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Recent Research Advances in Imaging of Prostate Cancer

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Journal of Biosciences and Medicines 2024年第6期12卷 114-128页

作者： Quansen Hu Shaoping Cheng Changsheng yuan Chenghua jin Urology Department The First Clinical Medical College of Yangtze University Jingzhou China

Imaging study plays a crucial role in the diagnosis of prostate cancer. As early screening and management of prostate cancer has evolved over the past decade, research is now focusing on how to detect clinically significant prostate cancer and avoid overdiagnosis accurately. This article provides an overview of recent advances in imaging in prostate cancer diagnosis, including new ultrasound imaging techniques, positron emission computed tomography, multiparametric magnetic resonance imaging, and emerging areas such as imaging histology, by systematically reviewing and summarizing the existing literature.

关键词： Prostate Cancer Novel Ultrasound Positron Emission Tomography/Computed Tomography Multiparametric Magnetic Resonance Imaging Imaging Histology

Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape

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Cancer Communications 2024年第6期44卷 670-694页

作者： Xin-Yu Zhang Jian-Bo Shi Shu-Fang jin Rui-Jie Wang Ming-Yu Li Zhi-yuan Zhang Xi Yang Hai-Long Ma Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiP.R.China National Clinical Research Center for Oral Diseases ShanghaiP.R.China Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology ShanghaiP.R.China Department of Second Dental Center Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityShanghaiP.R.China

Background:Metabolic reprograming and immune escape are two hallmarksof ***,how metabolic disorders drive immune escape in head andneck squamous cell carcinoma(HNSCC)remains ***,the aim ofthe present study was to investigate the metabolic landscape of HNSCC and itsmechanism of driving immune ***:Analysis of paired tumor tissues and adjacent normal tissues from69 HNSCC patients was performed using liquid/gas chromatography-mass spectrometry and *** tumor-promoting function of kynurenine(Kyn)was explored in vitro and in *** downstream target of Kyn wasinvestigated in CD8^(+)T *** regulation of CD8+T cells was investigatedafter Siglec-15 overexpression in *** engineering nanoparticle was establishedto deliver Siglec-15 small interfering RNA(siS15),and its association withimmunotherapy response were *** association between Siglec-15and CD8^(+)programmed cell death 1(PD-1)^(+)T cells was analyzed in a HNSCCpatient ***:A total of 178 metabolites showed significant dysregulation in HNSCC,including carbohydrates,lipids and lipid-like molecules,and amino *** these,amino acid metabolism was the most significantly altered,especiallyKyn,which promoted tumor proliferation and *** addition,most immune checkpoint molecules were upregulated in Kyn-high patientsbased on ***,tumor-derived Kyn was transferredinto CD8^(+)T cells and induced T cell functional exhaustion,and blockingKyn transporters restored its killing *** to the results,mechanistically,Kyn transcriptionally regulated the expression of Siglec-15 via arylhydrocarbon receptor(AhR),and overexpression of Siglec-15 promoted immuneescape by suppressing T cell infiltration and *** AhR in vivoreduced Kyn-mediated Siglec-15 expression and promoted intratumoral CD8^(+)Tcell infiltration and killing ***,a NH_(2)-modified mesoporous silicananoparticle was des

关键词： head and neck squamous cell carcinoma kynurenine Siglec-15 T cell exhaustion untargeted metabolomics

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医学CT序列图像的混合去噪算法

东北大学学报（自然科学版） 2024年第4期45卷 464-473页

作者：陈锦林原培新东北大学机械工程与自动化学院辽宁沈阳110819

医学CT(computer tomography)序列图像会因为各种原因而掺杂噪声,去噪能够有效地提高图像的质量.常见的去噪算法都是针对单张图像进行,考虑到CT序列图像之间具有很高的相似性,本文提出一种基于相邻图像结构相似性的混合去噪算法.该算法... 详细信息

医学CT(computer tomography)序列图像会因为各种原因而掺杂噪声,去噪能够有效地提高图像的质量.常见的去噪算法都是针对单张图像进行,考虑到CT序列图像之间具有很高的相似性,本文提出一种基于相邻图像结构相似性的混合去噪算法.该算法首先计算序列图像的最大和最小灰度值,根据灰度值绘制直方图,设定相关阈值参数,根据筛选之后的直方图计算窗宽窗位,然后进行调窗处理.之后计算目标图像与其前后相邻图像之间的结构相似性,最后根据结构相似性对3张图片混合使用BM3D和高斯滤波2种去噪算法.通过对比实验表明,该算法在均方误差、峰值信噪比和结构相似性三方面都有所提高,能够有效地提高图像质量.

