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Evaluating the environmental impact of selected chemical de-icers

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Transportation Safety and Environment 2019年第3期1卷 220-229页

作者： xiang Li Benoit Van Aken Erica Mckenzie Huichun zhang Bechara Abboud William Davenport Civil&Environmental Engineering Department Temple UniversityPhiladelphiaPAUSA Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina Department of Civil Engineering Case Western Reserve UniversityClevelandOHUSA Department of Transportation PhiladelphiaPAUSA

In this study,the environmental impacts of six commercial chloride-based de-icer products,including Rock Salt and Salt Brine,were *** nutrients,oxygen demand,heavy metal concentration,corrosion and toxicity of all six de-icers were *** an assumed 500-fold dilution,the test results were compared to the public water-quality *** results show that the selected chemical de-icers have little chance of severely damaging the environment and ecosystem under a normal dilution ***,attention needs to be paid to small water bodies and sensitive receiving water.

关键词： chemical de-icer environmental impact corrosion test toxicity

Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model

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Chinese Journal of Integrative Medicine 2021年第7期27卷 534-541页

作者： zhang Bo CHANG Hong-sheng HU Kai-li YU Xue LI Li-na XU xiang-qing School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China School of Basic Medicine Science Beijing University of Chinese MedicineBeijing100102China Experiment Center Encephalopathy DepartmentAffiliated Hospital of Shandong University of Chinese MedicineJinan250014China

Objective To study the antidepressant-like effect and action mechanism of geniposide and eleutheroside B combination treatment on the lipopolysaccharide(LPS)-induced depression mice *** Depression mice model was established by lipopolysaccharide(LPS)*** 48 mice were randomly divided into 6 groups(8 rats per group)according to a random number table,including normal,model,fluoxetine(20 mg/kg),geniposide(100 mg/kg)+eleutheroside B(100 mg/kg),geniposide+eleutheroside B+WAY 100635(0.03 mg/kg),geniposide+eleutheroside B+N-methyl-D-aspartic acid receptor(NMDA,75 mg/kg)groups,*** continuous administration for 10 days,autonomic activity tests after 30 min of administration were performed on the 10th *** the 11th day,except for the normal group,the mice in the other groups were intraperitoneally injected with LPS(1 mg/kg),and the behavioral tests were performed 4 h *** linked immunosorbent assay was used to detect tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)levels in mice *** mRNA expression of indoleamine 2,3-dioxygenase(IDO)and nuclear transcription factor(NF-κB)were detected by real-time quantitative polymerase chain ***-blot analysis was used to detect IDO and NF-κB protein expressions in hippocampus *** Compared with the normal group,a single administration of LPS increased the immobility time in the forced swimming test(FST)and tail suspension test(TST,P<0.01),without affecting autonomous *** with the model group,fluoxetine and geniposide+eleutheroside B administration significantly improved the immobility time of depressed mice in the FST and TST,decreased serum IL-1βcontent,inhibited the expression levels of NF-κB gene and protein in hippocampus tissues(P<0.05 or P<0.01).Compared with the model group,geniposide+eleutheroside B treatment significantly reduced serum TNF-αcontent and inhibited IDO mRNA and protein expressions in hippocampus(P<0.05 or P<0.01).In a

关键词： geniposide eleutheroside B antidepressant effect mechanism 5-hydroxytryptamine glutamate

A novel 12,23-epoxy dammarane saponin from Panax notoginseng

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Chinese Journal of Natural Medicines 2015年第4期13卷 303-306页

作者： YUAN Cen XU Fa-xiang HUANG Xiao-Jun LI Shao-Ping zhang Qing-Wen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao Institute of Traditional Chinese Medicine and Natural Products Jinan University

The present study investigated the chemical constituents of the roots and rhizomes of Panax *** were isolated by various column chromatographic methods,and their structures were elucidated by the extensive analysis of spectroscopic data and chemical evidences.A novel 12,23-epoxy dammarane-type saponin,named epoxynotoginsenoside A(1),together with four known compounds(2-5),was isolated and characterized.

