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Case Report:Takayasu's arteritis associated with Crohn's disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 631-634页

作者： you-shi liu you-hong FANG Ling-xiang RUAN you-ming LI Lin LI Ling-ling JIANG Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Children 's Hospital of Zhejiang University Hangzhou 310003 China Department of Radiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Takayasu's arteritis(TA),also known as the "pulseless disease," is a chronic vasculitis of the aorta and aortic *** with Crohn's disease is rare and has not been documented in China *** this paper we report on a case of Takayasu's arteritis associated with concurrent Crohn's disease.A 17-year-old Chinese male developed upper limb sourness and a sensation of fatigue,and his upper limb pulses were *** was diagnosed with TA and underwent an axillary artery bypass with autologous great saphenous vein on the left subclavian *** the surgery,he regained the normal blood *** patient also had years of diarrhea and developed an anal canal ulcer,and was diagnosed with inflammatory bowel disease and ulcerative colitis *** months after the TA surgery,he was hospitalized for severe stomachache and diarrhea and was finally diagnosed with Crohn's *** possible pathophysiological mechanisms responsible for concurrent existence of TA and Crohn's disease may be associated with immune disorders,especially autoimmunity.

关键词： Takayasu's arteritis Crohn's disease Inflammatory bowel disease Immune disorders

A generalized two-mode entangled state： Its generation,properties, and applications

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Frontiers of physics 2014年第4期9卷 451-459页

作者： Kai-Min Zheng shi-you liu Hao-Liang Zhang Cun-Jin liu Li-Yun Hu Center for Quantum Science and Technology College of Physics and Communication Electronics Jiangxi Normal University Nanchang 330022 China Key Laboratory of Optoelectronic and Telecommunication of Jiangxi Nanchang 330022 China

Using the technique of integration within an ordered product of operators we construct a generalized two-mode entangled state, which can be generated by an asymmetrical beam splitter （BS）. Some important properties of this state, such as orthogonality and Schmidt decomposition, are also dis- cussed by deriving the expression of BS operator in coordinate representation. As its applications, to conjugate state, obtain operator identities, generate new squeezing operators （squeezed state） are also presented. It is shown that the fidelity of quantum teleportation can be enhanced under certain case by using the asymmetrical new squeezed state as entangled resource.

关键词： entangled state beam splitter (BS) quantum teleportation

Automatic estimation of traveltime parameters in VTI mediausing similarity-weighted clustering

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Petroleum Science 2020年第2期17卷 363-375页

作者： shi-you liu Ying-Zhao Zhang Chao Li Wan-Yuan Sun Gang Fang Guo-Chang liu Zhanjiang Branch China National Offshore Oil Corporation Ltd.Zhanjiang 524000GuangdongChina State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China Key Laboratory of Marine Hydrocarbon Resources and Environmental Geology Ministry of Land and ResourcesQingdao Institute of Marine GeologyChina Geological SurveyQingdao 266071ShandongChina

Compared with hyperbolic velocity estimation methods,nonhyperbolic methods(such as shifted hyperbola)are better choices for large offsets or vertical transverse isotropy(VTI)*** local seismic event slope contains subsurface information,they can be used to estimate zero-offset two-way traveltime and normal moveout *** traditional velocity estimation methods require a great deal of manual work and are also prone to human *** order to estimate the traveltime parameters for VTI media automatically,in this paper,we propose to use predictive painting and similarity-weighted clustering to obtain traveltime *** predictive painting is used to estimate zero-offset two-way traveltime,and the shifted-hyperbola traveltime equation is used to obtain velocity and anisotropy *** first map local slopes to zero-offset two-way traveltime and moveout-parameters domain and then use similarity-weightedk-means clustering to find the maximum likelihood anisotropy parameters of the main subsurface *** order to demonstrate that,we apply the similarity-weighted clustering method to synthetic and field data examples and the results are of higher accuracy when compared to the ones obtained using multiparameter semblance-based *** estimation error section,it can be seen that the estimation error of multiparameter semblance-based method is about 3-5 times that of the proposed method.

