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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： you wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

THE SECOND-ORDER HYDROELASTIC ANALYSIS OF A SWATH SHIP MOVING IN LARGE-AMPLITUDE WAVES

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Journal of Hydrodynamics 2006年第6期18卷 631-639页

作者： TIAN Chao wu you-Sheng School of Naval Architecture Ocean and Civil Engineering Shanghai Jiaotong University Shanghai 200030China China Ship Scientific Research Center Wuxi 214082 China

Based on the second order hydroelasticity theory of ships, the numerical methods and the calculated results of the non-linear hydroelastic responses of a ship traveling in rough seas were investigated. The non-linear hydrodynamic actions induced by the rigid body rotations and the variations of instantaneous wetted surface area were included in the second order analysis. The first order wave potentials and responses, which are sure to make the major contributions to the second order hydrodynamic actions, were obtained by employing the translating and pulsating source Green function and the Kelvin steady wave flow solution based on the linear three-dimensional hydroelasticity theory. The influences of the forward speed and the steady wave flow on the responses, and the differences of the predicted non-linear responses were illustrated by the numerical examples of a SWATH ship traveling with forward speed of 12 kn in irregular waves.

关键词： hydroelaticity, non-linear responses, second order forces, translating and pulsating source, SWATH (Small Waterplane Area Twin Hull) ship

体认翻译学视域下“水”隐喻英译研究——以许渊冲《李白诗选》英译本为例

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语言与文化研究

语言与文化研究 2025年第1期33卷 169-173页

作者：吴优李国宏西华大学外国语学院成都610039

在李白诗歌中,存在大量水隐喻。本研究将在体认翻译学视域下,以许渊冲译《李白诗选》为语料,将水隐喻按照本体、结构和方位隐喻三个类型来探究其具体的隐喻翻译策略。研究发现:1)李白诗歌中本体隐喻相对较多,诗人多倾向于将具体可见的... 详细信息

在李白诗歌中,存在大量水隐喻。本研究将在体认翻译学视域下,以许渊冲译《李白诗选》为语料,将水隐喻按照本体、结构和方位隐喻三个类型来探究其具体的隐喻翻译策略。研究发现:1)李白诗歌中本体隐喻相对较多,诗人多倾向于将具体可见的事物映射到抽象不可见的情感中,极具感染力。2)水隐喻翻译主要有两种策略:一是映射对等翻译策略,即基于体验的普遍性,占27.8%;二是偏移等效翻译策略,即基于认知加工的差异性,占72.2%。3)译者多采用偏移等效的翻译策略,主张传递古诗的“言外之意”,使译文更为英语读者所接受。本研究一方面论证了体认翻译学的价值所在,另一方面也为李白诗歌翻译实践提供一点借鉴,促进中华文化更好地“走出去”。

关键词：体认翻译学水隐喻翻译策略李白诗歌许渊冲

A new analysis approach to the output constraint and its application in high-order nonlinear systems

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Science China(Information Sciences) 2023年第5期66卷 299-300页

作者： you wu Xuejun XIE Institute of Automation Qufu Normal University

Many practical nonlinear systems need to consider the output constraint due to performance requirements and safety specifications. In the past decade, barrier Lyapunov function (BLF) and nonlinear mapping (NM), which were first defined in [1,2], respectively, have become two representative tools to handle the output constraint. The biggest merit of the NM-based approach is to directly deal with the original output constraint rather than indirectly limit the relevant error signal in the BLF-based approach.

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A waveform modification method for testing dynamic properties of rock under high temperature

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 833-844页

作者： Tubing Yin Chao Wang you wu Bingqiang wu School of Resources and Safety Engineering Central South UniversityChangsha410083China

In this study,a waveform modification method was proposed using a self-designed heating device combined with the split Hopkinson pressure bar(SHPB)technique for determination of dynamic behaviors of rock at high ***,the temperature gradient distribution on the incident bar was measured according to the variation of elastic modulus of the bar with temperature,and the relationship between the longitudinal wave velocity and temperature of the bar was obtained based on onedimensional stress wave *** incident bar with a temperature gradient was divided into a series of microelements,and then the transmission coefficient of the whole incident bar was ***,the stress wave was modified by the transmission coefficient from 25℃ to 600℃.This method was used to study the dynamic properties of rock at high temperature,which not only preserves a classical SHPB device,but also effectively ensures the accuracy of the experimental results.A dynamic Brazilian disc experiment was carried out to explore the influences of loading rate and temperature on dynamic tensile strength of sandstone at high temperature using the proposed waveform modification method.

