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Application and Progress of Cultured Models of Gallbladder Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 695-704页

作者： Jiali Xing Peiwen Ding Xueshuai Wan gang Xu Yilei mao Xinting Sang Shunda Du Huayu Yang Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Clinical School Chengdu University of Traditional Chinese MedicineChengduSichuanChina Department of Oncology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuanChina Department of Liver Surgery and Liver Transplant Center West China Hospital of Sichuan UniversityChengduSichuanChina

Gallbladder carcinoma (GBC) is a malignant tumor of the bil-iary system that is aggressive, difficult to detect early, and has a low surgical resection rate and poor prognosis. Ap-propriate in vitro growth models are expected to focus on the study of the biological behavior and assess treatment effects. Nonetheless, cancer initiation, progression, and in-vasion include spatiotemporal changes and changes in the cell microenvironment intracellular communication, and in-tracellular molecules, making the development of in vitro growth models very challenging. Recent advances in bioma-terial methods and tissue engineering, particularly advances in bioprinting procedures, have paved the way for advances in the creative phase of in vitro cancer research. To date, an increasing number of cultured models of gallbladder disease have emerged, such as two-dimensional (2D) GBC growth cell cultures, three-dimensional (3D) GBC growth cell cul-tures, xenograft models, and 3D bioprinting methods. These models can serve as stronger platforms, focusing on tumor growth initiation, the association with the microenvironment, angiogenesis, motility, aggression, and infiltration. Bioprint-ed growth models can also be used for high-throughput drug screening and validation, as well as translational opportuni-ties for individual cancer therapy. This study focused on the exploration, progress, and significance of the development of GBC cultural models. We present our views on the short-comings of existing models, investigate new innovations, and plan future improvements and application possibilities for cancer models.

关键词： Gallbladder cancer 2D gallbladder cancer cell culture 3D gallblad-der cancer cell culture Xenograft model 3D bioprinting technology.

骨桥蛋白和p38MAPK信号通路在多房棘球蚴原头节发育中的作用

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动物医学进展 2025年第1期46卷 9-15页

作者：徐刚毛艺胡帅葛宇飞徐志张玉梦谢士伟张宏伟张示杰石河子大学第一附属医院新疆石河子832000 石河子大学医学院新疆石河子832000

为明确骨桥蛋白(OPN)和多房棘球蚴(Echinococcus multilocularis,Em)p38丝裂原活化蛋白激酶(p38MAPK)信号通路在Em发育过程的作用,剖检感染Em 4~6月的长爪沙鼠,提取Em原头节后,分别用不同浓度的p38MAPK抑制剂(SB202190)处理Em原头节,选... 详细信息

为明确骨桥蛋白(OPN)和多房棘球蚴(Echinococcus multilocularis,Em)p38丝裂原活化蛋白激酶(p38MAPK)信号通路在Em发育过程的作用,剖检感染Em 4~6月的长爪沙鼠,提取Em原头节后,分别用不同浓度的p38MAPK抑制剂(SB202190)处理Em原头节,选取合适的SB202190浓度后在体外将原头节分为DMSO组、anti-p38MAPK组、PBS组、OPN组、OPN+anti-p38MAPK组,采用伊红染色、caspase-3试剂盒检测caspase-3、EDU和Hoechst染色、活性氧(ROS)检测探针检测原头节的活性、凋亡和增殖情况。结果显示,抑制Em的SB202190适宜浓度为20μmol/L,SB202190增加Em的伊红染色率、caspase-3水平,减少EDU阳性、ROS水平,OPN可减少Em伊红染色率、caspase-3水平,增加EDU阳性率、ROS水平,且SB202190可逆转OPN对Em的结果,这些结果表明SB202190可抑制Em的活性和增殖、促进凋亡并与浓度正相关,而OPN可促进Em的活性和增殖、抑制凋亡,且SB202190可逆转OPN对Em的作用。研究结果为OPN和p38MAPK信号通路可能成为治疗多房棘球蚴病的新分子靶点提供证据。