关键词： Panax notoginseng Dammarane saponin Epoxynotoginsenoside A

老年2型糖尿病患者发生口腔衰弱风险的列线图预测模型构建

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实用临床医药杂志 2024年第16期28卷 98-103,108页

作者：仲蕾张会许静陆雅维项晓婷王珩安徽医科大学护理学院安徽合肥230601 安徽医科大学第一附属医院安徽合肥230032 安徽省公共卫生临床中心安徽合肥230032

目的分析老年2型糖尿病患者发生口腔衰弱的影响因素,并构建列线图预测模型。方法选取370例老年2型糖尿病患者作为研究对象,其中建模组纳入284例,验证组纳入86例。采用(OF-8)量表进行口腔衰弱筛查,得分≥4分为口腔衰弱筛查阳性。通过自... 详细信息

目的分析老年2型糖尿病患者发生口腔衰弱的影响因素,并构建列线图预测模型。方法选取370例老年2型糖尿病患者作为研究对象,其中建模组纳入284例,验证组纳入86例。采用(OF-8)量表进行口腔衰弱筛查,得分≥4分为口腔衰弱筛查阳性。通过自制调查问卷收集2组患者一般资料。采用多因素Logistic回归分析法分析2型糖尿病患者发生口腔衰弱的影响因素,并构建预测模型。采用Homser-Lemeshow拟合优度检验和受试者工作特征(ROC)曲线验证模型的拟合优度及预测效能。结果老年2型糖尿病患者中口腔衰弱的发生率为45.4%(129/284)。年龄、体质量指数(BMI)、四肢骨骼肌质量指数(ASMI)、吸烟、月收入、主观咀嚼困难是老年糖尿病患者发生口腔衰弱的影响因素(P<0.05)。内部、外部验证的ROC曲线下面积分别为0.887(95%CI:0.847~0.925)、0.839(95%CI:0.755~0.923)。Homser-Lemeshow检验显示χ^(2)=4.852,P=0.773,列线图模型的拟合优度良好。结论年龄、ASMI、BMI、吸烟、月收入、主观咀嚼困难是老年糖尿病患者发生口腔衰弱的影响因素,基于上述影响因素构建的列线图预测模型的效能较好。

关键词：老年人 2型糖尿病口腔衰弱列线图影响因素预测模型

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磷尾矿综合利用研究现状

化工矿物与加工 2024年第7期53卷 27-36页

作者：张守逊吴雨瑶郭永杰谢贤王翔昆明理工大学国土资源工程学院金属矿尾矿资源绿色综合利用国家地方联合工程研究中心国家磷资源开发利用工程技术研究中心

磷尾矿是对磷矿石进行选矿富集后产生的固体废弃物，其长期堆放不仅会占用大量土地，还会对土壤及地下水环境造成严重威胁，且因其中含有大量有价元素，还会造成资源浪费。本文介绍了磷尾矿的来源及危害，梳理了国内磷矿石选矿工艺，总... 详细信息

磷尾矿是对磷矿石进行选矿富集后产生的固体废弃物，其长期堆放不仅会占用大量土地，还会对土壤及地下水环境造成严重威胁，且因其中含有大量有价元素，还会造成资源浪费。本文介绍了磷尾矿的来源及危害，梳理了国内磷矿石选矿工艺，总结了磷尾矿中有价元素回收方法，如浮选法、化学选矿法、磁选法等；综述了磷尾矿材料化应用研究现状，主要包括3个方面：制备建筑材料，如地质聚合物、水泥、陶瓷等；制备功能材料，如陶粒、耐火材料、阻燃剂等；其他方面，如用作路基材料、制肥料、处理废水等。加快制定新型材料标准，降低磷尾矿综合利用成本，是未来需要着力解决的问题。

关键词：磷尾矿综合利用有价元素材料化建筑材料功能材料

A smart O_(2)-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3608-3621页

作者： Xiaojuan zhang Chuanchuan He Yun Sun Xiaoguang Liu Yan Chen Chen Chen Ruicong Yan Ting Fan Tan Yang Yao Lu Jun Luo xiang Ma Guangya xiang School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830011China

Drug transportation is impeded by various barriers in the hypoxic solid tumor,resulting in compromised anticancer ***,a solid lipid monostearin(MS)-coated CaO_(2)/MnO_(2) nanocarrier was designed to optimize doxorubicin(DOX)transportation comprehensively for chemotherapy *** MS shell of nanoparticles could be destroyed selectively by highly-expressed lipase within cancer cells,exposing water-sensitive cores to release DOX and produce O_(2).After the cancer cell death,the core-exposed nanoparticles could be further liberated and continue to react with water in the tumor extracellular matrix(ECM)and thoroughly release O_(2) and DOX,which exhibited cytotoxicity to neighboring *** DOX molecules could readily diffuse through ECM,in which the collagen deposition was decreased by O_(2)-mediated hypoxia-inducible factor-1 inhibition,leading to synergistically improved drug ***,DOX-efflux-associated P-glycoprotein was also inhibited by O_(2),prolonging drug retention in cancer ***,the DOX transporting processes from nanoparticles to deep tumor cells including drug release,penetration,and retention were optimized comprehensively,which significantly boosted antitumor benefits.

