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Numerical simulation analysis of tunnel backfill grout based on DEM-FDM coupling and particle inlet

Underground Space 2024年第1期14卷 285-299页

作者： Bin Yan Rui wang Bo-song Ding Fang Dai you wang School of Civil Engineering Central South University.Changsha 410075China

Shield tunnel backfill grouting is vital to stabilize tunnel settlement at a later stage;however,most shield tunnel backfill grouting designs lack a complete theoretical reference,and numerical simulations of the grouting process are rarely *** study presents the fundamental theories of grout diffusion and pressure variation for backfill grouting during shield ***,the numerical simulation methods coupled with discrete element methods(DEM)and finite difference methods(FDM)are achieved to simulate the process of grout injection from the grouting hole into the shield tail gap and generate grout pressure on the surrounding *** diffusion state of the grout in the shield tail gap and the squeezing effect on the surrounding rock under two shield tail disengagement modes are analyzed,as well as the impact of various grouting pressure on the surface *** results indicated that the grout diffusion in the shield tail gap can be divided into three stages:the stage of diffusion with each grouting hole as the starting point,the stage of interconnection and contact of the grout injected in each grouting hole,and the final gap filling *** of the three stages can be described using the proposed *** the grouting process,the grout is injected into the shield tail gap at a certain pressure,but the grout diffuses slowly to both sides and upwards,which causes a rapid rise of the principal stresses in the soil around the *** grouting is complete,the grout pressure gradually dissipates and stabilizes,and the principal stress *** addition,backfill grouting can reduce surface settlement,but it does not affect its distribution width.

关键词： Shield tunnel Backfill grouting Discrete element Finite difference Particle generator

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Who should be screened for colorectal cancer and how can it be prevented more effectively?

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3741-3746页

作者： you-Xiang wang Kai-Juan wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina College of Public Health Key Laboratory of Tumor Epidemiology of Henan ProvinceState Key Laboratory of Esophageal Cancer Prevention&TreatmentZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

In this editorial,we comment on the article published by Agatsuma et al in a recent issue of the World J Gastroenterol(2024;30:1368-1376).We firmly concur with Agatsuma et al regarding the vital significance of colorectal cancer(CRC)screening as a public health strategy to diminish disease *** exposed to risk factors for CRC,those with comorbid conditions,and those with limited health literacy should undergo ***,we believe that more regular screenings should be accompanied by a greater focus on primary prevention(PP)of *** remains a significant global health challenge,and its incidence is strongly linked to age,lifestyle,and socioeconomic *** is particularly noteworthy that the majority of CRC patients are diagnosed outside of established screening pathways and frequently at an advanced stage of the disease,and the majority of patients possess inadequate or even nonexistent knowledge regarding CRC,which significantly impacts the prognosis and imposes a substantial economic *** study revealed that CRC identified during hospital visits for comorbid conditions was typically diagnosed at an earlier stage than detected via symptomatic ***,early incidental detection of CRC aligns closely with the timing of discovery through routine cancer *** suggests that by adopting more inclusive screening protocols that combine opportunistic testing with traditional screening methods,health care systems can create a more comprehensive safety net for individuals at risk of ***,before maximizing the health benefits of screening programs,it is essential to make additional efforts prior to screening,such as raising awareness via public education,risk assessment,and personalized recommendations,enhancing the knowledge and skills of health care professionals,optimizing the accessibility and convenience of screening processes,ensuring the quality and safety of screening services,strengthening follow-up and su

关键词： Colorectal cancer Primary prevention Screening program Disease burden Health literacy Economic benefits

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Viscosity and structure of CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags for continuous casting of high titanium steel with different Tio2 absorption

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Journal of Iron and Steel Research International 2024年第8期31卷 1936-1946页

作者： Ya-tao Cui Xue-you wang Xu-bin Zhang Qiang-qiang wang Sheng-ping He College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effect of TiO_(2) absorption into two different CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags from the steel plant on the viscosity,melting performance and microstructure of slags was investigated through the measurement of the viscosity-temperature relationship,melting temperature and Raman *** parameter of the number of non-bridging oxygen per tetrahedrally-coordinated atom(NBO/T)was also calculated to explain the microstructure variation of molten slags with different TiO_(2) *** variation of the actual slag consumption and the depth of the liquid slag in mold was explained through the comparison of the viscosity and the melting temperature of two different *** viscosity of mold slags(basicity=0.6)decreased from 1.1 to 0.68 Pa s with the increase in the Ti0_(2) absorption from 0 to 10%,while that of slags(basicity=0.7)decreased from 0.76 to 0.56 Pa s with the Ti0_(2) absorption from 0 to 6%.The activation energy of both two groups of slags had the tendency to decrease with the increasing TiO_(2) *** network structure of both two groups of slags measured by the Raman spectra showed that the fraction of complex structure units(Q^(1),Q^(2),Q^(3) and A1-O-Al)decreased and simple structure units(Al-O-and Q^(0))increased with the increase in TiO_(2) ***/T also increased with the increase in the TiO2 absorption,indicating that the absorption of TiO_(2) into slags resulted in the destruction of silicate/aluminate ***,the absorption of TiO_(2) into the current CaO-BaO-SiO_(2)-Al_(2)O_(3) mold slags decreased the degree of polymerization of these slags and then led to the decrease of viscosity.

