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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria younes Ghady Loubnane Christopher Sleiman Sandra Rizk Department of Natural Sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

Integrated hazard assessment of rockfall incidents in the Cap Aokas Cliff Region

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Journal of Mountain Science 2024年第6期21卷 1916-1929页

作者： Zohra LADJEL Farid ZAHRI Riheb HADJI younes HAMED Karim ZIGHMI Kaddour BENMARCE Department of Earth Sciences Institute of Architecture and Earth SciencesFerhat Abbas UniversitySetif 19137Algeria Unit of Emerging Materials Research Ferhat Abbes UniversitySétif 19137Algeria Laboratory of Applied Research in Engineering Geology GeotechnicsWater Sciencesand EnvironmentFerhat Abbas UniversitySetif 19137Algeria International Association of Water Resources in the Southern Mediterranean Basin Gafsa 2112Tunisia Department of Earth Sciences Faculty of SciencesUniversity of GafsaGafsa 2112Tunisia

Rock fall accidents in mountainous cliff areas have significant consequences for human life and *** study aimed to evaluate the rockfall hazard in the Cap Aokas cliff region located along the northeast coast of Algeria by identifying the key factors contributing to rockfall *** employed a combination of kinematic analysis,Matterocking method,and 3D trajectory simulations to determine zones that are susceptible to rockfall *** using a probabilistic and structural approach in conjunction with photogrammetry,we identified the controlling *** kinematic analysis revealed the presence of five discontinuity families,which indicated both plane and wedge failure *** 3D trajectory simulations demonstrated that the falling blocks followed the stream *** then validated the susceptibility maps generated from the analysis using aerial photos and historical rockfall *** findings of this study enhance our understanding of rockfall phenomena and provide valuable insights for the development of effective strategies to mitigate rockfall hazards.

关键词： Trajectory simulations Probabilistic analysis Structural approach Rockfall hazard Cap Aokas cliff

An Occlusive Left Main Spontaneous Coronary Artery Dissection

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Open Journal of Thoracic Surgery 2013年第1期3卷 19-21页

作者： Mehdi Bamous Jacques Robin younes moutakiallah Fouad Nya Olivier Metton Jean Ninet Department of Cardiothoracic Surgery Luis Pradel Hospital University of Claude Bernard 1 Lyon France.

Spontaneous coronary artery dissection (SCAD) should be strongly suspected in young women with few or no traditional risk factors for atherosclerosis. Prompt diagnosis and treatment improve survival. The most appropriate strategy for managing SCAD is still controversial due to the heterogeneity of this population. We describe a case of spontaneous left main coronary artery (LMCA) dissection in a young women that was successfully managed by percutaneous coronary intervention (PCI) followed by coronary artery bypass grafting (CABG), this case illustrates the utility of coronary computed tomography (CT) and magnetic resonance imagery (MRI) in assessing complex coronary dissection, thereby helping to determine the best timing for surgery.

关键词： Coronary Dissection Coronary Artery Imaging MRI Computed Tomography CABG Arterial Grafts

Early Postoperative Anticoagulation by Enoxaparin after Mechanical Aortic Valve Replacement

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World Journal of Cardiovascular Surgery 2014年第7期4卷 109-115页

作者： younes moutakiallah Mehdi Bamous Roland Henaine Jacques Robin Jean Francois Obadia Jean Ninet Department of Cardiac Surgery C.Louis Pradel Cardiologic HospitalLyonFrance

Background: The use of low molecular weight heparin for early anticoagulation after mechanical aortic valve replacement is still a matter of debate even more that the early postoperative phase is associated with maximum of thrombo-embolic and bleeding risks. The objective of this study is to verify the efficacy and the safety of low molecular weight heparin for the early anticoagulation after mechanical aortic valve replacement. Methods and Results: It is a prospective study conducted over 6 months and interested 40 consecutive patients (32 male and 8 female) with a mean age 53.83 ± 16.93 years (19-75 years) who underwent a mechanical aortic valve replacement and received enoxaparin as bridging therapy between continuous unfractionated heparin and fully effective vitamin K antagonist therapy. There was no in-hospital death and no in-hospital thromboembolic events. We report 2 major bleeding events (5%). Conclusion: The use of low molecular weight heparin should be an alternative to explore for early anticoagulation after valve heart surgery and the results of our study must be verified by large randomized studies before drawing any hasty conclusions.