关键词：医学CT序列图像结构相似性混合去噪算法直方图调窗处理

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IMPROVING THE INTERESTINGNESS OF WEB USAGE MINING

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Journal of Shanghai Jiaotong university(Science) 2002年第1期7卷 15-22页

作者：杨怡玲管旭东尤晋元 Dept. of Computer Science & Eng. Shanghai Jiaotong Univ. Shanghai 200030 China

Improvement on mining the frequently visited groups of web pages was studied. First, in the data preprocessing phrase, we introduce an extra frame filtering step that reduces the negative influence of frame pages on the result page groups. Through recognizing the frame pages in the site documents and constructing the frame subframe relation set, the subframe pages that influence the final mining result can be efficiently filtered. Second, we enhance the mining algorithm with the consideration of both the site topology and the content of the web pages. By the introduction of the normalized content link ratio of the web page and the group interlink degree of the page group, the enhanced algorithm concentrates more on the content pages that are less interlinked together. The experiments show that the new approach can effectively reveal more interesting page groups, which would not be found without these enhancements.

关键词： data mining web mining web usage mining log analysis interestingness enhancement

Investigations of the dielectronic recombination of phosphorus-like tin at CSRm

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Chinese Physics B 2018年第6期27卷 268-273页

作者： Xin Xu Shu-Xing Wang Zhong-Kui Huang Wei-Qiang Wen Han-Bing Wang Tian-Heng Xu Xiao-Ya Chuai Li-Jun Dou Wei-Qing Xu Chong-Yang Chen Chuan-Ying Li Jian-Guo Wang Ying-Long Shi Chen-Zhong Dong Li-Jun Mao Da-Yu Yin Jie Li Jian-Cheng Yang you-jin yuan Xin-Wen Ma and Lin-Fan Zhu Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China Hefei 230026 China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China Hefei 230026 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China School of Physical Sciences University of the Chinese Academy of Sciences Beijing 100049 China Shanghai EBIT Laboratory Institute of Modern Physics and Key Laboratory of Nuclear Physics and Ion-beam Application （MOE） Fudan University Shanghai 200433 China National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026 China 7 The Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics Beijing 100088 China 8Institute for Fundamental Physics Tianshui Normal University Tianshui 741000 China 9 Key Laboratory of Atomic and Molecular Physics and Functional Materials of Gansu Province College of Physics and Electronic Engineering Northwest Normal University Lanzhou 730070 China

The electron–ion recombination for phosphorus-like^（112） Sn^（35＋）has been measured at the main cooler storage ring of the Heavy Ion Research Facility in Lanzhou, China, employing an electron–ion merged-beams technique. The absolute total recombination rate coefficients for electron–ion collision energies from 0 e V–14 e V are presented. Theoretical calculations of recombination rate coefficients were performed using the Flexible Atomic Code to compare with the experimental results. The contributions of dielectronic recombination and trielectronic recombination on the experimental rate coefficients have been identified with the help of the theoretical calculation. The present results show that the trielectronic recombination has a substantial contribution to the measured electron–ion recombination spectrum of^（112）Sn^（35＋）. Although a reasonable agreement is found between the experimental and theoretical results the precise calculation of the electron–ion recombination rate coefficients for M-shell ions is still challengeable for the current theory.

关键词： dielectronic recombination trielectronic recombination storage ring electron cooling

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应力加载对花岗岩粗糙裂隙渗透率影响规律

地球科学 2024年第5期49卷 1810-1820页

作者：那金谢康路袁可涵袁益龙油气地球化学与环境湖北省重点实验室(长江大学资源与环境学院) 湖北武汉430100 吉林大学地下水资源与环境教育部重点实验室吉林长春130021

本研究选取青海共和盆地干热岩靶区储热层印支期花岗岩为目标层,利用高压流体驱替实验装置开展岩心裂隙渗流-应力耦合下循环加卸载试验,分析应力加载过程对花岗岩粗糙裂隙渗透率影响规律,并通过数值模拟技术分析实验过程中花岗岩裂隙渗... 详细信息

本研究选取青海共和盆地干热岩靶区储热层印支期花岗岩为目标层,利用高压流体驱替实验装置开展岩心裂隙渗流-应力耦合下循环加卸载试验,分析应力加载过程对花岗岩粗糙裂隙渗透率影响规律,并通过数值模拟技术分析实验过程中花岗岩裂隙渗透率的演化特征.研究结果表明:(1)应力加载导致裂隙接触面产生变形,是影响裂隙渗流的主要因素,裂隙渗透率与围压呈负相关关系;(2)裂隙渗透率对不同应力加载模式敏感性存在差异;(3)在试验基础上得出数学经验公式,并通过数值模拟分析花岗岩裂隙通道内渗流演化规律,模拟结果同实验拟合较好.

