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Modified Approach for Establishing Filament-induced Permanent Middle Cerebral Artery Occlusion Rats and Mice Models

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Chinese Medical Sciences Journal 2011年第4期26卷 257-258页

作者： you-xin ji Ke-tao Lan Chuan-xin Geng Xiao Zou Song-ping Wang Department of Medical Oncology Qingdao Central Hospital Second Affiliated Hospital of Qingdao University Qingdao 266042 China

BRAIN ischemia stroke is a devastating disease,with more than 10％ stroke patients either severely disabled or *** rodent filament middle cerebral artery occlusion (MCAO)model can mimic human brain ischemic stroke well,its wide use was restricted by difficulty in surgery,especially in ligating pterygopalatineartery (PPA).Twenty-seven male Sprague-Dawley rats were randomly divided into A,B,C groups (n=9).All the rats were performed MCAO surgery with sutures of difference *** A used 4-0 blocking suture plus ipsilateral PPA block,group B used 3-0 blocking suture plus ipsilateral common carotid artery (CCA) block,and group C used 3-0 suture plus ipsilateral PPA ***-seven male C57BL/6 wild type mice were also randomly divided into a,b,c *** a used 5-0blocking suture plus ipsilateral PPA block,group b used 6-0blocking suture plus ipsilateral CCA block,group c use 6-0suture plus ipsilateral PPA block.

关键词： SD大鼠小鼠模型动脉闭塞大脑永久性立方纤维

New Understanding on the Memory Effect of Crystallized iPP

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Chinese Journal of Polymer Science 2014年第9期32卷 1224-1233页

作者： Xiang-yang Li Zhe Ma Feng-mei Su Nan Tian you-xin ji jie Lu Zhen Wang 李良彬 National Synchrotron Radiation Laboratory College of Nuclear Science and Technology University of Science and Technology of China Department of Mechanical Engineering Eindhoven University of Technology P.O. Box 513 5600MB Eindhoven The Netherlands Department of Polymer Science and Engineering CAS Key Lab of Soft Matter Chemistry University of Science and Technology of China

In this study, recovery processes of isotactic polypropylene （iPP） melted spherulites at 135 ℃ after melting at higher temperatures （170 ℃-176 ℃） were investigated with polarized optical microscopy and Fourier transform infrared spectroscopy. The recovery temperature was fixed to exclude the interference from heterogeneous nuclei. After melting at temperatures between 170 ℃ and 174 ℃, the melted spherulite could recover back to the origin spberulite at low temperatures. Interestingly, a distinct infrared spectrum from iPP melt and crystal was observed in the early stage of recovery process after melting at low temperatures, where only IR bands resulting from short helices with 12 monomers or less can be seen, which indicates that the presence of crystal residues is not the necessary condition for the polymer memory effect. Avrami analysis further indicated that crystallization mainly took place in melted lamellae. After melting at higher temperatures, melted spherulite cannot recover. Based on above findings, it is proposed that the memory effect can be mainly ascribed to melted lamellae, during which crystalline order is lost but conformational order still exists. These conformational ordered segments formed aggregates, which can play as nucleation precursors at low temperatures.

关键词： Memory effect Isotactic polypropylene Conformational ordering Topological connectivity Aggregate.

Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma

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Chinese Medical Sciences Journal 2016年第4期31卷 221-227页

作者： Ke-ke Nie Chuan-xin Geng Ling Zhang Shi-chao Liu Zhong-fa Zhang Rong Wang Xiao Zou you-xin ji Department of Oncology Qingdao Cancer Hospital Department of Oncology Qingdao Central Hospital2nd Affiliated Hospital of Qingdao University

