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Journal of Shanghai University(English Edition) 2001年第Z1期5卷 290-293页

作者： DING you-dong

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基布横动式Z字型织草装置的研制及摆幅分析

华南理工大学学报（自然科学版） 2014年第1期42卷 6-10页

作者：游东东刘鹏华南理工大学机械与汽车工程学院广东广州510640

为提高人造草坪基布的承载能力及草簇分布的均匀性,提出了一种偏心轮式基布横动装置,实现了人造草坪的Z字型织造,并研究了Z字型摆幅大小对人造草坪基布承载能力的影响.文中建立了基布横动装置的虚拟样机模型,并进行了机构的运动仿真和... 详细信息

为提高人造草坪基布的承载能力及草簇分布的均匀性,提出了一种偏心轮式基布横动装置,实现了人造草坪的Z字型织造,并研究了Z字型摆幅大小对人造草坪基布承载能力的影响.文中建立了基布横动装置的虚拟样机模型,并进行了机构的运动仿真和空机运行实验,针对草簇行距为19 mm(3/4英寸)的基布进行了4种不同摆幅的基布拉伸试验.结果表明:与直线型相比,Z字型人造草簇在基布上的分布更加均匀,基布的承载能力得到了较大的提升;当Z字型摆幅约为人造草坪行距的一半时,基布的承载能力更好.

关键词：织草机织造技术基布横动装置摆幅承载能力拉伸试验

Synthesis,biological evaluation and SAR studies of benzimidazole derivatives as H_1-antihistamine agents

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Chinese Chemical Letters 2012年第6期23卷 707-710页

作者： Xiao Jian Wang Mei Yang Xi Ji Hua Fu Fu Rong Zhang Gui Fang Cheng Da Li Yin Qi dong you Department of Medicinal Chemistry Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100050 China School of Pharmacy China Pharmaceutical University Nanjing 210009 China

A series of benzimidazole derivatives have been designed, synthesized and evaluated for H1 antihistamine activity. Six compounds have showed potent antihistamine H1 activity. The primary SAR analysis indicated that benzyl or benzylidinyl substituted on the exo-nitrogen atom and C2 of the benzimidazole were significant. Further experiments indicated that compound 17d displayed excellent activity to reduce mast cell degranulation, moderate anti-PAF activity and decreased potency on hERG compared to astennizole. Hence compound 17d could serve as anti-allergic agent for further development.

关键词： Benzimidazole derivatives Antihistamine activity SAR Anti-PAF activity hERG

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基于长期检测的桥梁全寿命智能维养系统

中外公路 2024年第2期44卷 274-281页

作者：叶智威张佳鑫谭海山樊蕾贺文董优吴旺林深圳市路桥建设集团有限公司广东深圳518001 香港理工大学土木与环境工程学院中国香港999077 深圳诚科工程咨询有限公司广东深圳518001

中国针对桥梁维修养护系统,主要以桥梁检测的数据为支撑进行状态排序,将有限的预算进行分配。该策略专注于维修低性能桥梁,集中在修复性养护而未过多关注预防性养护。从全寿命周期总成本考虑,以修复为主的决策方法虽初期投入少,但中后... 详细信息

中国针对桥梁维修养护系统,主要以桥梁检测的数据为支撑进行状态排序,将有限的预算进行分配。该策略专注于维修低性能桥梁,集中在修复性养护而未过多关注预防性养护。从全寿命周期总成本考虑,以修复为主的决策方法虽初期投入少,但中后期资源消耗大。该文在现有公路桥梁养护的基础上,发展出基于中国规范和检测数据,修复和预防相结合的智能化维养系统。系统模型主要包括两大模块,桥梁性能退化模型和智能维养决策模型。首先基于长期检测数据结合数理统计的动态马尔可夫(Markov)和威布尔(Weibull)模型对桥梁长期性能预测,在此基础上结合预防性养护理念建立数学模型,并采用群体智能算法进行优化求解。最终,以深圳坂银通道上某预应力混凝土箱梁桥为研究对象,采用实际桥梁检测数据对系统模型进行测试。结果表明:与传统维养方法相比,智能维养系统能节约10%的维养费用。