关键词：多房棘球蚴多房棘球蚴病骨桥蛋白 p38丝裂原活化蛋白激酶

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有孔屏蔽腔屏蔽效能的高次模分析

电波科学学报 2009年第3期24卷 510-513页

作者：石丹沈远茂高攸纲北京邮电大学电子工程学院北京100086

分析了有孔屏蔽腔的屏蔽效能,将传统的等效传输线分析模型扩展为包含TEmn和TMmn高次模的模型,并用该模型分析了缝隙偏离腔体壁中心的情况,得到了实用性较强的一般公式,该公式将腔体内部的高次模和腔体壁的损耗都考虑在内,在一定程度上... 详细信息

分析了有孔屏蔽腔的屏蔽效能,将传统的等效传输线分析模型扩展为包含TEmn和TMmn高次模的模型,并用该模型分析了缝隙偏离腔体壁中心的情况,得到了实用性较强的一般公式,该公式将腔体内部的高次模和腔体壁的损耗都考虑在内,在一定程度上消除了频率和腔体尺寸对于以往公式的限制。与其他运用传输线高次模分析腔体屏蔽效能的文献不同,本文中TEmn和TMmn的m和n可为任意值,而不需要采用n=0的假设,这更与腔体中的多种模式相符合。

关键词：腔体缝隙屏蔽效能偏离中心高次模

In Situ HRTEM Observation of Electron-Irradiation-Induced Amorphization and Dissolution of the E(Al_(18)Cr_2Mg_3) Phase in 7475 Al Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第2期28卷 147-151页

作者： mao-Hua Li Yan-Qing Yang Bin Huang Xian Luo Wei Zhang Yan-Xia Chen Ming Han Ji-gang Ru State Key Laboratory of Solidification Processing Northwestern Polytechnical University Beijing Institute of Aeronautical Materials

Electron irradiation effects on phase stability of the E （Al18Cr2Mg3） phase have been investigated by high- angle annular dark-field scanning transmission electron microscopy and high-resolution transmission electron microscopy （HRTEM）. The in situ HRTEM observations show that the Ala8Cr2Mg3 particles with different thickness undergo amorphization and dissolution under 300 keV electron irradiation at 25 ℃. The results indicate that the intermetallic compound Al18Cr2Mg3 is unstable under electron irradiation, and structural changes mainly depend on the thickness of particles. Amorphization in the thick particles is caused by a combination of chemical disordering and an increase in point defect concentration. Dissolution after amorphization in the thin particles is attributed to the diffusion of point defect towards the Al matrix.

关键词： Intermetallic compound Al18Cr2Mg3 Irradiation effects Amorphization Dissolution

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主扰回路对失配被扰回路的耦合效应

电波科学学报 2007年第1期22卷 134-137,165页

作者：石丹高攸纲沈远茂北京邮电大学电信工程学院北京100876

利用积分方法分析了主扰回路对失配被扰回路的耦合效应,得到了计算被扰回路耦合电压的一般公式,将积分方法的使用范围拓展到了高频范围,并用经典的耦合干扰分析方法进行了验证,得出Klewe理论和Jarvis模型得到的结果是此一般公式的特例... 详细信息

利用积分方法分析了主扰回路对失配被扰回路的耦合效应,得到了计算被扰回路耦合电压的一般公式,将积分方法的使用范围拓展到了高频范围,并用经典的耦合干扰分析方法进行了验证,得出Klewe理论和Jarvis模型得到的结果是此一般公式的特例。该公式在低频和高频条件下均适用,并能将传输线的反射,损耗,相移和平行长度不相等都考虑在内。

关键词：耦合主扰回路被扰回路高频反射

DRBin:metagenomic binning based on deep representation learning

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Journal of Genetics and Genomics 2022年第7期49卷 681-684页

