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Effects of ethanol and sex on propionate metabolism evaluated via a faster ^(13)C-propionate breath test in rats

World Journal of Gastroenterology 2023年第21期29卷 3269-3279页

作者： yosuke sasaki Naoyuki Kawagoe Tsunehiko Imai Yoshihisa Urita Department of General Medicine and Emergency Care Toho University School of MedicineTokyo 143-8541Japan

BACKGROUND Alcoholism is regarded as a risk factor for vitamin B_(12)(VB_(12))*** V B_(12) serves as a coenzyme of methylmalonyl-CoA mutase,a key enzyme in propionate metabolism,the ^(13)C-propionate breath test(PBT)has been studied as a non-invasive diagnostic modality for VB_(12) ***,the conventional PBT requires 2 h,which is inconvenient in clinical *** hypothesized that a faster PBT can be used to evaluate propionate metabolism and is more easily adaptable for clinical *** To evaluate a faster PBT for assessing the effects of long-term ethanol consumption on propionate metabolism in ethanol-fed rats(ERs).METHODS ERs were obtained by replacing standard drinking water(for control rats,CRs)with 16%ethanol solution in descendants of F344/DuCrj *** PBT was performed by administering ^(13)C-propionate aqueous solution to male and female ERs and CRs by inserting a metal tubule from the mouth to the stomach;exhaled gas was collected in a bag to measure its ^(13)CO_(2)/12CO_(2) isotope ratio via infrared isotope *** VB_(12) and alanine transaminase(ALT)levels were measured via chemiluminescence immunoassay and the lactate dehydrogenaseultraviolet method,*** evaluated statistical differences in mean body weight,change in ^(13)CO_(2)(Δ^(13)CO_(2)‰),peakΔ^(13)CO_(2)‰,and serum VB_(12) and ALT,between males and females and between ERs and CRs using the t-test and Mann-Whitney U test for normally and non-normally distributed variables,*** Males weighed significantly more than females(P<0.001);CRs weighed significantly more than ERs(P<0.008).Δ^(13)CO_(2) reached a peak(C_(max))at 20 min and 30 min in females and males,respectively,decreasing after 20-30 min without rebound in all *** had significantly higher C_(max) andΔ^(13)CO_(2) at 15-45 min than females(P<0.05;for all pairs).Propionate metabolism was enhanced in male ERs relative to male CRs,whereas metabolism did no

关键词： Alcoholism Breath test Carbon isotope Gut flora Propionate Vitamin B12

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Clinical differentiation of acute appendicitis and right colonic diverticulitis: A case-control study

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World Journal of Clinical Cases 2019年第12期7卷 1393-1402页

作者： yosuke sasaki Fumiya Komatsu Naoyasu Kashima Takahiro Sato Ikutaka Takemoto Sho Kijima Tadashi Maeda Takamasa Ishii Taito Miyazaki Yoshiko Honda Nagato Shimada Yoshihisa Urita Department of General Medicine and Emergency Care Toho University School of Medicine

BACKGROUND Acute right colonic diverticulitis (ARCD) is an important differential diagnosis of acute appendicitis (AA) in Asian countries because of the unusually high prevalence of right colonic diverticula. Due to qualitative improvement and the high penetration rate of computed tomography (CT) scanning in Japan, differentiation of ARCD and AA mainly depends on this modality. But cost, limited availability, and concern for radiation exposure make CT scanning problematic. Differential findings of ARCD from AA are based on several small studies that used univariate comparisons from Korea and Taiwan. Previous studies on clinical and laboratory differences between AA and ARCD are limited. AIM To determine clinical differences between AA and ARCD for differentiation of these two diagnoses by creating a logistic regression model. METHODS We performed an exploratory single-center retrospective case-control study evaluating 369 Japanese patients (age ≥ 16 years), 236 (64.0%) with AA and 133 (36.0%) with ARCD, who were hospitalized between 2012 and 2016. Diagnoses were confirmed by CT images. We compared age, sex, onset-to-visit interval, epigastric/periumbilical pain, right lower quadrant (RLQ) pain, nausea/vomiting, diarrhea, anorexia, medical history, body temperature, blood pressure, heart rate, RLQ tenderness, peritoneal signs, leukocyte count, and levels of serum creatinine, serum C-reactive protein (CRP), and serum alanine aminotrans-ferase. We subsequently performed logistic regression analysis for differentiating AA from ARCD based on the results of the univariate *** In the AA and ARCD groups, median ages were 35.5 and 41.0 years, respectively (p=0.011);median onset-to-visit intervals were 1 [interquartile range (IQR): 0-1] and 2 (IQR: 1-3) days, respectively (P < 0.001);median leukocyte counts were 12600 and 11500/mm3, respectively (P = 0.002);and median CRP levels were 1.1 (IQR: 0.2-4.1) and 4.9 (IQR: 2.9-8.5) mg/dL, respectively (P < 0.001). In th

