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Regulating bulkhead pressure of EPB shield machines through DEM modeling and data mining

Underground Space 2023年第1期8卷 15-29页

作者： Panpan Cheng Fang Liu youjun xu Yuanhai Li State Key Laboratory of Disaster Reduction in Civil Engineering Shanghai 200092China Key Laboratory of Geotechnical and Underground Engineering of the Ministry of Education Tongji UniversityShanghai 200092China School of Civil Engineering Inner Mongolia University of Science and TechnologyBaotou 014010China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China

Proper regulation of the earth pressure on the bulkhead of earth-pressure balanced(EPB)shield tunneling machines is significant to ensure safe *** study proposes a procedure for regulating the bulkhead pressure by combining numerical simulations and data mining,and applies the procedure to a metro line constructed in sandy pebble stratum using EPB ***,the relationship between the bulkhead pressure and the pressure on the tunnel face is carefully obtained from discrete element modeling,and the required supporting earth pressure is derived by considering the arching ***,aided with the machine learning method,a model is constructed for predicting the average bulkhead pressure per ring according to the operational parameters(i.e.,the average driving speed and the rotation speed of the screw conveyor).Given the target value of the bulkhead pressure,the optimal values of the operational parameters are obtained from the *** addition,an autoregressive moving average stochastic process model is developed to monitor the real-time fluctuation of the bulkhead pressure and guide the actions taken in time to avoid dramatic *** results indicate that the pressure difference between the tunnel face and the bulkhead is considerable,and the consideration of the arching effect can avoid overestimating the bulkhead pressure.A combination of the machine learning model and the stochastic process model provides a plausible performance in regulating the bulkhead pressure around the target value without dramatic fluctuation.

关键词： EPB shield machine Bulkhead pressure Discrete element method Support vector regression Autoregressive moving average model

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Optimal Control of Pseudoparabolic Equations With Pointwise Obstacle Type Constraints

Optimal Control of Pseudoparabolic Equations With Pointwise ...

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第25届中国控制与决策会议

作者： youjun xu Zigen Ouyang Cuie Xiao School of Mathematics and Physics University of South China School of Mathematical Sciences Fudan University Department of Mathematics and Computation Sciences Hunan City University

An optimal control problem for pseudoparabolic equations with pointwise obstacle type constraints is considered. There is a void interior even in the state constraint set, that is, without satisfying the Slater condit... 详细信息

ISBN: (纸本)9781467355339

关键词： Optimal control Pseudoparabolic equations State constraints

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Synthesis and Biological Evaluation of Entecavir 4＇-Ester Derivatives

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Chemical Research in Chinese Universities 2014年第5期30卷 749-754页

作者： FENG Deri LIU Jiaan LIANG Shuang WANG Yanyan xu youjun School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

Entecavir can significantly inhibit the replication of HBV-DNA, reduce the HBV-DNA level in blood se- rum. But suffering from low oral bioavailability, entecavir has low intestinal membrane permeability and poor meta- bolic stability. In this study, 12 different derivatives of entecavir 4＇-ester were regioselectively synthesized and their apical-to-basolateral permeabilities across Caco-2 cells and HBV-DNA inhibitory efficacies were evaluated. Most of the compounds showed high permeabilities across Caco-2 cells compared with entecavir, compounds 5b and 5e also exhibited comparable anti-HBV activities with that of entecavir, especially.

关键词： Entecavir Anti-HBV activity Intestinal membrane permeability

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A novel mitochondria-targeting tetrapeptide for subcellular delivery of nanoparticles

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Chinese Chemical Letters 2019年第7期30卷 1435-1439页

作者： Yanhui Sun Aiyan Zhan Shuang Zhou Xiao Kuang Hongyan Shen Hongzhuo Liu youjun xu School of Pharmaceutial Engineering Key Laboratory of Structure-Based Drug Design & Discovery(Ministry of Education) Shenyang Pharmaceutical University Shenyang 110016 China Wuya College of Innovation Shenyang Pharmaceutical University Shenyang 110016 China

Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases. Hence, mitochondria-targeting delivery strategies are highly significant and critically needed. In this study, we developed a small library of peptides simulating the mitochondria-targeting peptide SS-31, a promising tetra-peptide with antioxidant character, and subsequently evaluated the toxicity, antioxidant ability and mitochondrial delivery of nanoparticles. Among the designed peptides, RF-2 (DArg-Dmt-Arg-Phe-NH2) showed controlled toxicity and excellent protection against gentamicin-induced hair cell damage, as compared with SS-31. More importantly, RF-2-modified PLGA nanoparticles demonstrated high colocalization with mitochondria and comparable specific subcellular accumulation, when compared with SS-31. Taken together, the obtained results supported RF-2 as a mitochondriatargeting peptide with high potential as a targeted carrier.

