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Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization

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Signal Transduction and Targeted Therapy 2023年第3期8卷 905-907页

作者： Shao-bin Wang yosuke nagasaka Dionne Argyle Ayami nagasaka Praveen Yerramothu Bradley DGelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye underlies many forms of aberrant ocular angiogenesis and resultant vision loss,including in neovascular age-related macular degeneration(nvAMD),proliferative diabetic retinopathy(PDR).

关键词： degeneration ocular release

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Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1526-1534页

作者： Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney yosuke nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion Jan M.Deussing Srinivas R.Sadda Bradley D.Gelfand Jayakrishna Ambati Center for Advanced Vision Science University of Virginia School of MedicineCharlottesvilleVAUSA Department of Ophthalmology University of Virginia School of MedicineCharlottesvilleVAUSA Aravind Eye Care System MaduraiIndia Departamento de Oftalmologia e Ciências Visuais Escola Paulista de MedicinaUniversidade Federal de São PauloSão PauloBrazil Center for Digital Image Evaluation CharlottesvilleVAUSA Doheny Eye Institute Los AngelesLos AngelesCAUSA Molecular Neurogenetics Department of Stress Neurobiology and NeurogeneticsMax Planck Institute of PsychiatryMunichGermany Department of Ophthalmology David Geffen School of MedicineUniversity of California–Los AngelesLos AngelesCAUSA Department of Biomedical Engineering University of Virginia School of MedicineCharlottesvilleVAUSA Department of Pathology University of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology Immunologyand Cancer BiologyUniversity of Virginia School of MedicineCharlottesvilleVAUSA

Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global *** report that AβOs induce RPE degeneration,a clinical hallmark of geographic atrophy(GA),a vision-threatening late stage of AMD that is currently *** demonstrate that AβOs induce activation of the NLRP3 inflammasome in the mouse RPE in vivo and that RPE expression of the purinergic ATP receptor P2RX7,an upstream mediator of NLRP3 inflammasome activation,is required for AβO-induced RPE *** classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors(NRTIs)and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE *** findings crystallize the importance of P2RX7 and NLRP3 in a disease-relevant model of AMD and identify inflammasome inhibitors as potential treatments for GA.

关键词： degeneration activation upstream

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2021年日本福岛县冲地震的震源破裂过程分析——基于采用经验格林函数方法的波形反演

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世界地震工程 2021年第2期37卷 1-12页

作者：吴双兰野津厚長坂陽介港湾空港技術研究所日本神奈川県239-0826

利用中小震作为经验格林函数,选取0.2~2.0 Hz频段的强震数据进行波形反演,获得了2021年福岛县冲地震的破裂过程。结果表明:该地震的破裂主要集中在断层面距离震源约25 km的区域内,沿震源向东北延伸约5 km,向西南延伸约20 km;在该区域内... 详细信息

利用中小震作为经验格林函数,选取0.2~2.0 Hz频段的强震数据进行波形反演,获得了2021年福岛县冲地震的破裂过程。结果表明:该地震的破裂主要集中在断层面距离震源约25 km的区域内,沿震源向东北延伸约5 km,向西南延伸约20 km;在该区域内,识别出两个滑动量集中的区域,均分布在距离震源约15 km西南侧,主要滑动量集中区域最大滑动量约3.2 m,深度基本与震源一致;次要滑动量集中区域略比主要滑动量集中区域浅约18 km。该震源模型对应矩震级M_(w)7.3,破裂速度为2.4 km/s。通过选择不同的中小震组合进行波形反演,结果对该震源模型特性无显著影响,揭示了该震源模型的稳健性;基于该震源模型合成反演分析中未使用的强震观测台站强震动,获得的合成波形与观测波形有很好的相关性,充分证明了该震源模型时空特征的可靠性。

关键词： 2021年福岛县冲地震破裂过程经验格林函数波形反演强震动

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New pyrometallurgical process of EAF dust treatment with CaO addition

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 788-797页

作者： Romchat Chairaksa-Fujimoto yosuke Inoue Naoyoshi Umeda Satoshi Itoh Tetsuya nagasaka Department of Metallurgy Graduate School of Engineering Tohoku University Toho Titanium Co. Ltd. Honda Motor Co. Ltd.

The non-carbothermic zinc pyrometallurgical processing of electric arc furnace(EAF) dust was investigated on a laboratory scale. The main objective of this process was to convert highly stable zinc ferrite(Zn Fe2O4), which accounts for more than half of total zinc in the EAF dust, into Zn O and Ca2Fe2O5 by Ca O addition. The EAF dust was mixed with Ca O powder in various ratios, pressed into pellets, and heated in a muffle furnace in air at temperatures ranging from 700 to 1100°C for a predetermined holding time. All Zn Fe2O4 was transformed into Zn O and Ca2Fe2O5 at a minimum temperature of 900°C within 1 h when sufficient Ca O to achieve a Ca/Fe molar ratio of 1.1 was added. However, at higher temperatures, excess Ca O beyond the stoichiometric ratio was required because it was consumed by reactions leading to the formation of compounds other than Zn Fe2O4. The evaporation of halides and heavy metals in the EAF dust was also studied. These components could be preferentially volatilized into the gas phase at 1100°C when Ca O was added.

关键词： electric arc furnace dust pyrometallurgy zinc oxid

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粉尘处理工艺的开发——ISIJ先进技术创新计划

粉尘处理工艺的开发——ISIJ先进技术创新计划

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作者： Romchat Chairaksa yosuke Inoue Kazuyo Matsubae Akira Tsubonel Takehito Hiraki and Tetsuya nagasaka Graduate School of Environmental Studies Tohoku UniversitySendai 980-8579Japan 1 Aichi Steel Corp.Tokai 476-8666Japan

一种由ISIJ创新计划出资开发的被命名为"石灰添加法"的工艺,是用作处理电炉粉尘的新工艺,目前正在研究回收粉尘中的ZnO并将回收ZnO后的固态残渣来用作钢水精炼的熔剂。这个工艺由电炉粉尘与CaO反应、充分破碎和高强度磁选分离三步组成...

一种由ISIJ创新计划出资开发的被命名为"石灰添加法"的工艺,是用作处理电炉粉尘的新工艺,目前正在研究回收粉尘中的ZnO并将回收ZnO后的固态残渣来用作钢水精炼的熔剂。这个工艺由电炉粉尘与CaO反应、充分破碎和高强度磁选分离三步组成。该工艺的理论基于对CaO-FeO-ZnO系统相平衡的揭示。其中CaFeO可在CaO较高的区域与纯ZnO相平衡,而不是与电炉粉尘的主要成分ZnFe-2O平衡。将加入了2倍摩尔量的CaO粉尘加热到1000℃至1200℃,对电炉粉尘中ZnFeO向ZnO和CaFeO的转化进行了试验研究。试验表明不用Waelz工艺的碳热还原也可实现电炉粉尘中回收ZnO。

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