关键词： Mold slag Viscosity Melting temperature Slag consumption Liquid slag depth Structure

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Constructing energetic covalent organic frameworks with high stability and low sensitivity

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Chinese Chemical Letters 2024年第3期35卷 544-548页

作者： Hui-Min Guo Xiao-Yu Dong Shan wang Qian-you wang Shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Green Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China

Developing new functional explosives that display high stability,good energy performance,and low sensitivity are one of the key directions of energetic materials *** this work,two-dimensional(2D)Schiff-based energetic covalent organic frameworks(COFs)are prepared based on triaminoguanidine salts with different anions as building *** from the robust covalent bond in 2D extended polygons and strongπ-πinteractions in the eclipsed interlayers,the synthesized energetic COFs showed higher thermal stability and lower mechanical sensitivity than their precursor *** importantly,incorporating triaminoguanidine salts into COFs effectively increase the corrosion resistance to metal under high humidity conditions,which is due to the imine moieties in COFs functioning asπacceptors and offering strong bonding with metallic *** work provides a new pathway for the development of high-performance energetic materials.

关键词： Covalent organic frameworks Energetic materials High thermal stability Low sensitivity Corrosion resistance

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Experimental studies of H_(2)/Ar plasma in a cylindrical inductive discharge with an expansion region

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Chinese Physics B 2024年第10期33卷 321-330页

作者： Shi-Bo Li Si-Yu Xing Fei Gao you-Nian wang Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China

The electrical parameters of H_(2)/Ar plasma in a cylindrical inductive discharge with an expansion region are investigated by a Langmuir probe,where Ar fractions range from 0%to 100%.The influence of gas composition and pressure on electron density,the effective electron temperature and the electron energy probability functions(EEPFs)at different spatial positions are *** driver region,with the introduction of a small amount of Ar at 0.3 Pa,there is a rapid increase in electron density accompanied by a decrease in the effective electron ***,the shape of the EEPF transitions from a three-temperature distribution to a bi-Maxwellian distribution due to an increase in electron-electron ***,this phenomenon resulting from the changes in gas composition vanishes at 5 Pa due to the prior depletion of energetic electrons caused by the increase in pressure during hydrogen *** EEPFs for the total energy in expansion region is coincident to these in the driver region at 0.3 Pa,as do the patterns of electron density variation between these two regions for differing Ar *** 5 Pa,as the discharge transitions from H_(2)to Ar,the EEPFs evolved from a bi-Maxwellian distribution with pronounced low energy electrons to a Maxwellian distribution in expansion *** evolve may be attributed to a reduction in molecular vibrational excitation reactions of electrons during transport and the transition from localized electron dynamics in hydrogen discharge to non-localized electron dynamics in argon *** order to validate the experimental results,we use the COMSOL simulation software to calculate electrical parameters under the same *** evolution and spatial distribution of the electrical parameters of the simulation results agree well with the trend of the experimental results.

关键词： inductively coupled plasma transmission and distribution energy distribution functions

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Crossed renal ectopia with rectal cancer:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2122-2127页

作者： Zhen-Wei Tang Hui-Feng Yang Zhao-Yu Wu Chang-you wang Department of General Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Crossed renal ectopia(CRE)occurs when one kidney crosses the midline from the primary side to the contralateral side while the ureter remains on the primary *** cancer,one of the most common malignant tumors of the digestive tract,refers to cancer from the dentate line to the rectosigmoid *** concurrent presentation of CRE alongside rectal cancer is an uncommon clinical *** SUMMARY Herein,we report a 69-year-old male patient with rectal cancer who was diagnosed with CRE via computed tomography during *** thorough preoperative evaluations,the patient underwent Dixon *** We performed laparoscopic radical resection of rectal cancer and adequate lymph node removal in a patient with CRE with no postoperative discomfort.

