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Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number

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Chinese Journal of Aeronautics 2021年第3期34卷 71-81页

作者： Mingyang wang Chengwu YANG Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU Key Laboratory of Light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were *** showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the *** all the roughness locations,the variation trend for the profile loss with the roughness magnitude was *** the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,***,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss *** comparison,the leading edge roughness played a dominant role in the boundary layer development and performance *** take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively.

关键词： Aerodynamic performance Compressor airfoil Low Reynolds number Separation bubble Surface roughness Viscous dissipation

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Correlation of polymorphism in the interleukin-1 receptor antagonist gene intron 2 with alcoholic liver disease

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 41-45页

作者： Wei-Xing Chen gen-Yun Xu Chao-Hui Yu Ping wang Min Yu Ping Xu you-Shi Liu you-Ming Li Department of Gastroenterology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China.

BACKGROUND: Interleukin-1 receptor antagonist (IL-1ra) can inhibit the pro-inflammatory effects of IL-1, which recently has been thought to involve the pathogenesis of alcoholic liver disease (ALD). This study was undertaken to determine whether there is any association between IL-1ra gene polymorphism and ALD in a Chinese population.METHODS: The polymorphism of IL-1ra gene intron 2 (VNTR) was assessed in 165 alcoholics (43 alcohol-dependent subjects without liver diseases, 30 patients with alcoholic fatty liver, 61 patients with alcoholic hepatitis and 31 patients with alcoholic cirrhosis) and 65 healthy control subjects by PCR with DNA of peripheral blood mononuclear cells.RESULTS: The rate of IL-1RN*1 carriage was statistically higher in the alcoholics than in the control group (98.79% vs 93.85%, chi2=4.48, Pgene polymorphism is closely associated with race. IL-1RN*2 allele doesn't influence the susceptibility to ALD, but the gene carriers with ALD have additional risk for aggravation of the illness.

关键词： interleukin-1 receptor antagonist gene polymorphism alcoholic liver disease

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人参皂苷 Rg3激活线粒体功能改善慢性疼痛的机制

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中国药理学通报 2025年第1期41卷 94-100页

作者：张培根朱海丽高卉湖北科技学院医学部药学院湖北咸宁437100

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参... 详细信息

目的探究人参皂苷Rg3在慢性神经性疼痛中的作用及机制。方法筛选并分析慢性神经性疼痛数据中前额叶皮层内差异性表达基因;小鼠随机分为假手术组、模型组及给药组;采用坐骨神经慢性压迫损伤模型构建神经病理性疼痛动物模型,腹腔注射人参皂苷Rg3给药;记录小鼠痛觉行为变化;HE染色、尼氏染色、免疫印迹及免疫组化检测各组PFC脑组织神经和线粒体损伤情况;分子对接探究人参皂苷Rg3的作用靶点;Mito-Tracker检测线粒体膜电位;ATP试剂盒分析ATP含量。结果与假手术组相比,模型组小鼠表现为痛觉过敏和运动能力受损;PFC内神经及线粒体损伤(P<0.05)。与模型组相比,人参皂苷Rg3给药可增加小鼠机械痛阈值、热缩足潜伏期和转棒停留时间;同时降低PFC内炎性细胞、尼氏小体及Dnm1l阳性细胞数,下调c-Fos、IL-1β和Dnm1l蛋白表达水平(P<0.05)。分子对接显示人参皂苷Rg3可结合Dnm1l。在细胞水平,人参皂苷Rg3给药可升高线粒体膜电位和ATP含量(P<0.05)。结论人参皂苷Rg3可通过调控降低PFC内炎症因子和线粒相关蛋白表达,改善线粒体功能,缓解CCI小鼠痛觉过敏。

关键词：人参皂苷Rg3 慢性神经性疼痛线粒体前额叶皮层 CCI PFC

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Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1175-1199页

