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间充质干细胞治疗再生障碍性贫血:抑制或激活其病理演变过程中的相关靶点

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中国组织工程研究 2025年第31期29卷 6800-6810页

作者：张溥链刘宝茹杨敏遵义医科大学附属医院血液内科贵州省遵义市563000

背景:目前再生障碍性贫血的主要治疗方法是进行造血干细胞移植和免疫抑制治疗。然而,治疗后的并发症和不良反应严重影响了再生障碍性贫血患者的预后和生活质量。间充质干细胞有着独特的低免疫原性,可抑制T淋巴细胞、B淋巴细胞、树突细... 详细信息

背景:目前再生障碍性贫血的主要治疗方法是进行造血干细胞移植和免疫抑制治疗。然而,治疗后的并发症和不良反应严重影响了再生障碍性贫血患者的预后和生活质量。间充质干细胞有着独特的低免疫原性,可抑制T淋巴细胞、B淋巴细胞、树突细胞、自然杀伤细胞的增殖与活化,调节机体免疫,为再生障碍性贫血和移植物抗宿主病带来了良好的细胞治疗前景。目的:综述近几年间充质干细胞在再生障碍性贫血中的应用进展,以及间充质干细胞与再生障碍性贫血发病机制之间的相关性,为再生障碍性贫血患者提供新的治疗理论基础和更有效的治疗方案。方法:检索2003年1月至2024年2月中国知网和PubMed数据库,中文检索词为“再生障碍性贫血,间充质干细胞,造血干细胞,造血,造血微环境,造血干细胞移植,生物学,免疫,移植物抗宿主病”;英文检索词为“aplastic anemia,mesenchymal stem cell,hematopoietic stem cell,hematopoiesis,hematopoietic microenvironment,hematopoietic stem cell transplantation,biology,immuno-modulatory,immune regulation,graft-versus-host disease,chronic graft-versus-host disease,acute graft-versus-host disease”。排除低质量、重复、内容陈旧的文献,最终纳入88篇文献进行综述分析。结果与结论:①间充质干细胞作为一种多能干细胞,可通过细胞间直接接触、分泌多种造血相关因子、参与造血相关通路来重塑造血功能;②与间充质干细胞联合免疫抑制剂输注、单纯间充质干细胞输注相比,间充质干细胞联合造血干细胞移植治疗再生障碍性贫血患者更能发挥两种干细胞的疗效,显著降低慢性和Ⅲ-Ⅳ度急性移植物抗宿主病的发生率,提高患者的总生存期;③使用脐带来源和传代次数<6次的间充质干细胞,并且在造血干细胞移植前输注的方案可能是更有效的治疗选择;④间充质干细胞与再生障碍性贫血发病机制之间存在密切联系,通过抑制或激活再生障碍性贫血病理演变过程中相关的靶点,可能为再生障碍性贫血带来新的治疗方案。

关键词：再生障碍性贫血间充质干细胞造血干细胞移植细胞治疗造血微环境移植物抗宿主病发病机制综述

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Self-template-oriented synthesis of lead-free perovskite Cs_(3)Bi_(2)I_(9) nanosheets for boosting photocatalysis of CO_(2) reduction over Z-scheme heterojunction Cs_(3)Bi_(2)I_(9)/CeO_(2)

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Journal of Energy Chemistry 2022年第6期31卷 348-355,I0010页

作者： you-Xiang Feng Guang-Xing Dong Ke Su Zhao-Lei Liu Wen zhang min zhang Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China

Lead halide perovskite (LHP) nanocrystals have been intensely studied as photocatalysts for artificial photosynthesis in recent ***,the toxicity of lead in LHP seriously limits their potential for widespread ***,we first present the synthesis of 2D lead-free halide perovskite (Cs_(3)Bi_(2)I_(9)) nanosheets with self-template-oriented method,in which BiOI/Bi_(2)O_(2) nanosheets were used as the template and Bi ion source *** facile electrostatic self-assembly strategy,a Z-scheme heterojunction composed of Cs_(3)Bi_(2)I_(9)nanosheets and CeO_(2) nanosheets (Cs_(3)Bi_(2)I_(9)/CeO_(2)-3:1) was constructed as photocatalyst for the photo-reduction of CO_(2) coupled with the oxidation of H_(2)*** to the matching energy levels and the close interfacial contact between Cs_(3)Bi_(2)I_(9)and CeO_(2) nanosheets,the separation efficiency of the photogenerated carriers in Cs_(3)Bi_(2)I_(9)/CeO_(2)-3:1 composite was significantly ***,the environment-friendly halide perovskite heterojunction Cs_(3)Bi_(2)I_(9)/CeO_(2)-3:1presents impressive photocatalytic activity for the reduction of CO_(2)to CH_(4)and CO with an electron consumption yield of 877.04μmol g^(-1),which is over 7 and 15 times higher than those of pristine Cs_(3)Bi_(2)I_(9)and CeO_(2)nanosheets,exceeding the yield of other reported bismuth-based perovskite for photocatalytic CO_(2)reduction.