关键词： Early Anticoagulation Mechanical Aortic Valve Replacement Low Molecular Weight Heparin

Septic Pulmonary Emboli and Right Ventricular Obstruction in a Membranous Interventricular Septal Aneurysm

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Open Journal of Thoracic Surgery 2014年第3期4卷 59-61页

作者： Mehdi Bamous Abdessamad Abdou Noureddine Atmani Anis Sergouchni younes moutakiallah Hatim Ghadbane Mohamed Drissi Abdelatif Boulahya Department of Cardiovascular Surgery Mohammed 5th Military Hospital University Mohamed 5 Rabat Morocco

Although the majority of patients with perimembranous ventricular septal defect and septal aneurysm remained asymptomatic, some of them presented with serious complications during adulthood and thus required high risky surgery. In accordance with other rare condition, the incidence and natural history have not been well documented. This case describes the occurrence of a septic pulmonary emboli associated with right ventricular outflow tract obstruction in a young child.

关键词： Infective Endocarditis Ventricular Septal Defect Membranous Septum Aneurysm Right Ventricular Obstruction

Stress gastric ulcer after cardiac surgery: Pathogenesis risk factors and medical management

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World Journal of Cardiovascular Diseases 2013年第3期3卷 312-316页

作者： Mahdi Ait Houssa Noureddine Atmani Fouad Nya Abdessamad Abdou younes moutakiallah Mehdi Bamous Mohamed Drissi Abdelatif Boulahya Cardiac Surgery Department Military Hospital Institute Rabat Morocco

Stress ulcer lesions of upper gastrointestinal tract are well recognized in patients undergoing open cardiac surgery. Gastrointestinal bleeding following cardiac surgery is infrequent with significant morbidity and mortality. The pathogenesis of mucosal lesions and subsequent haemorrhage is complex and multifactorial. The diagnosis as well as the treatment of this complication remains a challenge for surgeons. Identifying the source of bleeding can be difficult. Despite of the successful control of haemorrhage using various combinations of endoscopic and pharmacological therapies, the mortality rate remains unchanged. Benefit of routine stress ulcer prophylaxis remains controversial.

关键词： Stress Gastric Ulcer Upper Gastrointestinal Bleeding Cardiac Surgery

Broken Rules,Broken Lives

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Beijing Review 2024年第36期67卷 26-27页

作者： younes Abouyoub Governance and State-Building Section United Nations Economic Social Commission for Western Asia(UN-ESCWA)

As we observe the 75th anniversary of the adoption of the 1949 Geneva Conventions(hereinafter referred to as the Conventions),which are deemed the most essential treaties in international humanitarian law as they provide a widely accepted and comprehensive framework for protecting individuals during armed conflicts,their relevance is underscored by the ongoing challenges in ensuring the protection of civilians,prisoners of war and the wounded.

关键词： anniversary wound law

Effect of aortic valve replacement on ventricular recovery and functional class in patients with reduced left ventricular function

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World Journal of Cardiovascular Diseases 2013年第9期3卷 543-550页

作者： Mahdi Ait Houssa younes moutakiallah Abdessamad Abdou Abdedaim Hatim Mohamed Drissi Brahim Amahzoune Youssef El Bekkali Atif Benyass Abdelatif Boulahya Cardiac Surgery Department Mohammed V Military HospitalRabatMorocco ICU of Cardiac Surgery Department Mohammed V Military HospitalRabatMorocco Cardiology Department Mohammed V Military HospitalRabatMorocco

