检索结果-南通市图书馆

Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-Hyun jeong Ji-Hun Jang Hea-young Cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

Prediction of Coastal Fecal Indicator Bacteria Concentrations Using Multivariate Data Analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering(A) 2012年第4期1卷 440-447页

作者： Ki beom Kim Jae Hoon Kim youngsul jeong young Seon jeong Sung-Jae Chung Walt Whitman High School Bethesda MD 20817 USA Washington Baptist University Annandale VA 22003 USA College of Engineering Khalifa University of Science Technology and Research Abu Dhabi UAE Marymount University Arlington VA 22207 USA

The application of multivariate data analysis, a method for coping with multi-colinearity among independent variables in analyzing coastal water quality data, is presented. This study investigates the statistical regression modeling of FIB （fecal indicator bacteria） concentrations at the outlet of Talbert Marsh in Orange County, California. The multivariate data modeling utilized FIB and physical variables measurements （n = 5,580） collected during a series of longitudinal study of the Talbert Marsh. For the statistical prediction modeling in predicting the FIB concentrations at the outlet of the Talbert Marsh, multivariate analysis techniques such as PCR （principal components regression）, PLS （partial least-squares） regression and SVM （support vector machine） regression were adopted. Statistical modeling results suggest that the statistical modeling predictions are all fell within the reasonable range of actual measurement data. In addition, it is indicated that the accuracy of SVM regression for predicting FIB concentrations at the Talbert Marsh outlet is better than that of other models.

关键词： Multivariate statistical analysis fecal pollution coastal saltwater marsh.

Conventional vs drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2017年第18期9卷 808-814页

作者： jeong Eun Song Do young Kim Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea

Transarterial chemoembolization(TACE) is the current standard of therapy for patients with intermediatestage hepatocellular carcinoma(HCC) according to the Barcelona Clinic Liver Cancer classification. The concept of conventional TACE(cTACE) is the selective obstruction of tumor-feeding artery by injection of chemotherapeutic agents, leading to ischemic necrosis of the target tumor via cytotoxic and ischemic effects. Drugeluting beads(DEBs) have been imposed as novel drugdelivering agents for TACE, which allows for higher concentrations of drugs within the target tumor and lower systemic concentrations compared with cTACE. Despite the theoretical advantages of DEB-TACE, it is still controversial in clinical practice as to whether DEBTACE is superior to cTACE in regard to overall survival and treatment response. In this review article, we summarize the clinical efficacy and safety of DEB-TACE for patients with intermediate or advanced stage HCC in comparison with cTACE.

关键词： Hepatocellular carcinoma Drug-eluting beads transarterial chemoembolization Transarterial chemoembolization

Vaporization reduction characteristics of aqueous ammonia solutions by the addition of ethylene glycol, glycerol and glycine to the CO_2 absorption process

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第3期24卷 494-498页

作者： Jong-beom Seo Soo-Bin Jeon Je-young Kim Gang-Woo Lee Jong-Hyeon Jung Kwang-Joong Oh Department of Environmental Engineering Pusan National University Busan 609735 Korea. Research Institute of Industrial Science & Technology Pohang 790330 Korea Research & Development Institute of Yoosung Co. Ltd. Ulsan 680070 Korea Faculty of Health Science Daegu Haany University Daegu 712715 Korea

Aqueous ammonia （NH3） solution can be used as an alternative absorption for the control of CO2 emitted from flue gases due to its high absorption capacity, fast absorption rate and low corrosion problem. The emission of CO2 from iron and steel plants requires much attention, as they are higher than those emitted from power plants at a single point source. In the present work, low concentration ammonia liquor, 9 wt.%, was used with various additives to obtain the kinetic properties using the blast furnace gas model. Although a solution with a high ammonia concentration enables high CO2 absorption efficiency, ammonium ions are lost as ammonia vapor, resulting in reduced CO2 absorption due to the lower concentration of the ammonia absorbent. To decrease the vaporization of ammonia, ethylene glycol, glycerol and glycine, which contain more than one hydroxyl radical, were chosen. The experiments were conducted at 313 K similar to the CO2 absorption conditions for the blast furnace gas model.

关键词： ammonia vaporization blast furnace gas ethylene glycol glycerol glycine

Flow characteristics of aluminum coated boron steel in hot press forming

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第4期19卷 913-916页

作者： jeong-Hwan JANG Jae-Ho LEE Bye ong-Don JOO young-Hoon MOON School of Mechanical Engineering Pusan National University

The flow characteristics of aluminum coated boron steel in hot press forming were ***,the effects of aluminum coated layer on press forming were analyzed during deep *** results show that aluminum coated boron steel exhibits a high sensitivity on temperature and strain *** coating layer appears in surface flaking in a temperature range of 700-800 ℃,but smooth surface is formed above 900 ℃.

关键词：热压成型流动特性铝涂层硼钢表面剥落温度范围冲压成形高灵敏度

The efficacy of *** adjuvant chemotherapy on biliary tract cancer after R0 resection

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第5期36卷 222-230页

作者： young Saing Kim Chi-young jeong Haa-Na Song Tae Hyo Kim Hong Jun Kim young-Joon Lee Soon Chan Hong Division of Hematology and Oncology Department of Internal MedicineGachon University Gil Medical Center Incheon 405.706 South Korea Department of Surgery Institute of Health Sciences Gyeongsang National University Hospital Gyeongsang National University School of Medicine 79 Gangnam-roJinju 660.702 South Korea Department of Internal Medicine Institute of Health Sciences Gyeongsang National University Hospital Gyeongsang National University School of Medicine Jinju 660.702 South Korea.

