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Overexpression of ETS-1 is associated with malignan＇ biological features of prostate cancer

Asian Journal of Andrology 2012年第6期14卷 860-863页

作者： Bo Li yosuke Shimizu Takashi Kobayashi Naoki Terada Koji Yoshimura Tomomi Kamba Yoshiki Mikami Takahiro Inoue Hiroyuki Nishiyama Osamu Ogawa Department of Urology Kyoto University Graduate School of Medicine Kyoto 606-8507 Japan Minimally Invasive Urology Center Shandong Provincial Hospital Affiliated to Shandong University Jinan 250000 China Department of Urology Columbia University Herbert Irving Cancer Center New York NY 10032 USA Department of Diagnostic Pathology Kyoto University Hospital Kyoto 606-8507 Japan Department of Urology Faculty of Medicine University of Tsukuba Ibaraki 305-8575 Japan

E26 transformation-specific-1 （ETS-1）, an ETS family transcription factor, has been reported to play an important role in a variety of physiological and pathological processes, but clinical implications of ETS-1 expression in prostate cancer （PCa）, particularly high-risk cases, including response to androgen-deprivation therapy （ADT） have yet to be elucidated. We examined the expression of ETS- 1 using immunohistochemical staining of paraffin-embedded prostate carcinoma tissue obtained by needle biopsy from 69 mostly advanced PCa patients. ETS-1 expression was compared with the clinicopathological characteristics of the 69 patients, including 25 who underwent ADT as a primary treatment. As a result, PCa patients with higher expression of ETS-1 were significantly more likely to be of high stage and high Gleason score （P〈O.05）. There was no significant association between ETS-1 expression and the initial prostate-specific antigen （PSA） level. In the 25 patients treated by ADT, the staining score for ETS-1 was significantly associated with rapid development of castration-resistant disease within 24 months （P〈O.05）, whereas the Gleason score and PSA level were not. In conclusion, increased ETS-1 expression was associated with a higher stage, higher Gleason score and shorter time to castration-resistant progression. These data suggest that immunostaining for ETS-1 could be a molecular marker for predicting a poor clinical outcome for PCa patients, oarticularlv those with hi^h-risk disease.

关键词： castration resistant E26 transformation-specific-1 (ETS-1) immunohistochemistry prostate cancer

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Laterally spreading tumors:Limitations of computed tomography colonography

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World Journal of Gastroenterology 2014年第46期20卷 17552-17557页

作者： Kazutomo Togashi Kenichi Utano Shigeyoshi Kijima yosuke Sato Hisanaga Horie Keijirou Sunada Alan T Lefor Hideharu Sugimoto Yoshikazu Yasuda Department of Coloproctology Aizu Medical CenterFukushima Medical UniversityAizuwakmatsu-cityFukushima 969-3492Japan Department of Surgery Jichi Medical UniversityShimotsukeTochigi 329-0498Japan Department of Radiology Jichi Medical UniversityShimotsukeTochigi 329-0498Japan Department of Gastroenterology Jichi Medical UniversityShimotsukeTochigi 329-0498Japan

AIM: To prospectively investigate the detection rate of laterally spreading tumors (LSTs) of the colorectum by computed tomography (CT) colonography (CTC).

关键词： Computed tomography colonography Laterally spreading tumor Colon neoplasm Advanced lesion Flat adenoma Detection rate

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Development and first evaluation of an attractant impregnated adhesive tape against blood-sucking flies

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Insect Science 2022年第2期29卷 603-612页

作者： Junwei J.Zhu Gwang-Hyun Roh yosuke Asamoto Kujtim Bizati Jen-Chieh Liu Alexander Lehmann Kyle Harrison David BTaylor Hironao Otake Agroecosystem Management Research Unit US Department of AgricultureAgricultural Research ServiceLincolnNebraskaUSA US Pacific Basin Agricultural Research Center US Department of AgricultureAgricultural Research ServiceHiloHawaiiUSA Oak Ridge Institute for Science and Education Oak RidgeTennesseeUSA Nitto Inc. TeaneckNew JerseyUSA Department of Entomology University of NebraskaLincolnNebraskaUSA