Objective To investigate the clinical effects and safety of bevacizumab combined with S-1 as the second-line treatment of recurrent and/or metastatic esophageal cancer after chemoradiation. Methods Patients with recurrent or metastatic esophageal cancer after chemoradiation were treated with bevacizumab and S-1. Bevacizumab was used by intravenous infusion, 7.5mg/kg body weight on day 1; S-1 was used by oral at 80mg/m^2·d on day 1-14, 21 days as a cycle of treatment and repeated until either progressive disease or intolerable toxicity occurred. Chest CT were performed and RECIST 1.1 was used for response evaluation. Kaplan-Meier method was used for survival analysis. Side effects were recorded and analyzed. Results Totally 78 patients were enrolled in the study, including 67 squamous cell carcinoma and 11 adenocarcinoma histologically. The overall response(CR+PR) rate was 22.4%(17/76) and disease control(CR+PR+SD) rate was 61.8%(47/76) respectively. The median follow-up time was 20 months(range from 9 to 44 months). The median progression-free survival(PFS) was 4.9 months(95% CI 4.4-5.5) and the median overall survival(OS) was 8.1 months(95% CI 7.6-9.2). The median PFS and OS of patients with metastasis diseases were 6.2 months(95% CI 3.3 to 6.3) and 8.5 months(95% CI 5.8 to 11.2), where PFS was longer than that of patients with local regional recurrence(median 5.0 months, 95% CI 3.0 to 5.5, P=0.017) and OS was longer than that of patients with regional disease and metastasis(median 8.0 months, 95% CI 4.6 to 9.5, P=0.010). The common adverse effects were mild to moderate neutropenia(84.2%), grade Ⅰ -Ⅱ hand and foot syndrome(51.3%), grade Ⅰ -Ⅱ nausea(48.7%), mild epistaxis(30.1%) and mild vomiting(14.5%). Esophageal bleeding occurred in 7.9% of patients. One patient(1.3%) died from massive bleeding which was caused by esophageal perforation. Conclusion Bevacizumab combined with S-1 was effective and safe for esophageal cancer patients who had recurrent or metastatic

关键词： anti-angiogenesis bevacizumab chemoradiation S-1 esophageal carcinoma

Icotinib plus osimertinib overcome epidermal growth factor receptor 19del/T790 M/C797S/V834L quadruplet resistance mutation in a patient with non-small cell lung cancer

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Chinese Medical Journal 2019年第9期132卷 1115-1116页

作者： Chao Zhu Yun-Hong you Ke-Ke Nie you-xin ji Department of Oncology Qingdao Central HospitalSecond Affiliated Hospital of Qingdao UniversityQingdaoShandong 266042China

To the Editor:A 66-year-old woman presented with a severe cough and was admitted into hospital in April *** emission tomography/computed tomography (PET/CT) scan showed a 2.0 cm×2.0 cm node located on the lower lobe ... 详细信息

关键词： Editor woman lung

Crizotinib plus erlotinib overcomes osimertinib resistance in a seriously-ill non-small cell lung cancer patient with acquiredamplification

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Chinese Medical Journal 2021年第3期134卷 373-374页

作者： Zhi-Mei Zhao Song-Ping Wang Lei Sun you-xin ji Department of Oncology Qingdao Central HospitalQingdao UniversityQingdaoShandong 266042China

To the Editor:A 59-year-old Chinese man who presented with a severe cough and short of breath was admitted into hospital in October,*** tomography scan showed a 4.0 cm2.0 cm tumor located on the lower lobe of right lung[Figure 1A]and multi-bone lesions,core needle biopsy was performed and adenocarcinoma was confirmed by *** of metastatic lung adenocarcinomawithT4N3M1cin stage IVB was made by oncologists and *** generation sequencing(NGS)with the biopsied tumor was done,and epidermal growth factor receptor(EGFR)exon 21 L858R mutation with mutant allele fractions(MAF)of 24.8%was ***(Betta Pharmaceuticals Co.,Ltd,Hangzhou,China),a firstgeneration EGFR tyrosine kinase inhibitor(TKI),at a dose of 125mg orally,three times a day was *** patient got a partial response(PR)after 5 months according to the Response Evaluation Criteria in Solid Tumors 1.1[Figure 1B].

关键词： lung admitted patient

Sorafenib in Liver Function Impaired Advanced Hepatocellular Carcinoma

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Chinese Medical Sciences Journal 2014年第1期29卷 7-14页

作者： you-xin ji Zhong-fa Zhang Ke-tao Lan Ke-ke Nie Chuan-xin Geng Shi-chao Liu Ling Zhang xing-jun Zhuang Xiao Zou Lei Sun Zong-chun Zhang Department of Oncology Qingdao Central Hospital The Second Affiliated Hospital of Qingdao University Department of Radiotherapy Qingdao Cancer Hospital Department of Oncology PLA 401 Hospital

