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Neoadjuvant therapy for resectable pancreatic cancers

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 583-585页

作者： yosuke Inoue Hiromichi ito Yu Takahashi Division of Hepato-Biliary-Pancreatic Surgery Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyoJapan

Pancreatic cancer(PC)is a potentially systemic disease with more diverse biology than generally *** present,surgical resection is the only curative therapy available for patients with PC,and its indications have long been discussed based on anatomical resectability.A recent consensus recommends neoadjuvant therapy(NAT)for anatomically borderline resectable(BR)cancers(1)as well as induction therapy for unresectable locally advanced(UR-LA)or metastatic(UR-M)cancers.

关键词： cancers therapy curative

Prospective controlled study on the effects of polyethylene glycol in capsule endoscopy

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World Journal of Gastroenterology 2012年第15期18卷 1789-1792页

作者： Takafumi ito Ken Ohata Akiko Ono Hideyuki Chiba yosuke Tsuji Hajime Sato Nobuyuki Matsuhashi Department of Gastroenterology Kanto Medical CenterNTT EastTokyo 1418625Japan Department of Health Policy and Technology Assessment National Institute of Public Health2-3-6 MinamiWako-shi 3293147Japan

AIM:To prospectively confirm whether a small amount of polyethylene glycol(PEG)ingested after swallowing endoscopy capsule improves image quality and completion ***:Forty-four consecutive patients referred to us for capsule endoscopy(CE)were randomized to two *** patients were restricted to clear fluids for 12 h before the *** in group A(22 cases)received no additional preparation,while those in group B(20 cases)ingested 500 mL of PEG within a 2 h period starting 30 min after swallowing the *** fluids and meals were allowed 2 h and 4 h after capsule ingestion,*** quality was assessed as the percentage of visualized bowel surface area as follows:1:90%.The small bowel record was divided into five segments by time,and the score for each segment was *** CE examinations were performed with the Pillcam SB capsule endoscopy sys-tem(Given Imaging ***.,Yoqnem).RESULTS:This study ended in December 2009,because sample size was considered large enough.A total of 44 patients were *** patients in group B were excluded from the analysis because small bowel images could not be obtained from these patients;one had a full stomach,while the other presented with a massive gastric ***,22 patients from group A and 20 patients from group B completed the *** was no significant difference in age(P=0.22),sex(P=0.31),and indication for *** significant adverse events occurred in any of the study *** group A,image quality deteriorated as the capsule progressed ***,in group B,image quality was maintained to the distal small *** each of the five segments,the visibility score was significantly higher in group B than in group A(segment 1:4.3± 0.7vs 4.7±0.5,P=0.03;segment 2:4.2±0.9vs 4.8 ±0.4,P=0.01;segment 3:4.0±1.0 vs 4.6±0.7,P =0.04;segment 4:3.6±1.1 vs 4.5±0.6,P=0.003;segment 5:2.7±1.0vs 4.4±0.8,P=0.00004).Thus,the use of PEG during CE e

关键词： Capsule endoscopy Completion rate Image quality Polyethylene glycol Preparation

Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions

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World Journal of Gastroenterology 2010年第23期16卷 2913-2917页

作者： yosuke Tsuji Ken Ohata Takafumi ito Hideyuki Chiba Tomohiko Ohya Toshiaki Gunji Nobuyuki Matsuhashi Department of Gastroenterology Kanto Medical CenterNTT EC Department of Endoscopy The Jikei University School of Medicine Center for Preventive Medicine Kanto Medical CenterNTT EC

