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China Petroleum Processing & Petrochemical Technology 2021年第3期23卷 23-29页

作者： zhang Dan Yang Ping zhang youhua Duan Linhai Meng Xiuhong School of Chemical Engineering Guangdong University of Petrochemical TechnologyMaoming 525000

An approach for dominating the channel form of the flexible MIL-53(Fe)was developed by using a surfactant-assisted modified *** surfactant tetraethylammonium hydroxide(TEAOH)can control the channel form of MIL-53(Fe)to be a“closed-pore”form,whereas the surfactant polyoxyethylene polyoxypropylene polyoxyethylene(P123)or polyvinyl alcohol(PVA)can dominate the channel form of MIL-53(Fe)for a“large-pore”*** photocatalytic performance of MIL-53(Fe)with different channel forms was investigated through the degradation of rhodamine B(Rh B)in water under violet light *** results showed that MIL-53(Fe)with a“large-pore”form exhibited higher photocatalytic activity than that of MIL-53(Fe)with a“closed-pore”***-53(Fe)modified with PVA exhibit the best photocatalytic activity for degrading almost 100%Rh B in 90 minutes.

关键词： MIL-53(Fe) surfactant photocatalysis

Chinese medicine formula HB01 for treating exudative age-related macular degeneration: a 6 consecutive months of clinical observation study

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Journal of Traditional Chinese Medicine 2017年第6期37卷 767-773页

作者： Luo Dan Deng Hui zhang youhua Deng Tingting Yuan Wei Wang Zhijun Jin Ming Department of Ophthalmology China-Japan Friendship Hospital Department of Graduate School Beijing University of Chinese Medicine

OBJECTIVE: To evaluate the clinical efficacy of Chinese medicine formula HB01 on exudative age-related macular degeneration(AMD) patients who received HB01 for 6 months by analyzing relative ***: From July 2006 to August 2015, 139 eligible exudative AMD patients(183 eyes) were enrolled into this study and received aqueous extract from herbs of HB01 by oral twice a day(100 m L for once) for 6 months. The best corrected visual acuity, center macular thickness(CMT), hemorrhage area, fluorescein leakage area as the main outcomes were estimated and compared before and after ***: After 3 and 6 months of treatment, visual acuity obtained a greater improvement(P < 0.01).After 1, 3 and 6 months of treatment, CMT obviously decreased(P < 0.05). After 3 and 6 months of treatment, the hemorrhage area and fluorescein leakage area also significantly narrowed(P < 0.01).During treatment, no significant adverse events relating to HB01 treatment were ***: On the basis of these results, HB01 could improve visual acuity, and reduce hemorrhage and fluorescein leakage of patients with exudative AMD, which may be an effective alternative and supportive treatment for exudative AMD.

关键词： Macular degeneration Visual acuity Chinese medicine formula HB01

Ketogenic diet for human diseases:the underlying mechanisms and potential for clinical implementations

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Signal Transduction and Targeted Therapy 2022年第2期7卷 402-422页

作者： Huiyuan Zhu Dexi Bi youhua zhang Cheng Kong Jiahao Du Xiawei Wu Qing Wei Huanlong Qin Department of Pathology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina Research Institute of Intestinal Diseases Tongji University School of MedicineShanghaiChina Department of Gastrointestinal Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghaiChina Shanghai Clinical College Anhui Medical UniversityHefeiChina

The ketogenic diet(KD)is a high-fat,adequate-protein,and very-low-carbohydrate diet regimen that mimics the metabolism of the fasting state to induce the production of ketone *** KD has long been established as a remarkably successful dietary approach for the treatment of intractable epilepsy and has increasingly garnered research attention rapidly in the past decade,subject to emerging evidence of the promising therapeutic potential of the KD for various diseases,besides epilepsy,from obesity to *** this review,we summarize the experimental and/or clinical evidence of the efficacy and safety of the KD in different diseases,and discuss the possible mechanisms of action based on recent advances in understanding the influence of the KD at the cellular and molecular *** emphasize that the KD may function through multiple mechanisms,which remain to be further *** challenges and future directions for the clinical implementation of the KD in the treatment of a spectrum of diseases have been *** suggest that,with encouraging evidence of therapeutic effects and increasing insights into the mechanisms of action,randomized controlled trials should be conducted to elucidate a foundation for the clinical use of the KD.

