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Fludarabine and cytarabine combined chemotherapy followed by transfusion of donor blood stem cells for treating relapse of acute leukaemia after allogeneic haematopoietic stem cell transplantation

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Chinese Medical Journal 2008年第18期121卷 1770-1774页

作者： you yong li Qiu-bai CHEN Zhi-chao li Wei-ming XIA ling-hui ZHOU Hao ZOU Ping Institute of Haematology Union Hospital Tongji Medical College of Huazhong University of Science and Technology WuhanHubei 430022 China

Background Relapse remains an obstacle to successful allogeneic haematopoietic stem cell transplantation （allo-HSCT） for patients with acute leukaemia and no standard treatment is available. We assessed fludarabine and cytarabine with transfusion of donor haematopoietic stem cell in treating the relapse of acute leukaemia after allo-HSCT. Methods Seven patients, median age 34 years, with relapse of acute leukaemia after allo-HSCT received combination chemotherapy of fludarabine with cytarabine for 5 days. Five patients suffered from acute myeloid leukaemia （2 refractory） and 2 refractory acute lymphoblastic leukaemia. After the transplantation, the median relapse time was 110 days （range, 38-185 days）. Two days after chemotherapy, 5 patients received infusion of donor＇s peripheral blood stem cells, mobilized by granulocyte colony stimulating factor. No prophylactic agents of graft versus host diseases were administered, Results Six patients achieved haematopoietic reconstitution. DNA sequence analysis at day 30 after treatment identified all as full donor chimera type. The median observation time was 189 days. After the treatment, the median time for neutrophilic granulocyte value 〉0.5×10^9/L and for platelet value 〉20×10^9/L were 13 days （range, 10-18 days） and 15 days （range, 11-24 days）, respectively. Graft versus host disease occurred in 2 patients （acute） and 3 （chronic）. Five patients suffered from pulmonary fungal infection （2 died）, 3 haemorrhagic cystitis and 2 cytomegalovirus viraemia. The other patients died of leukaemia related deaths. Three patients with chronic graft versus host disease who had received donor peripheral blood stem cells reinfusion have survived for 375 days, 232 days and 195 days, respectively. Conclusions Fludarabine with cytarabine plus the donor haematopoietic stem cell should be considered as an effective therapeutic regimen for relapse of acute leukaemia after alio-HSCT. The disease free state of patients may increase, though with

关键词： fludarabine allogeneic haematopoietic stem cell transplantation relapse acute leukaemia

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Solvent polarity-induced photoluminescence enhancement (SPIPE): A method enables several-fold increase in quantum yield of silicon nanoparticles

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Nano Research 2019年第2期12卷 315-322页

作者： Xiao-Bin Shen Bin Song Bei Fang Xiao Yuan you-yong li Shun-Yi Wang Shun-Jun Ji Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC) Soochow University Suzhou 215123 China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Fluorescent silicon nanoparticles (SiNPs) bring exciting opportunities for long-awaited silicon-based optical application, while intrinsic indirect band gap of silicon severely limits photoluminescent quantum yield (PLQY) of SiNPs. To address this critical issue, we herein demonstrate a facile and general method, Le., solvent polarity-induced photoluminescence enhancement (SPIPE)1 yielding several-fold increase in quantum yield (QY) of SiNPs. Typically, different kinds of 4-substituented-1,8-naphthalic anhydride molecules, Le., 4-Br-1,8-naphthalic anhydride (BNA)1 4-triphenylamino-1,8-naphthalic anhydride (TPNA)1 and 4-dimethylamino-1,8-naphthalic anhydride (DMNA)1 are rationally designed and synthesized, which serve as surface ligands for the production of BNA-, TPNA-, and DMNA-capped small-sized (diameter:- 3.8-5.8 nm) SiNPs with QY of^8%,~15%,~16%, respectively. Of particular significance, QY of the resultant SiNPs could be greatly enhanced from^10% to^50% through the SPlPE strategy. Taken together with the theoretical calculation and the results of time-correlated single photon counting, we reveal that actived excited-state charge transfer interactions between surface-covered ligand and silicon oxide coating would be responsible for the observed QY enhancement. Moreover, other five kinds of solvents (i.e., methanol, isopropanol, dimethyl sulfoxide, N,N-dimethylformamide, and acetonitrile) are further employed for the SiNPs treatment, and similar improvement of QY values are observed, convincingly demonstrating the universal evidence of SPIPE of the SiNPs.