Stable flies are one of the most important arthropod pests of livestock that reduce cattle weight gain and milk production leading to annual economic losses in excess of$2 billion to the US cattle *** host-seeking behavior is primarily mediated by associated odors from stable fly larval development environments and host *** present paper reports the development and evaluation of attractant-impregnated adhesive tapes to reduce stable fly attacks on *** bioassays showed that only m-cresol impregnated adhesive tapes caught significantly more stable flies(16±1)than the control tape without attractant added(7±1),with a 77%fly recapture ***-impregnated adhesive tapes deployed in cattle feedlots showed significant impacts in reducing fly population,with a total of one million stable flies captured over a period of three weeks(mean catches from 57596 to 102088 stable flies per trap per week).It further relieved cattle stress with a significant reduction of biting fly avoidance behavior,(6±0.4 cows observed with tail wagging in control vs.3±0.4 from the trap-deployed).The efficacy of the developed tapes lasted up to 1-week longevity,although 70%of m-cresol was released starting from the second *** m-cresol impregnated adhesive tape provided an 80%reduction in cattle stress due to stable fly *** is the first report of a technology developed by integrating an attractant compound into an adhesive material on a plastic film with demonstrated effectiveness in trapping biting flies that attack livestock animals.

关键词： cattle stress reduction mass trapping m-cresol-impregnated adhesive tapes Stomoxys calcitrans

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Horizontal structure of convergent wind shear associated with sporadic E layers over East Asia

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Earth and Planetary Physics 2023年第5期7卷 548-557页

作者： LiHui Qiu Xian Lu Tao Yu yosuke Yamazaki HuiXin Liu Yang-Yi Sun HaoNan Wu XiaoMin Zuo XiangXiang Yan Yan Yu YiFan Qi Institute of Geophysics&Geomatics China University of GeosciencesWuhan 430074China Department of Physics and Astronomy Clemson UniversityClemsonSC 29631USA Leibniz institute of Atmospheric Physics at the University of Rostock 18225 KühlungsbornGermany Department of Earth and Planetary Sciences Kyushu UniversityFukuoka 8190395Japan School of Mathematics and Physics China University of GeosciencesWuhan 430074China

At present,the main detection instruments for observing sporadic E(Es)layers are ground-based radars,dense networks of ground-based global navigation satellite system(GNSS)receivers,and GNSS radio occultation,but they cannot capture the whole picture of the horizontal structure of Es *** study employs the Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension model(WACCM-X 2.1)to derive the horizontal structure of the ion convergence region(HSICR)to explore the shapes of the large-scale Es layers over East Asia for the period from June 1 to August 31,*** simulation produced the various shapes of the HSICRs elongated in the northwest-southeast,northeast-southwest,or composed of individual small *** close connection between Es layer critical frequency(foEs)and vertical ion convergence indicates that the HSICR is a good candidate for revealing and explaining the horizontal structure of the large-scale Es layers.

关键词： sporadic E layer horizontal structure wind shear WACCM-X model

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The Effect of Workplace-Based Sports Participation on the Mental Status of Japanese Workers

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Journal of Power and Energy Engineering 2023年第3期11卷 150-156页

作者： yosuke Shibata Yasunari Kurita Toshiyuki Ojima Department of Community Health and Preventive Medicine Hamamatsu University School of Medicine Hamamatsu Japan Department of Shizuoka Physical Therapy Faculty of Health Science Tokoha University Shizuoka Japan