关键词： diseases epilepsy clinical

Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy

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Journal of Molecular Cell Biology 2016年第6期8卷 530-541页

作者： youhua zhang YouDong Pan ChangDong Lin YaJuan Zheng Hao Sun HaiLong zhang JunLei Wang MengYa Yuan Tao Duan QiaoLing Du JianFeng Chen State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 200040China

Intrahepatic cholestasis of pregnancy(ICP)is a cholestatic disorder with potentially deleterious consequences for *** a clear correlation between the elevated levels of maternal serum bile acids and deficient fetal outcome has been established in clinical practice,the underlying mechanisms remain ***,we report that bile acids induce NF-κB pathway activation via G protein-coupled bile acid receptor 1(Gpbar1),with consequent upregulation of inflammatory genes in trophoblasts,leading to aberrant leukocyte infiltration and inflammation in *** acid(UDCA),a drug used clinically to treat ICP,competes with other bile acids for binding with Gpbar1 and thus inhibits bile acid-induced inflammatory response in trophoblasts and improves fetal survival in pregnant rats with obstructive ***,inhibition of NF-κB by andrographolide is more effective than UDCA in benefiting placentas and ***,anti-inflammation therapy targeting Gpbar1/NF-κB pathway could be effective in suppressing bile acid-induced inflammation and alleviating ICP-associated fetal disorders.

关键词： fetal outcome G protein-coupled receptor maternal cholestasis placental inflammation ursodeoxycholic acid

Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2303-2306页

作者： Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang youhua zhang ZhanJun Yan YueBin zhang GuoHui Li JianFeng Chen State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Deportment of Orthopedics Suzhou Ninth People's HospitalSoochow UniversitySuzhou 215000China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)***4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of ***4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1.

关键词： α4β7 acute gp120

关于常曲率空间中子流形p-调和l-形式的一个消灭定理

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数学物理学报（A辑） 2024年第1期44卷 26-36页

作者：张友花福建师范大学数学与统计学院福州350000

令Mn(n≥3)是常曲率空间N^(n+m)(c)中的、具有平坦法丛的完备非紧致的浸入子流形.假设M^(n)(n≥3)满足四个不同的具体几何条件之一时,该文利用Bochner-Weitzenbock公式和Sobolev不等式,通过Duzaar-Fuchs截断函数方法,证明了M^(n)上不存... 详细信息

令Mn(n≥3)是常曲率空间N^(n+m)(c)中的、具有平坦法丛的完备非紧致的浸入子流形.假设M^(n)(n≥3)满足四个不同的具体几何条件之一时,该文利用Bochner-Weitzenbock公式和Sobolev不等式,通过Duzaar-Fuchs截断函数方法,证明了M^(n)上不存在非平凡的L^(β)p-调和l-形式,其中β≥p≥2.

关键词：子流形 p-调和形式消灭性定理

Sequence and Bioinformatics Analysis on MSTN Gene of the Hybrid Grouper Derived from(Epinephelus fuscoguttatus×Epinephelus polyphekadion)

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Agricultural Biotechnology 2023年第3期12卷 46-49,54页

作者： Liu CAO Pan CEHN youhua zhang Xiaomei FU Hai Huang Key Laboratory of Utilization and Conservation for Tropical Marine Bioresources of Ministry of Education Sanya 572022China Yazhou Bay Innovation Institute Sanya 572022China Hainan Key Laboratory for Conservation and Utilization of Tropical Marine Fishery Resources Sanya 572022China Hainan Tropical Ocean University Sanya 572022China

[Objectives]This study aimed to investigate the sequence structure and function of Myostatin(MSTN)gene in the hybrid grouper(Epinephelus fuscoguttatus,♀×Epinephelus polyphekadion,♂).[Methods]Genetic DNA samples were extracted from the caudal fins of the hybrid grouper and its parents to amplify their MSTN ***,MSTN gene sequences were analyzed using bioinformatics tools to predict their protein structures and functions.[Results]The hybrid grouper and its parents shared the same MSTN gene structure,consisting of three exons and two *** sequence of the gene could be translated into 376 amino acids,including an N-terminal signal peptide,a proteolytic processing site(RXXR motif),and nine conserved cysteine residues at C-terminal,which were the typical features of transforming growth factor beta(TGF-β)superfamily *** of protein sequence showed that MSTN was highly conserved between the hybrid grouper and its ***,exon 3,an important functional domain,exhibited a sequence similarity of 100%among *** addition,four variable amino acid residues were detected in exon 2 at positions 141,153,185 and 186 in the hybrid grouper,but they did not affect the secondary structure of the protein.[Conclusion]These results will provide molecular information for future investigation on the growth and heterosis of hybrid grouper species,and on the roles of MSTN gene in regulating the growth traits of the hybrid grouper.