关键词： silicon nanoparticles quantum yield fluorescent surface ligand solvent polarity

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Application of Genetic Algorithm to the QSAR Research of Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones-Novel and Specific Non-Nucleoside HIV-1 Reverse Transcription Inhibitors

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Chinese Chemical Letters 1998年第7期9卷 651-654页

作者： Ting Jun HOU Jun Mei WANG you yong li Xiao Jie XU(Chemistry department, Beida-Jiuyuan Molecular Design Laboratory, Peking University,Beijing 100871) Chemistry Department Beida-Jiuyuan Molec. Des. Laboratory Peking University Beijing 100871 China

Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

关键词： QSAR GA(genetic algorithm) HIV

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MOF and its derivative materials modified lithium-sulfur battery separator:a new means to improve performance

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Rare Metals 2024年第6期43卷 2418-2443页

作者： Rong-Wei Huang yong-Qi Wang Dan you Wen-Hao Yang Bin-Nan Deng Fei Wang Yue-Jin Zeng Yi-yong Zhang Xue li National Local Joint Engineering Research Center for lithium-Ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Batteries Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

In recent years,lithium-sulfur batteries(LSBs)are considered as one of the most promising new generation energies with the advantages of high theoretical speeific capacity of sulfur(1675 mAh·g^(-1)),abundant sulfur resources,and environmental friendliness storage technologies,and they are receiving wide attention from the ***,the problems of the shuttle effect and lithium dendrite growth in LSBs have limited their practical application,so there is a need to find ways to solve these *** is an excellent choice to use novel materials to modify battery *** those novel materials,the metal-organic framework(MOF)has the properties of regular pores and controllable *** applied as a positive electrode and diaphragm,it can restrain the shuttle effect and lithium dendrite growth,especially since it shows excellent performance in diaphragm ***,various design strategies and synthesis methods of MOF-modified separators are reviewed in this paper,and the applications of MOF in LSBs separators in different forms are introduced,including the composite of MOF and carbon-based materials,the compounding of MOF and polymer,self-carbonization to form MOF-derived *** the same time,different characterization techniques are systematically reviewed to obtain the physical and chemical properties of MOF particles and the working mechanism of MOF-modified diaphragm,which provides a basis for further research in this ***,some future research trends and directions are put forward to fully tap the future commercial potential of MOF-modified diaphragm in LSBs.

关键词： MOF lithium-sulfur battery Modified diaphragms Design strategies Prospect Characterization

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Concentration breaking on two optimization problems

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Science China Mathematics 2024年第7期67卷 1555-1570页

作者： yong Huang Qinfeng li Qiuqi li School of Mathematics Hunan UniversityChangsha410082China

In the present paper, we study the boundary concentration-breaking phenomena on two thermal insulation problems considered on lipschitz domains, based on Serrin's overdetermined result, the perturbation argument, and a comparison of Laplacian eigenvalues with different boundary conditions. Since neither of the functionals in the two problems is C^(1), another key ingredient is to obtain the global H?lder regularity of minimizers of both problems on lipschitz domains. Also, the exact dependence on the domain of breaking thresholds is given in the first problem, and the breaking values are obtained in the second problem on ball domains, which are related to 2π in dimension 2.

