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The current status of hormone treatment for prostate cancer patients in Korean real-world practice:a multi-institutional observational study

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Asian Journal of Andrology 2019年第2期21卷 115-120页

作者： Jung Kwon Kim Jung Jun Kim Taek Won Gang Tae Kyun Kwon Hong Sup Kim Seung Chui Park Jae-Shin Park Jong-Yeon Park Seok Joong Yoon Youn-Soo Jeon Jin Seon Cho Kwan Joong Joo Sung-Hoo Hong Seok-soo Byun the Korean Urological Oncology Society Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Hallym University Sacred Heart HospitalAnyang 14068Korea Department of Urology Kangbuk Samsung HospitalSeoul 03181Korea Department of Urology Seoul St.Mary HospitalSeoul 06591Korea 不详 Department of Urology Chonnam National University HospitalGwangju 61469Korea School of Medicine Kyungpook National University Medical CenterDaegu 41404Korea Department of Urology Konkuk University Medical CenterSeoul 05080Korea Department of Urology Wonkwang University HospitalIksan 54538Korea Department of Urology Daegu Catholic University Medical CenterDaegu 41911Korea Department of Urology Ulsan UniversityGangneung Asan HospitalGangneung 25440Korea Department of Urology Chungbuk National University HospitalCheongju 28644Korea Department of Urology Soonchunhyang University HospitalCheonan 31151Korea

We aimed to evaluate the current nationwide trend,efficacy,safety,and quality of life(QoL)profiles of hormone treatment in real-world practice settings for prostate cancer(PCa)patients in Korea.A total of 292 men with any biopsy-proven PCa(TanyNanyMany)from 12 institutions in Korea were included in this multi-institutional,observational study of prospectively collected data.All luteinizing hormone-releasing hormone(LHRH)agonists were allowed to be investigational drugs.Efficacy was defined as(1)the rate of castration(serum testosterone≤50 ng dl^-1)at 4-week visit and(2)breakthrough(serum testosterone>50 ng dl^-1 after castration).Safety assessments included routine examinations for potential adverse events,laboratory tests,blood pressure,body weight,and bone min era I density(BMD,at baseli ne and at the last follow-up visit).QoL was assessed using the Expa nded Prostate Cancer Index Composite-26(EPIC-26).The most comm on initial therapeutic regimen was LHRH agonist with an ti-androge n(78.0%),and the most commonly used LHRH agonist for combination and mono therapy was leuprolide(64.0%for combi natio n and 58.0%for monotherapy).The castration and breakthrough rates were 78.4%and 6.6%,respectively.The laboratory results related to dyslipidemia worsened after 4 weeks of hormone treatment.In addition,the mean BMD T-score was significantly lower at the last follow-up(mean:-1.950)compared to baseline(mean:-0.195).The mean total EPIC-26 score decreased from 84.8(standard deviation[s.d.]:12.2)to 78.3(s.d.:8.1),with significant deterioration only in the urinary domain(mean:23.5 at baseli ne and 21.9 at the 4-week visit).These findi ngs dem on strate the n ationwide trend of current practice setti ngs in hormone treatment for PCa in Korea.

关键词： efficacy hormonal treatment Korean population prostate cancer safety trend

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Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease

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World Journal of Gastroenterology 2012年第40期18卷 5771-5778页

作者： Hyun Jung Lee youn Nam Kim Hui Won Jang Han Ho jeon Eun Suk Jung soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo Nam Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Department of Biostatistics Yonsei University College of MedicineSeoul 120-752South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April 2011.We also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with DAIBD.An endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was evaluated.To determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were analyzed.RESULTS:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the DAIBD.An endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ulcers.However,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD variance.Patients with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the model.CONCLUSION:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD scores.However,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.

关键词：临床疾病肠道内镜多元回归分析评估模型严重程度开发利用有限元分析

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Pull-out tests and slope stability analyses of nailing systems comprising single and multi rebars with grouted cement

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Journal of Central South University 2012年第1期19卷 262-272页

作者： Sang-soo jeon Construction Technology Research Center Department of Civil EngineeringInje UniversityObang-dong 607KimhaeKyungsangnam-Do #621-749Korea

The pull-out capacities for soil nailing systems comprising of one single 29 mm diameter(type A) and four 16 mm diameter(type B) rebars with grouted cement were examined.A field test and numerical analysis for the type A and type B systems were carried out to investigate the pull-out capacities and the slope stability reinforcement efficiency in soil and rock slopes.The results of the pull-out tests show the mobilized shear force and load transfer characteristics with respect to soil depth.The load-displacement relationship was examined for both type A and type B systems.Slope stability analyses were carried out to study the relationships between soil and nail reinforcement and bending stiffness as well as combined axial tension and shear forces.Factors of safety were calculated in relation to the number of nails and their outside diameters.Both soil and rock slopes were included in this evaluation.

