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6-O-(Hydroxypropyltrimethylammonia)-β-cyclodextrin with Low Degree of Substitution: Convenient Preparation and its Application as a Chiral Selector in Capillary Electrophoresis

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Chinese Chemical Letters 2006年第3期17卷 407-410页

作者： Ming Gang ZHAO Ai you HAO jian li Xiu li liN School of Chemistry and Chemical Engineering Shandong University Jinan 250100

A cationic cyclodextrin derivative 6-O-（hydroxypropyltrimethylammonia）-β-cyclodextrin （GTA-β-CD） with low degree of substitution was prepared through a convenient method in solid phase. The product could be used as a valuable chiral selector in the capillary electrophoresis （CE） separation of some acidic drug enantiomers such as naproxen, ofloxacin, ibuprofen and warfarin.

关键词： 6-O-(Hydroxypropyltrimethylammonia)-β-cyclodextrin capillary electrophoresis chiral selector.

Inhibition of Cyclin F Promotes Cellular Senescence through Cyclin-dependent Kinase 1-mediated Cell Cycle Regulation

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Current Medical Science 2023年第2期43卷 246-254页

作者： Xun li you-jian li Meng-jie WANG Ke-peng OU Ya-qi CHEN GI Cancer Research Institute Tongji HospitalHuazhong University of Science and TechnologyWuhan430030China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing402160China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China College of Pharmaceutical Sciences and Chinese Medicine Southwest UniversityChongqing400715China

Objective Kidney renal clear cell carcinoma(KIRC)is a common renal malignancy that has a poor *** a member of the F box family,cyclin F(CCNF)plays an important regulatory role in normal tissues and ***,the underlying mechanism by which CCNF promotes KIRC proliferation still remains *** Bioinformatics methods were used to analyze The Cancer Genome Atlas(TCGA)database to obtain gene expression and clinical prognosis *** CCK8 assay,EdU assay,and xenograft assay were used to detect cell *** cell senescence and potential mechanism were assessed by SA-β-gal staining,Western blotting,as well as *** Our data showed that CCNF was highly expressed in KIRC ***,downregulation of CCNF inhibited cell proliferation in vivo and in *** studies showed that the reduction of CCNF promoted cell senescence by decreasing cyclin-dependent kinase 1(CDK1),increasing the proinflammatory factors interleukin(IL)-6 and IL-8,and then enhancing the expression of p21 and *** We propose that the high expression of CCNF in KIRC may play a key role in tumorigenesis by regulating cell ***,CCNF shows promise as a new biomarker to predict the clinical prognosis of KIRC patients and as an effective therapeutic target.

关键词： cyclin F kidney renal clear cell carcinoma clinical outcome cyclin-dependent kinase 1 senescence

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小儿重型颅脑损伤早期肠内营养支持临床效果

中国城乡企业卫生 2024年第5期39卷 46-49页

作者：李友健冯裕修陈智国广宁县人民医院脑科广东肇庆526300

目的探究观察小儿重型颅脑损伤早期肠内营养支持临床效果,为改善小儿重型颅脑损伤的营养状态提供帮助。方法抽取2018年1月—2020年12月广宁县人民医院收治的50例小儿重型颅脑损伤患儿为研究对象,采用计算机随机分组原则,将患儿分为对照... 详细信息

目的探究观察小儿重型颅脑损伤早期肠内营养支持临床效果,为改善小儿重型颅脑损伤的营养状态提供帮助。方法抽取2018年1月—2020年12月广宁县人民医院收治的50例小儿重型颅脑损伤患儿为研究对象,采用计算机随机分组原则,将患儿分为对照组和观察组各25例。对照组采用传统营养支持,观察组采用早期肠内营养支持。比较两组患儿的血清白蛋白(ALB)、血红蛋白(Hb)、血清总蛋白(TP)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平及并发症发生率。结果干预前,两组营养、免疫功能指标比较差异无统计学意义(P>0.05);干预4周后,两组营养、免疫功能指标明显改善,且观察组ALB、Hb、TP、IgA、IgM及IgG水平明显高于对照组,差异均有统计学意义(P<0.05)。观察组并发症发生率为8.00%,低于对照组的32.00%,差异有统计学意义(χ^(2)=4.500,P<0.05)。结论小儿重型颅脑损伤患儿应用早期肠内营养支持,可有效改善营养状态、免疫功能,还可减少并发症发生率,值得临床推广应用。

关键词：小儿重型颅脑损伤传统营养支持早期肠内营养支持营养状态免疫功能

Neoantigen cancer vaccines:a new star on the horizon

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Cancer Biology & Medicine 2024年第4期21卷 274-311页

作者： Xiaoling li jian you liping Hong Weijiang liu Peng Guo Xishan Hao Cell Biotechnology Laboratory Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical Research Center for Cancer Tianjin 300060China Haihe Laboratory of Synthetic Biology Tianjin 300090China Department of Thoracic Oncology Tianjin Cancer Hospital Airport HospitalTianjin 300308China Department of Thoracic Oncology Surgery Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China

Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer *** of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal *** neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint *** made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of ***,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents *** review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.