AIM:To assess risk factors for bleeding after gastric endoscopic submucosal dissection(ESD) and to develop preventive ***:This retrospective study was performed in a tertiary referral center.A total of 328 patients underwent ESD for 398 gastric neoplasms between July 2007 and June *** main outcome was association between post-ESD bleeding and the following:age;sex;comorbidities;daily use of medicine potentially related to gastric injury/bleeding;location,size,and histological depth of lesions;ulceration;experience of operator coagulating the ulcer floor,and duration of *** also determined the relationship between the location of post-ESD bleeding and risk factors for ***:Univariate analysis revealed significant risk factors:tumor location [odds ratio(OR),2.86;95% CI:1.21-6.79,P=0.024],coagulator experience(OR,4.29;95% CI:1.43-12.86,P=0.009),and medicine potentially related to gastric injury/bleeding(OR,2.80;95% CI:1.14-6.90,P=0.039).Multivariate logistic regression analysis confirmed significant,independent risk factors:tumor in lower third of stomach(OR,2.47;95% CI:1.02-5.96,P=0.044),beginner coagulator(OR,3.93;95% CI:1.29-11.9,P=0.016),and medicine(OR,2.76;95% CI:1.09-6.98,P=0.032).We classif ied cases of post-ESD bleeding into two groups(bleeding at the ulcer margin vs bleeding at the center) and found that bleeding at the margin occurred more frequently with beginner coagulators compared with experts(OR,16.00;95% CI:1.22-210.59,P=0.040).CONCLUSION:Beginner coagulators,tumor in the antrum,and medicines were significant risk factors for post-ESD *** at the ulcer margin frequently occurred with beginner operators.

关键词： Bleeding Endoscopic submucosal dissection Ulcer floor Anti-thrombotic drugs Coagulation

Influence of cognitive impairment on cardiac mortality after percutaneous coronary intervention in very elderly patients: a retrospective observational study

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Journal of Geriatric Cardiology 2019年第10期16卷 733-740页

作者： Tomoko Tomioka Ryokichi Takahashi yosuke Ikumi Shuhei Tanaka Yoshitaka ito Hiroki Shioiri Jiro Koyama Kanichi Inoue Department of Cardiology South-Miyagi Medical Center

Background Cognitive impairment (CI) increases cardiac mortality among very elderly patients. Percutaneous coronary intervention (PCI) for ischemic heart disease (IHD) patients is considered a favorable strategy for decreasing cardiac mortality. Here, we investigated the influence of CI on cardiac mortality after PCI in very elderly patients. Methods We performed a retrospective observational analysis of patients who received PCI between 2012 and 2014 at the South Miyagi Medical Center, Japan. IHD patients over 80 years old who underwent the Mini-Mental State Examination for CI screening during hospitalization and/or who had been diagnosed with CI were included. Participants were divided into CI and non-CI groups, and cardiac mortality and incidence of adverse cardiac events in a 3-year follow-up period were compared between groups. Statistical analyses were performed using the t-test,χ^2 test, and multivariable Cox regression analysis, with major comorbid illness and conventional cardiac risk factors as confounders. Results Of 565 patients, 95 were included (41 CI, 54 non-CI). Cardiac mortality during the follow-up period was significantly higher in the CI group (36%) compared with the non-CI group (13%)(OR = 4.3, 95% CI: 1.56–11.82, P < 0.05). CI was an independent cardiac prognostic factor after PCI and, for CI patients, living only with a CI partner was an independent predictor of cardiac death within three years. Conclusions CI significantly affected cardiac prognosis after PCI in very elderly patients, particularly those living with a CI partner. To improve patients’ prognoses, social background should be considered alongside conventional medical measures.

关键词： Cognitive impairments Family background Mortality Octogenarians Percutaneous coronary intervention

Moment stability in mean square of stochastic delay differential equation

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Moment stability in mean square of stochastic delay differen...

Ga Content Dependence of Cell Performance for Bifacial CIGS Thin Film Solar Cells

2011 Chinese Control and Decision Conference（CCDC）

作者： Shigeru Yamamoto yosuke Ikei Faculty of Electrical and Computer Engineering Kanazawa University Graduate School of Natural Science and Technology Kanazawa University

In this paper,we derive a moment stability region in terms of coefficient parameters for a stochastic delay differential *** a stochastic delay equation with both time delay and random effects is an essential model of control *** a main result,a fundamental stability problem is solved by delay-dependent stochastic *** adopt the domain-subdivision approach and use ito’s formula in the *** a given time delay,the stability of the stochastic delay differential equation is studied with variable power of *** is also shown that an unstable stochastic delay system become stable by an appropriate power of *** main results are illustrated by several numerical solutions of the stochastic delay model.

