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Frontiers of Medicine 2019年第1期13卷 12-23页

作者： Chenfei zhou jun Zhang Department of Oncology'. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.

关键词： gastrointestinal cancer immune checkpoint inhibitor combi nation therapy

Calculation of double-β decay half-lives using an improved Primakoff-Rosen formula

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Chinese Physics C 2021年第8期45卷 83-89页

作者： Qi-jun Zhi Xiao-Ping Zhang Ji-Lin you Qiang Zheng Zhong-zhou Ren School of Physics and Electronic Sciences Guizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyangChina State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China School of Science Tianjin University of TechnologyTianjin 300384China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

A systematic analysis on experimental data of the half-lives of nuclear double-β decays with two neutrinos(2vββ)is performed based on the analytical formula proposed by Primakoff and *** improve the formula by considering the shell effects and refining the energy dependence of the phase-space *** improved formula can closely describe all available experimental half-lives of 2vβ^(-)β^(-)decays,both for ground-state transitions and transitions from ground states of parent nuclei to the first 0+excited states of daughter *** calculated half-lives agree with the experimental data of ground-state transitions of all known eleven nuclei with an aver-age factor of *** predictions are provided for 2vββ-decay candidates with decay energies above 0.5 *** compare different theoretical predictions and emphasize the importance of experimental measurements on the half-lives of double-β transitions between the ground state of 48Ca,76 Ge,and 136Xe and the first 0+excited states of their corresponding daughter nuclei,which will be very useful for understanding the underlying mechanisms of double-β decays and for further studying the shell effects on nuclear transition matrix elements.

关键词： double-βdecay half-lives Primakoff-Rosen formula phase-space factor

Lower degree curves in X3,3? P2× P2

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Science China Mathematics 2019年第11期62卷 2309-2316页

作者： jun Li Yang zhou Shanghai Center for Mathematical Sciences Fudan UniversityShanghai 200433China Center of Mathematical Sciences and Applications Harvard UniversityCambridgeMA 02138USA

In this paper we study low-degree low-genus curves in a generic hypersurface X of degree(3, 3) in P^2× P^2. We prove that the genus 0 and genus 1 curves of degree up to(2, 2) are smooth and rigid. We then use the multiple cover formula to compute the Gromov-Witten invariants of X of degree up to(2, 2) and genus up to 2. This provides some initial conditions to determine the full genus 1 and genus 2 Gromov-Witten invariants via Bershadsky-Cecotti-Ooguri-Vafa’s Feynman rule, which is expected to be proved in the near future.

关键词： Gromov-Witten invariants Calabi-Yau threefolds multiple cover formula

An improved social force model (ISFM)-based crowd evacuation simulation method in virtual reality with a subway fire as a case study

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International Journal of Digital Earth 2023年第1期16卷 1186-1204页

作者： Jinbin Zhang jun Zhu Pei Dang Jianlin Wu Yuxuan zhou Weilian Li Lin Fu Yukun Guo Jigang you Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduPeople’s Republic of China Institute of Geodesy and Geoinformation University of BonnBonnGermany School of Engineering and Geomatics Southwest Petroleum UniversityChengduPeople’s Republic of China

Crowd evacuation simulation using virtual reality(VR)is significant for digital emergency response ***,existing evacuation simulation studies suffer from poor adaptation to complex environments,inefficient evacuations,and poor simulation effects and do not fully consider the impacts of specific disaster environments on crowd *** more realistically express the crowd evacuation results obtained under the influence offire environments and the subjective consciousness of pedestrians in subway stations,we designed a dynamic pedestrian evacuation path planning method under multiple constraints,analysed the influences of an‘environmental role’and a‘subjective initiative’on crowd evacuation,established an improved social force model(ISFM)-based crowd evacuation simulation method in VR,developed a prototype system and conducted experimental *** experimental results show that the crowd evacuation time of the ISFM is affected by the disaster *** simulation experiments without disaster scenarios,the improved model’s crowd evacuation efficiency improved by averages of 12.53%and 15.37%over the commercial Pathfinder software and the original social force model,*** method described herein can effectively support real-time VR crowd evacuation simulation under multiexit and multifloor conditions and can provide technical support for emergency evacuation learning and management decision analyses involving subwayfires.

