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Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer

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World Journal of Clinical Cases 2021年第12期9卷 2721-2730页

作者： Sha-Sha Jiang Chun-Guo Mao Yong-Geng Feng bin Jiang Shao-Lin Tao Qun-you Tan Bo deng Department of Thoracic Surgery Institute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Circulating tumor cells(CTCs) can be clustered into three subtypes according to epithelial-mesenchymal transition(EMT) markers: CTCs with epithelial markers(E-CTCs), CTCs with mesenchymal markers(M-CTCs), and CTCs with both markers(E&M-CTCs). CTC detection has clinical implications in the diagnosis of lung cancer(LC).AIM To clarify the diagnostic value of CTCs categorized by EMT markers in *** The study included 106 patients with lung adenocarcinoma, including 42 groundglass opacities(GGO) and 64 solid lesions, who underwent surgery between July 2015 and December 2019. Eleven patients with benign tumors and seventeen healthy controls were included. CTCs in peripheral blood and associated EMT markers were detected preoperatively using the CanPatrol TM technique. The diagnostic power of CTCs for discriminating LC cases from controls was analyzed by the receiver operating characteristic(ROC) curve. The CytoploRare technique was used in 20 cases and 18 controls for validation, and Kappa values were calculated to evaluate consistency between *** Of the 106 LC cases, 94(89.6%) had at least one CTC. CTCs were detectable in 35(83.3%) of 42 GGO cases. Total CTCs and E&M-CTCs were significantly more frequent in LC cases than in benign or healthy controls. The proportion of MCTCs plus E&M-CTCs increased gradually from healthy controls, to benign controls, to LC cases. The area under the ROC curve of total CTCs and E&M-CTCs was > 0.8 and > 10.75, respectively. The combined sensitivity of total-CTCs and E&M-CTCs was 85.85% for LC patients(80.95% for GGO patients) and the specificity was 78.57%.The Kappa value was 0.415,indicating relative consistency between CanPatrol TM and *** CTC detection is valuable for distinguishing LC from controls,and particularly E&M-CTC detection warrants further study.

关键词： Circulating tumor cells Epithelial-to-mesenchymal transition Diagnosis Lung cancer Ground-glass opacities CanPatrol

Finite element method for viscoelastic medium with damage and the application to structural analysis of solid rocket motor grain

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Science China(Physics,Mechanics & Astronomy) 2014年第5期57卷 908-915页

作者： deng bin SHEN Zhibin DUAN JingBo TANG GuoJin College of Aerospace Science and Engineering National University of Defense Technology

This paper studies the damage-viscoelastic behavior of composite solid propellants of solid rocket motors(SRM).Based on viscoelastic theories and strain equivalent hypothesis in damage mechanics,a three-dimensional(3-D)nonlinear viscoelastic constitutive model incorporating with damage is *** resulting viscoelastic constitutive equations are numerically discretized by integration algorithm,and a stress-updating method is presented by solving nonlinear equations according to the Newton-Raphson method.A material subroutine of stress-updating is made up and embedded into commercial code of *** material subroutine is validated through typical *** results indicate that the finite element results are in good agreement with the analytical ones and have high accuracy,and the suggested method and designed subroutine are efficient and can be further applied to damage-coupling structural analysis of practical SRM grain.

关键词： composite solid propellant viscoelasticity with damage f'mite element method integration algorithm stress-updatingmethod

In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus

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Journal of Integrative Medicine 2020年第2期18卷 152-158页

作者： deng-hai Zhang Kun-lun Wu Xue Zhang Sheng-qiong deng bin Peng Shanghai Health Commission Key Lab of Artificial Intelligence(AI)-Based Management of Inflammation and Chronic Diseases Sino-French Cooperative Central LabShanghaiPudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China Department of Traditional Chinese Medicine Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China Department of Research Affair Management Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China

Objective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus(2019-nCoV), an ongoing novel coronavirus that causes ***: There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology *** meeting both requirements were subjected to absorption, distribution, metabolism and excretion(ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV protein *** the second step we searched Chinese herbal databases to identify plants containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected ***: Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these26 herbal plants were related to regulating viral infection, immune/inflammation reactions and hypoxia ***: Chinese herbal treatments classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds.