作者： Peng Gao Xin Chang Dagan Zhang Yafei Cai gen Chen Hao wang Tianfu wang Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging Department of Biomedical EngineeringShenzhen UniversityShenzhen 518060China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Key Laboratory of Biomedicine in gene Diseases and Health of Anhui Higher Education Institutes College of Life SciencesAnhui Normal UniversityWuhu 241000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Materials Science and Engineering Central South UniversityChangsha 410083China College of Energy Soochow Institute for Energy and Materials Innovationsand Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China

Therapeutic nanoparticles are designed to enhance efficacy,real-time monitoring,targeting accuracy,biocompatibility,biodegradability,safety,and the synergy of diagnosis and treatment of diseases by leveraging the unique physicochemical and biological properties of well-developed ***,bio-inspired metal nanoclusters(NCs)consisting of several to roughly dozens of atoms(gens,and antibodies),DNA,and specific cells,create fluorescently visualized molecular *** resultant nanoparticles possess combinatorial properties and synergistic efficacy,such as simplicity,active bio-responsiveness,improved applicability,and low cost,for combination therapy,such as accurate targeting,bioimaging,and enhanced therapeutic and biocatalytic *** contrast to larger nanoparticles,bio-inspired metal NCs allow rapid renal clearance and better pharmacokinetics in biological ***,advances in nanoscience,interfacial chemistry,and biotechnologies have further spurred researchers to explore bio-inspired metal NCs for therapeutic *** current review presents a comprehensive and timely overview of various metal NCs for various therapeutic applications,with a special emphasis on the design rationale behind the use of biomolecules/cells as the main *** the different hybrid platform,we summarize the current challenges and emerging perspectives,which are expected to offer in-depth insight into the rational design of bio-inspired metal NCs for personalized treatment and clinical translation.

关键词： Metal nanoclusters Biomolecule Nanoparticles Hybrid system Synergistic properties Fluorescence Bioprobe Therapy

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Distribution of Cu and Pb in particle size fractions of urban soils from different city zones of Nanjing, China

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Journal of Environmental Sciences 2006年第3期18卷 482-487页

作者： wang Huan-hua LI Lian-qing WU Xin-min PAN gen-xing Institute of Resources Ecosystem and Environment of Agriculture Nanjing Agricultural University Nanjing 210095 China Chizhou Junior Teachers College Chizhou 247100 China

Soil samples from 4 defined city zones of Nanjing were randomly collected at 0-5 cm and 5-20 cm intervals and size fractions of soil particles were separated from undisturbed bulk soils by low energy dispersion procedure. The total contents of Cu and Pb in the different particle size fractions of the urban soils were analyzed by HNO3-HF-HClO4 digestion and flame atomic absorption spectrophotometer determination. The total content of Cu and Pb in soil particle size fractions varied with their size and with city zones as well. Both the content and variation with the size fractions of Pb was bigger than of Cu supporting our previous finding that there was Pb pollution to different degrees in the urban soils although the two elements were generally enriched in clay-sized fraction. Contaminated Pb tended to be preferentially enriched in the size fraction of 2000-250 μm and clay-sized fraction. While the size fractions of the soils from newly developed and preserved area contained smaller amount of Cu and Pb, the partitioning of them in coarse and fine particle size fractions were insignificant compared to that from inner residence and commercial area. The very high Pb level over 150 mg/kg of the fine particle fractions from the soils of the inner city could be a cause of high blood Pb level reported of children from the city as acute exposure to Pb of fine particles of the urban soil might occur by soil ingestion and inhalation by young children. Thus, much attention should be paid to the partitioning of toxic metals in fine soil particles of the urban soils and countermeasures against high health risk of Pb exposure by soil ingestion and dust inhalation should be practiced against the health problem of blood Pb for young children from the cities.

