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Pretreatment of Shaoyao Gancao Decoction(芍药甘草汤)Alters Pharmacokinetics of Intravenous Paclitaxel in Rats

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Chinese Journal of Integrative Medicine 2017年第1期23卷 70-75页

作者： WANG Yang HUANG Xi ZHONG Mei-zuo LU Ruo-huang XIA Zi-an FAN Rong liu Bo HUANG Wei GAN ping-ping Laboratory of Ethnopharmacology Institute of Integrated Traditional Medicine and Western MedicineXiangya HospitalCentral South UniversityChangsha 410008China Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Stomatology the Third Xiangya HospitalCentral South UniversityChangsha 410008China Department of geriatrics Xiangya Hosoital.Central South UniversityChanqsha 410008China

Objective：To investigate the effect of Shaoyao Gancao Decoction（芍药甘草汤,SGD）on the pharmacokinetics of intravenously administered paclitaxel in ***：Paclitaxel was intravenously administered to rats（3 mg/kg）with or without the concomitant administration of SGD（752 mg/kg,a single day or 14 consecutive days pretreatment）.The paclitaxel in the serum was quantified using a simple and rapid ultra performance liquid chromatography（UPLC）method for the pharmacokinetic *** pharmacokinetic parameters were calculated via a non-compartment model using the computer program DAS ***：The pharmacokinetic parameters of paclitaxel were significantly altered in response to 14 consecutive days of pretreatment with *** area under the curve（AUC0-t,from 4 820±197 to 4 205±186 ng·m L-1·h-1）and AUC0-∞（from 5 237±280 to 4 514±210 ng·m L-1·h-1）significantly decreased in response to the 14-day pretreatment with *** values of V dss（L/kg）were 10.74±1.08 and 9.35±0.49,those of CL（L/kg）were0.67±0.03 and 0.57±0.03 and the t1/2（h）values were 11.17±0.84 and 11.32±0.93,respectively,for the14-day SGD pretreatment and intravenous paclitaxel *** AUC0-t and AUC0-∞values decreased by13%and 14%（P〈0.01）,*** area under the curve decreased significantly（P〈0.01）,and the total clearance increased by 1.2-fold（P〈0.01）,after 14 consecutive days of pretreatment with SGD.A single-day pretreatment with SGD did not significantly affect the pharmacokinetic parameters of ***：SGD administration for 14 consecutive days increased the metabolism of paclitaxel,while a 1-day pretreatment had little *** results would contribute important information to the study on interaction between Chinese medicines and chemotherapy and also help to utilize SGD better in the adjunctive therapy of cancer patients.

关键词： paclitaxel Shaoyao Gancao Decoction pharmacokinetic drug interactions

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转炉激光炉气分析动态控制系统的开发

钢铁 2007年第12期42卷 20-24页

作者：何平刘浏尹卫平刘洪波陶传俊钢铁研究总院冶金工艺研究所北京100081 济南钢铁股份有限公司一炼钢厂山东济南250101

采用激光气体分析法开发出了新型转炉动态控制系统。与质谱法相比该系统具有投资少、故障低、性能稳定、系统延迟时间短等优点。根据冶金动力学理论,建立了转炉动态控制模型。本控制系统在40 t复吹转炉的大生产应用中终点碳预报精度在±... 详细信息

采用激光气体分析法开发出了新型转炉动态控制系统。与质谱法相比该系统具有投资少、故障低、性能稳定、系统延迟时间短等优点。根据冶金动力学理论,建立了转炉动态控制模型。本控制系统在40 t复吹转炉的大生产应用中终点碳预报精度在±0.02%的条件下命中率达到80.9%。

关键词：激光气体分析转炉动态控制

Steady States in SIRS Epidemical Model of Mobile Individual

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Communications in Theoretical Physics 2006年第1期45卷 105-108页

作者： ZHANG Duan-Ming HE Min-Hua YU Xiao-Ling PAN Gui-Jun SUN Hong-Zhang SU Xiang-Ying SUN Fan YIN Yah-ping LI Rui liu Dan Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We consider an epidemical model within soclally interacting mobile individuals to study the behaviors of steady states of epidemic propagation in 2D networks. Using mean-field approximation and large scale simulations, we recover the usual epidemic behavior with critical thresholds δc and pc below which infectious disease dies out. For the population density δ far above δc it is found that there is linear relationship between contact rate λ and the population density δ in the main. At the same time, the result obtained from mean-field approximation is compared with our numerical result, and it is found that these two results are similar by and large but not completely the same.