Whether workplace-based sports are part of a company’s employee welfare program in terms of mental status is unknown. This study examined the impact of workplace-based sports participation on the mental status of Japanese workers. It involved a single-arm intervention comprising participation in a company’s volleyball team. Data on mental status were collected using a simplified version of the Brief Job Stress Questionnaire. Overall, 11 individuals participated, 9 (81.8%) of whom were women;the mean participant age was 38.2 years. Because the intervention was conducted during busy periods, the median (25th and 75th percentiles) score for qualitative job overload significantly increased from 3.0 (2.0, 4.0) to 3.0 (3.0, 4.3) (p = 0.03). Nonetheless, the fatigue score significantly decreased from 3.0 (3.0, 4.3) to 3.0 (2.0, 4.0) (p = 0.03). These results indicate that participation in workplace-based sports can prevent the deterioration of mental status during busy periods.

关键词： Mental Health Occupational Stress Team Sports Volleyball Occupation Groups

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Investigation of emission properties of Tm^(3+) :Y_2O_3 transparent ceramic

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Chinese Optics Letters 2012年第9期10卷 67-71页

作者：易庆 Taiju Tsuboi 周圣明 yosuke Nakai 林辉腾浩 Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Faculty of Engineering Kyoto Sangyo University

A transparent and emitting ceramic of Y203 doped with 6% Tm3＋ ions is fabricated by vacuum sintering with ZrO2. Absorption, photoluminescence （PL）, and PL excitation （PLE） spectra are investigated in a spectral range of 200 to 2 100 nm at various temperatures between 296 and 12 K. Intense emission band appears at 450 to 465 nm in the visible range. Near-infrared emission bands are observed at 1 200 to 1 300 nm and 1400 to 1 550 nm, with intense peaks at 1270, 1450, and 1 523 nm. The luminescence mechanisms and potential applications of the emissions are discussed with the help of Judd-Ofelt theory and PLE spectra.

关键词： Tm Y2O3 transparent ceramic

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HALF-CUTTING METHOD during Hysterectomy for Large Uterine Cervical Myoma

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Open Journal of Obstetrics and Gynecology 2021年第9期11卷 1196-1201页

作者： yosuke Fukui Yuki Yamada Seiji Mabuchi Department of Obstetrics and Gynecology Nara Medical University Kashihara Japan Department of Gynecology Osaka International Cancer Institute Osaka Japan

Hysterectomy for large uterine cervical myoma is a challenging surgical procedure due to the limited operative field for lateral and posterior dissections. Existing procedures such as performing myomectomy before hysterectomy or performing retrograde hysterectomy remain suboptimal in expanding the operative field, especially in cases with a huge cervical myoma. In this report, we introduce a new procedure, the “HALF-CUTTING METHOD” which can be used to obtain an adequate surgical field during hysterectomy.

关键词： HALF-CUTTING METHOD Cervical Myoma Hysterectomy Surgical Field

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Endoscopic submucosal dissection for colorectal neoplasms:A review

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World Journal of Gastroenterology 2014年第43期20卷 16153-16158页

作者： Taku Sakamoto Genki Mori Masayoshi Yamada Yuzuru Kinjo Eriko So Seiichiro Abe yosuke Otake Takeshi Nakajima Takahisa Matsuda Yutaka Saito Endoscopy Division National Cancer Center Hospital

The introduction of colorectal endoscopic submucosal dissection(ESD)has expanded the application of endoscopic treatment,which can be used for lesions with a low metastatic potential regardless of their *** has the advantage of achieving en bloc resection with a lower local recurrence rate compared with that of piecemeal endoscopic mucosal ***,in the past,surgery was indicated in patients with large lesions spreading to almost the entire circumference of the rectum,regardless of the depth of invasion,as endoscopic resection of these lesions was technically ***,a prime benefit of ESD is significant improvement in the quality of life for patients who have large rectal *** the other hand,ESD is not as widely applied in the treatment of colorectal neoplasms as it is in gastric cancers owing to the associated technical difficulty,longer procedural duration,and increased risk of *** diversify the available endoscopic treatment strategies for superficial colorectal neoplasms,endoscopists performing ESD need torecognize its indications,the technical issues involved in its application,and the associated *** review outlines the methods and type of devices used for colorectal ESD,and the training required by endoscopists to perform this procedure.