关键词： Abdominal pain Acute abdomen Appendicitis Clinical difference Creactive protein Diverticulitis Right lower quadrant pain

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Clinical prediction of complicated appendicitis:A case-control study utilizing logistic regression

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World Journal of Clinical Cases 2020年第11期8卷 2127-2136页

作者： yosuke sasaki Fumiya Komatsu Naoyasu Kashima Takeshi Suzuki Ikutaka Takemoto Sho Kijima Tadashi Maeda Taito Miyazaki Yoshiko Honda Hiroaki Zai Nagato Shimada Kimihiko Funahashi Yoshihisa Urita Department of General Medicine and Emergency Care Toho University School of MedicineOta-kuTokyo 143-8541Japan Department of General and Gastroenterological Surgery Toho University Omori Medical CenterOtakuTokyo 143-8541Japan

BACKGROUND Since high-quality evidence on conservative treatment of acute appendicitis using antibiotics has increased,differentiation of patients with complicated appendicitis(CA)from those with simple appendicitis(SA)has become increasingly *** studies have revealed that male gender,advanced age,comorbid conditions,prehospital delay,fever,and anorexia are risk factors of perforated *** serum C-reactive protein(CRP)level and hyponatremia have also been reported as predictive biomarkers of ***,confounding between various factors is problematic because most previous studies were limited to univariate *** To evaluate non-laboratory and laboratory predictive factors of CA using logistic regression *** We performed an exploratory,single-center,retrospective case-control study that evaluated 198 patients(83.9%)with SA and 38 patients(16.1%)with *** were confirmed by computed tomography images for all *** compared age,sex,onset-to-visit interval,epigastric/periumbilical pain,right lower quadrant pain,nausea/vomiting,diarrhea,anorexia,medical history(of previous non-surgically treated appendicitis,diabetes,hypertension,dyslipidemia,liver cirrhosis,hemodialysis,chronic lung diseases,malignant tumors,immunosuppressant use,and antiplatelet use),vital signs,physical findings,and laboratory data to select the explanatory variates for logistic *** on the univariate comparisons,we performed logistic regression for clinical differentiation between CA and SA using only nonlaboratory factors and also including both non-laboratory and laboratory *** The 236 eligible patients consisted of 198 patients(83.9%)with SA and 38 patients(16.1%)with *** median ages were 34 years old[interquartile ranges(IR),24-45 years]in the SA group and 49 years old(IR,35-63 years)in the CA group(P<0.001).The median onset-to-visit interval was 1 d(IR,0-1)and 1 d(IR,1-2)in the SA and CA groups,respectively

关键词： Acute abdomen Abscess Appendicitis C-reactive protein Forecasting Intestinal perforation

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Coulometric determination of dissolved hydrogen with a multielectrolytic modified carbon felt electrode-based sensor

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Journal of Environmental Sciences 2013年第6期25卷 1077-1082页

作者： Hiroaki Matsuura yosuke Yamawaki Kosuke sasaki Shunichi Uchiyama Department of Life Science & Green Chemistry Faculty of EngineeringSaitama Institute of Technology Department of Applied Chemistry Graduate School of EngineeringSaitama Institute of Technology

A multielectrolytic modified carbon electrode （MEMCE） was fabricated by the electrolytic-oxidation/reduction processes. First, the functional groups containing nitrogen atoms such as amino group were introduced by the electrode oxidation of carbon felt electrode in an ammonium carbamate aqueous solution, and next, this electrode was electroreduced in sulfuric acid. The redox waves between hydrogen ion and hydrogen molecule at highly positive potential range appeared in the cyclic voltammogram obtained by MEMCE. A coulometric cell using MEMCE with a catalytic activity of electrooxidation of hydrogen molecule was constructed and was used for the measurement of dissolved hydrogen. The typical current vs. time curve was obtained by the repetitive measurement of the dissolved hydrogen. These curves indicated that the measurement of dissolved hydrogen was finished completely in a very short time （ca. 10 sec）. A linear relationship was obtained between the electrical charge needed for the electrooxidation process of hydrogen molecule and dissolved hydrogen concentration. This indicates that the developed coulometric method can be used for the determination of the dissolved hydrogen concentration.