关键词： small world epidemical model mobile individual mean-field equation

Al-Si合金表面制备ZrO_2等离子体电解氧化涂层的生长机制

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特种铸造及有色合金 2012年第12期32卷 1091-1094页

作者：王萍刘道新西北工业大学航空学院

采用等离子体电解氧化方法在Al-Si合金表面制备了氧化锆涂层。通过SEM、XRD研究了涂层的显微组织和相组成。结果表明,在氧化初期,涂层生长为典型的电化学极化控制的阳极沉积阶段,生长速率较快,且主要以向外生长为主;随处理时间的延长及... 详细信息

采用等离子体电解氧化方法在Al-Si合金表面制备了氧化锆涂层。通过SEM、XRD研究了涂层的显微组织和相组成。结果表明,在氧化初期,涂层生长为典型的电化学极化控制的阳极沉积阶段,生长速率较快,且主要以向外生长为主;随处理时间的延长及涂层增厚,涂层生长速率有所降低,且主要以向内生长为主。涂层主要由t-ZrO2、m-ZrO2、α-Al2O3和γ-Al2O3组成,t-ZrO2为涂层的主晶相。随着氧化反应的进行,涂层表面由等离子体放电形成的微孔逐渐过渡为重复堆积的陶瓷颗粒,颗粒尺寸为1～2μm。

关键词： Al—Si合金氧化锆等离子体电解氧化涂层

一种以超球体作为抗体识别区域的新的实值阴性选择算法

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计量学报 2011年第3期32卷 275-278页

作者：刘颖熊萍海军工程大学电气与信息工程学院湖北武汉430033 海军工程大学理学院湖北武汉430033

从几何模型出发，免疫问题实际上是一个空间划分的问题。将超球体作为免疫系统抗体识别区域，针对经典阴性选择算法的不足，提出了改善的方法，从根本上减少了误报和漏报率，降低了检测器的冗余可能性。仿真和实验实例表明，该算法适合... 详细信息

从几何模型出发，免疫问题实际上是一个空间划分的问题。将超球体作为免疫系统抗体识别区域，针对经典阴性选择算法的不足，提出了改善的方法，从根本上减少了误报和漏报率，降低了检测器的冗余可能性。仿真和实验实例表明，该算法适合于电路板的故障诊断，有较高的故障诊断率。

关键词：计量学人工免疫超球体实值阴性选择算法

Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicus.

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Molecular Plant 2021年第11期14卷 1935-1950页

作者： Yong Feng ping Wu Chao liu Liwei Peng Tao Wang Chao Wang Qian Tan Bixuan Li Yajuan Ou Hui Zhu Songli Yuan Renliang Huang Gary Stacey Zhongming Zhang Yangrong Cao State Key Laboratory of Agricultural Microbiology Hubei Hongshan Laboratoryand College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Divisions of Plant Sciences and Biochemistry C.S.Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA Oil Crops Research Institute of Chinese Academy of Agricultural Sciences Wuhan 430062China Present address:Rice Research Institute Jiangxi Academy of Agricultural SciencesNanchang 330200 China

An important question in biology is how organisms can associate with different microbes that pose no threat (commensals), pose a severe threat (pathogens) and those that are beneficial (symbionts). The root nodule symbiosis serves as important model system to address such questions in the context of plant-microbe interactions. It is now generally accepted that rhizobia have the abilities to actively suppress host immune responses during the infection process, analogous to the way in which plant pathogens can evade immune recognition. However, much remains to be elucidated with regard to the mechanisms by which the host recognizes the rhizobia as pathogens and how, subsequently, these pathways are suppressed to allow establishment of the nitrogen fixing symbiosis. In this study, we found that SymRK (Symbiosis Receptor-like Kinase) is required for rhizobial suppression of plant innate immunity in Lotus japonicus. SymRK associates with LjBAK1 (BRASSINOSTEROID INSENSITIVE 1-Associated receptor Kinase 1), a well characterized, positive regulator of plant innate immunity, and directly inhibits LjBAK1 kinase activity. Rhizobial inoculation enhances the association between SymRK and LjBAK1 in planta. LjBAK1 is required to regulate plant innate immunity and plays a negative role in mediating rhizobial infection in L. japonicus. The data indicate that the protein complex of SymRK-LjBAK1 serves as an intersection point between rhizobial symbiotic signaling pathways and innate immunity pathways, which provides an evidence that rhizobia might actively suppress the host's ability to mount a defense response in the legume-rhizobium symbiosis.

