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Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical,biological and environmental samples

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Journal of Pharmaceutical Analysis 2019年第6期9卷 373-391页

作者： Forough Karami Sara Ranjbar younes Ghasemi Manica Negahdaripour Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShirazIran Central Research Laboratory School of MedicineShiraz University of Medical SciencesShirazIran Chemistry Department Yasouj UniversityYasoujIran Department of Pharmaceutical Biotechnology School of PharmacyShiraz University of Medical SciencesShirazIran

Methotrexate(MTX)is a folate antagonist drug used for several diseases,such as cancers,various malignancies,rheumatoid arthritis(RA)and inflammatory bowel *** to its structural features,including the presence of two carboxylic acid groups and its low native fluorescence,there are some challenges to develop analytical methods for its *** is metabolized to 7-hydroxymethotrexate(7-OH-MTX),2,4-diamino-N10-methylpteroic acid(DAMPA),and the active MTX polyglutamates(MTXPGs)in the liver,intestine,and red blood cells(RBCs),***,the drug has a narrow therapeutic range;hence,its therapeutic drug monitoring(TDM)is necessary to regulate the pharmacokinetics of the drug and to decrease the risk of *** to environmental toxicity of MTX;its sensitive,fast and low cost determination in workplace environments is of great interest.A large number of methodologies including high performance liquid chromatography equipped with UVevisible,fluorescence,or electrochemical detection,liquid chromatography-mass spectroscopy,capillary electrophoresis,UVevisible spectrophotometry,and electrochemical methods have been developed for the quantitation of MTX and its metabolites in pharmaceutical,biological,and environmental *** paper will attempt to review several published methodologies and the instrumental conditions,which have been applied to measure MTX and its metabolites within the last decade.

关键词： Methotrexate Antifolate Anticancer Quantification High performance liquid chromatography

Efficient method for wind velocity estimation and power-extraction maximization using a fourth-order Luenberger observer in a wind-energy-conversion system

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Clean Energy 2022年第6期6卷 797-809页

作者： younes Azelhak Damien Voyer Hicham Medromi Laboratory of Research in Engineering(LRI) System Architecture Team(EAS)Hassan II University—ENSEM Casablanca 8118 Morocco EIGSI La Rochelle 17000 France 3Laboratory of Research in Engineering(LRI)System Architecture Team(EAS)Hassan II University—ENSEM Casablanca 8118Morocco

This paper proposes an advanced method for estimating numerous parameters in a wind-energy-conversion system with high precision,especially in a transient state,including the rotation speed and mechanical torque of the turbine as well as wind *** suggested approach is designed into two ***,a fourth-order Luenberger observer is proposed to take into account the significant fluctuations of the mechanical torque that can be caused by wind *** observer provides an accurate estimate of speed and mechanical torque in all weather conditions and especially when the wind is *** the same time,the wind velocity is calculated using the Luenberger observer outputs and a model of the mechanical power generated by the ***,these estimated parameters are exploited as input in a maximum-power-point tracking(MPPT)algorithm using the tip-speed ratio(TSR)to improve the sensorless strategy *** results were performed using MATLAB®/Simulink®for both wind gust and real wind *** have verified that for wind gusts with jumps ranging from 3 to 7 m/s,the new observer manages to better follow the rotation speed and the torque of the turbine compared to a usual *** addition,we demonstrated that by applying the proposed estimator in the improved TSR-MPPT strategy,it is possible to extract 3.3%more energy compared to traditional approaches.

关键词： wind velocity estimation mechanical parameters estimation MPPT algorithm wind-energy-conversion system

Fritz Ackermann:a true and unequalled friend

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Geo-Spatial Information Science 2023年第2期26卷 151-152页

作者： ed Mikhail Professor Emeritus&Former Head Geomatics Engineering Purdue UniversityWest LafayetteINUSA

I am certain that several other contributors to this memorial volume have expounded on the many attributes,both professional and personal,of Professor Fritz *** is unquestionable that he was a giant in our field,on whose shoulders current and future practitioners shall stand in order to keep the wheels of progress and advancement moving forward.