关键词： multielectrolytic modified carbon electrode (MEMCE) coulometric determination dissolved hydrogen

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Response of Stretched Cylindrical Diffusion Flame to Sinusoidal Oscillation of Air Flow Velocity

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Journal of Mechanics Engineering and Automation 2017年第6期7卷 321-326页

作者： yosuke Suenaga Hideki Yanaoka Mamoru Kikuchi Shun sasaki Department of Systems Innovation Science Iwate University Morioka 020-8551 Japan Mazda Motor Corporation Hiroshima 730-8670 Japan

An experimental study investigated the characteristics of a stretched cylindrical diffusion flame, with a convex curvature with respect to the air stream, in response to periodic air flow velocity oscillation. The fuel was methane diluted with nitrogen, and the oxidizer air. The oscillation frequency was varied from 5 to 250 Hz. The results are summarized as follows. Though the fluctuation amplitude of the air stream velocity gradient was constant with respect to the frequency, the amplitude of the fuel stream increased. The fluctuation amplitude of the flame radius changed quasi-steadily from 5 to 25 Hz, and decreased with increasing frequency in the frequency range greater than 50 Hz. The flame luminosity did not respond quasi-steadily at 5 Hz, and the oscillation amplitude of flame luminosity was less than that of a steady flame, over the same velocity fluctuation range. The oscillation amplitude of luminosity peaked at 50 Hz, and was greater than that of a steady flame. It is considered that this complex change in flame luminosity with respect to frequency was closely related to the phase difference in the respective time variations in the ratio of flame thickness to radius, the velocity gradients of the air and fuel streams, and the magnitude of these values, with the ratio of flame thickness to radius related to the flame curvature effect, the velocity gradient of the air stream correlated to the flame stretch effect, and the velocity gradient of the fuel stream impacting the fuel transportation.

关键词： Combustion diffusion flame velocity oscillation flame stretch flame curvature

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Contrast enhanced ultrasound of hepatocellular carcinoma

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World Journal of Radiology 2010年第2期2卷 68-82页

作者： Kazushi Numata Manabu Morimoto Masaaki Kondo yosuke Kunishi Tomohiko sasaki Akito Nozaki Katsuaki Tanaka Gastroenterological Center Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan

Sonazoid(Daiichi Sankyo,Tokyo,Japan),a secondgeneration of a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent,has been used clinically in patients with liver tumors and for harmonic gray-scale ultrasonography(US)in Japan since January ***-enhanced US has two phases of contrast enhancement:vascular and *** the late phase of Sonazoid-enhanced US,we scanned the whole liver using this modality at a low mechanical index(MI)without destroying the microbubbles, and this method allows detection of small viable hepatocellular carcinoma(HCC)lesions which cannot be detected by conventional US as perfusion defects in the late ***-injection of Sonazoid into an HCC lesion which previously showed a perfusion defect in the late phase is useful for confirming blood flow intothe *** MI intermittent imaging at 2 frames per second in the late phase is also helpful in differentiation between necrosis and viable hypervascular HCC ***-enhanced US by the coded harmonic angio mode at a high MI not only allows clear observation of tumor vessels and tumor enhancement, but also permits automatic scanning with Sonazoidenhanced three dimensional(3D)*** images combining US with contrast-enhanced CT or contrastenhanced MRI have made it easy to detect typical or atypical HCC *** these methods,Sonazoidenhanced US can characterize liver tumors,grade HCC lesions histologically,recognize HCC dedifferentiation, evaluate the efficacy of ablation therapy or transcatheter arterial embolization,and guide ablation therapy for unresectable *** article reviews the current developments and applications of Sonazoid-enhanced US and Sonazoid-enhanced 3D US for diagnosing and treating hepatic lesions,especially HCC.

关键词： Sonazoid Contrast-enhanced ultrasonography Contrast-enhanced three-dimensional ultrasonography Hepatic tumor Hepatocellular carcinoma Fusion image

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Impact of PSF and TOF in PET/CT:Performance evaluation and initial experience

Impact of PSF and TOF in PET/CT:Performance evaluation and i...

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2010中华医学会影像技术分会第十八次全国学术大会

作者： Katsuhiko Mitsumoto yosuke Tachiya Nobuyoshi Ohya Shinzo Takagi Masayuki sasaki Department of Health Sciences Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Kyushu University Hospital FukuokaJapan Department of Health Sciences Faculty of Medical SciencesKyusyu UniversityFukuokaJapan

Objective:We examined the effect of PSF and/or TOF on image quality of reconstructed PET/CT images. Methods:The NEMA IEC Body Phantom was *** background and spheres were filled with 18F solution to achieve a source-to...

