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Protease inhibitors in Bombyx mori silk might participate in protecting the pupating larva from microbial infection

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Insect Science 2016年第6期23卷 835-842页

作者： you-Shan Li Hua-Wei liu Rui Zhu Qing-you Xia ping Zhao State Key Laboratory of Silkworm Genome Biology Southwest University Chongqing Vitamin D Research Institute Shaanxi University of Technology Hanzhong Shaanxi Province School of Management Shaanxi University of Technology Hanzhong Shaanxi Province China

Pupae inside cocoons rarely suffer from disease. It is apparent that some factors in the cocoon exert antimicrobial effects whereby the pupae inside can be protected from microbial infection. In the present study, we investigated the expression of cocoon protease inhibitors using immunoblotting and activity staining. Enzymatic hydrolysis of cocoon proteins in vitro was performed to characterize their roles in protecting the cocoon from microbial proteases. We found that some protease inhibitors, particularly trypsin inhibitor-like （TIL）-type protease inhibitors, can be secreted into the cocoon layer during the spinning process, thereby providing effective protection to the cocoon and pupa by inhibiting the extracellular proteases that can be secreted by pathogens.

关键词： Bombyx mori cocoon enzymatic hydrolysis microbial proteases protease inhibitors pupating larva

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结肠癌并存急性阑尾炎72例临床分析

中华结直肠疾病电子杂志 2014年第6期3卷 487-488页

作者：张好刚李胜龙游柳平刘城杨维良哈尔滨医科大学附属第二医院普外科 150086

结肠癌并存急性阑尾炎并非罕见,在80年代国内外已有文献报道[1-3];近10年国内的相关报道逐渐增多[4-6]。我院自1985年至2010年共收治72例,现总结报道如下。临床资料男性患者53例,女性19例。年龄24~57岁,平均42岁,45岁以上28例,占6.1%。... 详细信息

结肠癌并存急性阑尾炎并非罕见,在80年代国内外已有文献报道[1-3];近10年国内的相关报道逐渐增多[4-6]。我院自1985年至2010年共收治72例,现总结报道如下。临床资料男性患者53例,女性19例。年龄24~57岁,平均42岁,45岁以上28例,占6.1%。患急性阑尾炎切除阑尾中发现回盲部或升结肠癌37例;急性阑尾炎施行阑尾切除术后,又因腹痛(35/72)、贫血(40/72)、体重减轻(33/72)、腹部肿块(31/72)、粘连性肠梗阻(3/72),再次收入院42例。

关键词：结直肠肿瘤误诊阑尾炎

On the power-law distributions of X-ray fluxes from solar flares observed with GOES

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Research in Astronomy and Astrophysics 2016年第10期16卷 99-106页

作者： you-ping Li Li Feng ping Zhang Si-Ming liu Wei-Qun Gan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences

The power-law frequency distributions of the peak flux of solar flare X-ray emission have been studied extensively and attributed to a system having self-organized criticality （SOC）. In this paper, we first show that, so long as the shape of the normalized light curve is not correlated with the peak flux, the flux histogram of solar flares also follows a power-law distribution with the same spectral index as the power- law frequency distribution of the peak flux, which may partially explain why power-law distributions are ubiquitous in the Universe. We then show that the spectral indexes of the histograms of soft X-ray fluxes observed by GOES satellites in two different energy channels are different： the higher energy channel has a harder distribution than the lower energy channel, which challenges the universal power-law distribution predicted by SOC models and implies a very soft distribution of thermal energy content of plasmas probed by the GOES satellites. The temperature （T） distribution, on the other hand, approaches a power-law dis- tribution with an index of 2 for high values of T. Hence the application of SOC models to the statistical properties of solar flares needs to be revisited.

关键词： Sun: flares -- Sun: X-rays Gamma rays -- methods: statistical

Three novel opportunistic scheduling algorithms in CoMP-CSB scenario

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Science China(Information Sciences) 2013年第8期56卷 250-261页

作者： WANG Hao liu Nan WU ping PAN ZhiWen you XiaoHu National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast University Signal and System at Department of Engineering Sciences Uppsala University

