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苯基次甲基苦参碱类化合物的合成及其表征

广西大学学报（自然科学版） 2010年第3期35卷 470-472页

作者：王立升尤叶君刘布鸣林霄陈明生广西大学化学化工学院广西南宁530004 广西中医药研究院化学研究所广西南宁530022

设计以苦参碱为原料、对其酰胺键的α位引入苯基次亚甲基。在四氢呋喃中,通过氢化钠作用与芳醛类化合物反应得到四个未见文献报道的苦参碱衍生物,并通过IR、1HNMR、MS对所合成的化合物进行结构表征。

关键词：苦参碱衍生物合成

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang jun-Zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan ye Xuemei Wang jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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碳排放权交易政策对中国城市绿色创新的影响及其异质性分析

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经济问题 2025年第1期 27-36页

作者：马军杰杨晨王晔同济大学法学院上海200092 厦门大学经济学院福建厦门361005

作为应对全球气候变化的重要杠杆,碳排放权交易政策不仅有力推动了减排目标的达成与低碳经济的蓬勃发展,而且在引领城市迈向绿色创新之路上发挥着关键作用。基于2006—2021年城市层面绿色专利数据构建双重差分模型,实证检验碳排放权交... 详细信息

作为应对全球气候变化的重要杠杆,碳排放权交易政策不仅有力推动了减排目标的达成与低碳经济的蓬勃发展,而且在引领城市迈向绿色创新之路上发挥着关键作用。基于2006—2021年城市层面绿色专利数据构建双重差分模型,实证检验碳排放权交易政策对城市绿色创新的激励作用以及区域异质性、政策机制异质性在其中的影响。研究结果显示,碳排放权交易政策对城市绿色创新有显著的促进作用,特别是在策略性创新领域。碳排放权交易政策在东部地区的实施效果优于中、西部地区,在非资源型城市的实施效果优于资源型城市,其中在Ⅱ型大城市效果最强。此外,政策机制设计也会对其实施效果产生重要影响,研究表明,有偿配发和高交易价格更能激励绿色创新。因此,为推动城市绿色创新和经济可持续发展,应加强绿色创新审查与补贴,优化碳排放交易政策,制定试点城市差异化策略,推行有偿配发模式,并建立健全严格的监管体系,加强碳排放权交易市场的透明度和信息披露。

关键词：碳排放权交易政策绿色创新双重差分模型区域异质性

Superlyophilic Interfaces Assisted Thermal Management

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Chemical Research in Chinese Universities 2022年第3期38卷 643-652页

作者： LUO Xianfeng ZHU Zhongpeng you jun TIAN ye JIANG Lei Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province College of Materials Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin150080P.R.China Key Laboratory of Bio-inspired Smart Interfacial Science and Technology Ministry of EducationSchool of ChemistryBeihang UniversityBeijing100191P.R.China Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190P.R.China School of Future Technology University of Chinese Academy of SciencesBeijing101407P.R.China

Thermal management has become a critical issue owing to the increasing need for various devices including heat dissipation and ***,the rapid growth of scientific reports is seen to improve thermal management efficiency by developing materials with high transfer coefficient and surface improvement to enhance heat transfer *** by nature,constructing superlyophilic interfaces has been proved to be an effective way for thermal management and applied in industry and daily ***,state-of-the-art developments of superlyophilic interfaces assisted thermal management are reported mainly from four perspectives around boiling,evaporation,radiation,and *** particular,we discussed the unique role of superlyophilic interfaces during the heat transfer process,such as increasing bubble detachment rate,superspreading assisted efficient evaporation,directional liquid transfer in textiles during radiative cooling,and so ***,challenges of thermal management assisted by superlyophilic interfaces toward future applications are presented.

关键词： Superhydrophilic Boiling heat transfer Evaporation Radiative cooling Condensation

Evaluation of ambient air quality in Guangzhou, China

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Journal of Environmental Sciences 2007年第4期19卷 432-437页

作者： ZHOU Kai ye you-hua LIU Qiang LIU Ai-jun PENG Shao-lin South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China. Graduate School of the Chinese Academy of Sciences Beijing 100039 China School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Department of Biology Hainan Normal University Haikou 571158 China Climatic and Agrometeorological Center of Guangdong Province Guangzhou 510080 China