关键词：桥梁维养系统智能维养结构退化马尔可夫模型 Weibull模型群体智能算法

Application of Space-time Conservation Element and Solution Element Method in Intake and Exhaust Flows of High Power Density Diesel Engine

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Defence Technology（防务技术） 2013年第3期9卷 171-175页

作者： Guo-dong you Chun-long XU Jun-feng XU Ming ZHU Zeng-quan WANG School of Mechatronics Engineering North University of China China North Engine Research Institute

A one-dimensional pipe flow model of single-cylinder diesel engine is established to investigate the intake and exhaust flow characteristics of diesel engine in the condition of high power density(HPD).A space-lime conservation element and solution element(CE/SE)method is used to derive the discrete equations of the partial differential equation for the intake and exhaust *** performance parameters of diesel engine with speed of 2100 r/min are *** simulated results are in accordance with the experimental *** effect of increased power density on charging coefficient is analyzed using a validated *** results show that the charging coefficient is slowly improved with the increase in intake pressure,and is obviously reduced with the increase in engine speed.

关键词：高功率密度柴油机时空守恒元排气流量柴油发动机应用进气压力偏微分方程发动机转速

Challenges and Innovations in the Sutong Bridge Foundation Project

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Engineering Sciences 2008年第1期6卷 15-22页

作者： you Qingzhong dong Xuewu Wu Shouchang Jiangsu Provincial Sutong Bridge Construction Commanding Department Nantong Jiangsu 226010 China

This article introduces three outstanding innovations, i.e. utilization of the steel casing for the piles to establish a construction platform for Sutong Bridge's large and deep-pile groups; 5000 ton steel cofferdam lowered as a whole and used as a protective structure against impact from ship collision; Permanent scour protection. This article also presents economical and reasonable design method for large bridge foundation and explains the significance of innovation and technical integration to large and complicated project construction based on the above theory.

关键词： foundation construction platform steel cofferdam ship collision lowering of steel cofferdam permanent scour protection

Pathologic assessment of hepatocellular carcinoma in the era of immunotherapy:a narrative review

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 472-493页

作者： Han Wang you-Wen Qian Hui dong Wen-Ming Cong Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina

Background and Objective:Immune checkpoint inhibitor(ICI)-based therapy has achieved impressive success in various cancer *** ICIs have been unprecedentedly approved as the treatment regimens for advanced hepatocellular carcinoma(HCC)in recent ***,numerous clinical trials are being performed to exploit more ICIs into initially unresectable HCC and postoperative HCC to expectantly induce adequate tumor downstaging for further resection or implement adjuvant treatment for relapse-free survival,*** this review,we aim to summarize some pragmatic histomorphologic,immunohistochemical,and molecular pathologic parameters which promisingly indicate the response of neoadjuvant/conversion ICI-related therapy and predict the efficacy of adjuvant/therapeutic ICI-related therapy for ***:We searched PubMed using the terms hepatocellular carcinoma,immunotherapy,immune checkpoint inhibitor,immune checkpoint blockade,conversion therapy,neoadjuvant therapy,adjuvant therapy,biomarker,pathologic evaluation,pathologic assessment till February *** Content and Findings:Although there is no consensus regarding the pathologic evaluation of relevant HCC specimens,it is encouraging that a few of studies have concentrated on this field,and moreover,the methods and parameters noted on other cancer types are also worthy of *** the pathologic assessment of HCC specimens underwent immunotherapy,a suitable sampling scheme,identifying immunotherapy-related pathologic response,and quantification of pathologic response rate should be *** the patients of HCC who are scheduled to receive immunotherapy,tumor-infiltrating lymphocyte,intratumoral tertiary lymphoid structure,programmed cell death ligand 1,Wnt/β-catenin,microsatellite instability and mismatch repair,tumor mutational burden and tumor neoantigen,as well as some other signaling pathways are the potential predictive biomarkers of treatment response of ***:The managem