Coordinated scheduling/beamforming(CSB),which belongs to the coordinated multi-point(CoMP) transmission,has received lots of attention recently due to its great potential to mitigate inter-cell interference(ICI) and to increase the cell-edge throughput,and meanwhile it only requires limited base station cooperation and is easy to ***,to the best of our knowledge,there are no effective scheduling algorithms with low complexity and overhead in CoMP-CSB scenario as ***,in this paper,we propose three novel opportunistic scheduling algorithms in CoMP-CSB *** of them jointly consider the intended channel condition of the scheduled user from its serving cell and the orthogonality between the intended channel and the corresponding interference channels to concurrently scheduled users in nearby cells,thus exploiting multi-user diversity(MUD) and mitigating ICI at the same *** 1 cooperatively chooses the most orthogonal user pair within a candidate user set in which all users have a large local channel feedback,while Algorithm 2 concurrently schedules the user pair with the largest ratio between the local channel feedbacks and the aforementioned orthogonality within the same candidate user *** 3 performs in the way similar to the proportional fairness scheduling,while making a proper modification for its usage in CoMP-CSB *** performance of the proposed scheduling algorithms are evaluated through *** show that,they all can significantly enhance the received signal to interference plus noise ratio(SINR) with relatively good fairness guarantee,thus achieving larger throughputs and utilities than several well-known scheduling *** 2 even outperforms Algorithm 1 when the aforementioned candidate user set is big enough in size and has a bit more overhead/***,Algorithms 3 is the best one among all the three proposed algorithms,but it requires more overhead/complexity than Alg

关键词： coordinated multi-point(CoMP) coordinated scheduling/beamforming(CSB) inter-cell interference(ICI) multi-user diversity(MUD) opportunistic scheduling.

LAPTM4β在人结直肠癌耐药细胞株中的表达及意义

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中华结直肠疾病电子杂志 2015年第5期4卷 50-54页

作者：刘家麒宁丽李云龙游柳平王春敬黄跃南哈尔滨医科大学附属第二医院普外科 150081 哈尔滨医科大学附属第二医院妇产科 150081 哈尔滨医科大学附属第二医院重症监护病房 150081

目的建立耐奥沙利铂(L-OHP)的人结直肠癌耐药细胞株(HT-29/L-OHP),检测相关耐药基因LAPTM4β的表达,探讨其在L-OHP耐药中的作用机制。方法采用药物浓度梯度递增间歇诱导法建立人结直肠癌耐药株HT-29/L-OHP;应用LAPTM4β-35蛋白抑制剂作... 详细信息

目的建立耐奥沙利铂(L-OHP)的人结直肠癌耐药细胞株(HT-29/L-OHP),检测相关耐药基因LAPTM4β的表达,探讨其在L-OHP耐药中的作用机制。方法采用药物浓度梯度递增间歇诱导法建立人结直肠癌耐药株HT-29/L-OHP;应用LAPTM4β-35蛋白抑制剂作用于HT-29/L-OHP细胞株后,流式细胞技术检测细胞凋亡,比较其与HT-29/L-OHP细胞株对于L-OHP的耐药情况;应用RT-PCR检测LAPTM4βmRNA的表达;应用Western blot测定LAPTM4β-35蛋白的表达。结果成功建立人结直肠癌耐药细胞株HT-29/L-OHP,流式细胞技术检测结果表明应用LAPTM4β-35蛋白抑制剂作用于HT-29/L-OHP细胞株后,其对于L-OHP的耐药明显低于HT-29/L-OHP细胞株。HT-29/LOHP细胞株中LAPTM4βmRNA表达水平明显高于亲本细胞株HT-29,分别为5.613±0.139和1.105±0.187,(P<0.05),LAPTM4β-35蛋白在HT-29/L-OHP细胞和HT-29细胞的相对表达量2.203±0.080和1.033±0.070,(P<0.05)。结论 LAPTM4β在结直肠癌耐药细胞株中过表达,与结直肠癌奥沙利铂耐药密切相关,可以作为结直肠癌耐药的一个敏感的生物学标志物。

关键词：结直肠肿瘤抗药性,肿瘤奥沙利铂 LAPTM4β

Effects of Al component content on optoelectronic properties of Al_xGa_(1-x)N

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Chinese Physics B 2018年第10期27卷 495-500页

作者： Yan-Jun Ji Jun-ping Wang you-Wen liu College of Science Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Aeronautical Engineering Bingzhou UniversityBingzhou 256603China

Using density functional theory, the electronic structures, lattice constants, formation energies, and optical properties of AlxGa1-xN are determined with Al component content x in a range from 0 to 1. As x increases, the lattice constants decrease in e-exponential form, and the band gap increases with a band bending parameter b=0.3954. The N–Al interaction force in the（0001） direction is greater than the N–Ga interaction force, while the N–Al interaction force is less than the N–Ga interaction force in the（10ī0） direction. The formation energies under different Al component content are negative and increase with Al component content increasing. The static dielectric function decreases, the absorption edge has a blue shift, and the energy loss spectrum moves to high energy with the Al component content increasing.