关键词： Lead-free perovskite Z-scheme heterojunction Cs_(3)Bi_(2)I_(9)nanosheets Photocatalytic CO_(2)reduction H_(2)O oxidation

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基于E-R建模的MIS系统设计

十堰职业技术学院学报 2004年第4期17卷 69-72页

作者：戴友元张明欧阳彦阶十堰职业技术学院计算机工程系湖北十堰442000

　本文较全面地讨论了一个MIS系统的开发设计。在该系统的设计开发中既采用程序设计技术解决具体问题又运用设计方法学指导系统整体设计,从而使设计出来的系统具有高可用性和结构稳健性。同时,建立了数据库E-R模型。

关键词：信息管理系统 E—R建模 PowerBuilder程序设计退耕还林

8周运动预适应增强脂肪干细胞治疗心肌梗死大鼠的效果

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中国组织工程研究 2025年第7期29卷 1363-1370页

作者：娄国张敏付常喜江苏经贸职业技术学院江苏省南京市211168 南京旅游职业学院江苏省南京市211100 徐州工程学院体育学院江苏省徐州市221008

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是... 详细信息

背景:干细胞移植是心肌梗死的崭新疗法,然而梗死区域极其恶劣的微环境造成干细胞存活率低下并导致远期疗效甚微。运动预适应是一种通过运动诱导机体产生内源性保护效应的方式,可作为心脏康复预防与治疗的新策略。目的:评估运动预适应是否能够增强大鼠心肌梗死后脂肪干细胞移植的心脏保护效应,探讨血管生成在其中的作用机制。方法:6周龄雄性SD大鼠随机分为对照组、造模组、干细胞组以及干细胞运动组。利用冠状动脉闭塞术制作急性心肌梗死模型,对照组同期行假手术;干细胞运动组于造模前进行8周有氧运动,造模后30 min进行脂肪干细胞移植;干细胞组仅进行脂肪干细胞移植。干细胞移植后1 d和7 d,利用免疫印迹法测定心肌总Akt(t-Akt)、磷酸化Akt(p-Akt)、血管内皮生长因子(VEGF)、总内皮型一氧化氮合酶(t-eNOS)和磷酸化内皮型一氧化氮合酶(p-eNOS)蛋白表达量,计算p-Akt/t-Akt和p-eNOS/t-eNOS比值;4周后利用彩色多普勒超声诊断系统检测心脏结构与功能以及心肌血流量,TTC染色法检测心肌梗死面积,Masson染色法检测心肌间质胶原沉积,免疫荧光染色法测定心肌毛细血管密度,TUNEL染色法评估心肌细胞凋亡。结果与结论:(1)干细胞移植后4周:与对照组比较,造模组左心室缩短分数、左心室射血分数、心肌毛细血管密度和心肌血流量下降(P0.05);与造模组比较,干细胞组上述指标均无显著性变化(P>0.05),干细胞运动组磷酸化p-Akt蛋白表达量以及p-Akt/t-Akt比值上调(P0.05),干细胞运动组p-Akt、VEGF、p-eNOS蛋白表达量以及p-Akt/t-Akt、p-eNOS/t-eNOS比值升高(P<0.05)。结果表明:运动预适应可增强脂肪干细胞对心肌梗死大鼠心脏重塑的治疗效果,其机制与促进心肌血管生成并增加血流灌注有关。

关键词：干细胞脂肪干细胞运动预适应心肌梗死血管生成心脏重塑血流灌注

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao Gao Xingzhao zhang Dacheng Ma Chuanlei Zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

Thermal Expansion of CsNiCl_(3)by Electron Paramagnetic Resonance and Optical Absorption Spectra

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Chinese Physics Letters 2000年第6期17卷 448-450页

作者： GUO Sheng-Li zhang Yong you Xiao-Zeng min Nai-Ben State Key Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093 Institute of Coordination Chemistry State Key Laboratory of Coordination ChemistryNanjing UniversityNanjing 210093 Department of Physics Nanjing Institute of MeteorologyNanjing 210044

Electron paramagnetic resonance(EPR)measurement of CsNiCl_(3)compound has been performed at 192 GHz in the temperature range from 300 to 5 K,along the axes of main g *** energy levels and the g-factors are *** linear thermalexpansion coefficient(2.77×10^(-5)K^(-1))for the Ni^(2+)-Cl^(-)bond distance is studied by combining EPR and optical absorption spectra with changing temperature.