关键词：边坡稳定性分析灌浆水泥现场测试系统土壤深度数值分析荷载传递拉出试验

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Effect of geogrid reinforcement on soft and medium dense soils

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Journal of Central South University 2011年第5期18卷 1638-1645页

作者： jeon Sang-soo Department of Civil Engineering Construction Technology Research CenterINJE UniversityObang-dong 607KimhaeKyungsangnam-Do #621-749South Korea

The field tests were carried out to examine the reinforcement effect of a geogrid on various conditions of embankment height,the number of passages of vibratory roller,the number of reinforced layer of geogrid,and soil properties.The test results of the dynamic earth pressure indicate that the soil reinforced by geogrid is very effective to increase the stiffness of soil,especially in soft soil.The dynamic earth pressure ratio,which is defined as the ratio of dynamic earth pressure to self weight of soils,exponentially decreases as the embankment height increases.The dynamic earth pressure ratio increases up to 80% for soft soils reinforced by both one layer of geogrid in place of no reinforced soils and two layers in place of a single layer of geogrid.

关键词：土工格栅加筋土壤特性加固效果路基高度振动压路机实地测试压力测试土压力

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高脂高盐饮食对大鼠醛固酮分泌和高血压的影响

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营养学报 2021年第4期43卷 384-388页

作者：钟宝彭诚 youn-soo Cha 吉林农业科技学院吉林132101 韩国全北国立大学韩国全州全北54896

目的探讨高脂高盐饮食通过增加醛固酮分泌及相关基因的表达,导致大鼠高血压的发病机制。方法五周龄的Sprague-Dawley(SD)雄性大鼠,随机分成控制组(NC,脂肪10%);高脂饮食组(HF,脂肪60%);高脂和高盐饮食组(HFS,脂肪60%,盐8%),每组5只。NC... 详细信息

目的探讨高脂高盐饮食通过增加醛固酮分泌及相关基因的表达,导致大鼠高血压的发病机制。方法五周龄的Sprague-Dawley(SD)雄性大鼠,随机分成控制组(NC,脂肪10%);高脂饮食组(HF,脂肪60%);高脂和高盐饮食组(HFS,脂肪60%,盐8%),每组5只。NC、HF组灌胃蒸馏水,HFS组灌胃盐水,灌胃量为10 mL/kg。每次灌胃2h后,测量大鼠的收缩压(systolic blood pressure),连续测量15次取平均值。12周后,使用商业试剂盒,分析大鼠血清的总胆固醇(total cholesterol,TC)、甘油三脂(triglyceride,TG)、醛固酮(aldosterone)含量,并通过PCR分析肾脏中醛固酮相关基因的表达。结果与NC组比较,HF和HFS组大鼠的体重和血压显著升高(P<0.01),血清中的总胆固醇、甘油三酯、醛固酮含量显著升高(P<0.01),大鼠肾脏醛固酮相关的基因:胆固醇侧链裂解酶(cholesterol side-chaincleavageenzyme,Cyp11a1)、醛固酮合成酶(aldosteronesynthase,Cyp11b2)、1型3β-羟基类固醇脱氢酶(3β-hydroxysteroid dehydrogenase type 1,Hsd3b1)、类固醇合成快速调节蛋白(steroidogenic acute regulatory protein,Star)mRNA表达显著升高(P<0.01)结论实验证明血清中醛固酮含量的增加以及相关基因的表达上升是导致高血压发生的重要机制。

关键词：高脂高盐饮食大鼠醛固酮高血压

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世界上唯一一个负碳国家——不丹

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新世纪智能 2018年第6期 4-6页

作者： soo youn

旅游,我们一直都认为是会增加碳排放,加重环境负担的。但是不丹这个旅游业高度发展的国家,却做到了负碳。怎样才能在发展旅游的同时做到环保呢?这也是现在日益受欢迎的南极旅游应该重点考虑的。Bhutan is probably the world’s happies...

旅游,我们一直都认为是会增加碳排放,加重环境负担的。但是不丹这个旅游业高度发展的国家,却做到了负碳。怎样才能在发展旅游的同时做到环保呢?这也是现在日益受欢迎的南极旅游应该重点考虑的。Bhutan is probably the world’s happiest country.It’s also one of the greenest.That’s no coincidence.In fact,King Jigme Singye Wangchuck developed his signature Gross

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Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors

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Light(Science & Applications) 2014年第1期3卷 5-12页

作者： Byoungchoo Park soo Hong Yun Chan youn Cho young Chan Kim Jung Chul Shin Hong Goo jeon Yoon Ho Huh Inchan Hwang Ku youn Baik young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi Department of Electrical and Biological Physics Kwangwoon UniversitySeoul 139-701Republic of Korea Department of Electronic Materials Engineering Kwangwoon UniversitySeoul 139-701Republic of Korea

Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver anodes.We demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)condition.Moreover,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection configurations.We highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors.