关键词： High temperature Split Hopkinson pressure bar(SHPB) Dynamic loading Rock materials Mechanical properties

Length-Changeable Incremental Extreme Learning Machine

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Journal of Computer Science & Technology 2017年第3期32卷 630-643页

作者： you-Xi wu Dong Liu He Jiang School of Computer Science and Software Hebei University of Technology Tianjin 300130 China School of Economics and Management Hebei University of Technology Tianjin 300130 China Hebei Province Key Laboratory of Big Data Calculation Tianjin 300401 China School of Software Dalian University of Technology Dalian 116621 China

Extreme learning machine （ELM） is a learning algorithm for generalized single-hidden-layer feed-forward networks （SLFNs）. In order to obtain a suitable network architecture, Incremental Extreme Learning Machine （I-ELM） is a sort of ELM constructing SLFNs by adding hidden nodes one by one. Although kinds of I-ELM-class algorithms were proposed to improve the convergence rate or to obtain minimal training error, they do not change the construction way of I-ELM or face the over-fitting risk. Making the testing error converge quickly and stably therefore becomes an important issue. In this paper, we proposed a new incremental ELM which is referred to as Length-Changeable Incremental Extreme Learning Machine （LCI-ELM）. It allows more than one hidden node to be added to the network and the existing network will be regarded as a whole in output weights tuning. The output weights of newly added hidden nodes are determined using a partial error-minimizing method. We prove that an SLFN constructed using LCI-ELM has approximation capability on a universal compact input set as well as on a finite training set. Experimental results demonstrate that LCI-ELM achieves higher convergence rate as well as lower over-fitting risk than some competitive I-ELM-class algorithms.

关键词： single-hidden-layer feed-forward network (SLFN) incremental extreme learning machine (I-ELM) random hidden node convergence rate universal approximation

Bioabsorbable fabrication of molybdenum nitride/carbon nanocomposites for supercapacitors and metal ion batteries with robust stability

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Rare Metals 2023年第12期42卷 4212-4225页

作者： Qiang-Hong wu Huan-Zhong Zeng you-Zhi wu Fen Ran State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou 730050China

Metal nitride is one of the best anode materials of the energy storage device;however,the low stability of the pure metal nitride limits its wide *** this work,a new method of bioabsorbable fabrication was developed for preparing molybdenum nitride that corporates into the porous carbon *** molybdenum ions in pollutions could be easily absorbed by Ligustrum quihoui,and the transportation,accumulation,and circulation of molybdenum ions in Ligustrum quihoui were *** obtained composite material of biochar and molybdenum nitride is employed as anode material of supercapacitors and batteries which exhibits good electrochemical performance,especially the rate and long lifespan ***,it is found that the specific capacity is344 F·g^(-1)at current density of 0.5 A·g^(-1)in 2 mol·L^(-1)KOH,and the capacitance retention and coulomb efficiency are above 90%after 10,000 *** should be noted that the novel approach combines fabricating anode materials with advanced nanostructure and suppressing the environmental problems with metal pollution at the same time.

关键词： Metal pollution Ligustrum quihoui Supercapacitors Metal ions batteries Anode materials

Probing the catalytic activity of M-N_(4−x)O_(x) embedded graphene for the oxygen reduction reaction by density functional theory

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Frontiers of Chemical Science and Engineering 2021年第5期15卷 1206-1216页

作者： Fan Ge Qingan Qiao Xin Chen you wu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China School of Chemistry and Materials Science Ludong UniversityYantai264025China Center for Computational Chemistry and Molecular Simulation College of Chemistry and Chemical EngineeringSouthwest Petroleum UniversityChengdu610500China Oil&Gas Field Applied Chemistry Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringSouthwest Petroleum UniversityChengdu610500China