关键词： Hepatocellular carcinoma(HCC) immune checkpoint blockade pathologic evaluation neoadjuvant therapy conversion therapy adjuvant therapy

Constructing energetic covalent organic frameworks with high stability and low sensitivity

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Chinese Chemical Letters 2024年第3期35卷 544-548页

作者： Hui-Min Guo Xiao-Yu dong Shan Wang Qian-you Wang Shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Green Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China

Developing new functional explosives that display high stability,good energy performance,and low sensitivity are one of the key directions of energetic materials *** this work,two-dimensional(2D)Schiff-based energetic covalent organic frameworks(COFs)are prepared based on triaminoguanidine salts with different anions as building *** from the robust covalent bond in 2D extended polygons and strongπ-πinteractions in the eclipsed interlayers,the synthesized energetic COFs showed higher thermal stability and lower mechanical sensitivity than their precursor *** importantly,incorporating triaminoguanidine salts into COFs effectively increase the corrosion resistance to metal under high humidity conditions,which is due to the imine moieties in COFs functioning asπacceptors and offering strong bonding with metallic *** work provides a new pathway for the development of high-performance energetic materials.

关键词： Covalent organic frameworks Energetic materials High thermal stability Low sensitivity Corrosion resistance

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挤压铸造压射机构的卡擦可靠性分析

华南理工大学学报（自然科学版） 2013年第7期41卷 32-37页

作者：宋雷邵明游东东华南理工大学机械与汽车工程学院广东广州510640

压射机构是挤压铸造设备的核心部件之一,卡擦现象是影响压射机构正常工作、压室寿命的关键技术难题.文中首先通过有限元方法计算得到压室和冲头半径方向变形量,并对压射机构发生卡擦现象的原因进行了定性分析,发现在挤压铸造工艺过程中... 详细信息

压射机构是挤压铸造设备的核心部件之一,卡擦现象是影响压射机构正常工作、压室寿命的关键技术难题.文中首先通过有限元方法计算得到压室和冲头半径方向变形量,并对压射机构发生卡擦现象的原因进行了定性分析,发现在挤压铸造工艺过程中,压室和冲头的间隙变小是压射机构发生卡擦现象的直接原因,压室和冲头各个部位的不均匀变形是导致卡擦现象发生的重要原因.基于此,建立了压射机构卡擦现象可靠性分析模型,采用Monte Carlo模拟法计算得到KDJ-250T挤压铸造机压射机构的卡擦可靠度,提出了压室结构改进方案.结果显示,利用文中提出的卡擦可靠性分析方法可对压射机构工作性能做出合理的评估,也有助于在设计过程中合理选择压室和冲头之间的配合间隙.

关键词：挤压铸造压射机构卡擦可靠性分析 Monte Carlo模拟法

Synthesis and antitumor activities of structure-related small molecular compounds of gambogic acid

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Chinese Chemical Letters 2007年第6期18卷 659-662页

作者： Nian Guang Li Qi dong you Xue Feng Huang Jin Xin Wang Qing Long Guo Xiao Guang Chen Yan Li Hong Yan Li Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009China Department of Physiology China Pharmaceutical UniversityNanjing 210009China Institute of Materia Medica Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Through simplifying the complicated skeleton of the natural product gambogic acid, two series derivatives of chromone and xanthone were synthesized and examined for their antitumor activities against several cancer cells in vitro by MTT method. The results showed that appropriate introduction of prenyl group to the small molecular compounds could elevate their antitumor activities. The structure–activities relationship of synthesized compounds certified that the bridgecore in gambogic acid was very important for keeping its antitumor activities.

关键词： Gambogic acid Small molecular compounds Antitumor activity