关键词： Rectal cancer Crossed renal ectopia Anatomy Laparoscopic surgery Case report

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Rapid Access to Chiralα-Alkylated Azacycles via NiH-Catalyzed Asymmetric Migratory Hydroalkylation of N-Heterocyclic Alkenes

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CCS Chemistry 2024年第4期6卷 898-904页

作者： Changpeng Chen Wenqing Guo Deyong Qiao Junqian Zhou you wang Shaolin Zhu State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsChemistry and Biomedicine Innovation Center(ChemBIC)School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093 School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007 Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong UniversityShanghai 200240

Asymmetric migratory hydrofunctionalization of isomeric mixtures of alkenes provides a complementary approach for the selective introduction of a functional group into a remote C(sp3)-H ***,the simultaneous control of both regio-and enantioselectivity in this migratory process is a ***α-alkyl-substituted azacycles are key motifs in pharmaceuticals,natural products,and ***,we report a NiH-catalyzed asymmetric migratory hydroalkylation process for their efficient and selective *** this process,easily available isomeric mixtures of N-heterocyclic alkenes can be directly employed as starting materials,convergently delivering a variety of enantioenrichedα-alkylated azacycles with high levels of regio-and *** synthetic utility of this transformation is demonstrated by the facile synthesis of two bioactive alkaloids,(+)-connine and(R)-*** obtained chiralα-alkylated azacycles also readily undergo diverse derivatization,such as deconstructive halogenation and ring contraction.

关键词： alkenes alkylation asymmetric catalysis isomerization nickel

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Uninvolved liver dose prediction in stereotactic body radiation therapy for liver cancer based on the neural network method

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4146-4156页

作者： Huai-Wen Zhang you-Hua wang Bo Hu Hao-Wen Pang Department of Radiotherapy Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Oncology Gulin People’s HospitalLuzhou 646500Sichuan ProvinceChina Key Laboratory of Nondestructive Testing(Ministry of Education) Nanchang Hang Kong UniversityNanchang 330063Jiangxi ProvinceChina Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND The quality of a radiotherapy plan often depends on the knowledge and expertise of the plan *** To predict the uninvolved liver dose in stereotactic body radiotherapy(SBRT)for liver cancer using a neural network-based *** A total of 114 SBRT plans for liver cancer were used to test the neural network ***-organs of the uninvolved liver were automatically *** between the volume of each sub-organ,uninvolved liver dose,and neural network prediction model were established using *** the cases,70%were selected as the training set,15%as the validation set,and 15%as the test *** regression R-value and mean square error(MSE)were used to evaluate the *** The volume of the uninvolved liver was related to the volume of the corresponding *** all sets of Rvalues of the prediction model,except for D_(n0)which was 0.7513,all R-values of D_(n10)-D_(n100)and D_(nmean)were>*** MSE of the prediction model was also *** We developed a neural network-based method to predict the uninvolved liver dose in SBRT for liver *** is simple and easy to use and warrants further promotion and application.

关键词： Dose prediction Sub-organ Machine learning Stereotactic body radiotherapy Liver cancer

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Clinical experience sharing on gastric microneuroendocrine tumors: A case report

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World Journal of Clinical Cases 2024年第4期12卷 795-800页

作者： you-Jun wang Da-Ming Fan Yu-Shuang Xu Qi Zhao Zhen-Fang Li Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Pathology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND The majority of gastric neuroendocrine tumors(G-NENs)are present in various lesions under endoscopy,and they can be polypoid uplifts,submucosal tumors or papules,erosions,and *** lesions are mostly confined to the mucosal or submucosal layer,usually less than 2 cm,and exclusively localized to the gastric body or *** type 1 G-NENs,about 22%of cases have no visible lesions under an endoscope,and such lesions can only be detected via biopsies(microcar-cinoids).CONCLUSION In the case under study,the patient did not have any visible raised lesions under a gastroscope,and the lesions were found only after a random *** article combines the endoscopic manifestations and clinical features of the lesions in this case to improve the diagnosis of G-NENs.

关键词： Neuroendocrine tumor Micro carcinoids Endoscopy Case report

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A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters

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Eco-Environment & Health 2024年第1期3卷 30-44页

作者： Ya-Nan Yao you wang Hengling Zhang Yanxia Gao Tao Zhang Kurunthachalam Kannan School of Environmental Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China Wadsworth Center New York State Department of HealthAlbanyNew YorkNY 12237USA

Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human *** their estrogenic properties,the potential health risks associated with exposure to BPs have become a public health *** review aims to summarize sources and pathways of exposure to BPs and associated health *** exposure,primarily through the use of sunscreens,constitutes a major pathway for BP *** a recommended application rate,dermal exposure of BP-3 via the application of sunscreens may reach or exceed the suggested reference *** exposure pathways to BPs,such as drinking water,seafood,and packaged foods,contribute minimal to the overall *** is a minor pathway of exposure;however,its contribution cannot be *** exposure to BPs is an order of magnitude higher in North America than in Asia and *** conducted on laboratory animals and cells have consistently demonstrated the toxic effects of BP *** are estrogenic and elicit reproductive and developmental ***,neurotoxicity,hepatotoxicity,nephrotoxicity,and carcinogenicity have been reported from chronic BP *** addition to animal and cell studies,epidemiological investigations have identified associations between BPs and couples'fecundity and other reproductive disorders,as well as adverse birth *** studies are urgently needed to understand the risks posed by BPs on human health.

关键词： Benzophenone ultraviolet light filters Human exposure BP-3 Health effects Risk assessment

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