关键词： urban soil city zone soil contamination particle size fraction heavy metals lead health risk

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Mechanisms and capacity of high-pressure soaking after hydraulic fracturing in tight/shale oil reservoirs

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Petroleum Science 2021年第2期18卷 546-564页

作者： Jing wang Hui-Qing Liu gen-Bao Qian Yong-Can Peng State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China Shaanxi Cooperative Innovation Center of Unconventional Oil and Gas Exploration and Development Xi’an Shiyou UniversityXi’an710065ShaanxiChina CNPC Xinjiang Oilfield Karamay834000XinjiangChina

Huff-n-puff by water has been conducted to enhance oil recovery after hydraulic fracturing in tight/shale oil ***,the mechanisms and capacity are still unclear,which significantly limits the application of this *** order to figure out the mechanisms,the whole process of pressurizing,high-pressure soaking,and depressurizing was firstly discussed,and a mechanistic model was ***,the simulation model was verified and employed to investigate the significances of high-pressure soaking,the contributions of different mechanisms,and the sensitivity analysis in different *** results show that high-pressure soaking plays an essential role in oil production by both imbibition and elasticity after hydraulic *** contribution of imbibition increases as the increase in bottom hole pressure(BHP),interfacial tension,and specific surface area,but slightly decreases as the oil viscosity *** addition,it first decreases and then slightly increases with the increase in matrix *** optimal soaking time is linear with the increases of both oil viscosity and BHP and logarithmically declines with the increase in matrix permeability and specific surface ***,it shows a rising tendency as the interficial tension(IFT)***,a general model was achieved to calculate the optimal soaking time.

关键词： Enhanced oil recovery High-pressure soaking Huff-n-puff Imbibition Tight/shale oil

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Geochemical and Geological Characterization of Marine-Continental Transitional Shale: A Case Study in the Ordos Basin, NW China

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 809-821页

作者： WEI Zhifu wang gen wang Yongli MA Xueyun ZHANG Ting HE Wei YU Xiaoli Key Laboratory of Petroleum Resources Research Gansu ProvinceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesCAS Center for Excellence in Life and PaleoenvironmentBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

The organic-rich shale of the Shanxi and Taiyuan Formation of the Lower Permian deposited in a marinecontinental transitional environment are well developed in the Ordos Basin,NW China,which is considered to contain a large amount of shale hydrocarbon *** study takes the Lower Permian Shanxi and Taiyuan shale collected from well SL~# in the Ordos Basin,NW China as an example to characterize the transitional shale *** on organic geochemistry data,X-ray diffraction(XRD)analysis,field-emission scanning electron microscopy(FE-SEM)observations,the desorbed gas contents of this transitional shale were systematically studied and the shale gas potential was *** results indicate that the Lower Permian Shanxi and Taiyuan shale has a relatively high total organic carbon(TOC)(average TOC of 4.9%)and contains type III kerogen with a high mature to over mature *** analyses show that an important characteristic of the shale is that clay and brittle minerals of detrital origin comprise the major mineral composition of the marine-continental transitional shale samples,while the percentages of carbonate minerals,pyrite and siderite are relatively ***-SEM observations reveal that the mineral matrix pores are the most abundant in the Lower Permian shale samples,while organic matter(OM)pores are rarely *** analysis suggests that the mineral compositions mainly govern the macropore development in the marine-continental transitional shale,and mineral matrix pores and microfractures are considered to provide space for gas storage and *** addition,the desorption experiments demonstrated that the marine-continental transitional shale in the Ordos Basin has a significantly potential for shale gas exploration,ranging from 0.53 to 2.86 m^3/t with an average value of 1.25m^3/t,which is in close proximity to those of terrestrial shale(1.29 m^3/t)and marine shale(1.28 m^3/t).In summary,these results demonstrated that the L

关键词： marine-continental transitional shales desorbed gas pore structure FE-SEM Ordos Basin

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Synthesis,Crystal Structure and Fluorescence Property of [Y(sip)(H_2O)_4]_n with 5-Sulfoisophthalate Ligand

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1057-1062页

作者： wang Yan PAN Zhao-Rui wang Zuo-Wei HU Zheng LI Yi-Zhi ZHENG He-gen Coordination Chemistry Institute State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China Key Laboratory for Mesoscopic Chemistry. of Ministry of Education College of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The title complex, [Y（sip）（H2O）4], （sip = 5-sulfoisophthalate）, has been synthesized and characterized by elemental analysis, IR spectra and single-crystal X-ray analysis. The crystal belongs to the orthorhombic system, space group Pna21, a = 7.235（4）, b = 16.456（5）, c = 10.316（3） A, V = 1228.2（9） A^3, Z = 4, Mr = 404.14, Dc = 2.186 g/cm63, F（000） = 808,μ= 4.979 mm^-1, the final R = 0.0474 and wR = 0.1125 for 2122 observed reflections with I 〉 2σ（I）. The structural analysis shows that the intermolecular hydrogen bonds and π-π interactions result in a three-dimensional supramolecular structure. The complex shows intense luminescence in solid state at room temperature.

