检索结果-南通市图书馆

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel and Optimized Method for Electro-focusing and Moving Neutralization Reaction Boundary Formed by HCl and NaOH

引用

Chinese Chemical Letters 2001年第2期12卷 179-182页

作者： Shu Lin ZHOU Cheng Xi CAO you Zhao he wen Kui CheN Yi Tai QIAN Department of Chemistry University of Science and Technology of ChinaHefei 230026 Institute of Allergy Research Wannan Medical CollegeAnhui Wuhu 241001

A novel method is developed for electro-focusing and moving neutralization reaction boundary (MNRB) created with HCl and NaOH. The optimized conditions are screened out. By using this method, the experiments are performed on MNRB formed with HCl and NaOH in agarose gel. The experiments are quantitatively in coincidence with the predictions with the theory of moving chemical reaction boundary (MCRB).

关键词： Electrolyte Electrolysis Electromigration Isoelectric focusing (IEF) Moving chemical reaction boundary (MCRB)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Personal Review:Research on ethanol synthesis from syngas

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第5期9卷 714-719页

作者： Jie he wen-nan ZHANG Qingdao Institute of Biomass Energy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266071 China

It is a very fine substitutable energy technology to synthesize ethanol from biomass-derived syngas. This paper summarized the development of preparing ethanol from syngas, and especially elaborated on the research status of catalysts for the process. Based on the relative researches on the reaction mechanism, structure and performance of the catalysts, the optimum design of catalysts with high activity was presented in this review, which set the theoretical and application foundation for the industrial production of ethanol from syngas.

关键词： Syngas Catalyst Ethanol Biomass Promoter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analytical models for the penetration of semi-infinite targets by rigid,deformable and erosive long rods

引用

Acta Mechanica Sinica 2010年第4期26卷 573-583页

作者： he-Ming wen Bin Lan CAS Key Laboratory for Mechanical Behavior and Design of Materials University of Science and Technology of China 230027 Hefei China

A theoretical study is presented herein on the pen- etration of a semi-infinite target by a spherical-headed long rod for Yp 〉 S, where Yp is the penetrator strength and S is the static target resistance. For Yp 〉 S, depending upon initial impact velocity, there exist three types of penetration, namely, penetration by a rigid long rod, penetration by a deforming non-erosive long rod and penetration by an erosive long rod. If the impact velocity of the penetrator is higher than the hydrodynamic velocity （VH）, it will penetrate the target in an erosive mode; if the impact velocity lies between the hydrodynamic velocity （VH） and the rigid body velocity （VR）, it will penetrate the target in a deformable mode; if the impact velocity is less than the rigid body velocity （VR）, it will penetrate the target in a rigid mode. The critical conditions for the transition among these three penetration modes are proposed. It is demonstrated that the present model predictions correlate well with the experimental observations in terms of depth of penetration （DOP） and the critical transition conditions.

关键词： Long rod Semi-infinite target - Penetration Alekseevskii-Tate model Rigid body velocity - Hydrodynamic velocity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Secure and Efficient Mutual Authentication Scheme for NFC Mobile Devices

引用

Journal of Electronic Science and Technology 2017年第3期15卷 240-245页

作者： you-Han Tung wen-Shenq Juang Department of Information Management National Kaohsiung First University of Science and Technology Kaohsiung 824

As the technology of mobile devices spreads fast,the price of mobile devices is getting *** of the people have mobile devices,and these devices have the technology of near field communication（NFC）.With the long time development and research,the mobile devices use NFC technology on the payment and authentication applications,and replace the smartcard,the access control card,and the credit card by using the card emulation *** helps the development of NFC *** recent years,more and more users begin using NFC technology on mobile payment and *** researches have proposed the related NFC authentication protocols,but their schemes are still lack of some security properties and functions,which are necessary for NFC authentication *** this paper,we propose a secure and efficient NFC authentication scheme between two NFC devices by the help of the authentication server that provides mutual authentication.

关键词： Index Terms--Authentication protocol informationsecurity mutual authentication near fieldcommunication (NFC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gauges for the Cookie-cutter Sets

引用

Acta Mathematica Sinica,English Series 2009年第12期25卷 2119-2126页

作者： Yu Xia DAI Sheng you wen Department of Mathematics Hubei University Wuhan 430062 P. R. China

Let E be a cookie-cutter set with dimH E =s. It is known that the Hausdorff s-measure and the packing s-measure of the set E are positive and finite. In this paper, we prove that for a gauge function g the set E has positive and finite Hausdorff g-measure if and only if 0 〈 liminft→0 g（t）/ts 〈 ∞. Also, we prove that for a doubling gauge function g the set E has positive and finite packing g-measure if and only if 0 〈 lim supt→0 g（t）/ts 〈 ∞.