关键词： Tumor Nanoparticle Chemotherapy Hypoxia HIF-1 Transportation CaO_(2) MnO_(2)

China's Carbon Neutrality: Leading Global Climate Governance and Green Transformation

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Chinese Journal of Urban and Environmental Studies 2021年第3期9卷 103-124页

作者： zhang Yongsheng CHAO Qingchen CHEN Ying zhang Jianyu WANG Mou zhang Ying YU xiang Research Institute for Eco-Civilization Chinese Academy of Social Sciences National Climate Center BRI Green Development Institute

China aims to peak carbon emissions before 2030 and achieve carbon neutrality by 2060. It is a strategic decision made after deliberate consideration by the Central Government. Such goals reflect China’s responsibility as a major country in responding to global climate change, its vision of the future world development, and its commitment to green transformation. After the 18 th CPC National Congress, China has undergone a fundamental change in its development *** the environment is no longer regarded as a burden upon economic growth, but as a driving force for high-quality development. Emissions reduction has also changed from a task inflicted upon local governments to a goal people identify with. More than 120 countries have proposed carbon neutrality targets in different ways by now. The global consensus on carbon neutrality marks the end of the traditional industrial era and the start of a new development *** concept of carbon neutrality redefines and reshapes the entire development paradigm. It is a self-revolution of the mode of production and life. It not only poses an unprecedented challenge but also provides a strategic opportunity for China. China is likely to lead the world in future green transformation and global climate governance.

关键词： Carbon neutrality carbon emissions peak green transformation global climate governance

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浅析乘用车增程技术现状与发展趋势

汽车科技 2024年第2期 56-63页

作者：邓湘范鹏毕帅廖显敏张星宇岚图汽车科技有限公司武汉430056

目前,新能源汽车主要以纯电动、混合动力、燃料电池等多种技术路线并行发展,在产业加速变革和支持政策持续调整完善过程中,各种技术路线发展的比较优势也在不断变化。企业为迎合市场需求,正积极谋划研究符合未来变革趋势的技术路线及发... 详细信息

目前,新能源汽车主要以纯电动、混合动力、燃料电池等多种技术路线并行发展,在产业加速变革和支持政策持续调整完善过程中,各种技术路线发展的比较优势也在不断变化。企业为迎合市场需求,正积极谋划研究符合未来变革趋势的技术路线及发展方向,亟需在多种路线竞相发展中选择符合企业自身实际的技术路线。本文通过分析新能源汽车技术路线关系,概述了当前新能源汽车发展趋势及主流技术路径,着重阐述了增程式电动汽车的市场需求、技术构型、优劣势对比分析,同时对于未来增程核心技术的发展方向进行了判断与分析,并提出了观点及建议。

关键词：新能源汽车技术路径增程式电动汽车增程器

Spontaneous remission of Pneumocystisjiroveci pneumonia in 2 non-AIDS immunocompromised patients

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Chinese Medical Journal 2013年第1期126卷 184-185页

作者： MU xiang-dong WANG Guang-fa MA Jing zhang Cheng SU Li CHEN Jian Department of Respiratory Medicine Peking University FirstHospital Beijing 100034 China

Pneumocystis jiroveci （P. jiroveci） pneumonia （PCP） in non-AIDS immunocompromised patients ismuch more critical than that in AIDS patients,1 Without treatment, mortality of PCP in immunocompromised patients approaches 100 percent, and there were no reports of spontaneous remissions of PCP without anti-PCP therapy.2 Here we report 2 non-AIDS immunocompromised patients in whom PCP developed and remitted without treatment.

关键词： Pneumocystis jiroveci pneumonia non-AIDS immunocompromised patients spontaneous remission