关键词： 2019-nCoV Wuhan coronavirus Drugs Chinese herbal Pneumonia Natural compounds Molecular docking Network pharmacology

Predicting lean blow-off of bluffbody stabilized flames based on Damkohler number

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Chinese Journal of Aeronautics 2019年第2期32卷 308-323页

作者： Zhonghao WANG bin HU Aiming deng Junhua ZHANG Qingjun ZHAO Institute of Engineering Thermophysics Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Light-duty Gas-turbine Chinese Academy of Sciences

Lean Blow-Off(LBO) prediction is important to propulsion system design. In this paper,a hybrid method combining numerical simulation and Da(Damk?hler) model is proposed based on bluffbody stabilized flames. In the simulated reacting flow, Practical Reaction Zone(PRZ) is built based on OH radical concentration, and it is considered to be the critical zone that controls *** number is obtained based on the volume-averaged parameters of PRZ. The flow time scale(s_f)indicates the residence time of the fresh mixture flowing through the PRZ. It is obtained based on the characteristic length and volume-averaged axial velocity of the PRZ. The chemical time scale(s_c) indicates the shortest time needed to trigger the reaction of the mixture. It is obtained by commercial software CHEMKIN through monitoring the transient variation of the reactor temperature. The result shows that the average Da number under different LBO conditions is 1.135(the Da number under each LBO condition ranges from 0.673 to 1.351). This indicates that the flow time scale and chemical time scale are comparable. The combustion is in a critical state where LBO is easy to occur. With the increase of the fuel mass flow rate(the global fuel/air ratio increases from 0.004761 to 0.01095), s_f increases from 0.001268 s to 0.007249 s, and s_c decreases from 0.00124 s to0.00089 s. Accordingly, Da number increases from 1.023 to 8.145, which shows that the combustion becomes more stable. The above results show that the method proposed in the present study can properly predict the LBO limits of combustors, which provides important technical supports for combustor design and optimization.

关键词： Bluffbody stabilized flames Damkohler number Hybrid method LBO Time scales

Autofocus technique for ISAR imaging of uniformly rotating targets based on the ExCoV method

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Journal of Systems Engineering and Electronics 2017年第2期28卷 267-275页

作者： Chengguang Wu Hongqiang Wang bin deng Yuliang Qin Wuge Su Institute of Space Electronic Technology School of Electronic Science and EngineeringNational University of Defense Technology Changsha 410073 China

The inverse synthetic aperture radar (ISAR) imaging can be converted into a sparse reconstruction problem and solved by the l1norm minimization algorithm. The basis matrix in sparse ISAR imaging is usually characterized by the unknown rotation rate of a moving target, thus the rotation rate and the sparse signal should be jointly estimated. Especially due to the imperfect coarse motion compensation, we consider the phase error correction problem in the context of the sparse signal reconstruction. To address this issue, we propose an iterative reweighted method, which jointly estimates the rotation rate, corrects the phase error and reconstructs a high resolution ISAR image. The proposed method gives a gradual and interweaved iterative process to refine the unknown parameters to achieve the best sparse representation for the ISAR signals. Particularly, in ISAR image reconstruction, the l1norm minimization algorithm is sensitive to user parameters. Setting these user parameters are not trivial and the reconstruction performance depends significantly on their choices. Then, we consider an expansion-compression variance-component (ExCoV) based method, which is automatic and demands no prior knowledge about signal-sparsity or measurement-noise levels. Both numerical and electromagnetic data experiments are implemented to show the effectiveness of the proposed method. It is shown that the proposed method can estimate the rotation rate and correct the phase errors simultaneously, and its superior performance is proved in terms of high resolution ISAR image. © 2017 Beijing Institute of Aerospace Information.

关键词： Error compensation Error correction Errors Image processing Image reconstruction Inverse problems Inverse synthetic aperture radar Iterative methods Motion compensation Numerical methods Rotation Signal reconstruction Synthetic aperture radar

Model tests on interaction between soil and geosynthetics subjected to localized subsidence in landfills

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 433-444页

作者： bin ZHU deng GAO Jun-chao LI Yun-min CHEN MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Department of Civil EngineeringZhejiang UniversityHangzhou 310058China

In a landfill, excessive tensile strains or failure of the liner system due to localized subsidence underneath the geosynthetic liner, is a concern in design and operation of the landfill. The localized subsidence can be commonly withstood by reinforcements such as geogrids. A total of nine model tests were carried out to study the influence of soil arching in overburden sandy soil on the geosynthetics and the interaction between the soil and the geosynthetics. The localized subsidence was modeled by a strip trapdoor under the geosynthetic reinforcements. The reinforcement includes several layers of polyvinylchlorid （PVC） membrane or both PVC membrane and a compacted clay layer. Test results show that the vertical soil pressure acting on the geosynthetics within the subsidence zone is strongly related to the deflection of the geosynthefics. The soil pressure acting on the deflected geosynthetics will decrease to a minimum value with respect to its deflection if the final deflection is large enough, and this minimum value is almost independent of the overburden height. Otherwise, the deflection of geosynthetics cannot result in a full degree of soil arching, and the soil pressure within the subsidence zone increases with the increase of overburden height. Deflections and strains of the geosynthetics obviously decrease with the increase of their tensile stiffness. The presence of a compacted clay layer buffer can therefore reduce both deflections and strains of the geosynthetics. Finally, a composite liner structure is recommended for landfills to withstand the localized subsidences.