关键词： Immunotherapy neoantigen cancer vaccine solid tumors high-throughput sequencing bioinformatics PDOs AI HLA TCR

Exploring the Cation Regulation Mechanism for Interfacial Water Involved in the Hydrogen Evolution Reaction by In Situ Raman Spectroscopy

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Nano-Micro Letters 2024年第3期16卷 303-312页

作者： Xueqiu you Dongao Zhang Xia‑Guang Zhang Xiangyu li Jing‑Hua Tian Yao‑Hui Wang jian‑Feng li School of Ocean Information Engineering Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent ProcessingJimei UniversityXiamen 361021People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005People’s Republic of China Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsCollege of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007People’s Republic of China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005People’s Republic of China

Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER ***,investigating interfacial water is extremely challenging owing to the interference caused by bulk water molecules and complexity of the interfacial ***,the behaviors of interfacial water in different cationic electrolytes on Pd surfaces were investigated by the electrochemistry,in situ core-shell nanostructure enhanced Raman spectroscopy and theoretical simulation *** spectral evidence reveals a red shift in the frequency and a decrease in the intensity of interfacial water as the potential is shifted in the positively *** comparing the different cation electrolyte systems at a given potential,the frequency of the interfacial water peak increases in the specified order:li+

关键词： In situ Raman Interfacial water Hydrogen evolution reaction Cations

Optimizing 2D-metal contact in layered Tin-selenide via native oxide modulation

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Nano Research 2024年第4期17卷 3014-3020页

作者： Yue Zheng Qi you Zhentian Yin jian Tang Ke jiang Zihao Xie Henan li Cheng Han Yumeng Shi International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China

The discovery of two-dimensional(2D)semiconductor has opened up new avenues for the development of short-channel field-effect transistors(FETs)with desired electrical *** them,orthorhombic tin-selenide(SnSe)has garnered increasing attention due to its potential applications in a variety of electronic,optoelectronic,and thermoelectric ***,the realization of high-performance SnSe FETs with low contact resistance(Rc)remains a ***,we systematically investigate the contact of few-layer SnSe FETs through the modulation of native oxide on SnSe by using different *** is found that chromium(Cr)-contacted devices possess the best FET performance,such as electron mobility up to 606 cm^(2)/(V·s)at 78 K,current on/off ratio exceeding 1010,and saturation current of~550μA/μm,where a negligible Schottky barrier(SB)of~30 meV and a low contact resistance of~425Ωμm are achieved.X-ray photoelectron spectroscopy(XPS)and cross-sectional electron dispersive X-ray spectroscopy(EDX)results further reveal that the improved contact arises from the Cr-induced reduction of native oxide(SnOx)to Sn,which thins the tunneling barrier for efficient electron *** findings provide a deep insight into the 2D-metal contact of SnSe and pave the way for its applications in future nanoelectronics.

关键词： few-layer SnSe field-effect transistors(FETs) Cr contact native oxide contact resistance(Rc) Schottky barrier(SB)

Development in oxide metallurgy for improving the weldability of high -strength low-alloy steel-Combined deoxidizers and microalloying elements

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1263-1284页

作者： Tingting li jian Yang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during *** chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact *** work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input *** complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF ***,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually *** alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF ***,Cr,or Al addition leads to the formation of undesirable *** reduces the high-temperature stability of the ***,V,and B can enhance HAZ ***-containing precipitates present good thermal *** or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with *** formation of the B-depleted zone around the inclusion promotes IAF *** interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be *** the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of

关键词： oxide metallurgy technology heat affected zone high-strength low-alloy steel intragranular acicular ferrite microalloying element

Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

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Acta Geochimica 2024年第3期43卷 441-458页

作者： Qing-Qing Zhang you-Wei Chen jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(lization *** contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China

Value of CA19-9, CA125 and CEA combined magnetic resonance imaging in the diagnosis of pancreatic cancer

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Journal of Hainan Medical University 2018年第2期24卷 133-136页

作者： Ying Huang you-li jian Hong Chen Chengdu City PI Du District People's Hospital Chengdu PI 611730China

Objective:To study the value of CA19-9, CA125 and CEA combined magnetic resonance imaging (MRI) in the diagnosis of pancreatic cancer, and to provide a reference for clinical diagnosis and ***:A total of 110 cases of pancreatic cancer admitted to our hospital from November 2015 to November 2017 were selected as the observation group, and another 80 normal pancreas organizers who participated in the physical examination in the same period were selected as the control group. The change of magnetic resonance scanning parameters and serum CA19-9, CA125 and CEA detection were compared between the two groups of subjects at the same time, contrast scan and serum magnetic resonance detection of CA19-9, CA125 and CEA positive rate, and to evaluate the four alone and in combination with the diagnosis of pancreatic cancer specificity, sensitivity, negative predictive value and positive predictive ***:The T1WI of the observation group was low or slightly low signal, T2WI was slightly high signal, and the tumor of fat suppression sequence was low signal, which was in line with the typical characteristics of pancreatic cancer. The serum levels of CA19-9, CA125 and CEA in the observation group were significantly higher than those in the control group, and the difference was statistically significant. Compared with the two groups, the positive rates of MRI and serum CA19-9, CA125 and CEA in the observation group were higher than those in the control group, and the difference was statistically significant. The sensitivity and accuracy of MRI scan combined with three serological markers were higher than those of single detection. The specificity was between ***: CA19-9, CA125 and CEA combined magnetic resonance imaging (MRI) have good sensitivity and accuracy in diagnosis of pancreatic cancer, but their specificity is common, which should be used for reference.

关键词： CA19-9 CA125 CEA Magnetic resonance imaging Pancreatic cancer