关键词： moving Fritz Ackermann

Wavelet networks for reducing the envelope fluctuations in WirelessMan-OFDM systems

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Digital Communications and Networks 2016年第2期2卷 77-83页

作者： Radouanelqdour younes Jabrane Regional Center for education Careers and Training. Marrakesh. Morocco OSCARS Laboratory National School of Applied Sciences Cadi Ayyad University Marrakesh Morocco

The IEEE 802.16d standard specified Orthogonal Frequency Division Multiplexing （OFDM） modulation for the Worldwide Interoperability for Microwave Access （WiMAX） physical layer. However, the main weakness of OFDM is the high Peak-to-Average Power Ratio （PAPR）. In this paper, we present two new approaches based on Wavelet Networks （WNs） for reducing the PAPR in the fixed WiMAX system. The training data is obtained from the ACE-AGP algorithm. The results of the simulations show the effec- tiveness of the proposed schemes even for high order modulation such as 64-QAM. Furthermore, the proposals allow reduction in the complexity and convergence time in comparison with other methods. 2016 Chongqing University of Posts and Telecommunications. Production and Hosting by Elsevier B.V.

关键词： WiMAX/OFDMPAPR reductionWavelet NetworkCubic metricACE-AGP

Neural network control for earthquake structural vibration reduction using MRD

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1171-1182页

作者： Khaled ZIZOUNI Ley la FALI younes SADEK Ismail Khalil BOUSSERhaNE ArcihPEL Laboratory University TAHRI MohammedBecharPB 417Algeria FIMAS Laboratory University TAHRJ MohammedBecharPB 417Algeria Laboratory of Smart-Grid and Renewable Energies University TAHRI MohammedBecharPB 417Algeria

Structural safety of building particularly that are intended for exposure to strong earthquake loads are designed and equipped with high technologies of control to ensure as possible as its protection against this brutal load. One of these technologies used in the protection of structures is the semi-active control using a Magneto Rheological Damper device. But this device need an adequate controller with a robust algorithm of current or tension adjustment to operate which is further discussed in the following of this paper. In this study, a neural network controller is proposed to control the MR damper to eliminate vibrations of 3-story scaled structure exposed to Tohoku 2011 and Boumerdes 2003 earthquakes. The proposed controller is derived from a linear quadratic controller designed to control an MR damper installed in the first floor of the structure. Equipped with a feedback law the proposed control is coupled to a clipped optimal algorithm to adapt the current tension required to the MR damper adjustment. To evaluate the performance control of the proposed design controller, two numerical simulations of the controlled structure and uncontrolled structure are illustrated and compared.

关键词： MR damper semi-active control earthquake vibration neural network linear quadratic control

Optimal site selection for geothermal heated greenhouses in cold climates:a fuzzy logic and geographic information system approach

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Clean Energy 2024年第2期8卷 8-26页

作者： Amirhossein Mirabadi Saeid Minaei younes Noorollahi Morteza Almasi Department of Agricultural Systems Science and Research BranchIslamic Azad UniversityTehranIran Biosystems Engineering Department Faculty of AgricultureTarbiat Modares UniversityTehranIran Energy Modelling and Sustainable Energy System(METSAP)Research Lab. Faculty of New Sciences and TechnologiesUniversity of TehranIran

This paper presents a comprehensive model for selecting optimal sites for geothermal heated greenhouses in the agricultural *** research involves two main components:assessing the geothermal energy resource using geological,geochemical and geophysical indicators;and developing a siting model based on fuzzy logic that considers technical,environmental and socio-economic fac*** study focuses on East Azerbaijan province in Iran-a cold *** results indicate that~3.24%of the total area of the province is suitable for constructing geothermal greenhouses,resulting in potential savings of~148000 and 745978 m3 of natural gas in areas with high and very high suitability,respectively.