关键词： Legume-rhizobial symbiosis LjBAK1 Plant innate immunity Protein phosphorylation SymRK

Development of preoperative prognostic models including radiological features for survival of singular nodular HCC patients

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 72-80页

作者： Dong-Yang Ding Lei liu He-Lin Li Xiao-Jie Gan Wen-Bin Ding Fang-Ming Gu Da-Peng Sun Wen Li Ze-Ya Pan Sheng-Xian Yuan Wei-ping Zhou Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200438China Department of Radiodiagnosis Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200438China

Background:Early singular nodular hepatocellular carcinoma(HCC)is an ideal surgical indication in clinical ***,almost half of the patients have tumor recurrence,and there is no reliable prognostic prediction ***,it is unclear whether preoperative neoadjuvant therapy is necessary for patients with early singular nodular HCC and which patient needs *** is critical to identify the patients with high risk of recurrence and to treat these patients preoperatively with neoadjuvant therapy and thus,to improve the outcomes of these *** present study aimed to develop two prognostic models to preoperatively predict the recurrence-free survival(RFS)and overall survival(OS)in patients with singular nodular HCC by integrating the clinical data and radiological ***:We retrospective recruited 211 patients with singular nodular HCC from December 2009 to January 2019 at Eastern Hepatobiliary Surgery Hospital(EHBH).They all met the surgical indications and underwent radical *** randomly divided the patients into the training cohort(n=132)and the validation cohort(n=79).We established and validated multivariate Cox proportional hazard models by the preoperative clinicopathologic factors and radiological features for association with RFS and *** analyzing the receiver operating characteristic(ROC)curve,the discrimination accuracy of the models was compared with that of the traditional predictive ***:Our RFS model was based on HBV-DNA score,cirrhosis,tumor diameter and tumor capsule in *** nomogram had fine calibration and discrimination capabilities,with a C-index of 0.74(95%CI:0.68-0.80).The OS nomogram,based on cirrhosis,tumor diameter and tumor capsule in imaging,had fine calibration and discrimination capabilities,with a C-index of 0.81(95%CI:0.74-0.87).The area under the receiver operating characteristic curve(AUC)of our model was larger than that of traditional liver cancer staging system,Korea model and N

关键词： Early-stage hepatocellular carcinoma Singular nodular Radiological features Preoperative prognostic model Recurrence-free survival,Overall survival,Linear equation Neoadjuvant treatment

Investigation of Dynamic Behavior in 1D Non-uniform Granular System

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Communications in Theoretical Physics 2005年第3X期44卷 551-554页

作者： ZHANG Duan-Ming SU Xiang-Ying YU Bo-Ming LI Rui PAN Gui-Jun SUN Hong-Zhang YIN Yan-ping SUN Fan HE Min-Hua liu Dan Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We present a non-uniform granular system in one-dimensional case, whose granularity distribution has the fractal characteristic. The particles are subject to inelastic mutual collisions and obey Langevin equation between collisions. By Monte Carlo simulation we study the dynamic actions of the system. Far from the equilibrium, i.e., τ 〉〉 τe, the results of simulation indicate that the inhomogeneity of the system and the inelasticity of the particles have great influences on the dynamic properties of the system, and correspondingly the influence of the inhomogeneity is more significant.

关键词： inelasticity restitution coefficient e inhomogeneity fractal dimension D non-uniform granular system

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单壁碳纳米管的稳定性研究

人工晶体学报 2006年第3期35卷 494-496页

作者：刘华刘佐才刘吉平北京理工大学理学院北京100081 北京理工大学材料科学与工程学院北京100081

采用化学气相沉积法(CVD),以正己烷为碳源制备单壁碳纳米管(SWNTs),研究了纯化后的单壁碳纳米管在空气中的稳定性,分别对刚纯化后和在空气中放置5d、10d和15d后的样品进行了SEM、HRTEM和TG表征,结果发现单壁碳纳米管的氧化程度随在空气... 详细信息

采用化学气相沉积法(CVD),以正己烷为碳源制备单壁碳纳米管(SWNTs),研究了纯化后的单壁碳纳米管在空气中的稳定性,分别对刚纯化后和在空气中放置5d、10d和15d后的样品进行了SEM、HRTEM和TG表征,结果发现单壁碳纳米管的氧化程度随在空气中放置时间的延长而增加,15d后几乎完全转化为无定形碳。表明单壁碳管在空气中不稳定,很容易氧化,需要密闭保存。

关键词：单壁碳纳米管化学气相沉积稳定性