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Role of macrophage polarization in diabetic foot ulcer healing:A bibliometric study

World Journal of Diabetes 2025年第1期16卷 169-186页

作者： you-wen zhang Lei Sun Yan-Nan Wang Shi-Yu Zhan Department of Peripheral Vascular Disease Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Surgery The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001Shandong ProvinceChina Department of Surgery Longkou Traditional Chinese Medicine HospitalYantai 265701Shandong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are a significant contributor to disability and mortality in diabetic *** polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU ***,the complex mechanism,the difficulty in clinical translation,and the large heterogeneity present significant ***,this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU *** To examine the relevant literature on macrophage polarization in DFU *** A bibliometric analysis was conducted using the Web of Science *** literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software(VOSviewer and CiteSpace)and bibliometric online *** obtained literature was then subjected to visualization and analysis of different countries/regions,institutions,journals,authors,and keywords to reveal the research’s major trends and *** The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023,especially in the latter *** researchers were the most prolific in this field,with 217 publications,while American researchers had been engaged in this field for a longer *** Tan of Nanjing Drum Tower Hospital and Qian Ding of Nanjing University were the first to publish in this *** Jiao Tong University was the institution with the most publications(27).The keywords“bone marrow”,“adjustment,replacement,response,tissue repair”,and“activation,repair,differentiation”appeared more *** study of macrophage polarization in DFU healing focused on the regulatory mechanism,gene expression,and other *** This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polar

关键词： Diabetic foot Wound healing Macrophage polarization Bibliometric analysis Research cooperation Research trend

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Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites

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World Journal of Gastroenterology 2016年第12期22卷 3363-3371页

作者： Chao Chen Ren-Pin Chen Hai-Hua Lin wen-you zhang Xie-Lin Huang Zhi-Ming Huang Department of Gastroenterology the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China Ren-Ji College of wenzhou Medical University Wenzhou 325000 Zhejiang Province China

AIM: To investigate the role of tolvaptan in regulating aquaporin(AQP)-2 expression and fecal water content in cirrhotic rats with ***: Cirrhosis with ascites was induced in rats by repetitive dorsal injection of CCl4 for 14 wk. In total, 84 cirrhotic rats with ascites divided into three groups(vehicle, 3 mg/kg and 5 mg/kg tolvaptan), and then further divided into five subgroups(days 1, 2, 3, 4, and 5). Blood samples were obtained to measure vasopressin and sodium concentrations. Rats were killed and colonic mucosa was scraped for analysis of protein expression and AQP-2 transcriptional level. The whole layer was fixed for hematoxylin&eosin(HE) staining and feces were collected for determination of fecal water content. CONCLUSION: Compared with vehicle, vasopressin decreased significantly in the tolvaptan groups from day 2 to a similar level in each treatment group. AQP-2 showed significant upregulation in cirrhotic rats with ascites compared with an untreated control group(100% ± 22.9% vs 22.2% ± 10.23%, P < 0.01). After administration of tolvaptan, AQP-2 expression began to decrease significantly from day 2 in each treatment group, but no significant difference was finally found between the treatment groups. Fecal water content inthe distal colon was increased by 5 mg/kg tolvaptan on day 1(66.8% ± 9.3% vs 41.4% ± 6.3%, in the vehicle group, P < 0.05). Fecal water content returned to baseline at day 4 at the latest in both treatment groups, and did not correspond to the change in AQP-2 expression. HE staining of the colonic mucosa showed no mucosal damage related to ***: Upregulation of AQP-2 in the distal colon is found in cirrhotic rats with ascites. Tolvaptan inhibits its expression and may decrease water reabsorption and induce diarrhea.

关键词： Tolvaptan Aquaporin-2 Cirrhosis Ascites

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Vitamin D status and the risk of pancreatic cancer： a meta-analysis

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Chinese Medical Journal 2013年第17期126卷 3356-3359页

作者： LIU Shang-long ZHAO Yu-pei DAI Meng-hua you Lei wen zhang XU Jian-wei Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background Vitamin D status in relation to pancreatic cancer risks is still inconsistent. This study was performed to evaluate the association between vitamin D status and risk of pancreatic cancer using a meta-analysis approach. Methods A systemic review of all relevant literature in English was performed by searching Pubmed, Web of Science and Embase to identify eligible studies from the earliest available date to April 1, 2012. The search terms ＂vitamin D＂, ＂25-hydroxyvitamin D＂, ＂pancreatic cancer＂ or ＂pancreatic neoplasms＂ were used to retrieve relevant papers. Inclusion criteria were：（1） the exposure of interest was intake of vitamin D or blood levels of vitamin D; （2） the outcome of interest was pancreatic cancer; （3） data on high and low intake or blood vitamin D in cases and controls were available; （4） odds ratio （OR） estimates with 95% confidence interval （CI） were provided; （5） primary epidemiological data were provided reporting pancreatic cancer incidence. The combined OR values and their 95% CIs were calculated via a meta-analysis. The potential presence of publication bias was estimated using Egger＇s regression asymmetry test. Results Nine studies with a total of 1 206 011 participants met the inclusion criteria. The test for heterogeneity showed there were significant differences among the included studies （I^2=70.9%, P=0.001）, so a randomized-effects model was used in the meta-analysis. The pooled OR of pancreatic cancer for the highest versus the lowest categories of vitamin D level was 1.14 （95% CI 0.896-1.451）, and the Z-score for the overall effect was 1.06 （P=-0.288）, showing that there was no significant association between vitamin D levels and the risk of pancreatic cancer. Egger＇s test indicated there was a low possibility of publication bias in this study （P=0.348）. Conclusion Dietary vitamin D or circulating concentrations of 25-hydroxyvitamin D are not associated with the risk of pancreatic cancer based on evidence from currently publis

