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Vasorelaxant effects of 50 commonly used traditional herbal prescriptions on isolated rat aortic rings

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Journal of Traditional Chinese Medicine 2020年第4期40卷 629-639页

作者： Bumjung Kim Cheolmin Jo Somin Lee Hanna choi Kwang-Woo Kim Inhye Ham ho-young choi Kyungjin Lee Department of Oriental Health Management Kyung Hee Cyber UniversitySeoul 02447Republic of Korea Department of Herbal pharmacology College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Herbal pharmacology Graduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea Department of Biomedical Science and Technology Graduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea

OBJECTIVE:To investigate the vasorelaxant activities of 50 common traditional herbal prescriptions(THPs)on isolated rat aortic ***:An electric extractor was used to extract *** aortic rings were precontracted using phenylephrine in organ chambers containing Krebs-Henseleit *** of THPs were added in increasing concentrations(10-1000μg/mL)to investigate vasorelaxant *** vasorelaxant effects of THPs were calculated as percentage of contraction in response to ***:Several THPs such as Tianwangbuxin Dan,Banxiaxiexin Tang,and Mahuang Tang,significantly relaxed precontracted aortic *** contrast,Xiaochaihu Tang,Shensuyin,and Guizhifuling Wan significantly contracted aortic ***,these THPs increasingly relaxed or contracted aortic rings relaxed by ***:Our findings suggest that hypertension can be treated using *** some THPs can counteract treatment of *** studies should be developed on use of THPs for treatment of hypertension are critical,and guidelines for use of traditional herbal medicines to treat hypertension.

关键词： Hypertension Vasodilation Vasoconstriction Herbal medicine

A Cu-Pd alloy catalyst with partial phase separation for the electrochemical CO_(2) reduction reaction

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Journal of Energy Chemistry 2024年第6期93卷 8-15,I0001页

作者： Gyeong ho Han Jung Yong Seo Minji Kang Myung-gi Seo youngheon choi Soo young Kim Sang Hyun Ahn School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Republic of Korea Lotte Chemical Institute of Technology Daejeon 34110Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Cu catalysts can convert CO_(2) through an electrochemical reduction reaction into a variety of useful carbon-based ***,this capability provides an obstacle to increasing the selectivity for a single ***,we report a simple fabrication method for a Cu-Pd alloy catalyst for use in a membrane electrode assembly(MEA)-based CO_(2) electrolyzer for the electrochemical CO_(2) reduction reaction(ECRR)with high selectivity for CO *** the composition of the Cu-Pd alloy catalyst was fabricated at 6:4,the selectivity for CO increased and the production of multi-carbon compounds and hydrogen is *** a Cu-Pd alloy catalyst with 6:4 ratio as the cathode of the MEAbased CO_(2) electrolyzer showed a CO faradaic efficiency of 92.8%at 2.4 V_(cell).We assumed that these results contributed from the crystal planes on the surface of the Cu-Pd *** phases of the Cu-Pd alloy catalyst were partially separated through annealing to fabricate a catalyst with high selectivity for CO at low voltage and C_(2)H_4 at high *** results of CO-stripping testing confirmed that when Cu partially separates from the lattice of the Cu-Pd alloy,the desorption of~*CO is suppressed,suggesting that C-C coupling reaction is favored.

关键词： Cu-Pd catalyst Electrodeposition Electrochemical carbon dioxide reduction Partial phase separation Membrane electrode assembly-based electrolyzer

Arteriovenous Graft Modeling and Hemodynamic Interpretation

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Open Journal of Fluid Dynamics 2012年第4期2卷 324-330页

作者： Hyoung-ho Kim young ho choi Sang-ho Suh Jeong Sang Lee young hoon Jung young ho So Department of Mechanical Engineering Soongsil University Seoul South Korea Department of Radiology Seoul National University Boramae Hospital Seoul South Korea Department of Thoracic and Cardiovascular Surgery Seoul National University Boramae Hospital Seoul South Korea

Arteriovenous graft (AVG) is artificially made with graft for hemodialysis in the patients with renal failure. Stenosis in the arterial or venous anastomosis of AVG results in its malfunction. Here, we made an AVG hemodynamic model with three different anastomotic angles (20°, 30°, 40°) and analyzed hemodynamic parameters such as velocity vectors, WSS and OSI in the arterial and venous anastomosis to find what helps in developing new surgical techniques to reduce stenosis in the anastomosis. Recirculation flow, low WSS and high OSI in the venous anastomosis were demonstrated in 30° and 40°?models, and recirculation flow, high WSS and high OSI in the arterial anastomosis were shown in all models. Conclusively, higher anastomosis angle in the venous anastomosis cause stenosis, but stenosis in the arterial anastomosis happens irregardless of anastomosis angle.