关键词： geothermal energy site selection GIS fuzzy logic resource assessment

A Novel Approach to Fabricate Carbon Nanomaterials-Nanoparticle Solids through Aqueous Solutions and Their Applications

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Nanomanufacturing and Metrology 2021年第4期4卷 226-236页

作者： hammad younes haiping Hong G.P.Peterson Department of Electrical Engineering South Dakota School of Mines and TechnologySouth DakotaRapid City 57701USA Department of Mechanical Engineering Khalifa University of Science and TechnologyMasdar InstitutePO Box 54224Abu DhabiUAE Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

A better understanding of the bonding and aggregation processes occurring between carbon nanomaterials and metal oxide particles in aqueous solutions is important in the development of novel nanosolids for applications in the areas of sensor development,highly conductive paint,nanotube alignment,polymer composites,Li-ion batteries,and many other *** current investigation reviews these processes and presents a detailed description of the aggregation processes occurring between carbon nanomaterials and metal oxide particles(metals)in various aqueous *** results indicate that the charge attraction between the particles results in a strong homogeneous bonding that occurs within the aqueous solution and for the first time demonstrate and describe the aggregation process of these *** relative importance of many parameters that impact the aggregation process is identified and discussed,and guidelines for controlling the aggregation process are *** is a simple and cost-effective process to manufacture a novel nano-solid based on carbon nanomaterial and metal *** addition,the process is easy to scale up and *** methodology could lead to many significant applications as well as commercialization.

关键词： Nanosolid Aggregation technique Nanofluids Charge attraction Nanoparticles Nanomanufacturing

Microwave Tunneling and Robust Information Transfer Based on Parity-Time-Symmetric Absorber-Emitter Pairs

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Research 2019年第1期2019卷 105-114页

作者： Zhicheng Xiao younes Ra’di Sergei Tretyakov Andrea Alù Department of Electrical and Computer Engineering The University of Texas at AustinAustinTX 78712USA Advanced Science Research Center City University of New YorkNew YorkNY 10031USA Department of Electronics and Nanoengineering Aalto UniversityFI-00076 AaltoFinland

Robust signal transfer in the form of electromagnetic waves is of fundamental importance in modern technology,yet its operation is often challenged by unwanted modifications of the channel connecting transmitter and ***-time-(PT-)symmetric systems,combining active and passive elements in a balanced form,provide an interesting route in this ***,we demonstrate a PT-symmetric microwave system operating in the extreme case in which the channel is shorted through a small reactance,which acts as a nearly impenetrable obstacle,and it is therefore expected to induce large reflections and poor *** placing a gain element behind the obstacle,and a balanced lossy element in front of it,we observe full restoration of information and overall transparency to an external observer,despite the presence of the *** theory,simulations,and experiments unambiguously demonstrate stable and robust wave tunneling and information transfer supported by PT symmetry,opening opportunities for efficient communication through channels with dynamic changes,active filtering,and active metamaterial technology.

关键词： obstacle Tunnel element

Global modeling and simulation of vehicle to analyze the inertial parameters effects

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第3期7卷 338-366页

作者： younes Abbassi Youcef Ait-Amirat Rachid Outbib Department of Energy University of Technology of Belfort-Montbeliard Belfort 90010 France Department of Energy University of Franche-Comte Belfort 90010France LSIS Laboratory University of Aix-Marseille Marseille 13397France

This paper mainly studies the comparison of the global vehicle models and the effects of the inertial parameters due to the center of gravity(CG)positions when we consider that the vehicle has only one *** paper proposes a new nonlinear model vehicle model which considers both unsprung mass and sprung mass *** CG positions and inertial parameters effects are analyzed in terms of the published vehicle dynamics *** this end,two 14 degree-of-freedom(DOF)vehicle models are developed and compared to investigate the vehicle dynamics responses due to the different CG height and inertial parameters *** proposed models describe simultaneously the vehicle motion in longitudinal,lateral and vertical directions as well as roll,pitch and yaw of the vehicle about corresponding *** passive and active moments and the forces acting on the vehicle are also described and they are considered as a direct consequence of acceleration,braking and steering *** proposed model M1 takes both the CG of sprung mass,unsprung mass and total vehicle mass into *** second model M2 assumes that the vehicle is one solid body which has a single CG as reported in majority of *** two vehicle models are compared and analyzed to evaluate vehicle ride and handling dynamic responses under braking/acceleration and cornering *** results show that the proposed model M1 could offer analytically some abilities and driving performances,as well as improved roll and pitch in a very flexible manner compared to the second model M2.

关键词： Vehicle dynamics lagrange equations modeling center of gravity inertial parameters load transfers nonlinear vehicle models simulation