关键词： meta-analysis pancreatic cancer vitamin D

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饥饿对草鱼血清游离氨基酸的影响

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淡水渔业 2007年第3期37卷 26-29页

作者：游文章文华马琳武汉工程大学湖北省新型反应器与绿色化学工艺重点实验室武汉430073 中国水产科学研究院长江水产研究所湖北荆州434000

将池塘捕获的体重(1.70±0.80)kg的草鱼(Ctenopharyngodon idella)饲养在室内水族箱内,分别测定了空腹(禁食1 d,26样本)、饥饿15 d(15样本)、饥饿30 d(15样本)的草鱼血清游离氨基酸含量。结果显示:草鱼血清游离氨基酸总量基本恒定,空腹... 详细信息

将池塘捕获的体重(1.70±0.80)kg的草鱼(Ctenopharyngodon idella)饲养在室内水族箱内,分别测定了空腹(禁食1 d,26样本)、饥饿15 d(15样本)、饥饿30 d(15样本)的草鱼血清游离氨基酸含量。结果显示:草鱼血清游离氨基酸总量基本恒定,空腹、饥饿15 d和饥饿30 d的氨基酸总量无显著差异;处于饥饿状态的草鱼血清游离必需氨基酸总量极显著地高于空腹状态,非必需氨基酸总量极显著地低于空腹状态;血清赖氨酸、缬氨酸、异亮氨酸、亮氨酸和胱氨酸含量因饥饿显著升高,而组氨酸、苯丙氨酸、天冬氨酸、丝氨酸、谷氨酸和酪氨酸因饥饿显著降低;饥饿15 d和饥饿30 d各氨基酸含量均未见差异。草鱼血清游离氨基酸含量在正常摄食情况下主要受饲料蛋白质影响,处于饥饿状态下主要来源于肌体蛋白质的分解,比较正常摄食后和饥饿状态下血清游离氨基酸的组成可评价饲料蛋白质的质量。

关键词：草鱼(Ctenopharyngodon idella) 血清游离氨基酸禁食

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高超声速组合发动机预冷器抗结霜涂层技术研究

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推进技术 2017年第2期38卷 463-470页

作者：张友法张文文郑日恒李志永张志刚王勤智东南大学材料科学与工程学院江苏南京211189 江苏省先进金属材料高技术研究重点实验室江苏南京211189 北京动力机械研究所高超声速冲压发动机技术重点实验室北京100074

为了研究高超声速组合发动机预冷器表面的结霜问题,开展了超低温冷却表面涂层技术及其抗结霜性能的研究。研究了不同温度下,不凝性气体混入、高速气流剪切对结霜过程的影响。结果表明:在-20℃,Zn O超疏水表面,可以延迟表面霜晶的形成长... 详细信息

为了研究高超声速组合发动机预冷器表面的结霜问题,开展了超低温冷却表面涂层技术及其抗结霜性能的研究。研究了不同温度下,不凝性气体混入、高速气流剪切对结霜过程的影响。结果表明:在-20℃,Zn O超疏水表面,可以延迟表面霜晶的形成长达7min,结霜量减少了一半。与单独加风速和单独加入甲醇的外加环境相比,外加流动剪切和甲醇的组合最能够抑制表面结霜,超疏水表面可在10min内不发生水珠的冻结。在-150℃,超疏水表面霜晶的形核率低,仍具有一定抑制结霜的效果。

关键词：组合发动机空气预冷器抗结霜不凝性气体超疏水

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Pyoung and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： wen-Jin Yuan Yi-Juan Zheng Bing-Rong zhang Yi-Jie Lin you Li Yan-Yan Qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： wen-Chong Zhen Jing Sun Xue-Ting Bai Qian zhang Zi-Han Li Yi-Xin zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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13种饲料原料蛋白质对尼罗罗非鱼的营养价值

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中国水产科学 2000年第2期7卷 37-42页

作者：吴建开雍文岳游文章文华廖朝兴中国水产科学研究院长江水产研究所!湖北荆州434000

以Cr2 O3为指示物 ,以 70 %基础饲料和 30 %的待测饲料原料组成试验饲料 ,测定尼罗罗非鱼对 13种饲料原料的蛋白质和必需氨基酸的表观消化率。以有效必需氨基酸含量计算了饲料原料中蛋白质的必需氨基酸指数 ,并和鱼体必需氨基酸含量进... 详细信息

以Cr2 O3为指示物 ,以 70 %基础饲料和 30 %的待测饲料原料组成试验饲料 ,测定尼罗罗非鱼对 13种饲料原料的蛋白质和必需氨基酸的表观消化率。以有效必需氨基酸含量计算了饲料原料中蛋白质的必需氨基酸指数 ,并和鱼体必需氨基酸含量进行比较 ,评价了饲料原料蛋白质对尼罗罗非鱼的营养价值。结果表明 ,氨基酸总量消化率和蛋白质消化率接近 ;秘鲁鱼粉、大豆粕和玉米蛋白质的有效必需氨基酸指数均在70 %以上 ,其营养价值分别是动物蛋白、植物蛋白和能量饲料原料中最高的 ;酵母饲料的营养价值在所有饲料原料中最低 ;血粉和羽毛粉的营养价值较低 (只高于酵母饲料 ) ;其余饲料原料蛋白质营养价值都较高

关键词：尼罗罗非鱼饲料原料蛋白质有效必需氨基酸指数营养价值

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