关键词： Ateriovenous Fistula Bypass Graft Hemodynamic Interpretation Numerical Analysis

Deciphering metastatic route-specific signals and their microenvironment interactions in peritoneal metastasis of gastric cancer

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Cancer Communications 2024年第4期44卷 514-517页

作者： Ki Tae Kim Jae Eun Lee Jae-ho Cheong In Cho Yoon young choi Department of Molecular Genetics&Dental Pharmacology School of DentistrySeoul National UniversitySeoulRepublic of Korea Dental Research Institute and Dental Multi-omics Center Seoul National UniversitySeoulRepublic of Korea Portrai Inc. SeoulRepublic of Korea Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoulRepublic of Korea Department of Surgery Soonchunhyang Bucheon HospitalSoonchunhyang University College of MedicineBucheonRepublic of Korea

Gastric cancer(GC)is a pervasive global malignancy with high mortality rates due to distant metastasis[1].GC metastasis can occur via hematogenous route,peri-toneal route,and specifically through ovarian spread in females[2].Among these,peritoneal metastasis is the most prevalent and challenging condition to treat[3].The Cancer Genome Atlas(TCGA)has uncovered four molec-ular subtypes of GC:microsatellite instability,Epstein-Barr virus-related,chromosomal instability,and genomically stable[4].

关键词： metastasis peritoneal cancer

Development of vehicle-recognition method on water surfaces using LiDAR data:SPD^(2)(spherically stratified point projection with diameter and distance)

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Defence Technology（防务技术） 2024年第6期36卷 95-104页

作者： Eon-ho Lee Hyeon Jun Jeon Jinwoo choi Hyun-Taek choi Sejin Lee The Department of Mechanical Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea Ocean System Engineering Research Division Korea Research Institute of Ships and Ocean Engineering(KRISO)Daejeon 34103Republic of Korea The Division of Mechanical&Automotive Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea

Swarm robot systems are an important application of autonomous unmanned surface vehicles on water *** monitoring natural environments and conducting security activities within a certain range using a surface vehicle,the swarm robot system is more efficient than the operation of a single object as the former can reduce cost and save *** is necessary to detect adjacent surface obstacles robustly to operate a cluster of unmanned surface *** this purpose,a LiDAR(light detection and ranging)sensor is used as it can simultaneously obtain 3D information for all directions,relatively robustly and accurately,irrespective of the surrounding environmental *** the GPS(global-positioning-system)error range exists,obtaining measurements of the surface-vessel position can still ensure stability during platoon *** this study,a three-layer convolutional neural network is applied to classify types of surface *** aim of this approach is to redefine the sparse 3D point cloud data as 2D image data with a connotative meaning and subsequently utilize this transformed data for object classification ***,we have proposed a descriptor that converts the 3D point cloud data into 2D image *** use this descriptor effectively,it is necessary to perform a clustering operation that separates the point clouds for each *** developed voxel-based clustering for the point cloud ***,using the descriptor,3D point cloud data can be converted into a 2D feature image,and the converted 2D image is provided as an input value to the *** intend to verify the validity of the proposed 3D point cloud feature descriptor by using experimental data in the ***,we explore the feasibility of real-time object classification within this framework.

关键词： Object classification Clustering 3D point cloud data LiDAR(light detection and ranging) Surface vehicle

Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo young Cho Dong Hae ho Sae Byeok Jo Jeong ho Cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

Efficacy of Uterine Artery Embolization for Patients with Postpartum Hemorrhage

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Open Journal of Radiology 2013年第2期3卷 51-55页

作者： young ho choi Yasutaka Baba Shunichiro Ikeda young ho So Sadao Hayashi Masayuki Nakajo Department of Radiology Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima Japan Department of Radiology SMG-SNU Boramae Medical Center Seoul Republic of Korea

Purpose: To investigate the efficacy of uterine arterial embolization (UAE) in patients with post-partum hemorrhage (PPH). Materials and Methods: The subjects were 40 women (mean age, 33 years;age range, 21 - 42 years) who underwent UAE for PPH at two institutes from June 2001 to May 2011. The rates of clinical success (avoidance of hysterectomy) and complications were calculated. Differences in related factors between primary PPH and secondary PPH and between caesarean section and vaginal delivery were examined. The risk factors associated with hysterectomy were also examined. Results: The overall clinical success rate was 90% (93% of primary PPH, 77% of secondary PPH, and 87.5% of PPH with cesarean section), and the overall complication rate was 10%. There were significant differences in time to PPH (P hods. The significant factors associated with hysterectomy were cesarean section (P = 0.02), severe PPH (>1000 mL bleeding, P = 0.03), and embolization of non-uterine arteries (P = 0.02).