关键词： Time delay Stochastic Stabilization

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Ga Content Dependence of Cell Performance for Bifacial CIGS ...

Evaluation of an oral moisture-checking device for screening dry mouth

第十五届国际光伏科学与工程大会

作者： yosuke Kanda Shunsuke Kijima Yusuke Komiya Hiroki Ishizaki Naoomi Yamada Tokio Nakada Dept.of Electrical Engineering and Electronics Aoyama Gakuin University 5-10-1Sagamihara Kanagawa 229-8558 Japan Dept.of Electrical Engineering and Electronics Aoyama Gakuin University 5-10-1Sagamihara Kanagawa 229-8558 Japan Dept.of Electrical Engineering and Electronics Aoyama Gakuin University 5-10-1Sagamihara Kanagawa 229-8558 Japan Dept.of Electrical Engineering and Electronics Aoyama Gakuin University 5-10-1Sagamihara Kanagawa 229-8558 Japan Dept.of Electrical Engineering and Electronics Aoyama Gakuin University 5-10-1Sagamihara Kanagawa 229-8558 Japan Dept.of Electrical Engineering and Electronics Aoyama Gakuin University 5-10-1Sagamihara Kanagawa 229-8558 Japan

＜正＞ Bifacial CIGS solar cell with a ZnO:Al/ZnO/CdS/CIGS/ito/SLG structure using ito （Indium Tin Oxide） back contacts have been fabricated. In this contribution, the details of fabrication and performance of bifacial CIGS thin film solar cells are described. The cell performance of the CIGS device was improved by optimizing Ga content in the CIGS layer. A best cell showed total area efficiencies of 12.6% and 7.4% for front and rear side illumination, respectively. This result implies that the maximum equivalent cell efficiency of 20.0% could be obtained when both sides of the bifacial device were illuminated simultaneously under AM1.5, 100 mW/cm2 conditions.

关键词： Cu (In,Ga)Se2 Bifacial Thin Film Solar Cells Transparent Conducting Oxides ito

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Open Journal of Stomatology 2013年第8期3卷 440-446页

作者： yosuke Fukushima Tetsuya Yoda Shoichiro Kokabu Ryuichiro Araki Tsubasa Murata Yoshimasa Kitagawa Ken Omura Shuji Toya Kayoko ito Saori Funayama Hiroshi Iwabuchi Kazuhiro Asano Yutaka Imai Akihide Negishi Satoshi Yokoo Goichi Matsumoto Eiro Kubota Hideki Watanabe Mikio Kusama Kojiro Onizawa Takuya Goto Seiji Nakamura Ryuichi Nakazawa Kiyoshi Harada Takashi Fujibayashi Community Health Science Center Saitama Medical University Saitama Japan Department of Dentistry and Oral Surgery Tochigi National Hospital Tochigi Japan Department of Oral and Maxillofacial Surgery Division of Medicine Interdisciplinary Graduate School of Medicine and Engi- neering Univer-sity of Yamanashi Kofu and Tamaho Japan Department of Oral and Maxillofacial Surgery Dokkyo Medical University School of Medicine Tochigi Japan Department of Oral and Maxillofacial Surgery Faculty of Medicine Sai-tama Medical University Saitama Japan Department of Oral and Maxillofacial Surgery Institute of Clinical Medicine University of Tsukuba Tsukuba Japan Department of Oral and Maxillofacial Surgery Jichi Medical University Tochigi Japan Department of Oral and Maxillofacial Surgery Kanagawa Dental College Yokosuka Japan Department of Stomatology and Oral Surgery Gunma University Graduate School of Medicine Maebashi Japan Division of Gereatric Dentistry Niigata University Medical & Dental Hospital Niigata Japan Oral and Maxillofacial Surgery Dry Mouth Clinic The Nippon Dental University Niigata Hospital Niigata Japan Oral Diagnosis and Medicine Department of Oral Pathobiological Science Graduate School of Dental Medicine Hokkaido University Sapporo Japan Oral Surgery Department of Oral Restitution Division of Oral Health Sciences Graduate School Tokyo Medical and Dental University Tokyo Japan Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Fukuoka Japan