关键词： Landfill Soil arching Trapdoor Model test Geosynthetics

High resolution range profile analysis based on multicarrier phase-coded waveforms of OFDM radar

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Journal of Systems Engineering and Electronics 2011年第3期22卷 421-427页

作者： Kai Huo bin deng Yongxiang Liu Weidong Jiang Junjie Mao Institute of Space Electronic Technology School of Electronic Science and EngineeringNational University of Defense TechnologyChangsha 410073P.R.China

Orthogonal frequency division multiplexing（OFDM） radar with multicarrier phase-coded waveforms has been recently introduced to achieve high range *** conventional method for obtaining the high resolution range profile（HRRP） is based on matched filters.A method of synthesizing HRRP based on the fast Fourier transform（FFT） and decoding is *** mathematical expressions of HRRP are derived by assuming an elementary scenario of point-scattering *** on the characteristic of OFDM multicarrier signals,it mainly analyzes the influence on HRRP exerted by several factors,such as velocity compensation errors,the sampling frequency offset,and so *** conclusions are significant for the design of the OFDM imaging ***,the simulation results demonstrate the validity of the conclusions.

关键词： orthogonal frequency division multiplexing(OFDM) high resolution range profile(HRRP) multicarrier phase-coded frequency offset.

Zeolite-encaged gold catalysts for the oxidative condensation of furfural

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 67-77页

作者： Weijie Li Mingyang Gao bin Qin Xin deng Landong Li School of Materials Science and Engineering Nankai UniversityTianjin 300350China College of Chemistry Nankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

The oxidative condensation between renewable furfural and fatty alcohols is a crucial avenue for producing high-quality liquid fuels and valuable furan *** selectivity control in this reaction process remains a significant ***,we report the strategy of confining well dispersed gold species within ZSM-5 structure to construct highly active Au@ZSM-5 zeolite catalysts for the oxidative condensation of *** results and spectroscopy analyses demonstrate the efficient encapsulation of isolated and cationic Au clusters in zeolite ***@ZSM-5(K)catalyst shows remarkable performance with 69.7%furfural conversion and 90.2%furan-2-acrolein selectivity as well as good recycle *** is revealed that the microstructure of ZSM-5 zeolite can significantly promote oxidative condensation activity through confinement *** work presents an explicit example of constructing zeolite encaged noble metal catalysts toward targeted chemical transformations.

关键词： zeolite encapsulation gold oxidative condensation furfural

Inhibiting bulging deformation of liquid metal free surface by magnetic pressure

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Journal of Iron and Steel Research International 2021年第7期28卷 818-829页

作者： Yang Li An-yuan deng bin Yang Hao Xu En-gang Wang Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang 110004LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110004LiaoningChina

A new method was presented to inhibit bulging deformation and fluctuation of free surface by magnetic pressure.A research combined with numerical and experimental methods was conducted to investigate the feasibility and inhibition *** parameters including magnetic flux density,frequency and action area of magnetic pressure were *** results show that the method is feasible,and the bulged free surface is fully inhibited by the proper magnetic *** inhibition efficiency increases as the increase in magnetic flux density and frequency,which shows a linear rela-tionship with the magnetic flux *** frequency has a great influence on the inhibition efficiency when the frequency is changed from 0.15 to 5.00 ***,the frequency more than 5.00 kHz has little influence on the inhibition efficiency and is recommended in application *** the ratio of the action area to the area of bulged free surface is 0.8,the best inhibition is ***,when the ratio is more than 1.2,a distinct W-shaped free surface is *** surficial and internal flow is strengthened with proper magnetic pressure ***,under the action of magnetic pressure,the fluctuation amplitude of free surface decreases from 4.0 to 1.2 mm and the main fluctuation with frequency of 2.34 Hz is dispersed into several minor fluctuations with frequency of 0.4-4.3 Hz.

关键词： Magnetic pressure High-frequency electromagnetic field Level fluctuation Level deformation Skin effect Electromagnetic metallurgy