关键词： Colorectum Endoscopic submucosal dissection Short-term outcomes Training indication for endoscopic treatment

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Temperature effect on emission spectra and fluorescence lifetime of the ~4I_(13/2) state of Er^(3+)-doped Gd_2SiO_5 crystal

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Chinese Optics Letters 2011年第9期9卷 60-63页

作者：丁雨憧赵广军 yosuke Nakai Taiju Tsuboi Key Laboratory of Materials for High Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences Faculty of Engineering Kyoto Sangyo University

By measuring the emission spectra and the fluorescence lifetime of the ^4I13/2 state of Er^3＋ ions in Gd2SiO5 crystal at different temperatures, the effects of temperature on the spectra and the lifetime of the ^4I13/2 state are investigated. When the temperature increases, the emission line width for the ^4I13/2 →^4I15/2 transition is broadened, and the main emission lines at 1 596, 1 609, and 1 644 nm shifte toward shorter wavelengths. The measured lifetime of the ^4I13/2 state decreases from 13.2 to 8.4 ms with temperature increase from 13 to 300 K, which is mainly due to the temperature dependence of multiphonon relaxation between the ^4I13/2 and ^4I15/2 states and the changing population distribution among the Stark levels within the ^4I13/2 state. The experimental results imply that low temperature condition is better for the -l.6μm laser output.

关键词： Electromagnetic wave emission Emission spectroscopy Erbium Fluorescence Gadolinium Silicon compounds

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Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection

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World Journal of Gastroenterology 2020年第35期26卷 5354-5361页

作者： Toshihiro Nishizawa Kosuke Sakitani Hidekazu Suzuki Shuntaro Yoshida yosuke Kataoka Yousuke Nakai Hirotoshi Ebinuma Takanori Kanai Osamu Toyoshima Kazuhiko Koike Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 1570066Japan Department of Gastroenterology Narita HospitalInternational University of Health and WelfareChiba 2868520Japan Department of Gastroenterology Sakitani Endoscopy ClinicChiba 2740825Japan Department of Internal Medicine Tokai University School of MedicineKanagawa 2591193Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 1138655Japan Department of Internal Medicine Keio University School of MedicineTokyo 1608582Japan

We have previously reported that Helicobacter pylori(***)-associated nodular gastritis could occur in both the antrum and the *** nodularity-like appearance(hereafter,called as cardiac nodularity)had a high predictive accuracy for the diagnosis of *** *** the previous study,we included only the patients who were evaluated for *** infection for therst time,and excluded patients with a history of ***,the prevalence and clinical features of cardiac nodularity remains *** To perform this cross-sectional study to explore the characteristics of cardiac *** Consecutive patients who underwent esophagogastroduodenoscopy betweenMay,2017 and August,2019 in the Toyoshima Endoscopy Clinic were enrolled in this *** included ***-negative,***-positive,and *** patients,and excluded patients with unclear *** status and eradication *** infection was diagnosed according to serum *** antibody and the urea breath test or *** nodularity was defined as a miliary nodular appearance or the presence of scattered whitish circular small colorations within 2 cm of the esophagogastric *** was visualized as whitish in the narrow-band imaging *** collected data on the patients’baseline *** A total of 1078 patients were finally *** ***-negative patients,cardiac nodularity and antral nodularity were recognized in 0.14%*** ***-positive patients,cardiac nodularity and antral nodularity were recognized in 54.5%and 29.5%,*** ***-eradicated patients,cardiac nodularity and antral nodularity were recognized in 4.5%and 0.6%,*** frequency of cardiac nodularity was significantly higher than that of antral nodularity in ***-positive and-eradicated *** frequencies of cardiac nodularity and antral nodularity in ***-eradicated patients were significa

关键词： Cardia Nodularity Helicobacter pylori Diagnosis Gastritis

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