Objective: This multicenter clinical study was to assess the clinical usability of an oral moisture-checking device in detecting the dry mouth patients and evaluating the optimal measurement site. Materials and Methods: The study group comprised 250 patients with dry mouth and 241 healthy volunteer subjects at 13 medical centers. This device was used to measure the moisture degrees of the lingual mucosa and the buccal mucosa. Subjective oral dryness, objective oral dryness, and saliva flow rates were also compared between the two groups. For statistical analysis, receiver-operating characteristic analysis was performed to calculate the area under the curve (AUC). Results: The moisture degree of the lingual mucosa was significantly lower in the dry mouth group (27.2 ± 4.9) than that in the healthy group (29.5 ± 3.1, AUC = 0.653). When a lingual mucosa moisture degree of 31.0 or higher was defined as normal, less than 27.0 as dry mouth, and 27.0 to less than 31.0 as borderline zone of dry mouth, both the sensitivity and the specificity for the diagnosis of dry mouth were close to 80%. Conclusion: These results suggest that the oral moisture-checking device is a usable screening device for dry mouth.

关键词： Dry Mouth Oral Moisture-Checking Device ROC Analysis

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神经胶质细胞对平行记忆形成的调节

神经损伤与功能重建 2023年第8期18卷 F0003-F0003页

作者： Teppei Kanaya Ryo ito yosuke M Morizawa Daichi Sasaki Hiroki Yamao Hiroshi Ishikane Yuichi Hiraoka Kohichi Tanaka Ko Matsui Super Network Brain Physiology Graduate School of MedicineTohoku UniversitySendaiJapan Super Network Brain Physiology Graduate School of Life SciencesTohoku UniversitySendaiJapan Department of Psychology Graduate School of HumanitiesSenshu UniversityKawasakiJapan Laboratory of Molecular Neuroscience Medical Research Institute(MRI)Tokyo Medical and Dental University(TMDU)TokyoJapan.

神经胶质细胞的活动可以影响学习和记忆的储备和效率。本研究采用小脑依赖水平光动力反应运动学习小鼠模型,研究在线训练期间短期记忆(STM)的形成和离线休息期间长期记忆(LTM)的形成。研究显示,在线和离线学习效果的差异很大。STM早期... 详细信息

神经胶质细胞的活动可以影响学习和记忆的储备和效率。本研究采用小脑依赖水平光动力反应运动学习小鼠模型,研究在线训练期间短期记忆(STM)的形成和离线休息期间长期记忆(LTM)的形成。研究显示,在线和离线学习效果的差异很大。STM早期形成较好者的LTM形成往往受到抑制,而没有明显急性训练效果的STM形成较晚者常常在离线学习中有明显提高。含有LRRC8A的阴离子通道可释放谷氨酸。在星形胶质细胞(包括小脑伯格曼胶质细胞)中特异性地条件性敲除LRRC8A导致STM形成的完全丧失,而在休息期间LTM形成仍然存在。在线训练期间,通过通道视紫红质-2或古菌红素-T(ArchT)对神经胶质细胞的活性进行光遗传学调控,可分别导致STM形成的增强或抑制。STM和LTM可能在在线训练期间同时触发,但LTM在离线期的后期才表达。STM似乎并不稳定,在线培训期间的形成的记忆并没有在LTM中出现。此外,我们发现在休息期间,胶质细胞ArchT的光活化导致LTM形成的增加。这些数据表明STM的形成和LTM的形成是平行的独立过程。可以根据胶质细胞的反应来决定策略的重点是STM还是LTM。

关键词：伯格曼胶质细胞小脑运动学习水平光动力学反应光遗传学并行存储器形成