关键词： spectral inequalities symmetry breaking Laplacian eigenvalue

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Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming Xiao Heng Zheng Ping Yuan Jun-Hui Luo lin-lin Shen Jie-Feng Tan Xian-you Luo De li yong Chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan University State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan University

Hard carbon （HC） has emerged as one of the superior anode materials for sodium-ion batteries （SIBs）,with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl （decreasing from 5.71 at%to 2.12 at%） and hydroxyl groups （decreasing from 7.73 at % to 6.26 at%）.Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na+.Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na+*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g-1to an impressive 251.97 m Ah·g-1at a current density of 50 mA·*** at 400 mA·g-1,the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·***,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Closed pores Hard carbon Oxygen functional groups Sodium-ion batteries Spark plasma sintering

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Heterostructure:application of absorption-catalytic center in lithium-sulfur batteries

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Rare Metals 2024年第4期43卷 1461-1487页

作者： Fei Wang Chun-Man Yang yong-Qi Wang Dan you Wen-Hao Yang Rong-Wei Huang Ji-Yue Hou Qian Wang Ying-Jie Zhang Ying Wang Yue-Jing Zeng Yi-yong Zhang Xue li National Local Joint Engineering Research Center for lithium-Ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Batteries Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming650093China College of Electrical Information Engineering Panzhihua UniversityPanzhihua617000China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China

Due to the high theoretical specific capacity(1675 mAh·g^(-1)),low cost,and high safety of the sulfur cathodes,they are expected to be one of the most promising rivals for a new generation of energy storage ***,the shuttle effect,low conductivity of sulfur and its discharge products,volume expansion,and other factors hinder the commercialization of lithium-sulfur batteries(LSBs).The development of sulfur-fixing materials and the design of multifunctional materials to enhance the electrochemical performance of LSBs have been the main research priorities in recent *** of the advantages of high conductivity,built-in electric field,and good synergism,more and more researchers have employed heterostructure into sulfur-fixing materials to enhance the catalytic and absorption ability for *** this review,the principle of heterostructure and the mechanism of enhancing the performance of lithium-sulfur batteries are *** applications of heterostructure in cathode and interlayer of LSBs in the latest years are ***,the cutting-edge troubles and possibilities of heterostructures in LSBs are briefly presented.

关键词： lithium-sulfur batteries(LSBs) Heterostructure Built-in electric field Catalytic Absorption

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Seismic responses of an intensively constructed metro station-passageway-shaft structure system

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 760-775页

作者： Ruohan li yong YUAN Hong CHEN Xinxing li Emilio BILOTTA Department of Geotechnical Engineering Tongji UniversityShanghai 200092China Department of Civil Architectural and Environmental EngineeringUniversity of Naples Federico IINaples 80125Italy State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China Shanghai Tunnel Engineering&Rail Transit Design and Research Institute Shanghai 200235China

Intensive construction methods offer benefits for metro station development,yet they present challenges for seismic design due to the spatially asymmetric configuration of passageway-shaft *** this study,a detailed numerical model of a station-passageway-shaft structure system built using intensive construction methods was developed and the deformation and damage modes under seismic loadings were *** results indicate that inconsistent deformation between the shaft and the station generates interaction through the connecting passageway,leading to damage near the opening of the station structure and both ends of the connecting passageway Damage is more severe under longitudinal *** with the opening plan that spans four segments,the opening plan that spans five segments exacerbates the overall degree of damage to the structure *** transverse excitation,the presence of interior structures intensifies the damage to the station and connecting passageway,while with such internal structure in place the impact is relatively minor under longitudinal *** with steel segments near the station opening can appreciably attenuate the *** contrast,introducing flexible joints at both ends of the connecting passageway intensifies the ***,reinforcement using steel segments emerges as an optimal seismic mitigation strategy.

