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Cellular strategies to induce immune tolerance after liver transplantation:Clinical perspectives

World Journal of Gastroenterology 2024年第13期30卷 1791-1800页

作者： Ai-Wei Zhou jing jin yuan Liu Department of Liver Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Nursing Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Liver Transplantation Shanghai Immune Therapy InstituteShanghai 200127China

Liver transplantation(LT)has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative ***,long-term side-effects of immunosuppressants,like infection,metabolic disorders and malignant tumor are gaining more *** tolerance is the status in which LT recipients no longer need to take any immunosuppressants,but the liver function and intrahepatic histology maintain *** approaches to achieve immune tolerance after transplantation include spontaneous,operational and induced *** first two means require no specific intervention but withdrawing immunosuppressant gradually during *** clinical factors or biomarkers so far could accurately predict who are suitable for immunosuppressant withdraw after *** the understanding to the underlying mechanisms of immune tolerance,many strategies have been developed to induce tolerance in LT *** strategy is one of the most promising methods for immune tolerance induction,including chimerism induced by hematopoietic stem cells and adoptive transfer of regulatory immune *** safety and efficacy of various cell products have been evaluated by prospective preclinical and clinical trials,while obstacles still exist before translating into clinical ***,we will summarize the latest perspectives and concerns on the clinical application of cellular strategies in LT recipients.

关键词： Cellular therapy Induced tolerance Liver transplantation Regulatory T cells Regulatory dendritic cells

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基于统一建模语言的分布式企业信息系统软件体系结构模型

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上海交通大学学报 2000年第7期34卷 979-982,986页

作者：饶若楠尤晋元上海交通大学计算机科学与工程系上海200030

讨论了分布式企业信息系统软件体系结构建模的基本问题和统一建模语言 ( Unified Mod-eling Language,UML)的体系结构建模特性 ,在此基础上提出了基于 UML的分布式企业信息系统软件体系结构模型 ***由组件、连接件、接口件和约束组成 ,... 详细信息

讨论了分布式企业信息系统软件体系结构建模的基本问题和统一建模语言 ( Unified Mod-eling Language,UML)的体系结构建模特性 ,在此基础上提出了基于 UML的分布式企业信息系统软件体系结构模型 ***由组件、连接件、接口件和约束组成 ,采用 UML的一个子集作为体系结构建模语言 ,用例视图、逻辑视图、构件视图和配置视图是表示 UDESAM的 4个视图 .给出了基于 UDESAM的软件开发过程和以体系结构为中心、以面向对象为指导思想、基于构件、由用例驱动的软件开发策略 ,并以一个基于

关键词：软件体系结构统一建模语言分布式企业信息系统

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Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 125-135页

作者： Sijie Zhou Junyanrui Li Xichen Cui Ying Wang Ying-jin yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species *** chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been applied to explore large-scale genomic rearrangements,yet it has been observed that these rearrangements occur exclusively in genomic regions containing loxPsym ***,we found that SCRaMbLE of synthetic yeast harboring synthetic chromosome V and X can generate a variety of synthetic segment insertions into wild-type chromosomes,ranging from 1 to 300 ***,it was revealed that the novel insertions impacted the transcriptional level of neighboring regions and affected the production of exemplar pathway of ***,our results improve the understanding of the ability of SCRaMbLE to generate complex structural variations in nonsynthetic regions and provide a potential model to explore genomic transposable events.

关键词： genomic rearrangements synthetic yeast genome SCRaMbLE inter-chromosomal insertions synthetic biology

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Chemico-biological conversion of carbon dioxide

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Journal of Energy Chemistry 2024年第2期89卷 371-387,I0009页

作者： Liangwei Hu Junzhu Yang Qi Xia jin Zhang Hongxin Zhao yuan Lu Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China College of Biological and Chemical Engineering Jiaxing UniversityJiaxing 314000ZhejiangChina

The unabated carbon dioxide(CO_(2))emission into the atmosphere has exacerbated global climate change,resulting in extreme weather events,biodiversity loss,and an intensified greenhouse *** address these challenges and work toward carbon(C)neutrality and reduced CO_(2)emissions,the capture and utilization of CO_(2)have become imperative in both scientific research and *** cutting-edge approach to achieving efficient catalytic performance involves integrating green bioconversion and chemical *** innovative strategy offers several advantages,including environmental friendliness,high efficiency,and *** study provides a comprehensive review of existing technical routes for carbon sequestration(CS)and introduces two novel CS pathways:the electrochemicalbiological hybrid and artificial photosynthesis *** also thoroughly examines the synthesis of valuable Cnproducts from the two CS systems employing different catalysts and *** both systems heavily rely on electron transfer,direct and mediated electron transfer has been discussed and summarized in ***,this study explores the conditions suitable for different catalysts and assesses the strengths and weaknesses of *** also explored the biocompatibility of the electrode materials and developed novel *** materials were specifically engineered to combine with enzymes or microbial cells to solve the biocompatibility problem,while improving the electron transfer efficiency of ***,this review summarizes the relevant systems developed in recent years for manufacturing different products,along with their respective production efficiencies,providing a solid database for development in this *** novel chemical-biological combination proposed herein holds great promise for the future conversion of CO_(2)into advanced organic ***,it offers exciting prospects for utilizing CO_(2)in synthesizing

