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Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology

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World Journal of Hepatology 2018年第12期10卷 934-943页

作者： Daisuke Uehara Yoichi Hayashi yosuke Seki Satoru Kakizaki Norio Horiguchi Hiroki Tojima Yuichi yamazaki Ken Sato Kazuki Yasuda Masanobu Yamada Toshio Uraoka Kazunori Kasama Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Department of Computer Science Meiji University Tama-ku Weight Loss and Metabolic Surgery Center Yotsuya Medical Cube Department of Metabolic Disorder Diabetes Research Center Research Institute National Center for Global Health and Medicine Department of Internal Medicine Division of Endocrinology and Metabolism Gunma University Graduate School of Medicine

AIM To construct a non-invasive prediction algorithm for predicting non-alcoholic steatohepatitis(NASH), we investigated Japanese morbidly obese patients using artificial intelligence with rule extraction *** Consecutive patients who required bariatric surgery underwent a liver biopsy during the operation. Standard clinical, anthropometric, biochemical measurements were used as parameters to predict NASH and were analyzed using rule extraction technology. One hundred and two patients, including 79 NASH and 23 non-NASH patients were analyzed in order to create the predictionmodel, another cohort with 77 patients including 65 NASH and 12 non-NASH patients were analyzed to validate the *** Alanine aminotransferase, C-reactive protein, homeostasis model assessment insulin resistance, albumin were extracted as predictors of NASH using a recursive-rule extraction algorithm. When we adopted the extracted rules for the validation cohort using a highly accurate rule extraction algorithm, the predictive accuracy was 79.2%. The positive predictive value, negative predictive value,sensitivity and specificity were 88.9%, 35.7%, 86.2% and 41.7%, *** We successfully generated a useful model for predicting NASH in Japanese morbidly obese patients based on their biochemical profile using a rule extraction algorithm.

关键词： Non-alcoholic steatohepatitis Artificial intelligence Rule extraction Morbid obesity Liver biopsy Non-invasive prediction

Evaluation of preferable insertion routes for esophagogastroduodenoscopy using ultrathin endoscopes

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World Journal of Gastroenterology 2014年第17期20卷 5045-5050页

作者： Satoshi Ono Keiko Niimi Mitsuhiro Fujishiro Yu Takahashi Yoshiki Sakaguchi Chiemi Nakayama Chihiro Minatsuki Rie Matsuda Itsuko Hirayama-Asada yosuke Tsuji Satoshi Mochizuki Shinya Kodashima Nobutake Yamamichi Atsuko Ozeki Lumine Matsumoto Yumiko Ohike Tsutomu yamazaki Kazuhiko Koike Center for Epidemiology and Preventive Medicine Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Gastroenterology Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Endoscopy and Endoscopic Surgery Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan

AIM: To evaluate the discomfort associated with esophagogastroduodenoscopy (EGD) using an ultrathin endoscope through different insertion routes.

关键词： Esophagogastroduodenoscopy Ultrathin endoscope Visual analog scale

Deficits in Magnocellular Pathway in Developmental Dyslexia: A Functional Magnetic Resonance Imaging-Electroencephalography Study

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Journal of Behavioral and Brain Science 2013年第2期3卷 168-178页

作者： Hisako Yamamoto yosuke Kita Tomoka Kobayashi Hiroko yamazaki Makiko Kaga Hideki Hoshino Takashi Hanakawa Hitoshi Yamamoto Masumi Inagaki Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP) Tokyo Japan Department of Pediatrics St. Marianna University School of Medicine Kanagawa Japan Integrative Brain Imaging Center National Center of Neurology and Psychiatry (NCNP) Tokyo Japan

Background: Magnocellular deficit theory is among the different hypotheses that have been proposed to explain the pathophysiology of developmental dyslexia (DD). Dysfunction of the magnocellular system in DD has been investigated using mainly visual evoked potentials (VEPs), particularly transient VEPs, although recently abnormal steady-state VEPs have also been reported. The brain regions responsible for the abnormal VEPs in DD have yet to be elucidated, however. In this study, we performed functional magnetic resonance imaging and electroencephalography (fMRI-EEG) simultaneously to elucidate the brain areas that were found in a previous study to be activated through stimulation of the magnocellular system, and then investigated the mechanism involved in the dysfunction seen in ***: Subjects were 20 healthy individuals (TYP group;13 men, 7 women;mean ± standard deviation age, 26.3 ± 5.53 years) and 2 men with DD (aged 42 and 30 years). Images of brain activity were acquired with 3-Tesla MRI while the viewing the reversal of low-spatial frequency and low-contrast black-and-white sinusoidal gratings. EEG was recorded concurrently to obtain steady-state ***: Stimulus frequency-dependent VEPs were observed in the posterior region of the brain in the TYP group;however, VEP amplitudes in both DD patients were clearly smaller than those in TYP. fMRI images revealed that both the primary and secondary visual cortices were activated by black-and- white sinusoidal gratings in the TYP group, whereas activity in the visual cortex overall was reduced in both DD ***: Present low spatial and high reversal frequency visual stimuli activated the primary visual cortex presumably through predominant activation of the magnocellular pathway. This finding indicates that some cases of adult patients of DD involve impairment of the visual magnocellular system.

关键词： Developmental Dyslexia Simultaneous Functional MRI-EEG Visual Evoked Potential Magnocellular Deficit Theory Magnocellular Pathway

A case of severe acalculous cholecystitis associated with sorafenib treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 115-118页

作者： yosuke Aihara Hitoshi Yoshiji Masaharu yamazaki Yasuhide Ikenaka Ryuichi Noguchi Chie Morioka Kosuke Kaji Haruki Tastumi Keisuke Nakanishi Maiko Nakamura Junichi Yamao Masahisa Toyohara Akira Mitoro Masayoshi Sawai Motoyuki Yoshida Masao Fujimoto Masahito Uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical UniversityNara 634-8522Japan

Sorafenib,a multikinase inhibitor,is the first and only drug,which improves significantly the overall survival in patients with advanced hepatocellular carcinoma(HCC).However,many patients experience diverse side effects,some of them severe and *** date,acute acalculous cholecystitis has not been documented in association with a HCC patient treated with ***,we report the case of a 43-yearold woman with hepatitis C virus-related advanced *** received sorafenib,and later complained ofa sudden onset of severe right hypocondrial pain with rebound tenderness and muscle *** examination showed mild elevation of transaminases,biliary enzymes,bilirubin,inflammation markers,and a marked peripheral *** computed tomography(CT) revealed a swollen gallbladder with exudate associated with severe inflammation without stones or ***,sorafenib treatment was stopped immediately,and steroid-pulse therapy was *** therapy drastically improved all clinical manifestations along with normalization of CT findings,eosinophilia,and liver *** summary,we herein report a rare case of acute severe acalculous cholecystitis associated with sorafenib in the patient with advanced HCC.

关键词： Hepatocelluar carcinoma Sorafenib Acalculous cholecystitis