关键词： crystal structure hydrogen bond network structure luminescence

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Modeling assessment of recovering iron from red mud by direct reduction： magnetic separation based on response surface methodology

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Journal of Iron and Steel Research International 2018年第5期25卷 497-505页

作者： Ran wang Zheng-gen Liu Man-sheng Chu Hong-tao wang Wei Zhao Li-hua Gao School of Metallurgy Northeastern UniversityShenyang 110819 Liaoning China Northeastern Institute of Metal Materials Co. LtdShenyang 110108 Liaoning China

Red mud, the waste generated during alumina production, contains iron and other valuable metals. To recover the iron efficiently from red mud, a three-factor five-level central composite design in response surface methodology was used to study the effects of process parameters, such as FC/O （the molar ratio of fixed carbon in coal to reducible oxygen of iron oxide in red mud）, reduction temperature, reduction time, and their interaction on the iron recovery rate and total iron content in magnetic product obtained from the process of direct reduction-magnetic separation. The relevant assessment model was established. The model could predict the changing rules of iron recovery rate and total iron content in the magnetic product affected by the process parameters. The results show that the iron recovery rate is significantly influenced by three factors and reduction temperature plays the most important role. The iron recovery rate and total iron content in magnetic product could be up to 98.37 and 82.52%, respectively, under the numerically optimal process parameters condition of reduction temperature of 1400 ℃, FC/O of 0.80 and reduction time of 100 min obtained by the assessment model. The predicted values are in good agreement with the experimental values.

关键词： Red mud - Iron recovery Direct reduction Magnetic separation Response surface methodology

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Efficacy profiles for different concentrations of Lactobacillus acidophilus in experimental colitis

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World Journal of Gastroenterology 2013年第32期19卷 5347-5356页

作者： Lin-Lin Chen Yi-you Zou Fang-gen Lu Fu-Jun Li Guang-Hui Lian Department of Gastroenterology Xiangya Hospital of Central South University Department of Gastroenterology Second Xiangya Hospital of Central South University

AIM:To determine the efficacy profiles of different concentrations of Lactobacillus acidophilus(***)for treating colitis using an experimental murine ***:Colitis was established in 64 BALB/c mice by adding 5%dextran sodium sulfate(DSS)to the drinking water and allowing ad libitum access for 7 *** mice were then randomly divided into the following control and experimental model groups(n=8 each;day 0):untreated model control;negative-treatment model control(administered gavage of 1 mL/10 g normal saline);experimental-treatment models C4-C8(administered gavage of 104,105,106,107,or 108CFU/10 g ***,respectively);positive-treatment model control(administration of the anti-inflammatory agent prednisone acetate at 45 g/10 g).Eight mice given regular water(no DSS)and no subsequent treatments served as the normal control *** weight,fecal traits,and presence of fecal occult blood were assessed *** animals were sacrificed on post-treatment day7 to measure colonic length,perform histological scoring,and quantify the major bacteria in the proximal and distal *** differences were determined by one-way ANOVA and post-hoc Student-Newman-Keuls ***:All treatments(*** and prednisone acetate)protected against colitis-induced weight loss(PC4>C5>C7>C8>C6;P0.05).The C6 group also had the lowest disease activity index scores among the model *** bacterial profiles in the proximal colon were similar between all of the experimental-treatment model groups(all P>0.05).In contrast,the bacterial profile in the distal colon of the C6 group showed the distinctive features(P<0.05 vs all other experimental-treatment model groups)of Lactobacillus

关键词： Lactobacillus acidophilus Bifidobacterium Colonic flora Therapeutic dose Experimental colitis Efficacy profile

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