关键词：花岗岩应力加载裂隙渗透率渗流-应力耦合数值模拟地热能源

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin jin Yiming Qin Feifei yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Genomics,transcriptomics,and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

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Insect Science 2024年第3期31卷 773-791页

作者： Li-Lin Luo Yang Lin Jun-Hong Linghu Wei Gong yuan-Hong Luo Man Liu Dao-Chao jin Guy Smagghe Tong-Xian Liu Shun-Hua Gui Tian-Ci Yi Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangGuizhouChina Guizhou Institute of Biology Guizhou Academy of SciencesGuiyangChina Institute of Plant Health and Medicine Guizhou UniversityGuiyangChina

Neuropeptides are crucial in regulation of a rich variety of developmental,physiological,and behavioral functions throughout the life cycle of *** an integrated approach of multiomics,we identified neuropeptide precursors in the greater wax moth Galleria mellonella,which is a harmful pest of honeybee hives with a worldwide ***,a total of 63 and 67 neuropeptide precursors were predicted and annotated in the *** genome and transcriptome,in which 40 neuropeptide precursors were confirmed in the *** ***,we identified 12 neuropeptide precursor genes present in *** but absent in honeybees,which may be potential novel pesticide target *** hives were contaminated with heavy metals such as lead,enabling its bioaccumulation in *** bodies through the food chain,we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of *** neuropeptide *** treatment by Pb,the expression of neuropeptide F1 was found to be significantly downregulated,implying that this neuropeptide might be associated with responding to the heavy metal stress in *** study comprehensively identified neuropeptide precursors in ***,and discussed the effects of heavy metals on insect neuropeptides,with the example of *** results are valuable for future elucidation of how neuropeptides regulate physiological functions in *** and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

关键词： Galleria mellonella genomics heavy metal stress neuropeptide peptidomics transcriptomics

Species-level Microbiota of Biting Midges and Ticks from Poyang Lake

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Biomedical and Environmental Sciences 2024年第3期37卷 266-277,I0001-I0003页

作者： GONG Jian WANG Fei Fei LIU Yang Qing PU Ji DONG Ling Zhi ZHANG Si Hui HUANG Zhen Zhou HUANG Yu yuan LI Ya Ben YANG Cai Xin TAO yuan Meihui ZHAO Li Jun jin Dong LIU Li Yun YANG jing LU Shan Department of Epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Jiangxi Provincial Key Laboratory of Animal-Origin and Vector-Borne Diseases Nanchang Center for Disease Control and PreventionNanchang 330038JiangxiChina Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Objective The purpose of this study was to investigate the bacterial communities of biting midges and ticks collected from three sites in the Poyang Lake area,namely,Qunlu Practice Base,Peach Blossom Garden,and Huangtong Animal Husbandry,and whether vectors carry any bacterial pathogens that may cause diseases to humans,to provide scientific basis for prospective pathogen discovery and disease prevention and *** Using a metataxonomics approach in concert with full-length 16S rRNA gene sequencing and operational phylogenetic unit(OPU)analysis,we characterized the species-level microbial community structure of two important vector species,biting midges and ticks,including 33 arthropod samples comprising 3,885 individuals,collected around Poyang *** A total of 662 OPUs were classified in biting midges,including 195 known species and 373 potentially new species,and 618 OPUs were classified in ticks,including 217 known species and 326 potentially new ***,OPUs with potentially pathogenicity were detected in both arthropod vectors,with 66 known species of biting midges reported to carry potential pathogens,including Asaia lannensis and Rickettsia bellii,compared to 50 in ticks,such as Acinetobacter lwoffii and Staphylococcus *** found that Proteobacteria was the most dominant group in both midges and ***,the outcomes demonstrated that the microbiota of midges and ticks tend to be governed by a few highly abundant *** sp7 was predominant in biting midges,while Coxiella sp1 was enriched in ***,Coxiella spp.,which may be essential for the survival of Haemaphysalis longicornis Neumann,were detected in all tick *** identification of dominant species and pathogens of biting midges and ticks in this study serves to broaden our knowledge associated to microbes of arthropod *** Biting midges and ticks carry large numbers of known and potentially novel bacteria,and carry a wide

关键词： Biting midge Tick Microbiota Pantoea Coxiella