关键词： earthquake intensive construction metro station numerical simulation

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Resilience and response:Unveiling the impacts of extreme droughts on forests through integrated dendrochronological and remote sensing analyses

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Forest Ecosystems 2024年第4期11卷 491-501页

作者： Han Shi Xi Peng yong-Jiao Zhou Ai-Ying Wang Xue-Kai Sun Na li Quan-Sheng Bao Gude Buri Guang-you Hao CAS Key Laboratory of Forest Ecology and Silviculture Institute of Applied EcologyChinese Academy of SciencesShenyang110016China Daqinggou Ecological Research Station Institute of Applied EcologyChinese Academy of SciencesShenyang110016China University of Chinese Academy of Sciences Beijing100049China School of life Science and Engineering Shenyang UniversityShenyang110044China Wudantala Forestry Forestry and Grassland Administration of Horqin Northeast CountyTongliao028100China

Extreme droughts are anticipated to have detrimental impacts on forest ecosystems,especially in water-limited regions,due to the influence of climate ***,considerable uncertainty remains regarding the patterns in species-specific responses to extreme ***,we conducted a study integrating dendrochronology and remote sensing methods to investigate the mosaic-distributed maple-oak(native)natural forests and poplar plantations(introduced)in the Horqin Sandy Land,Northeast *** assessed the impacts of extreme droughts on tree performances by measuring interannual variations in radial growth and vegetation *** results showed that precipitation and self-calibrated palmer drought severity index(scPDSI)are the major factors influencing tree-ring width index(RWI)and normalized difference vegetation index(NDVI).The severe droughts between 2000 and 2004 resulted in reduced RWI in the three studied tree species as well as led to NDVI reductions in both the maple-oak natural forests and the poplar *** RWI reached the nadir during the2000-2004 severe droughts and remained at low levels two years after the severe drought,creating a legacy *** contrast to the lack of significant correlation between RWI and scPDSI,NDVI exhibited a significant positive correlation with scPDSI indicating the greater sensitivity of canopy performance to droughts than radial ***,interspecific differences in RWI and NDVI responses were observed,with the fast-growing poplar species experiencing a more significant RWI decrease and more negative NDVI anomaly during severe droughts than native species,highlighting the species-specific trade-offs between drought resilience and growth *** study emphasizes the importance of combining tree-level radial growth with landscape-scale canopy remote sensing to understand forest resilience and *** study improves our understanding of forest responses to extreme drought and highlights species di

关键词： Introduced tree species Native tree species NDVI Severe drought Tree-ring width

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Modeling analysis of cobalt-based Fischer-Tropsch catalyst particles

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Chinese Journal of Chemical Engineering 2024年第6期70卷 82-92页

作者： Huashuai Wu Gang Wang yong Yang yongwang li College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China National Energy Research&Development Center for Coal to liquid Fuels Synfuels China CompanyLimitedBeijing 101400China

The influences of particle size,shape,and catalyst distribution on the reactivity and hydrocarbon product selectivity of a cobalt-based catalyst for Fischer-Tropsch synthesis were investigated in the present work.A self-consistent kinetic model for Fischer-Tropsch reaction proposed here was found to correlate experimental data well and hence was used to describe the consumption rates of reactants and formation rates of hydrocarbon *** perturbed-chain statistical associating fluid theory equation of state was used to describe vapor-liquid equilibrium behavior associated with Fischer-Tropsch *** interaction between intraparticle diffusion and Fischer-Tropsch reaction was investigated in *** showed that in order to avoid the adverse influence of intraparticle diffusional limitations on catalyst reactivity and product selectivity,the use of small particles is *** eggshell spherical particles are shown to keep the original catalyst reactivity and enhance the selectivity of heavy hydrocarbon *** suitable layer thickness for a spherical particle with a diameter of 2 mm is nearly 0.15 *** the same outer diameter of 2 mm,the catalyst reactivity and heavy product selectivity of hollow cylindrical particles with a layer thickness of 0.25 mm are found to be larger than eggshell spherical *** the viewpoint of catalytic performance,hollow cylindrical particles are a better choice for industrial applications.

关键词： Fischer-Tropsch synthesis Kinetic modeling Vapor-liquid equilibria Numerical simulation Intraparticle diffusion Particle shapes

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