关键词： Mitochondrial targeting Peptide SS-31 Toxicity Nanoparticles Zebrafish

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Exploration on learning molecular docking with deep learning models

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Quantitative Biology 2023年第3期11卷 320-331页

作者： Qin Xie Wei Ma Jianhang Zhang Shiliang Li Xiaobing Deng youjun xu Weilin Zhang Infinite Intelligence Pharma Beijing 100083China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Background:Molecular docking-based virtual screening(VS)aims to choose ligands with potential pharmacological activities from millions or even billions of *** process could significantly cut down the number of compounds that need to be experimentally ***,during the docking calculation,many molecules have low affinity for a particular protein target,which waste a lot of computational ***:We implemented a fast and practical molecular screening approach called DL-DockVS(deep learning dock virtual screening)by using deep learning models(regression and classification models)to learn the outcomes of pipelined docking programs ***:In this study,we showed that this approach could successfully weed out compounds with poor docking scores while keeping compounds with potentially high docking scores against 10 DUD-E protein targets.A self-built dataset of about 1.9 million molecules was used to further verify DL-DockVS,yielding good results in terms of recall rate,active compounds enrichment factor and runtime ***:We comprehensively evaluate the practicality and effectiveness of DL-DockVS against 10 protein *** to the improvements of runtime and maintained success rate,it would be a useful and promising approach to screen ultra-large compound libraries in the age of big *** is also very convenient for researchers to make a well-trained model of one specific target for predicting other chemical libraries and high docking-score molecules without docking computation again.

关键词： molecular docking ultra-large virtual screening deep learning

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CRL的一种改进方案

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计算机工程 2005年第16期31卷 137-138页

作者：吴健徐佑军武汉大学计算机学院武汉430072

提出了一种改进的CRL方案,通过对CRL结构的改进,大大减少了证书用户查找撤销证书的时间。方案使用的基于排序的折半查找算法比较成熟,整体方案易于实现。

关键词：公钥基础设施证书撤销列表折半查找

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qHerb: quantitative content database for herb medicine studies

qHerb: quantitative content database for herb medicine studi...

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2019中国化学会第十五届全国计算（机）化学学术会议

作者：梁浩 youjun xu Luhua Lai 北京大学 Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University

Herb medicines（HMs） have been used for treating various diseases since pre-historic times and remain popular globally at modern age. HMs have long been challenged for the non-quantitative nature, which largely hinders mechanism understanding and optimization. Though a number of databases have been established by collecting the structures, targets and activities of natural products in HMs, none of them encloses content data, which is the prerequisite for quantitative HM researches. We have developed the first quantitative HM content database qHerb. We collected 1116 HMs from 135 families, together with the curated information of their edible part, preparation process, collection place and date. Among them, 301 HMs are recorded in the Chinese Pharmacopoeia（2015 Edition） and approved for clinical use. The content data were collected for 3039 well studied natural products. q Herb can be used for the quantitative evaluation on the combinatorial effect of active natural products at whole herb level, the optimization of available HM formulae or even the design of novel HM formulae, and the control of undesirable toxic natural products such as aristolochic acid by selecting proper herbs with little or no harmful ingredient. Thus, qHerb meets the demands for quantitative HM studies in many regards and provides supports to bring the HM research into quantitative era.

关键词： herb medicines content data quantitative

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Pontryagin’s Maximum Principle for a Advection-Diffusion-Reaction Equation

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Applied Mathematics 2012年第12期3卷 1888-1891页

作者： youjun xu Cuie Xiao Hui Zhu Department of Mathematics and Computation Sciences Hunan City University Yiyang China School of Mathematics and Physics University of South China Hengyang China

In this paper we investigate optimal control problems governed by a advection-diffusion-reaction equation. We present a method for deriving conditions in the form of Pontryagin’s principle. The main tools used are th... 详细信息

关键词： Optimal Control Pontryagin’s Maximum Principle State Constraint

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Windows NT下多线程网间实时通信程序的设计

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计算机工程与应用 2000年第1期36卷 124-127页

作者：徐佑军武汉水利电力大学计算机系武汉430072

该文论述了在ＷｉｎｄｏｗｓＮＴ、９５环境下利用多线程、命名管道技术，结合实际，以ＶＣ４．０为开发工具进行实时数据通信程序设计，实现了ＭＩＳ网、调度自动化系统网之间的实时数据共享。

关键词： Windows NT 多线程实时数据通信程序设计

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空间如何塑造劳动关系——双重劳动空间中的育儿嫂与雇主互动

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社会学评论 2024年第3期12卷 212-234页

作者：许友君复旦大学社会发展与公共政策学院

基于上海市育儿嫂和雇主互动的经验资料,本研究发现,家政服务的劳动空间由工作空间与家庭空间构成,并且此双重劳动空间通过两套有着不同劳动要求与劳动想象的空间逻辑塑造了劳动关系。当劳动者与雇主选择的空间逻辑不一致时,为了获得最... 详细信息

基于上海市育儿嫂和雇主互动的经验资料,本研究发现,家政服务的劳动空间由工作空间与家庭空间构成,并且此双重劳动空间通过两套有着不同劳动要求与劳动想象的空间逻辑塑造了劳动关系。当劳动者与雇主选择的空间逻辑不一致时,为了获得最佳体验而采取的空间行动会造就双方都无法满意的体验困境,导向紧张的劳动关系。其中,雇主会采取营造亲密关系与全面监管的方式模糊空间边界,而育儿嫂会以强调纯粹的雇佣关系与制造监管死角与之对抗。只有在双方的空间逻辑趋向一致、空间行动协同的少数情况下,劳动关系才是和谐的。通过引入社会空间视角,本文摆脱了常见的背景同质性预设,完善了结构不平等叙事,同时拓展了对劳动者能动性的理解。

关键词：双重劳动空间劳动关系照料劳动家政工社会空间

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