In this work,the detailed oxygen reduction reaction(ORR)catalytic performance of M-N_(4−x)O_(x)(M=Fe,Co,and Ni;x=1−4)has been explored via the detailed density functional theory *** results suggest that the formation energy of M-N_(4−x)O_(x)shows a good linear relationship with the number of doped O *** adsorption manner of O_(2)on M-N_(4−x)O_(x)changed from end-on(x=1 and 2)to side-on(x=3 and 4),and the adsorption strength gradually *** on the results for binding strength of ORR intermediates and the Gibbs free energy of ORR steps on the studied catalysts,we screened out two highly active ORR catalysts,namely Co-N_(3)O_(1)and Ni-N_(2)O_(2),which possess very small overpotentials of 0.27 and 0.32 V,*** activities are higher than the precious Pt *** structure analysis reveals one of the reasons for the higher activity of Co-N_(3)O_(1)and Ni-N_(2)O_(2)is that they have small energy gaps and moderate highest occupied molecular orbital energy ***,the results of the density of states reveal that the O doping can improve the electronic structure of the original catalyst to tune the adsorption of the ORR intermediates.

关键词： M-N-C catalyst oxygen doping oxygen reduction reaction catalytic activity density functional theory

Regional Meteorological Patterns for Heavy Pollution Events in Beijing

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Journal of Meteorological Research 2017年第3期31卷 597-611页

作者： ting you renguang wu gang huang guangzhou fan college of atmospheric sciences chengdu university of information technologyChengdu 610225 center for monsoon system research institute of atmospheric physicschinese academy of sciencesBeijing 100029 state key laboratory of numerical modeling for atmospheric sciences and geophysical fluid dynamics institute of atmospheric physicschinese academy of sciencesBeijing 100029 laboratory for regional oceanography and numerical modeling qingdao national laboratory for marine science and technologyQingdao 266237 joint center for global change studies Beijing100875 university of chinese academy of sciences Beijing 100049

The present study investigates meteorological conditions for the day-to-day changes of particulate matter （PM） concentration in Beijing city during the period 2008-2015. The local relationship of PM concentration to surface air temperature, pressure, wind speed, and relative humidity displays seasonal changes and year-to-year variations. The average correlation coefficient with PMI0 in spring, summer, fall, and winter is 0.45, 0.40, 0.38, and 0.30 for air tem- perature; -0.45, -0.05, -0.40, and -0.45 for pressure; 0.13, 0.04, 0.53, and 0.50 for relative humidity; and -0.18, -0.11, -0.45, and -0.33 for wind speed. A higher correlation with wind speed is obtained when wind speed leads by halfa day. The heavily polluted and clean days, which are defined as the top and bottom 10% of the PM values, show obvious differences in the regional distribution of air temperature, pressure, and wind. Polluted days correspond to higher air temperature in all the four seasons, lower sea level pressure and anomalous southerly winds to the south and east of Beijing in spring, fall, and winter, and a northwest-southeast contrast in the pressure anomaly and anom- alous southerly winds in summer. Higher relative humidity is observed on polluted days in fall and winter. The pol- luted days are preceded by an anomalous cyclone moving from the northwest, accompanied by lower pressure and higher air temperature, in all four seasons. This feature indicates the impacts of moving weather systems on local meteorological conditions for day-to-day air quality changes in Beijing.

关键词： PM10 Beijing local meteorology seasonal dependence weather system

The application of three-dimensional hydroelastic analysis of ship structures in Pekeris hydro-acoustic waveguide environment

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Acta Mechanica Sinica 2014年第1期30卷 59-66页

作者： Ming-Song Zou you-Sheng wu Yan-Min Liu China Ship Scientific Research Center

The hydroelastic analysis and sonoelastic analysis methods are incorporated with the Green＇s function of the Pekeris ocean hydro-acoustic waveguide model to produce a three-dimensional sonoelastic analysis method for ships in the ocean hydro-acoustic environment. The seabed condition is represented by a penetrable boundary of prescribed density and sound speed. This method is employed in this paper to predict the vibration and acoustic radiation of a 1 500 t Small Water Area Twin Hull （SWATH） ship in shallow sea acoustic environment. The wet resonant frequencies and radiation sound source levels are predicted and compared with the measured results of the ship in trial.

关键词： Hydroelasticity Sonoelasticity Acousticwaves Shallow sea Free surface effect Seabed effect -SWATH ship