关键词： Subway stationfire improved social force model crowd evacuation simulation virtual reality path planning

The progress in the verification of key technologies for floating structures near islands and reefs

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Journal of Hydrodynamics 2021年第1期33卷 1-12页

作者： you-sheng Wu jun Ding Xue-kang Gu Chun-yan Ji Xiong-bo Zheng Guo-ping zhou Dao-lin Xu Li Ma China Ship Scientific Research Center Wuxi 214082China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China Shanghai Merchant Ship Design and Research Institute Shanghai 201203China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266000China

In 2019 a Scientific Research&Demonstration Platform was deployed near islands and reefs in South China Sea by a joint research group of 7 institutes and universities in *** is a simplified small model of a two-module semi-submersible-type *** test on site has continued for more than one and half years since then for long-term observations to validate the developed key technologies for design and behavior predictions of floating structures deployed near islands and *** integrated information system was set up to continuously collect and inspect the data of the encountered waves,structure responses,connector forces,mooring line forces,anti-corrosion status of the platform,the performance efficiencies of a floating breakwater nearby and a wave energy converter attached on the *** this paper,the status of the on-site measurements and validations of the key technologies are briefly described.

关键词： near islands and reefs inhomogeneous wave environment multi-module floating structures VLFS floating breakwater wave responses hydroelastic analysis predictions on-site measurements validation verification

Natural Variation of Leaf Thickness and Its Association to Yield Traits in indica Rice

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Journal of Integrative Agriculture 2014年第2期13卷 316-325页

作者： LIU Chuan-guang zhou Xin-qiao CHEN Da-gang LI Li-jun LI Ju-chang CHEN you-ding Rice Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of New Technology in Rice Breeding

Leaf thickness is an important morphological trait in rice. Its association to the yield potential, as of now has not been documented because of the shortage of the equipment which could conveniently measure the leaf thickness in rice. In this study, the thickness of top three leaves of 208 cultivars had been determined by a nondestructive rice leaf thickness instrument for the research of the natural variation of leaves thickness and its association to yield traits in indica rice. The results showed that the flag leaf was the thickest, and the 2nd leaf was thicker than the 3rd leaf. Analysis of variance indicated the existence of wide genetic diversity of leaf thickness among the investigated indica rice genotypes. The tight correlation among the thicknesses of the top three leaves means that the leaf thickness traits share one genetic control system. Leaf thickness had a significant positive correlation with leaf length and a positive correlation with leaf width, indicated that thicker leaf was beneficial to increasing the single leaf area. The results of correlation analysis revealed that thicker leaf should be profitable to the leaf erection, higher numbers of grains per panicle and higher grains weight per panicle. However, the significantly negative correlation between leaf thickness and number of panicles per plant counteracted the profitability from increased grains weight per panicle, so that the correlations of the thicknesses of the top three leaves to yield and biomass were positive but not significantly. It has made great progress in the genetic improvement of leaves thickness in inbred indica rice breeding in Guangdong Province, China, since the 1990s.

关键词： indica rice leaf thickness variation yield

Design and development of an ACCT for the Shanghai advanced proton therapy facility

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Nuclear Science and Techniques 2022年第10期33卷 41-52页

作者： Hong Zhang jun-zhou Li Rui Hou Sun An Shi-Quan Xu you-Chun Liu Peng-Jiao Zhang Jie Song Yue-Lin Zhang College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China

The Shanghai advanced proton therapy facility is a proton cancer treatment device designed and built by the Shanghai Institute of applied physics at the Chinese academy of *** accelerator part comprises a proton linear accelerator(linac)injector and a circular *** alternating current current transformer(ACCT)is used for non-intercepting beam current measurement at the drift tube linac *** to the beam characteristics,the ACCT is required to complete real-time beam current and pulse width measurements at currents of3-30 mA,frequencies of 1-10 Hz,and pulse widths of40-400μ*** this paper,we report the design and development of an *** designed ACCT was simulated using CST Microwave Studio,and calibrated using an oscilloscope and signal *** in the output signal of the ACCT were investigated as a function of ceramic gap size,number of coil turns,and *** to the simulation and experimental results,the optimal number of coil turns was found to be *** addition,a low-pass filter was adopted to filter the noise introduced during long-distance signal transmission using a coaxial cable with the length of 20 *** calibration results show that the corresponding rise time of the ACCT is 800 ns with the sensitivity of 8.2 V/A and a droop of less than 1%,meeting the design requirements.