关键词： GaN photocathode electronic structure optical properties

Expression of Nitrilases in Brassica juncea var. tumida Tsen in Root Galls Caused by Plasmodiophora brassicae

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Journal of Integrative Agriculture 2012年第1期11卷 100-108页

作者： liu Yan YIN you-ping WANG Zhong-kang LUO Yuan-li Bioengineering College Chongqing University Chongqing 400030 P.R. China Fuling Agricultural Science Institute of Chongqing Chongqing 400030 P.R. China

Five commonly-used reference genes： ACT （actin）, UBE （ubiquitin-conjugating enzyme）, RPL2 （ribosomal protein L2）, BRP II （RNA polymerase II subunit）, and NADH （nicotinamide adenine dinucleotide） were examined using geNorm software as reference genes for RT-qPCR. Among the tested reference genes, ACT and UBE were the most stable in all samples. In parallel, expression analysis of nitrilases in Brassica juncea var. tumida, was performed to preliminarily investigate the molecular interactions between nitrilase and clubroot development at 10, 15, 20, 25, 30, and 40 d postinoculation （dpi） with a suspension of resting spores of Plasmodiophora brassicae. The results showed that different gene expressions of nitrilases were regulated during the initial periods of clubroot development. The expression level of BjNIT1 increased sharply from 20 to 40 dpi in infected roots while there were no remarkable changes in healthy roots. From 15 to 30 dpi, the expression levels of BjNIT2 and BjNIT4 in infected roots were lower than those in non-infected roots. Finally, BjNIT2 in treatment was down approximately to control at 40 dpi. Our results suggest that BjNIT1, which promoted overproductions of auxin, might be involved in P. brassicae infection of B. juncea.

关键词： Brassica juncea var. tumida Tsen reference gene Plasmodiophora brassicae clubroot

Effects of submicron diamonds on the growth of copper in Cu-diamond co-deposition

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International Journal of Minerals,Metallurgy and Materials 2012年第1期19卷 72-76页

作者： you-yang Wei Wei-ping Li Hui-cong liu Yong-zheng liu Li-qun Zhu The key Laboratory of the Ministry of Education of China for Aerospace Materials and Performance Beijing 100191 China School of Materials Science and Engineering Beihang University Beijing 100191 China Beijing Institute of Aeronautical Materials Science and Technology on Advanced Composites Laboratory Beijing 100095 China

Submicron diamonds were co-deposited on aluminum substrates with copper from the acid copper sulfate electrolyte by electro- lyte-suspension co-deposition. After submicron diamonds were added to the electrolyte, the shape of copper grains transformed from oval or round to polyhedron, the growth mode of copper grains transformed from columnar growth to gradual change in size, and the preferred ori- entation of copper grains transformed from （220） to （200）. Analyzing the variation of cathodic overpotential, it was found that the cathodic overpotential tended to remain tmchanged when copper plane （220） grew in the process of electrodepositing pure copper, while it tended to decrease with time when copper plane （200） grew in the process of co-deposition. It was inferred that copper plane （200） was propitious to the deposition of submicron diamonds.

关键词： composite coatings copper diamond co-deposition gradient materials grain growth

Electrical Conduction of Some Fe3S3 Ring Compounds

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有机化学 2003年第Z1期23卷 72-73页

作者： WANG Jian liu ping you Gang Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002

　　M3S3 cluster six-membered ring compounds are very interesting compounds liking aromatic benzene, and Cu, Pd, B and so on can also form M3S3 cluster besides Fe. [1,2] In recent years electrical conduction of some metal com plexes has been studied. [3,4] The study of electrical conduction through DNA molecules has illustrated that DNA is a semiconductor, but its principle of electrical conduction has not been revealed. [5,6] Electrical conduction of artificial synthesized Fe-S cluster compounds has not been reported. We hope to infer the function on electrical conduction of metal active centers of iron-sulfur proteins through study of electrical conduction of Fe3S3 ring compounds, paving the way for the discovery of new advanced biological functional materials.……

关键词： electrical conduction functional materials DNA molecules