关键词： temperature. Electron tensor

省级地球物理站网仪器运行监控系统设计与实现

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地震研究 2025年第1期48卷 141-150页

作者：瞿旻张敏刘高川杨正纲张扬宫杰王恒知云南省地震局云南昆明650224 江苏省地震局江苏南京210014 中国地震台网中心北京100045

顺应地震监测业务改革方向,为提升地球物理站网仪器运维效率,设计了一套地球物理站网仪器运行监控系统。系统包括基于B/S架构设计的监控软件平台、手机监控App软件和基于C/S架构设计的调试工具,通过实时获取地球物理仪器状态流和数据流... 详细信息

顺应地震监测业务改革方向,为提升地球物理站网仪器运维效率,设计了一套地球物理站网仪器运行监控系统。系统包括基于B/S架构设计的监控软件平台、手机监控App软件和基于C/S架构设计的调试工具,通过实时获取地球物理仪器状态流和数据流,对仪器时钟准确性、连通性,数据完整性、有效性等进行自动化分析,实现辖区范围内地球物理站网仪器运行状态的实时监控。该系统可对仪器运行状态异常、产出数据不符合规范要求等情况进行异常告警,提示运维人员第一时间排查故障,从而提高了地球物理站网仪器运行率和数据质量;系统对获取的数据进行备份,提高了地球物理台网数据完整性,并为今后实现数据质量实时监控等数据服务提供了技术路线。

关键词：地球物理站网仪器运行监控自动化分析异常告警

Matrix-injection-based transformation method for discrete-time systems with time-varying delay

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Science China(Information Sciences) 2023年第5期66卷 289-290页

作者： Chuan-Ke zhang Ke-you XIE Yong HE Jinhua SHE min WU School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education School of Engineering Tokyo University of Technology

Dear editor,In order to identify the influence of time-varying delays on the stability of control systems represented in a discretetime mode, developing stability criteria of discrete-time delayed systems has received serious attention in the past few decades (see [1–3] and their references).Consider the following linear discrete-time system with a time-varying delay:

关键词： Lyapunov functions

MOF-Derived Ni1-xCox@Carbon with Tunable Nano-Microstructure as Lightweight and Highly Efficient Electromagnetic Wave Absorber

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Nano-Micro Letters 2020年第11期12卷 90-106页

作者： Lei Wang Mengqiu Huang Xuefeng Yu Wenbin you Jie zhang Xianhu Liu min Wang Renchao Che Laboratory of Advanced Materials Department of Materials Science and Collaborative Innovation Center of Chemistry for Energy Materials(iChem)Fudan UniversityShanghai 200438People’s Republic of China Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationZhengzhou 450002People’s Republic of China

Intrinsic electric-magnetic property and special nano-micro architecture of functional materials have a significant effect on its electromagnetic wave energy conversion,especially in the microwave absorption(MA) ***,porous Ni1-xCox@Carbon composites derived from metal-organic framework(MOF)were successfully synthesized via solvothermal reaction and subsequent annealing *** from the coordination,carbonized bimetallic Ni-Co-MOF maintained its initial skeleton and transformed into magnetic-carbon composites with tunable nano-micro *** the thermal decomposition,generated magnetic particles/clusters acted as a catalyst to promote the carbon sp^2 arrangement,forming special core-shell ***,pure Ni@C microspheres displayed strong MA behaviors than other Ni1-xCox@Carbon ***,magnetic-dielectric Ni@C composites possessed the strongest reflection loss value-59.5 dB and the effective absorption frequency covered as wide as 4.7 ***,the MA capacity also can be boosted by adjusting the absorber content from 25% to 40%.Magnetic-dielectric synergy effect of MOF-derived Ni1-xCox@Carbon microspheres was confirmed by the off-axis electron holography technology making a thorough inquiry in the MA mechanism.

关键词： Metal-organic frameworks Polarization Magnetic coupling Microwave absorption Electromagnetic parameters