关键词： Nonhyperbolic moveout Predictive painting k-means clustering Seismic velocity analysis Vertical transverse isotropy

Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 265-268页

作者： you-shi liu Geng-Yun Xu Dong-Qing Cheng you-Ming Li Department of Gastroenterology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. lys_2002cn@***

BACKGROUND: Alcoholic liver disease (ALD) is a serious and potentially fetal consequence of alcohol use. The diagnosis of ALD is based on alcohol consumption, physical signs and symptoms, and laboratory tests. The aim of the present study was to assess the reliability of carbohydrate-deficient transferrin (CDT) in the diagnosis of ALD.METHODS: According to the diagnostic criteria for ALD by the Chinese Medical Association in 1995, 76 patients with ALD, 55 patients with alcoholism, 32 patients with nonalcoholic liver disease (NALD), and 27 healthy subjects (controls) were studied. Serum CDT was assayed by isoelectric focusing immunofixation and Comassie blue staining. The levels of alamine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyltransferase (GGT) were also examined.RESULTS: The positive rate of CDT in the patients with ALD was 93.4%(71/76), which was higher than that in those with alcoholism (52.7%, 29/55, P<0.001), in those with NALD(9.4%, 3/32, P<0.001), and in healthy controls, respectively. The sensitivity and specificity of CDT for ALD was 93.4% and 71.9%, respectively.CONCLUSION: CDT may help diagnose alcoholic liver disease.

关键词： carbohydrate-deficient transferrin alcoholic liver disease diagnosis

Development of an enhanced online tritium monitoring system using plastic scintillation fiber array

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-11页

作者： Cheng, Wen-Yu Deng, Ke Zeng, you-shi liu, Wei Zhang, Qin Chinese Acad Sci Shanghai Inst Appl Phys Shanghai 201800 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Tritium, a radioactive nuclide discharged by nuclear power plants, poses challenges for removal. Continuous online monitoring of tritium in water is crucial for real-time radiation data, given its predominant existence in the environment as water. This paper presents the design, simulation, and development of a tritium monitoring device utilizing a plastic scintillation fiber (PSF) array. Experimental validation confirmed the device's detection efficiency and minimum detectable activity. The recorded detection efficiency of the device is 1.6x10-3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$1.6\times 10{-3}$$\end{document}, which exceeds the theoretically simulated value of 4x10-4\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$4\times 10{-4}$$\end{document} by four times. Without shielding, the device can achieve a minimum detectable activity of 3165BqL-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$3165\,\hbox {Bq}\,\hbox {L}{-1}$$\end{document} over a 1600-second measurement duration. According to simulation and experimental results, enhancing detection efficiency is possible by increasing the number and length of PSFs and implementing rigorous shielding measures. Additionally, reducing the diameter of PSFs can also improve detection efficiency. The minimum detectable activity of the device can be further reduced using the aforementioned methods.

关键词： Tritium Plastic scintillating fiber array Detector WATER SOIL

Correlation of polymorphism in the interleukin-1 receptor antagonist gene intron 2 with alcoholic liver disease

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 41-45页

作者： Wei-Xing Chen Gen-Yun Xu Chao-Hui Yu Ping Wang Min Yu Ping Xu you-shi liu you-Ming Li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China.

BACKGROUND: Interleukin-1 receptor antagonist (IL-1ra) can inhibit the pro-inflammatory effects of IL-1, which recently has been thought to involve the pathogenesis of alcoholic liver disease (ALD). This study was undertaken to determine whether there is any association between IL-1ra gene polymorphism and ALD in a Chinese population.METHODS: The polymorphism of IL-1ra gene intron 2 (VNTR) was assessed in 165 alcoholics (43 alcohol-dependent subjects without liver diseases, 30 patients with alcoholic fatty liver, 61 patients with alcoholic hepatitis and 31 patients with alcoholic cirrhosis) and 65 healthy control subjects by PCR with DNA of peripheral blood mononuclear cells.RESULTS: The rate of IL-1RN*1 carriage was statistically higher in the alcoholics than in the control group (98.79% vs 93.85%, chi2=4.48, P<0.050). And the IL-1RN*1 allele frequency was more common in the alcoholics than in the control group (86.67% vs 76.92%, chi2=6.56, P<0.025). IL-1RN*1 heterozygote was significantly more frequent in the patients with alcoholic hepatitis or those with cirrhosis than in the alcohol-dependent subjects without liver diseases (32.79%, 29.03% vs 9.30%; chi2=7.84, chi2=4.84; P<0.010, P<0.050). The IL-1RN*2 allele frequency in the patients with alcoholic hepatitis and the patients with cirrhosis was also significantly higher than in those alcoholics without liver diseases (13.93%, 17.74% vs 4.65%; chi2=4.79, chi2=6.78; P<0.050, P<0.010). But the frequencies of IL-1RN*1 heterozygote and IL-1RN*2 allele appear to be not different between the patients with alcoholic fatty liver and the alcoholics without liver diseases.CONCLUSIONS: IL-1ra gene polymorphism is closely associated with race. IL-1RN*2 allele doesn't influence the susceptibility to ALD, but the gene carriers with ALD have additional risk for aggravation of the illness.