关键词： Grouper MSTN gene Growth traits Gene structure

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基于互联网的市场行情可视化信息系统

计算机工程 2005年第23期31卷 216-218页

作者：袁红春张友华上海水产大学信息学院上海200090 中国科学技术大学自动化系合肥230026

提出了基于Internet的空间数据和非空间数据分布存储的空间数据仓库模型,并将其与数据挖掘技术相结合,开发了基于Internet的农产品市场行情时空演变可视化信息系统。该系统由来自Web网页的数据源、驻留Web数据自动抓取工具和非空间数据... 详细信息

提出了基于Internet的空间数据和非空间数据分布存储的空间数据仓库模型,并将其与数据挖掘技术相结合,开发了基于Internet的农产品市场行情时空演变可视化信息系统。该系统由来自Web网页的数据源、驻留Web数据自动抓取工具和非空间数据库的服务器以及驻留空间数据库、具有可视化展示和空间数据挖掘功能的客户机组成。为提高系统客户机的运行效率,系统采用了多种策略,如分布存储策略、瘦客户机策略、模糊匹配以及批处理策略等。系统具有界面友好、操作简便、可视化程度高等优点。

关键词：空间数据仓库空间数据挖掘分布存储瘦客户机模糊匹配

Construction of eukaryotic expression vector carrying human TSLC1 gene and its expression in HepG2 cells

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The Chinese-German Journal of Clinical Oncology 2007年第4期6卷 322-324页

作者： Li Qin Yongjun Tian Zhengmao zhang youhua Hao Dongliang Yang Division of Clinical Immunology Tongji Hospital Tongji Medical College Huazhong University of Science andTechnology Wuhan 430030 China

Objective： To construct the eukaryotic expression vector for human TSLC1 gene, and to express TSLC1 in HepG2 cells for investigating its effect on HepG2 cell growth. Methods： Full length of TSLC1 cDNA was amplified from RNA of normal human liver by RT-PCR, and cloned into pCI-neo expression vector. The recombinant plasmid pCI-TSLC1 was identified with restriction enzyme and sequenced, and then was stably transfected into HepG2 cells with lipofectamine 2000. The positive clones were examined by western-blotting and immunofluorescence, cell growth was analyzed with MTT assay. Results： The eukaryotic expression vector pCI-TSLC1 was successfully constructed and the stable cell line highly expressing TSLC1 protein was obtained. The growth of TSLCl-transfected cells was significantly suppressed in vitro. Conclusion： The HepG2 stable cell line could highly express TSLC1 protein, which provided a basis for further exploring the roles of TSLC1 in hepatocellular carcinoma.

关键词： TSLC1 gene eukaryoUc expression carcinoma, hepatocellular

生物质一体化制氢中催化剂的选择与失活再生研究

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太阳能学报 2011年第7期32卷 1069-1074页

作者：辛善志张尤华许庆利张素平颜涌捷华东理工大学生物质能研究中心上海200237

对生物质流化床快速热裂解-固定床催化重整一体化制氢中有效催化剂的选择及其性能变化进行了研究。选取空白试验、白云石、镍基催化剂进行对比实验。结果表明:高温有利于氢气产率和气相产品气碳元素选择性的提高,镍基催化剂的催化效果... 详细信息

对生物质流化床快速热裂解-固定床催化重整一体化制氢中有效催化剂的选择及其性能变化进行了研究。选取空白试验、白云石、镍基催化剂进行对比实验。结果表明:高温有利于氢气产率和气相产品气碳元素选择性的提高,镍基催化剂的催化效果明显强于白云石,后者对一氧化碳有较好的选择性。对镍基催化剂的连续催化及循环失活再生研究表明,每次再生后的催化剂其活性都有一定程度的下降,对甲烷的催化效果降低比较明显。XRD及SEM研究表明实验中催化剂失活的主要原因是镍金属晶粒在载体表面的烧结。

关键词：生物质白云石镍催化剂烧结失活