On the basis of the reported air quality index （API） and air pollutant monitoring data provided by the Guangzhou Environment Monitoring Stations over the last twenty-five years, the characteristics of air quality, prominent pollutants, and variation of the average annual concentrations of SOE, NOE, total suspended particulate （TSP）, fine particulates （PM10）, CO and dustfall in Guangzhou City were analyzed. Results showed that TSP was the prominent pollutant in the ambient air environment of Guangzhou City. Of the prominent pollutants, TSP accounted for nearly 62%, SOE 12.3%, and NOx 6.4%, respectively. The average API of Guangzhou over 6 years was higher than that of Beijing, Tianjin, Nanjing, Hangzhou, Suzhou and Shanghai, and lower than that of Shenzhen, Zhuhai and Shantou. Concentrations of air pollutants have shown a downward trend in recent years, but they are generally worse than ambient air quality standards for USA, Hong Kong and EU. SOE and NOx pollution were still serious, impling that waste gas pollution from all kinds of vehicles had become a significant problem for environmental protection in Guangzhou. The possible causes of worsening air quality were also discussed in this paper.

关键词： air pollution index (API) total suspended particulates (TSP) atmospheric quality Guangzhou

Detection and Estimation of False Data Injection Attacks for Load Frequency Control Systems

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 861-870页

作者： jun ye Xiang Yu Hangzhou Innovation Institute Beihang UniversityHangzhouChina School of Automation Science and Electrical Engineering Beihang UniversityBeijingChina

False data injection attacks(FDIAs)against the load frequency control(LFC)system can lead to unstable operation of power *** this paper,the problems of detecting and estimating the FDIAs for the LFC system in the presence of external disturbances are ***,the LFC system model with FDIAs against frequency and tie-line power measurements is ***,a design procedure for the unknown input observer(UIO)is presented and the residual signal is generated to detect the *** UIO is designed to decouple the effect of the unknown external disturbance on the residual *** that,an attack estimation method based on a robust adaptive observer(RAO)is proposed to estimate the state and the FDIAs *** order to improve the performance of attack estimation,the H¥technique is employed to minimize the effect of external disturbance on estimation errors,and the uniform boundedness of the state and attack estimation errors is proven using Lyapunov stability ***,a two-area interconnected power system is simulated to demonstrate the effectiveness of the proposed attack detection and estimation algorithms.

关键词： External disturbance false data injection attacks load frequency control robust adaptive observer unknown input observer

Residual index for measurement configuration optimization in robot kinematic calibration

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Science China(Technological Sciences) 2023年第7期66卷 1899-1915页

作者： ye Hao WU jun State Key Laboratory of Tribology in Advanced Equipment and Institute of Manufacturing Engineering Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipment and Control Beijing 100084China

To improve the efficiency and accuracy of kinematic calibration,the selection of measurement configurations is an important *** previous research,optimal measurement configurations mainly are selected by maximizing observability ***,the traditional observability indices only focus on the identification efficiency of the error parameters,while the purpose of robot kinematic calibration is to improve *** solve the inconsistency of the purpose between the observability index and calibration,the concept of the residual index to represent the residual distribution of the end effector after robot kinematic calibration with the measurement noise is *** on the quadratic form minimization of residuals,this article defines a specific residual index,O^(r),which is dimensionless and strictly better with the increase of measurement *** indices are used to select measurement configurations in the kinematic calibration of a 5-DOF 2UPU/SP-RR hybrid robot,and the calibration results show that the proposed residual index is better than the traditional indices in the accuracy and stability of the end effector residual.

关键词： residual index observability index kinematic calibration measurement configuration optimization

基于三矩形谐振腔非通MIM波导的四重法诺传感

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原子与分子物理学报 2025年第3期42卷 116-123页

作者：王叶壮沈宏君陈俊坤王雅雯宁夏大学物理学院银川750000

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共... 详细信息

为了得到高灵敏度的生物传感器,设计了一种可以激发出四重法诺共振的非通金属-绝缘体-金属(Metal-Insulator-Metal,MIM)波导传感器.采用了上下对称结构,由一个竖放矩形谐振腔和两个横放矩形谐振腔与总线波导共同作用而得到了四重法诺共振.采用了有限时域差分方法计算了此结构的传输特性与Z方向的归一化磁场,并详细分析了其法诺共振的产生机理.通过计算结构几何参数调节后的透射光谱,从而得出了四处法诺共振峰透射率和共振位置可以通过改变结构几何参数而获得独立调节.此外还发现在结构中添加不同浓度的葡萄糖溶液可以实现高折射率传感灵敏度(S),获得最高灵敏度2736.98nm/RIU,可以看出此结构对于折射率变化有很高的灵敏度,这为设计和优化纳米级别的折射率传感器提供了新的思路,还可以应用于电路构建前进行性能测试.

关键词：金属-绝缘体-金属传感器谐振腔法诺共振灵敏度

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