关键词： Carbon dioxide Bioelectric synthesis Artificial photosynthesis Synthetic product

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Charge resolution in the isochronous mass spectrometry and the mass of ^(51)Co

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Nuclear Science and Techniques 2021年第4期32卷 30-37页

作者： Xu Zhou Meng Wang Yu-Hu Zhang Hu-Shan Xu you-jin yuan Jian-Cheng Yang Yu.A.Litvinov S.A.Litvinov Bo Mei Xin-Liang Yan Xing Xu Peng Shuai yuan-Ming Xing Rui-Jiu Chen Xiang-Cheng Chen Chao-Yi Fu Qi Zeng Ming-Ze Sun Hong-Fu Li Qian Wang Tong Bao Min Zhang Min Si Han-Yu Deng Ming-Zheng Liu Ting Liao jin-Yang Shi Yu-Nan Song Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China GSI Helmholtzzentrum fu¨r Schwerionenforschung Planckstraße 164291 DarmstadtGermany Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Science Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China CNRS/IN2P3 IJCLabUniversite´Paris-Saclay91405 OrsayFrance

Isochronous mass spectrometry(IMS)of heavyion storage rings is a powerful tool for the mass measurements of short-lived *** IMS experiments,masses are determined through precision measurements of the revolution times of the ions stored in the ***,the revolution times cannot be resolved for particles with nearly the same mass-to-charge(m/q)*** overcome this limitation and to extract the accurate revolution times for such pairs of ion species with very close m/q ratios,in our early work on particle identification,we analyzed the amplitudes of the timing signals from the detector based on the emission of secondary ***,the previous data analysis method is further improved by considering the signal amplitudes,detection efficiencies,and number of stored ions in the ring.A sensitive Z-dependent parameter is introduced in the data analysis,leading to a better resolution of ^(34)Ar^(18+) and ^(51)Co^(27+) with A/Z=17/*** mean revolution times of ^(34)Ar^(18+) and ^(51)Co^(27+) are deduced,although their time difference is merely 1.8 *** uncorrected,overlapped peak of these ions has a full width at half maximum of 7.7 *** mass excess of ^(51)Co was determined to be-27;332e41T keV,which is in agreement with the previous value of-27;342e48T keV.

关键词： Isochronous mass spectrometry Charge resolution Signal amplitude Micro-channel plate ^(51)Co

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一种基于分布组件协调的脚本语言Concerto

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上海交通大学学报 2001年第2期35卷 188-191页

作者：严莉萍鲍敢峰尤晋元上海交通大学计算机科学与工程系上海200030

针对现有脚本语言只适合顺序计算的缺点 ,提出了协调脚本语言 ***脚本既适合描述分布组件系统的协调问题 ,又统一了现有的计算脚本 ,提供了一个多种脚本语言混合编程的解决方案 .在运行方面 ,提出 Concerto协调代码作为脚本语言编译器... 详细信息

针对现有脚本语言只适合顺序计算的缺点 ,提出了协调脚本语言 ***脚本既适合描述分布组件系统的协调问题 ,又统一了现有的计算脚本 ,提供了一个多种脚本语言混合编程的解决方案 .在运行方面 ,提出 Concerto协调代码作为脚本语言编译器的目标代码 .以 Petri网为基础 ,由 Concerto引擎对协调代码解释生成 Petri网模型 ,对分布组件系统进行并发死锁验证 ,并与计算系统交互 ,控制分布组件的运行 .