关键词： cookie-cutter set gauge function Hausdorff gauge packing gauge

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients

引用

World Journal of Gastroenterology 2015年第28期21卷 8653-8659页

作者： Guo-Hong Ge Yun Ye Xin-Bei Zhou Li Chen Cong he Dan-Feng wen you-wen Tan Department of hepatosis The Third Hospital of Zhenjiang Affiliated Jiangsu University

AIM:To investigate the virological relapse rate in hepatitis B e antigen(HBeAg)-negative patients after antiviral therapy discontinuation and analyze the factors associated with virological ***:Among patients diagnosed with chronic hepatitis B infection between May 2005 and July2010,204 were eligible for *** Kaplan-Meier method and log-rank test were used to calculate the cumulative rate of relapse and compare cumulative relapse rates between *** Cox proportional hazards regression model was used to evaluate the predictive factor of virological ***:The 2 and 1 year cumulative risks of virological relapse after antiviral therapy discontinuation were 79.41%(162/204) and 43.82%(71/162),*** analysis revealed that only post treatment hepatitis B surface antigen(HBsAg)level was associated with virological relapse {P= 0.011).The cumulative risk of virological relapse was higher in the patients with HBsAg levels ≥1500 IU/L than in those with HBsAg levels he area under the curve was 0.603(P= 0.033).The cutoff HBsAg value for predicting virological relapse was 1443IU/L CONCLUSION:We found that the virological relapse rate remained high after antiviral therapy discontinuation in the HBeAg-negative patients and that the post treatment HBsAg levels predicted virological relapse.

关键词： Chronic hepatitis B Virological relapse hepatitis B surface antigen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A_1 Weights and d-Homogeneous Measures on Ahlfors d-Regular Space

引用

Acta Mathematica Sinica,English Series 2012年第5期28卷 901-908页

作者： Yu Xia DAI Sheng you wen Zhi Xiong wen Department of Mathematics Huazhong University of Science and Technology Department of Mathematics Hubei University

Let X be an Ahlfors d-regular space and rn a d-regular measure on X. We prove that a measure μ on X is d-homogeneous if and only if μ is mutually absolutely continuous with respect to m and the derivative Dmμ（x） is an A1 weight. Also, we show by an example that every Ahlfors d-regular space carries a measure which is d-homogeneous but not d-regular.

关键词： Ahlfors regular space homogeneous measure Ahlfors regular measure weight

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A spherical cavity expansion model for penetration of ogival-nosed projectiles into concrete targets with shear-dilatancy

引用

Acta Mechanica Sinica 2011年第6期27卷 1001-1012页

作者： Tao he he-Ming wen Xiao-Jun Guo CAS Key Laboratory for Mechanical Behavior and Design of Materials University of Science and Technology of China 230027 Hefei China

A dynamic spherical cavity-expansion penetration model is suggested herein to predict the penetration and perforation of concrete targets struck normally by ogivalnosed *** dilatancy as well as compressibility of the material in comminuted region are considered in the paper by introducing a dilatant-kinematic relation.A procedure is first presented to compute the radial stress at the cavity surface and then a numerical method is used to calculate the results of penetration and perforation with friction being taken into *** influences of various target parameters such as shear strength,bulk modulus,density,Poisson＇s ratio and tensile strength on the depth of penetration are *** is shown that the model predictions are in good agreement with available experimental *** is also shown that the shear strength plays a dominant role in the target resistance to penetration.

关键词： Spherical cavity expansion Shear dilatancy Ogival-nosed projectile Concrete target Penetration Perforation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stress-state dependence of dynamic strain aging:Thermal hardening and blue brittleness

引用

International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 854-866页

作者： wen-qi Liu Jun-he Lian Advanced Manufacturing and Materials Department of Mechanical EngineeringAalto UniversityPuumiehenkuja 302150 EspooFinland Impact and Crashworthiness Lab Department of Mechanical EngineeringMassachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139-4307USA

This study aims to discover the stress-state dependence of the dynamic strain aging(DSA)effect on the deformation and fracture behavior of high-strength dual-phase(DP)steel at different deformation temperatures(25-400°C)and reveal the damage mechanisms under these various *** achieve different stress states,predesigned specimens with different geometric features were *** electron microscopy was applied to analyze the fracture modes(e.g.,dimple or shear mode)and underlying damage mechanism of the investigated *** is present in this DP steel,showing the Portevin-Le Chatelier(PLC)effect with serrated flow behavior,thermal hardening,and blue brittleness *** show that the stress state contributes distinctly to the DSA effect in terms of the magnitude of thermal hardening and the pattern of blue *** low stress triaxiality or Lode angle parameter promotes DSA-induced blue ***,the damage mechanisms also show dependence on the stress states in conjunction with the DSA effect.

关键词： dynamic strain aging effect Portevin-Le Chatelier effect damage mechanism dimple fracture shear fracture dual-phase steel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：