关键词： Beam current monitors ACCT Particle beam diagnostics

Role of the Λ(1600) in the K^-p→Λπ^0π^0 reaction

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Communications in Theoretical Physics 2020年第4期72卷 64-70页

作者： He zhou Ju-jun Xie Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBejing 101408China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China

Role of theΛ(1600)is studied in the K^-p→Λπ^0π^0 reaction by using the effective Lagrangian approach near the *** perform a calculation for the total and differential cross sections by considering the contributions from theΛ(1600)andΛ(1670)intermediate resonances decaying intoπ^0∑^*0(1385)with∑^*0(1385)decaying intoπ^0Λ.Additionally,the non-resonance process from u-channel nucleon pole is also taken into *** our model parameters,the current experimental data on the total cross sections of the K^-p→Λπ^0π^0 reaction can be well *** is shown that we really need the contribution from the A(1600)with spin-parity J^P=1/2^+,and that these measurements can be used to determine some of the properties of theΛ(1600)***,we also plot theπ0Λinvariant mass distributions which could be tested by the future experimental measurements.

关键词： KN scattering effective Lagrangian approach hyperon resonance

一株同步硝化反硝化菌株的筛选及其生物电化学脱氮性能研究

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南京农业大学学报 2025年第1期48卷 133-143页

作者：田瑞瑞付欢郑云黄新琦周俊雍晓雨南京工业大学生物与制药工程学院江苏南京211816 南京师范大学地理科学学院江苏南京210023

[目的]本文旨在获得具有高效脱氮性能的异养硝化-好氧反硝化(heterotrophic nitrification-aerobic denitrification,HN-AD)功能菌株,构建生物电化学-同步硝化反硝化(bio-electrochemical systems-simultaneous nitrification and denitrification,BES-SND)耦合系统,实现脱氮效率的提升。[方法]从活性污泥中筛选HN-AD菌株,鉴定后通过摇瓶试验分析其脱氮性能。然后进一步研究碳源、C/N、溶解氧等外界因素对菌株同步硝化反硝化性能的影响。将菌株接种到微生物燃料电池(microbial fuel cells,MFC)的生物阴极,分析低C/N条件下BES-SND体系的脱氮性能。[结果]从活性污泥中筛选出一株具有同步硝化反硝化性能的HN-AD菌株,命名为Alcaligenes aquatilis N3。确定该菌株发生SND反应的最适碳源为乙酸钠、C/N值为20、溶解氧为3.70 mg·L^(-1)。在BES-SND脱氮体系中,C/N值分别为2、4、6、8时,菌株*** N3的总氮去除率分别为20.51%、26.67%、37.76%和48.50%。在C/N=2的试验条件下,BES-SND系统的总氮去除速率在第5天仍为1.79 mg·L^(-1)·d^(-1)。[结论]在低碳环境下,*** N3菌株依然可以在BES-SND耦合脱氮体系中实现脱氮,降低了脱氮过程对碳源的依赖性,具有一定的实际环境应用潜力。

关键词：同步硝化反硝化异养硝化-好氧反硝化生物电化学低C/N值微生物燃料电池

A direct coupling analysis method of hydroelastic responses of VLFS in complicated ocean geographical environment

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Journal of Hydrodynamics 2019年第3期31卷 582-593页

作者： jun Ding you-sheng Wu Ye zhou Zhi-wei Li Chao Tian Xue-feng Wang Zheng-wei Zhang Xiao-long Liu China Ship Scientific Research Center Wuxi 214082 China School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China

In this paper a direct coupling analysis method (DCAM) of hydroelastic responses of a very large floating structures (VLFS) in complicated geographical environment is presented. In this method the three-dimensional hydroelasticity theory of floating bodies is combined with the shallow water wave theory, to allow for proper description of the influence of uneven seabed and sheltering effect of islands on the hydroelastic responses of a VLFS deployed near island and reefs in shallow sea. This method and the numerical procedures were verified and validated by comparison-between the predictions and the model test results of a 3-module VLFS and an 8-module VLFS in two simulated shallow sea regions with different seabed topography.

关键词： Direct coupling analysis method very large floating structure (VLFS) hydroeiasticity complicated environment