hip mass and an enlarged left inguinal lymph node,but also a huge heterogeneous enhancing mass on the ***,we removed the metastatic lesions,which was a small cell neuroendocrine carcinoma with 50% of the Ki-67 index in the histopathological *** 3 wk,we performed a total pancreatectomy and a total *** weeks after the 1st operation,we detected a recurrence at the operative bed on his left hip,and subsequently removed the recurring *** patient was receiving chemotherapy based on etoposide and cisplatin treatment.

关键词： Pancreas Neuroendocrine tumor Skin neoplasm Neopla

Technical issues and new devices of ESD of early gastric cancer

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World Journal of Gastroenterology 2011年第31期17卷 3585-3590页

作者： Wan Sik lee Jin Woong Cho young Dae Kim Kyu Jong Kim Byung ik Jang Division of Gastroenterology Department of Internal MedicineChonnam University Medical School Division of Gastroenterology and Hepatology Department of Internal MedicinePresbyterian Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of MedicineChosun University Division of Gastroenterology Department of Internal MedicineKosin University College of Medicine Division of Gastroenterology Department of Internal MedicineYeungnam University College of Medicine

Endoscopic submucosal dissection(ESD) is a highly refined technique compared to conventional endoscopic mucosal *** enables complete resection of early gastric cancer(EGC) which has no possibility of lymph node *** for ESD of EGC generally entails early gastric cancer confined to the mucosa with well differentiated histology,though there are clinically suitable expanded *** ESD requires specific skill and expertise,endoscopists need to be familiarized with basic methods and the use of special *** essence of the technique is to dissect the submucosal layer with direct vision and maintain thecutting plane above the underlying proper muscle *** there are some differences in the detailed technical aspect,the cardinal method of ESD is now well established and ***,research and development of new ESD devices that render more efficient,safe ESD are still in progress to improve the overall result of ESD on early gastric cancer.

关键词： Endoscopic submucosal dissection Technique Device Early gastric cancer

Mechanically resilient,alumina-reinforced carbon nanotube arrays for in-plane shock absorption in micromechanical devices

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Microsystems & Nanoengineering 2023年第3期9卷 73-81页

作者： Eunhwan Jo Hojoon lee Jae-ik lee Jongbaeg Kim School of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Neurosurgery Massachusetts General HospitalHarvard Medical School25 Shattuck StBostonMA 02115USA

Microelectromechanical systems(MEMS)are of considerable interest due to their compact size and low power consumption when used in modern *** devices intrinsically incorporate three-dimensional(3D)microstructures for their intended operations;however,these microstructures are easily broken by mechanical shocks accompanying high-magnitude transient acceleration,inducing device *** various structural designs and materials have been proposed to overcome this limit,developing a shock absorber for easy integration into existing MEMS structures that effectively dissipates impact energy remains ***,a vertically aligned 3D nanocomposite based on ceramic-reinforced carbon nanotube(CNT)arrays is presented for in-plane shock-absorbing and energy dissipation around MEMS *** geometrically aligned composite consists of regionally-selective integrated CNT arrays and a subsequent atomically thick alumina layer coating,which serve as structural and reinforcing materials,*** nanocomposite is integrated with the microstructure through a batch-fabrication process and remarkably improves the in-plane shock reliability of a designed movable structure over a wide acceleration range(0-12,000g).In addition,the enhanced shock reliability through the nanocomposite was experimentally verified through comparison with various control devices.

关键词： shock plane arrays

Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization

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World Journal of Gastroenterology 2013年第28期19卷 4537-4544页

作者： young-Joo Jin Jin-Woo lee Seoung-Wook Park Jung Il lee Don Haeng lee young Soo Kim Soon Gu Cho Yong Sun Jeon Kun young lee Seung-ik Ahn Department of Internal Medicine Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea Department of Internal Medicine Yonsei University College of Medicine Seoul 120-752 South Korea Department of Internal Medicine and Center for Advanced Medical Education by Brain Korea 21 Project Inha University School of Medicine and Utah-Inha DDS and Advanced Therapeutics Research Center Incheon 400-711 South Korea Department of Radiology Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea Department of Surgery Inha University Hospital Inha University School of Medicine Incheon 400-711 South Korea

AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE.

关键词： Ruptured hepatocellular carcinoma Surgery Transarterial embolization