作者： gang mao Yulin Wu Yang Zhang Xuan Wang Yan Zhu Bo Liu Yadong Wang Junyi Li School of Computer Science and Technology Harbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055China College of Science Harbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055China Technology(Shenzhen) ShenzhenGuangdong 518055China Center for Bioinformatics School of Computer Science and TechnologyHarbin Institute of TechnologyHarbinHeilongjiang 150001China

Metagenomic binning is the process of sorting genome or contig sequences obtained by metagenomic sequencing of environmental DNA or genetically heterogeneous groups of organisms into categories representing the individual species or genetically homogenous groups (e.g., strains) from which they originated (Rasheed and Rangwala, 2013). Conventionally, whole-genome sequencing of single species requires culture and isolation of microorganisms.

关键词： originated representing sorting

One-pot Three-component Synthesis of 4,4'-Arylidene-bis(3-methyl-pyrazolones) Derivatives in Water

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Chemical Research in Chinese Universities 2012年第6期28卷 999-1002页

作者： JIA Xu-dong DUAN Hal-feng LIN Ylng-jle CAO Jun-gang LIANG Da-peng WU mao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changehun 130012 P. R. China

Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4＇-arylidene-bis（3-methyl-pyrazolones） derivatives in *** this green synthetic protocol,the solvent water itself catalyzed the reaction via hydrogen bonding,thus avoiding the use of any other catalyst to make the work up procedure ***-pot,environmental friendly and convenient are the highlights.

关键词： 4 4'-Arylidene-bis(3-methyl-pyrazolones) Catalysis Multi-component reaction

Preparation of Polyaniline-coated Composite Aerogel of MnO2 and Reduced Graphene Oxide for High-performance Zinc-ion Battery

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Chinese Journal of Polymer Science 2020年第5期38卷 514-521,I0007页

作者： Jing mao Fang-Fang Wu Wen-Hui Shi Wen-Xian Liu Xi-Lian Xu gang-Feng Cai Yi-Wen Li Xie-Hong Cao College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Center for Membrane Separation and Water Science&Technology Ocean CollegeZhejiang University of TechnologyHangzhou 310014China

Aqueous zinc-ion batteries,especially Zn-Mn02 battery,have attracted intensive attention owing to their unique features of high capacity,environmental friendliness,and ***,the problem of Mn dissolution hinders the development of zinc-ion batteries with long-term usage and high-rate *** this work,a novel preparation method for the polyaniline(PANI)-coated composite aerogel of Mn02 and rGO(MnO2/rGO/PANI)electrode is *** obtained composite possesses high electrical conductivity,and also effectively suppresses the dissolution of *** fabricated Mn02/rGO/PANI//Zn battery exhibits a high capacity of 241.1 mAh·g^-1 at 0.1 A·g^-1,and an excellent capacity retention of 82.7%after 600 charge/discharge *** addition,the rapid diffusion coefficient of the Mn02/rGO/PANI electrode was further examined by galvanostatic intermittent titration *** work provides new insights into the development of high-performance Zn-Mn02 battery with a better understanding of its diffusion kinetics.

关键词： Mn02 Polyaniline Composite aerogels Aqueous zinc-ion batteries Galvanostatic intermittent titration techniques

Transarterial radioembolization with Yttrium-90:current status and future prospects

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Gastroenterology Report 2020年第2期8卷 164-165,I0003页

作者： Hua-Yu Yang Bao Jin gang Xu Le-Jia Sun Shun-Da Du Yi-Lei mao Department of Liver Surgery Peking Union Medical College(PUMC)HospitalPUMC&Chinese Academy of Medical Sciences(CAMS)BeijingP.R.China

In recent years,transarterial radioembolization(TARE)with Yttrium-90(Y90)has emerged as a technique for treating malignant neoplasms in the *** with other locoregional therapies,such as transarterial chemoembolization(TACE),patients who underwent TARE with Y90 have higher tumor response rates and better ***,no significant treatment-related complications or treatment-related deaths have been reported[1].We here review the clinical application of TARE and its associated issues.

关键词： neoplasms arterial treatment 现状及未来