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Clinical Outcomes of Patients Who Perform High-Load Activities after Total Hip Arthroplasty in Snowy Agricultural Areas

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Surgical Science 2018年第8期9卷 248-255页

作者： Tetsuya Kawano Hiroaki Kijima Toshiaki Aizawa Shin Yamada Natsuo Konishi Hitoshi Kubota Hiroshi Tazawa Takayuki Tani Norio Suzuki Keiji Kamo Yoshihiko Okudera Ken sasaki Masashi Fujii yosuke Iwamoto Itsuki Nagahata Takanori Miura Naohisa Miyakoshi Yoichi Shimada Department of Orthopedic Surgery Kita-Akita Municipal Hospital Akita Japan Akita Hip Research Group Akita Japan Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: In snowy agricultural areas, weeding and snow shoveling are essential activities, and sports activities are common recreational activities. Clarifying the relationships between the degrees of these activities after total hip arthroplasty (THA) and the clinical outcomes may enable us to predict the results of THA for high-load activity patients. Methods: The subjects were 227 post-THA patients who were followed up between 2012 and 2014. Patient-reported outcomes were investigated by the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) and a questionnaire on postoperative activity. In addition, the Japanese Orthopaedic Association Hip Score (JOA score) was used to quantify hip function. Results: Patients who resumed activities had significantly higher JOA and JHEQ scores than patients who had given up their activities. However, 25.8% of patients had not resumed weeding with a squatting posture. Furthermore, 20% had not resumed sports activities. The most common reason for giving up these activities was fear of implant failure. Conclusions: If the patients were informed that there is no problem restarting their activities after THA, the patients could resume activities and their clinical outcomes may be improved.

关键词： Total Hip Arthroplasty Postoperative Activities Weeding Snow Shoveling

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神经胶质细胞对平行记忆形成的调节

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神经损伤与功能重建 2023年第8期18卷 F0003-F0003页

作者： Teppei Kanaya Ryo Ito yosuke M Morizawa Daichi sasaki Hiroki Yamao Hiroshi Ishikane Yuichi Hiraoka Kohichi Tanaka Ko Matsui Super Network Brain Physiology Graduate School of MedicineTohoku UniversitySendaiJapan Super Network Brain Physiology Graduate School of Life SciencesTohoku UniversitySendaiJapan Department of Psychology Graduate School of HumanitiesSenshu UniversityKawasakiJapan Laboratory of Molecular Neuroscience Medical Research Institute(MRI)Tokyo Medical and Dental University(TMDU)TokyoJapan.

神经胶质细胞的活动可以影响学习和记忆的储备和效率。本研究采用小脑依赖水平光动力反应运动学习小鼠模型,研究在线训练期间短期记忆(STM)的形成和离线休息期间长期记忆(LTM)的形成。研究显示,在线和离线学习效果的差异很大。STM早期... 详细信息

神经胶质细胞的活动可以影响学习和记忆的储备和效率。本研究采用小脑依赖水平光动力反应运动学习小鼠模型,研究在线训练期间短期记忆(STM)的形成和离线休息期间长期记忆(LTM)的形成。研究显示,在线和离线学习效果的差异很大。STM早期形成较好者的LTM形成往往受到抑制,而没有明显急性训练效果的STM形成较晚者常常在离线学习中有明显提高。含有LRRC8A的阴离子通道可释放谷氨酸。在星形胶质细胞(包括小脑伯格曼胶质细胞)中特异性地条件性敲除LRRC8A导致STM形成的完全丧失,而在休息期间LTM形成仍然存在。在线训练期间,通过通道视紫红质-2或古菌红素-T(ArchT)对神经胶质细胞的活性进行光遗传学调控,可分别导致STM形成的增强或抑制。STM和LTM可能在在线训练期间同时触发,但LTM在离线期的后期才表达。STM似乎并不稳定,在线培训期间的形成的记忆并没有在LTM中出现。此外,我们发现在休息期间,胶质细胞ArchT的光活化导致LTM形成的增加。这些数据表明STM的形成和LTM的形成是平行的独立过程。可以根据胶质细胞的反应来决定策略的重点是STM还是LTM。

关键词：伯格曼胶质细胞小脑运动学习水平光动力学反应光遗传学并行存储器形成

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