关键词： attenuated total reflection optical sensors photocurrent generation polymer photovoltaic devices surface plasmon

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Expression of prothymosin α predicts early recurrence and poor prognosis of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 171-177页

作者： Sang Yun Ha Dae Hyun Song soo Hyun Hwang soo youn Cho Cheol-Keun Park Department of Pathology Samsung Medical CenterSungkyunkwan University School of Medicine

BACKGROUND：Prothymosinα（PTMA）is a nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation.PTMA was overexpressed in several human malignancies including hepatocellular carcinoma（HCC）.However,the prognostic significance of PTMA protein expression in HCC remains unclear.In the present study,we evaluated PTMA protein expression by immunohistochemistry in order to elucidate the prognostic roles of PTMA in HCC patients.METHODS： By immunohistochemistry, we investigated the expression of PTMA protein in tumor tissue from 226 HCC patients who underwent curative hepatectomy. Univariate and multivariate analyses were performed to evaluate its predic- tive value for tumor recurrence and survival of patients. The median follow-up period was 120 months. RESULTS： PTMA expression was observed in 162 （71.7%） of the 226 HCC patients and was significantly associated with higher Edmondson grade, microvascular invasion, intrahe- patic metastasis, higher American Joint Committee on Cancer （AJCC） T-stage, and lower albumin level. PTMA expression was an independent predictor of early recurrence （P=0.001）. PTMA expression showed an unfavorable influence on recurrence- free survival （RFS）（P〈0.001）. Subgroup analysis showed that among patients with tumor size _〈5.0 cm （140 patients）, patients at AJCC T-stage I （95 patients） and patients with a-fetoprotein ≤20 ng/mL （83 patients）, the differences in RFS between PTMA- positive and PTMA-negative groups were also statistically sig- nificant （P=0.017, P=0.002 and P=0.002, respectively）. In addi- tion, PTMA expression was an independent predictor of shorter RFS （P=0.011）. PTMA expression showed an unfavorable influ- ence on overall survival （P=0.014）, but was not an independent predictor of shorter overall survival （P=0.161）. CONCLUSIONS： PTMA protein expression might be a novel predictor of early recurrence and RFS in HCC patients, even those at early stage or with a-fetoprotein-negative after curative hepatectomy. PTMA could be used as an immunohistoch

关键词： prothymosin a hepatocellular carcinoma recurrence

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Refining the American Urological Association and American Society for Radiation Oncology guideline for adjuvant radiotherapy after radical prostatectomy using the pathologic Gleason score

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Asian Journal of Andrology 2017年第1期19卷 20-25页

作者： Wan Song young Suk Kwon Seong soo jeon Isaac Yi Kim Section of Urologic Oncology Rutgers Cancer Institute of New Jersey Rutgers The State University of New Jersey New Brunswick NJ 08903 USA Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea.

Recently, it has been suggested that the guideline for adjuvant radiotherapy （ART） following radical prostatectomy （RP） sponsored by the American Urological Association and American Society for Radiation Oncology （AUA/ASTRO） may result in a significant overtreatment. Thus, the objective of the present study was to refine the AUA/ASTRO guideline for ART in patients at risk for biochemical recurrence （BCR） after RP. To this end, we reviewed our prospectively maintained database and selected 193 patients who met the AUA/ASTRO ART criteria. With a median follow-up of 24.0 months, BCR rate was 17.6% （34/193）. When stratified by the Gleason score, BCR rate in men with Gleason score 6 was 6.8%. There was no significant association between BCR-free survival and surgical margin （P= 0.690） and pathologic stage （P= 0.353） in patients with the Gleason score 6. However, in patients with positive surgical margins （PSMs）/pathologic stage ≥T3, there was a significant difference in BCR-free survival according to Gleason score （≤7 vs8-10, P= 0.047）. Multivariate Cox regression analysis demonstrated that pathologic stage ≥T3 （HR = 2.106; P = 0.018）, PSMs （HR = 2.411; P = 0.003）, and pathologic Gleason score 8-10 （HR = 4.715; P 〈 0.001） were independent predictors of BCR after RP. Therefore, in addition to pathologic stage 〉T3 and PSMs, Gleason score 8-10 predicts 8CR after RP. In patients with Gleason score 6, observation rather than ART may be more appropriate regardless of stage and surgical margin status.

关键词： adjuvant radiotherapy biochemical recurrence radical prostatectomy

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High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets

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Journal of Energy Chemistry 2022年第4期31卷 814-823页

作者： Jiae Um Seung Uk Yoon Hoseong Kim Beom Sik youn Hyoung-Joon Jin Hyung-Kyu Lim young soo Yun Program in Environmental and Polymer Engineering Inha Universityncheon 22212 South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Gangwon-do 24341 South Korea KU-KIST Graduate School of Converging Science and Technologyea University 145 Anam-roSeongbuk-guSoul02841 South Korea Department of Integrative Energy Engineering 145 Anam-roSongbuk-guKorea UniversitySeoul 02841 South Korea

The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage change.It is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage plateau.Herein,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic microstructure.First-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À).

关键词： Turbostratic graphite Graphene nanosheet Defective carbon Anode Potassium-ion batteries

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