关键词： interleukin-1 receptor antagonist gene polymorphism alcoholic liver disease

Plasmon-enhanced self-powered GaN/ZnTe core/shell nanopillar array photodetector

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Nano Research 2024年第6期17卷 5569-5577页

作者： Jianqi Dong Dongqi Zhang Yi Ma Daotong you Jinping Chen Bin liu Xingfu Wang Zengliang shi Chunxiang Xu State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials National Laboratory of Solid State MicrostructuresSchool of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Photonics Technology Jinan UniversityGuangzhou 510632China Guangdong Engineering Research Center of Optoelectronic Functional Materials and Devices Institute of SemiconductorsSouth China Normal UniversityGuangzhou 510631China

Nanostructure photodetectors,as the core component of optoelectronic devices,are mainly focused on the precise preparation of mixed-component nano-heterostructures and the realization of zero power consumption ***,we successfully fabricated n-GaN/p-ZnTe core/shell nanopillar array and realized self-power ultraviolet/violet *** radial heterojunction nanodevice reveals high light-dark current ratio of 104 at 0 V bias,indicating effective carriers’*** more,by integrating plasmonic effect,the responsivity and detectivity of the Au nanoparticles decorated device are increased from 3.85 to 148.83 mA/W and 4.45×1011 to 2.33×1012 Jones under 325 nm UV light *** the rise and the fall time are decreased 1.3 times and 6.8 times under 520 nm visible light irradiation at 0 V *** high photocurrent gain is derived from that the oscillating high-energy hot electrons in Au nanoparticles spontaneously inject into the ZnTe conduction band to involve the photodetection *** work presents an effective route to prepare high-performance self-power photodetector and provides a promising blueprint to realize different functional photoelectronic devices based on core/shell nanostructure.

关键词： GaN/ZnTe core/shell nanopillar array self-power ultraviolet/visible photodetector plasmonic effect

Pathology of pain and its implications for therapeutic interventions

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2851-2899页

作者： Bo Cao Qixuan Xu Yajiao shi Ruiyang Zhao Hanghang Li Jie Zheng Fengyu liu you Wan Bo Wei Department of General Surgery First Medical CenterChinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health CommissionPeking UniversityBeijing 100191China

Pain is estimated to affect more than 20%of the global population,imposing incalculable health and economic *** pain management is crucial for individuals suffering from ***,the current methods for pain assessment and treatment fall short of clinical *** from advances in neuroscience and biotechnology,the neuronal circuits and molecular mechanisms critically involved in pain modulation have been *** research achievements have incited progress in identifying new diagnostic and therapeutic *** this review,we first introduce fundamental knowledge about pain,setting the stage for the subsequent *** review next delves into the molecular mechanisms underlying pain disorders,including gene mutation,epigenetic modification,posttranslational modification,inflammasome,signaling pathways and *** better present a comprehensive view of pain research,two prominent issues,sexual dimorphism and pain comorbidities,are discussed in detail based on current *** status quo of pain evaluation and manipulation is summarized.A series of improved and innovative pain management strategies,such as gene therapy,monoclonal antibody,brain-computer interface and microbial intervention,are making strides towards clinical *** highlight existing limitations and future directions for enhancing the quality of preclinical and clinical *** to decipher the complexities of pain pathology will be instrumental in translating scientific discoveries into clinical practice,thereby improving pain management from bench to bedside.

关键词： pain thereby summarized

Constructing the Impossible Differential of Type-II GFN with Boolean Function and Its Application to WARP

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Chinese Journal of Electronics 2024年第1期33卷 80-89页

作者： Jiali shi Guoqiang liu Chao LI College of Liberal Arts and Sciences National University of Defense Technology Hunan Engineering Research Center of Commercial Cryptography Theory and Technology Innovation State Key Laboratory of Information Security Institute of Information Engineering

Type-Ⅱ generalized Feist el network(GFN) has attracted a lot of attention for its simplicity and high *** differential attack is one of the powerful cryptanalytic approaches for word-oriented block ciphers such as Feistel-like *** deduce the impossible differential of Type-Ⅱ GFN by analyzing the Boolean function in the middle *** main idea is to investigate the expression with the variable representing the plaintext(ciphertext) difference words for the internal state *** adopting the miss-in-the-middle approach,we can construct the impossible differential of Type-Ⅱ *** an illustration,we apply this approach to WARP,a lightweight 128-bit block cipher with a 128-bit key which was presented by Banik et *** SAC *** structure of WARP is a 32-branch Type-Ⅱ ***,we find two 21-round truncated impossible differentials and implement a 32-round key recovery attack on *** the 32-round key recovery attack on WARP,some observations are used to mount an effective *** the advantage of the early abort technique,the data,time,and memory complexities are 2125.69chosen plaintexts,2126.6832-round encryptions,and 2100-bit,*** the best of our knowledge,this is the best attack on WARP in the single-key scenario.

关键词： Ciphers Boolean functions Parallel processing Complexity theory