关键词：脚本语言分布组件协调 Petri网

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Transient self-assembly driven by chemical fuels

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ChemPhysMater 2024年第1期3卷 1-23页

作者： Ling Wang jin yuan jingcheng Hao Key Laboratory of Colloid and Interface Chemistry Shandong UniversityMinistry of EducationJinan 250100China School of Chemistry and Chemical Engineering Qilu Normal UniversityJinan 250200China

Self-assembly has been extensively studied in chemistry,physics,biology,and materials engineering and has become an important“bottom-up”approach in creating intriguing structures for different *** dissipative self-assembly to construct fuel-dependent,energy-consuming,and dynamic nonequilibrium systems is important for developing intelligent life-like ***,dissipative self-assembly has become a research hotspot in materials chemistry,biomedical science,environmental chemistry,and physical *** in-depth understanding of the process and mechanism provides useful insights to the researchers for devel-oping materials using dissipative self-assembly and also helps guide future innovation in material *** critical review comprehensively analyzes various chemical fuel input and energy consumption mechanisms,supported by numerous illustrative *** transient assemblies,including gels,vesicles,micelles,and nanoparticle aggregates,have been systematically studied in our and other *** relationship between the molecular structure of precursors and temporal assemblies in dissipative self-assemblies is discussed from the perspective of physical *** dissipative self-assembly methods to construct functional assemblies provides important implications for constructing high-energy,nonequilibrium,and intelligent functional materials.

关键词： Self-Assembly Chemical Fuel Consumption mechanisms Functional assemblies

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FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

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Rare Metals 2024年第6期43卷 2730-2738页

作者： jin-Hang Xue Qiu-Hong Sun Cheng Han yuan-Dong Yang Shao-Jie Xu Qi-Peng Li jin-Jie Qian College of Life and Environmental Science Wenzhou UniversityWenzhou 325000China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325000China College of Chemistry and Chemical Engineering Zhaotong UniversityZhaotong 657000China

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and *** this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets(denoted as GCS-O).These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination ***,the growth of FeNi Prussian blue analogue(PBA)on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous *** resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·L^(-1).Meanwhile,it also achieves a high sensitivity of 2496μA·mmol^(-1)·L·cm^(-2),a limit of detection of 100nmol·L^(-1)(S/N=3),and commendable long-term *** relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation

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Engineering g-C_(3)N_(4)based materials for advanced photocatalysis:Recent advances

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Green Energy & Environment 2024年第2期9卷 166-197页

作者： Xin-Lian Song Lei Chen Li-Jiao Gao jin-Tao Ren Zhong-Yong yuan National Institute for Advanced Materials School of Materials Science and EngineeringSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin300350China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin300071China

Photocatalysis driven by abundant yet intermittent solar energy has considerable potential in renewable energy generation and environmental *** outstanding electronic structure and physicochemical properties of graphitic carbon nitride(g-C_(3)N_(4)),together with unique metal-free characteristic,make them ideal candidates for advanced photocatalysts *** review summarizes the up-to-date advances on g-C_(3)N_(4)based photocatalysts from ingenious-design strategies and diversified photocatalytic ***,the advantages,fabrication methods and limitations of each design strategy are systemically *** order to deeply comprehend the inner connection of theory–structure–performance upon g-C_(3)N_(4)based photocatalysts,structure/composition designs,corresponding photocatalytic activities and reaction mechanisms are jointly discussed,associated with introducing their photocatalytic applications toward water splitting,carbon dioxide/nitrogen reduction and pollutants degradation,***,the current challenges and future perspectives for g-C_(3)N_(4)based materials for photocatalysis are briefly *** design strategies and limitations are also instructive for constructing g-C_(3)N_(4) based materials in other energy and environment-related applications.

关键词： Graphitic carbon nitride g-C_(3)N_(4) Design strategies Photocatalysis Photocatalysts Reaction mechanism

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Effect of nitrile butadiene rubber hardness on the sealing characteristics of hydraulic O-ring rod seals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第1期25卷 63-78页

作者： Xiaoxuan LI Bingqing WANG Xudong PENG Yuntang LI Xiaolu LI yuan CHEN Jie jin College of Quality and Safety Engineering China Jiliang UniversityHangzhou310018China College of Mechanical and Electrical Engineering China Jiliang UniversityHangzhou310018China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou310023China

The nitrile butadiene rubber(NBR)hardness effect on the sealing characteristics of hydraulic O-ring rod seals is analyzed based on a mixed lubrication elastohydrodynamic *** studies are conducted to reveal the mechanism of the influence of rubber hardness on the static and dynamic behavior of *** optimized selections of rubber hardness are then investigated under different *** show that the low hardness seal is prone to stress concentration due to the extrusion effect under high pressure conditions;it is also more prone to leaking.A high hardness seal can better prevent leakage by reducing film thickness but it will cause large frictional power loss and increase the probability of wear *** choice of low hardness is recommended to reduce friction with the premise that leakage requirements are met.

关键词： Nitrile butadiene rubber(NBR)hardness Sealing characteristics Optimized selection O-ring seal

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