Objective: The aim of the study was to assess the effects of aortic valve replacement (AVR) in patients with aortic stenosis (AS) or regurgitation (AR) and left ventricular (LV) dysfunction. Patients and methods: Retrospective analysis identified 75 consecutive patients with left ventricular ejection fraction (LVEF) assessed by echocardiography < 40% who underwent AVR for AS (n = 40) or AR (n = 35) between 1994 and 2011. Exclusion criteria were previous myocardial infarction or concomitant valvular disorders other than aortic disease. Follow-up evaluated the New York Heart Association (NYHA) functional class, LVEF and survival rate. Results: Mean ages were respectively 56.5 ± 9.3 and 47.9 ± 11.7 years in AS and AR groups, p = 0.001. Before surgery, 88% and 75% of patients were in NYHA III-IV respectively in AS and AR. In the AS group, the mean LVEF and aortic valve area (AVA) were respectively 32.2% ± 8% and 0.65 ± 0.15 cm2. AR group had a mean LVEF of 33.8 ± 6.7% and a mean LV systolic diameter of 62 ± 8.8 mm. All patients underwent AVR under cardiopulmonary bypass. There were 5 operative deaths (12.5%) in AS group and 6 (17.6%) in AR group, p = 0.57. LVEF increased to 49% ± 14.7% and 51.2% ± 10.9% in the AS and AR groups after echocardiography control. The survival rates at 1, 5 and 10 years were respectively 94.4%, 87% and 80% in AS group and 95.2%, 93% and 89% in AR group. Conclusion: Despite higher perioperative mortality in patients with aortic valve disease (AS or AR) and LV dysfunction, long-term outcome is excellent. We, therefore, conclude that AVR can be performed and it should not be denied to patients on the basis of low EF alone.

关键词： Aortic Valve Disease Aortic Valve Replacement Left Ventricular Dysfunction

Single-Stage Repair of a Critical Aortic Coarctation, a Bicuspid Aortic Stenosis and an Ascending Aortic Aneurysm

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World Journal of Cardiovascular Surgery 2016年第5期6卷 73-78页

作者： Siham Bellouize younes moutakiallah Mahdi Ait Houssa Aniss Seghrouchni Noureddine Atmani Mohamed Drissi Abdedaïm Hatim Ilyass Asfalou Jamal El Fenni Abdelatif Boulahya Department of Cardiovascular Surgery Mohammed V Teaching Military Hospital Rabat Morocco Faculty of Medicine and Pharmacy of Rabat Mohammed V University Rabat Morocco Intensive Care of Cardiovascular Surgery Mohammed V Teaching Military Hospital Rabat Morocco Department of Cardiology Mohammed V Teaching Military Hospital Rabat Morocco Department of Radiology Mohammed V Teaching Military Hospital Rabat Morocco

We report a 26-year-old man with critical aortic coarctation, severe bicuspid aortic valve stenosis, infective endocarditis and ascending aortic aneurysm. He underwent simultaneously in singlestage a Bentall’s procedure and an extra-anatomic ascending-descending aortic bypass grafting by 14-mm Dacron tube, through median sternotomy. The immediate postoperative outcome was favourable. The CT scan control for 7 years after surgery showed a good patency of the extra-anatomic bypass.

关键词： Aortic Coarctation Bicuspid Aortic Stenosis Ascending Aortic Aneurysm Single Stage Extra-Anatomic Bypass

Mitral Valve Commissurotomy: Which One between the Three Techniques Gives a Better Long-Team Outcome?

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World Journal of Cardiovascular Diseases 2017年第2期7卷 37-45页

作者： Mahdi Aithoussa Noureddine Atmani Ayoub Abetti Mehdi Bamous Abdessamad Abdou younes moutakiallah Anis Seghrouchni Fouad Nya Siham Bellouize Mohamed Drissi Ilyas Asfalou Abdelatif Boulahya Department of Cardiac Surgery Mohamed V Military Hospital Mohammed V University Rabat Morocco Department of Cardiology Mohamed V Military Hospital Mohammed V University Rabat Morocco

Objective: we sought to compare long-term results of three techniques: CMC, OMC and PMC in patients with rheumatic mitral stenosis. Patients and Method: Between January 1994 and December 2015, 183 patients underwent mitral valve surgery for rheumatic mitral restenosis. All patients were investigated by echocardiography-Doppler performed by a senior cardiologist. The patients were divided into 3 groups: patients who have previously closed mitral commissurotomy (CMC n = 101), patients with previously open mitral commissurotomy (OMC n = 28) and those treated by Balloon mitral valvuloplasty (PMC = 54). Results: The three groups were comparable in term of major demographic data. Mitral restenosis occurred precociously in groups treated by PMC (7 ± 4 years), followed by group with OMC 11.4 ± 4 years and CMC group but it occurred later CMC 16.8 ± 7.8 years (p Conclusion: CMC produces better long-term outcome than OMC and PMC. However, it would be premature to conclude to its superiority.

关键词： Rheumatic Mitral Stenosis Closed Mitral Commissurtomy Open Mitral Commissurotomy Balloon Mitral Valvuloplasty