Objective To explore the efficacy and safty of sorafenib in Child-Pugh class B to class C hepatocellular carcinoma （HCC）. Methods In this three-center open-label study from November 2011 to May 2013, we randomly assigned 189 patients with advanced Child-Pugh class B or C HCC patients into two groups, one group with 95 patient to receive sorafenib （400 mga time, twice a day） and the other group with 94 patients to receive best supportive care. The primary end points were progression-free survival and overall survival. Results The median progression-free survival was 2.2 months and 1.9 months in the sorafenib group and best supportive care group respectively （Hazard ratio in the sorafenib group, 0.55; 95% confidence interval, 0.40-0.75; P=O.O02）. The median overall survival was 4.0 months and 3.5 months in the sorafenib group and best supportive care group respectively （Hazard ratio in the sorafenib group, 0.48; 95% confidence interval, 0.35-0.68; P〈0.001）. The main adverse effect of sorafenib was rash and ache of the skin （in 51.7% patients）. The incidences of severe rash, diarrhea, and dry skin were 5.6%, 5.6%, and 2.2% in the sorafenib group. One patient reached partial response in the sorafenib group. Conclusions Sorafenib is safe in patients with liver function impaired advanced HCC. It is effective in terms of progression-free survival and overall survival compared with best supportive care. Liver functions are the important predictive factors.

关键词： sorafenib hepatocullelar carcinoma best supportive care survival

A molecular insight into coke formation process of vacuum residue in thermal cracking reaction

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Petroleum Science 2024年第3期21卷 2130-2138页

作者： ji-Guang Li xin Guo Huan-Di Hou Heavy Oil Processing Department Sinopec Research Institute of Petroleum Processing Co.LtdBeijing100083China

Understanding the coking behaviors has been considered to be really essential for developing better vacuum residue processing technologies.A battery of thermal cracking tests of typical vacuum residue at 410℃ with various reaction time were performed to evaluate the coke formation *** total yields of ideal components including naphtha,atmospheric gas oil(AGO)and vacuum gas oil(VGO)of thermal cracking reactions increased from 10.89%to 40.81%,and the conversion ratios increased from8.05%to 43.33%with increasing the reaction time from 10 to 70 *** asphaltene content increased from 12.14%to a maximum of 22.39%and then decreased,and this maximum of asphaltene content occurred at the end of the coking induction *** asphaltenes during the coking induction period,at the end and after coking induction period of those tested thermal cracking reactions were characterized to disclose the structure changing rules for coke formation process,and the coke formation pathways were discussed to reveal the coke formation process at molecular level.

关键词： Vacuum residue Thermal cracking Asphaltene Coking induction period Sulfur Nitrogen

Copper-catalyzed enantioselective desymmetrizing C(sp^(2))-H functionalization of azide-ynamides via α-imino copper carbenes

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Science China Chemistry 2024年第9期67卷 2982-2988页

作者： En-He Huang Li-Gao Liu you-Wei Yin Hao-Xuan Dong ji-jia Zhou xin Lu Bo Zhou Long-Wu Ye Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

α-Imino metal carbenes are versatile intermediates in organic synthesis,and have broad applications in the assembly of divergent ***,the catalytic enantioselective desymmetrization based onα-imino metal carbenes has not been developed to ***,we disclose an enantioselective desymmetrizing C(sp^(2))-H functionalization of azide-ynamides viaα-imino copper carbenes,leading to the efficient assembly of divergent chiral indoloazepines in generally moderate to excellent yields with high ***,this reaction represents the first enantioselective desymmetrization based onα-imino metal *** synthetic transformations and biological tests show the potential utility of this ***,computational studies are employed to elucidate the reaction mechanism and the origin of enantioselectivity.

关键词： enantioselective desymmetrization metal carbenes copper catalysis nitrene transfer alkynes

Experimental and numerical investigation of two blended blade and endwall configurations

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Chinese Journal of Aeronautics 2024年第9期37卷 150-163页

作者： Tongtong MENG xin LI Ling ZHOU Lucheng ji Institute for Aero Engine Tsinghua UniversityBeijing 100084China Schoolof Aerospace Engineering Bejing Institute of TechnologyBeijing 0081China

The Blended Blade and Endwall(BBEW)technique has proven to be effective in control-ling the intersection of boundary layer in corner region of the compressor *** this study,the experiment and analysis of two different BBEW designs are ***,based on a linear cas-cade with 0.7 Mach number inflow,two different configurations,BBEW 1 and BBEW 2,are well ***,according to the experimental result,control effects of these two BBEW configu-rations are validated and compared subsequently under various working *** results demonstrate a reduction in total pressure loss of 12.8%and 29%at the design point for BBEW 1 and BBEW 2,***,the BBEW technique proves effective in suppressing the development of the boundary layer and preventing corner *** by detailed numerical analysis,improvements around the corner region,especially for the boundary layer,are extracted to show the mechanisms and distinctions between the two *** results indicate that BBEW 1 significantly restrains the development of boundary layer before separation occurs,while BBEW 2 directly controls the strength and scale of the corner separation.

关键词： Aerodynamic Computational fluid dynamic Experiment Corner separation Blended Blade and Endwall(BBEW)