Background: The optimal treatment strategy for biliary tract cancer(BTC) after curative?intent resection remains con?troversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine?based adjuvant chemotherapy for BTC patients undergoing microscopically margin?negative(R0) ***: We retrospectively analyzed the clinical data of BTC patients who underwent curative?intent R0 resection. Patients were eligible if they received either fluoropyrimidine?based adjuvant chemotherapy or observation after R0 ***: A total of 153 patients were included. In the entire patient cohort, no significant differences were observed in 5?year overall survival(OS) rates(48.4% vs. 39.6%, P = 0.439) or 3?year recurrence?free survival(RFS) rates(49.1% vs. 39.5%, P = 0.299) between patients who received fluoropyrimidine?based adjuvant chemotherapy or observation. However, for patients with stages Ⅱ and Ⅲ BTC, chemotherapy significantly improved 5?year OS rate(52.4% vs. 35.6%, P = 0.002) and 3?year RFS rate(55.5% vs. 39.1%, P = 0.021) compared with ***: Fluoropyrimidine?based adjuvant chemotherapy may prolong the survival of patients with stages Ⅱ and Ⅲ BTC after R0 resection.

关键词： Biliary tract cancer Adjuvant chemotherapy Fluoropyrimidine R0 resection Prognosis

Risks of non-conservative design according to ASME B31.1 for high-temperature piping subjected to long-term operation in the creep range

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2019年第5期30卷 59-69页

作者： Hyeong-Yeon Lee Seok-Kwon Son Min-Gu Won Ji-young jeong Korea Atomic Energy Research Institute National Fusion Research Institute School of Mechanical Engineering Sungkyunkwan University

This study investigates the risks of non-conservative piping design according to ASME B31.1 for hightemperature piping subjected to long-term operation at high temperature in a creep regime based on a sensitivity analysis of the hold time. Design evaluations of hightemperature piping were conducted over a range of hold times in the creep regime according to ASME B31.1,which implicitly considers the creep effects, and the French high-temperature design code of the RCC-MRx, which explicitly considers the creep effects. Conservatisms were quantified among the codes in terms of the hold times. In the case of B31.1, the design evaluation results do not change depending on the hold time at high temperature,whereas in the case of RCC-MRx, they do. It was shown that the design limits of RCC-MRx were exceeded when the hold time exceeded certain values, whereas those of B31.1 were satisfied regardless of the hold times. Thus, the design evaluations according to B31.1 did not consistently yield conservative results and might lead to non-conservative results in the case of long-term operations in the creep range.

关键词： ASME B31.1 Creep Hold time Hightemperature piping RCC-MRx Sensitivity analysis

Hot electron generation on metal catalysts under surface reaction:Principles, devices, and application

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第6期29卷 727-733页

作者： Ievgen I.Nedrygailov Hyosun Lee Si Woo Lee jeong young Park Center for Nanomaterials and Chemical Reactions Institute for Basic Science Graduate School of EEWS Korea Advanced Institute of Science and Technology(KAIST)

Understanding the fundamental mechanisms for charge transfer in supported catalysts is of great importance for heterogeneous catalysis. Several experimental and theoretical results suggest that charge flow through metal-support interfaces leads to the catalytic enhancement that is often observed in mixed catalysts. Therefore, it is crucial to directly probe this charge flow in metal-support catalysts during catalytic reactions. In this review, we consider the main aspects of research studying the processes that create and allow interfacial transfer of highly excited（hot） charge carriers in supported catalysts, and discuss the effect of this charge transfer on catalytic activity. We show a close connection between the phenomena of hot electron creation and chemical energy dissipation that accompanies catalytic reactions at both the gas/solid and liquid/solid interfaces. The intensity of hot electron flow is well correlated with the turnover rates of corresponding reactions, which opens up the possibility for developing new operando methodologies for studying chemical processes on catalytic surfaces.

关键词： Hot electron Energy dissipation Heterogeneous catalysis Metal-support interactions Nanodiode

Long-term clinical outcome between beta-blocker with ACEI or ARB in patients with NSTEMI who underwent PCI with drug-eluting stents

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2019年第3期16卷 280-290页

作者： Yong Hoon Kim Ae-young Her Eun-Seok Shin Myung Ho jeong Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Division of Cardiology Department of Internal MedicineUlsan Medical CenterUlsan HospitalUlsanSouth Korea Chonnam National University Hospital GwangjuSouth Korea

Background Because limited comparative data are available,we decided to compare 2-year major clinical outcomes between beta-blockers (BB) with angiotensin converting enzyme inhibitors (ACEI) and BB with angiotensin receptor blockers (ARB) therapy in patients with non-ST-segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).Methods A total 11,288 NSTEMI patients who underwent PCI with DES were enrolled and they were divided into two groups,the BB with ACEI group (n = 7600) and the BB with ARB group (n = 3688).The major clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death,recurrent myocardial infarction (re-MI),total revascularization [target lesion revascularization (TLR),target vessel revascularization (TVR),non-TVR] rate during the 2-year follow-up *** After propensity score-matched (PSM) analysis,two PSM groups (3317 pairs,n = 6634,C-statistic = 0.695) were *** the cumulative incidences of all-cause death,cardiac death,TLR,and non-TVR were similar between the two groups,MACE (HR = 0.832,95% CI: 0.704?0.982,P = 0.030),total revascularization rate (HR = 0.767,95% CI: 0.598?0.984,P = 0.037),and TVR rate (HR = 0.646,95% CI: 0.470?0.888,P = 0.007) were significantly lower in the BB with ACEI group after *** In this study,we suggest that the combination of BB with ACEI may be beneficial for reducing the cumulative incidences of MACE,total revascularization rate,and TVR rather than the BB with ARB after PCI with DES in NSTEMI patients.

关键词： Angiotensin converting enzyme inhibitor Angiotensin receptor blocker Beta-blocker Myocardial infarction