关键词： Postpartum Hemorrhage Uterine Artery Embolization Uterus Preservation

Multiphase cooperation for multilevel strain accommodation in a single-crystalline BiFeO3 thin film

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Chinese Physics B 2024年第9期33卷 57-66页

作者： Wooseon choi Bumsu Park Jaejin Hwang Gyeongtak Han Sang-Hyeok Yang Hyeon Jun Lee Sung Su Lee Ji young Jo Albina Y.Borisevich Hu young Jeong Sang ho Oh Jaekwang Lee young-Min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Samsung Electronics Hwaseong 18448Republic of Korea Department of Physics Pusan National UniversityBusan 46241Republic of Korea LG Energy Solution Daejeon 34122Republic of Korea Department of Materials Science and Engineering Kangwon National UniversityRepublic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea Center for Nanophase Materials Sciences Oak Ridge National LaboratoryTN 37831USA Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Energy Engineering KENTECH Institute for Energy Materials and DevicesKorea Institute of Energy Technology(KENTECH)Naju 58330Republic of Korea

The functionalities and diverse metastable phases of multiferroic BiFeO3(BFO)thin films depend on the misfit *** mixed phase-induced strain relaxation in multiphase BFO thin films is well known,it is unclear whether a singlecrystalline BFO thin film can accommodate misfit strain without the involvement of its ***,understanding the strain relaxation behavior is key to elucidating the lattice strain–property *** this study,a correlative strain analysis based on dark-field inline electron holography(DIH)and quantitative scanning transmission electron microscopy(STEM)was performed to reveal the structural mechanism for strain accommodation of a single-crystalline BFO thin *** nanoscale DIH strain analysis results indicated a random combination of multiple strain states that acted as a primary strain relief,forming irregularly strained *** STEM-based bond length measurement of the corresponding strained nanodomains revealed a unique strain accommodation behavior achieved by a statistical combination of multiple modes of distorted structures on the unit-cell *** globally integrated strain for each nanodomain was estimated to be close to􀀀1.5%,irrespective of the nanoscale strain states,which was consistent with the fully strained BFO film on the SrTiO3 *** functional theory calculations suggested that strain accommodation by the combination of metastable phases was energetically favored compared to single-phase-mediated *** discovery allows a comprehensive understanding of strain accommodation behavior in ferroelectric oxide films,such as BFO,with various low-symmetry polymorphs.

关键词： BiFeO_(3) scanning transmission electron microscopy electron holography multiferroic material strain mapping

Unraveling the Harmonious Coexistence of Ruthenium States on a Self-Standing Electrode for Enhanced Hydrogen Evolution Reaction

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Energy & Environmental Materials 2024年第6期7卷 303-311页

作者： Joonhee Ma Jin Hyuk Cho Chaehyeon Lee Moon Sung Kang Sungkyun choi ho Won Jang Sang Hyun Ahn Seoin Back Soo young Kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Korea Department of Chemical and Biomolecular Engineering Institute of Emergent MaterialsSogang UniversitySeoul 04107Korea Department of Cogno-Mechatronics Engineering College of Nanoscience and NanotechnologyPusan National UniversityBusan 46241Korea Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Korea School of Chemical Engineering and Material Science Chung-Ang UniversitySeoul 06974Korea

The development of cost-effective,highly efficient,and durable electrocatalysts has been a paramount pursuit for advancing the hydrogen evolution reaction(HER).Herein,a simplified synthesis protocol was designed to achieve a self-standing electrode,composed of activated carbon paper embedded with Ru single-atom catalysts and Ru nanoclusters(ACP/Ru_(SAC+C))via acid activation,immersion,and high-temperature *** initio molecular dynamics(AIMD)calculations are employed to gain a more profound understanding of the impact of acid activation on carbon ***,the coexistence states of the Ru atoms are confirmed via aberration-corrected scanning transmission electron microscopy(AC-STEM),X-ray photoelectron spectroscopy(XPS),and X-ray absorption spectroscopy(XAS).Experimental measurements and theoretical calculations reveal that introducing a Ru single-atom site adjacent to the Ru nanoclusters induces a synergistic effect,tuning the electronic structure and thereby significantly enhancing their catalytic ***,the ACP/Ru_(SAC+C)exhibits a remarkable turnover frequency(TOF)of 18 s^(−1)and an exceptional mass activity(MA)of 2.2 A mg^(−1),surpassing the performance of conventional Pt *** self-standing electrode,featuring harmoniously coexisting Ru states,stands out as a prospective choice for advancing HER catalysts,enhancing energy efficiency,productivity,and selectivity.

关键词： electrocatalysis electronic coupling effect hydrogen evolution reaction selfstanding electrode