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High doses of bifendate elevate serum and hepatic triglyceride levels in rabbits and mice: animal models of acute hypertriglyceridemia

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Acta Pharmacologica Sinica 2006年第6期27卷 673-678页

作者： kam-ming KO China Clear Water Bay Department of Biochemistry Hong Kong University of Science & Technology

Aim:To investigate the effects of bifendate on serum and hepatic lipids level inrabbits and ***:Animals were administered bifendate[powdered pillsuspended in 0.5% sodium carboxymethylcellulose(CMC)]at increasing doses(0.25-1 g/kg,ig).Blood lipid and apolipoprotein levels were measured usingcommercially available assay ***:The treatment of rabbits with a singledose of bifendate(0.3 g/kg)caused a time-dependent and biphasic change inserum triglyceride(TG)levels,with the value reaching a maximum(3-fold increasecompared to the baseline value)between 24 and 36 h *** micewere orally treated with bifendate(0.25-1 g/kg),serum TG levels increased by39%-76% and 14%-39% at 24 and 48 h post-dosing,*** given atdaily doses of 0.25 and 1 g/kg for 4d,bifendate increased serum TG levels(56%-79%),with concomitant elevations in apolipoprotein A-I and apolipoprotein Blevels at 24 h after the last *** levels were also increased(11%—43%)inliver samples of mice receiving single or multiple doses of ***,bifendate treatment caused slight reductions in serum and hepatic total choles-terol levels(9%-13%).The hypertriglyceridemia induced by bifendate was ame-liorated by fenofibrate but not inositol nicotinate treatment in ***:The findings suggest that bifendate treatment at high oral doses can cause anacute elevation in serum and hepatic TG levels.

关键词： bifendate fenofibrate inositol nicotinate triglycerides total cholesterol acute hypertriglyceridemia

Homoclinic and heteroclinic solutions of cubic strongly nonlinear autonomous oscillators by hyperbolic Lindstedt-Poincaré method

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Science China(Technological Sciences) 2010年第3期53卷 692-702页

作者： SZE kam Yim Department of Mechanical Engineering The University of Hong Kong

The hyperbolic Lindstedt-Poincaré method is applied to determine the homoclinic and heteroclinic solutions of cubic strongly nonlinear oscillators of the form x + c1 x + c3 x 3= ε f (μ,x,x).In the method,the hyperbolic functions are employed instead of the periodic functions in the Lindstedt-Poincaré *** value of parameter μ under which there exists homoclinic or heteroclinic orbit can be determined by the perturbation *** applications are studied in *** illustrate the accuracy of the present method,its predictions are compared with those of Runge-Kutta method.

关键词： Lindstedt-Poincaré Method nonlinear autonomous oscillator homoclinic orbit heteroclinic orbit

OPTIMAL PROPORTIONAL REINSURANCE UNDER DEPENDENT RISKS

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Journal of Systems Science & Complexity 2012年第6期25卷 1171-1184页

作者： Fengqing HU kam C YUEN Department of Mathematics and Center for Financial Engineering Soochow University Department of Statistics and Actuarial Science University of Hong KongHong KongChina

This paper considers a correlated risk model with thinning-dependence structure. The au- thors investigate the optimal proportional reinsurance that maximizes the adjustment coefficient and the optimal proportional reinsurance under mean variance principle for the proposed model. The au- thors derive the optimal solutions and the numerical illustrations to show the impact of the dependence among the classes of business on the optimal reinsurance arrangements.

关键词： Adjustment coefficient mean-variance principle optimal proportional reinsurance thinning-dependence structure.

铜绿假单胞菌对肺血管内皮细胞功能的影响及其机制

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中国医学科学院学报 2024年第1期46卷 1-10页

作者：张雷王俊轶何翔吴敏李国平黄锦伟澳门科技大学中药质量研究国家重点实验室中国澳门999078 成都市第三人民医院呼吸健康研究所过敏与精准医学实验室成都610000 北达科他大学医学与健康科学院生物医学科学系美国北达科他州大福克斯58203 中国科学院大学温州研究院浙江温州325000

目的探究铜绿假单胞菌(PA)感染对肺血管内皮细胞功能的影响,并探讨其加重小鼠肺部炎症反应的可能机制。方法PAO1菌株感染人肺微血管内皮细胞HULEC-5a 2 h后,采用逆转录实时荧光定量PCR(RT-qPCR)检测自噬相关基因5(ATG5)、6-磷酸果糖-2-... 详细信息

目的探究铜绿假单胞菌(PA)感染对肺血管内皮细胞功能的影响,并探讨其加重小鼠肺部炎症反应的可能机制。方法PAO1菌株感染人肺微血管内皮细胞HULEC-5a 2 h后,采用逆转录实时荧光定量PCR(RT-qPCR)检测自噬相关基因5(ATG5)、6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3(PFKFB3)和钙黏蛋白5(CDH5)的mRNA表达,免疫荧光检测ATG5、PFKFB3和血管内皮钙黏蛋白(VE-cadherin)的蛋白表达。采用小干扰RNA(siRNA)分别敲减ATG5、PFKFB3后,RT-qPCR检测ATG5、PFKFB3和CDH5的mRNA表达,免疫荧光检测PFKFB3和VE-cadherin的蛋白表达,并采用乳酸测定试剂盒检测细胞内乳酸的水平。采用PAO1菌株感染小鼠后,肺组织切片病理染色观察小鼠肺部炎症,激光共聚焦显微镜观察并分析荧光标记的内皮细胞PFKFB3和VE-cadherin的表达量。结果与对照组比较,PAO1感染HULEC-5a细胞后,PFKFB3 mRNA和蛋白表达均增加(P均<0.05),CDH5 mRNA表达减少(P=0.023),VE-cadherin蛋白表达减少(P<0.001),且连续性被破坏,乳酸含量升高(P=0.017)。与PAO1感染HULEC-5a细胞比较,PAO1感染敲减PFKFB3的HULEC-5a细胞后,CDH5 mRNA表达增加(P=0.043),VE-cadherin荧光连续性得到恢复,乳酸含量降低(P=0.047);PAO1感染敲减ATG5的HULEC-5a细胞后,PFKFB3 mRNA(P=0.013)和蛋白表达(P=0.003)均增加,CDH5 mRNA(P=0.020)和VE-cadherin蛋白表达(P=0.001)均减少,乳酸含量升高(P=0.015)。PAO1感染小鼠后,病理HE染色结果显示,肺泡内明显的红细胞渗漏,炎症细胞浸润,肺泡间隔增宽和部分血管内皮细胞脱落。免疫荧光染色结果显示,与正常小鼠比较,PAO1感染小鼠内皮细胞PFKFB3表达增加,VE-cadherin荧光减弱,且不连续。结论PA可能通过AGT5调控PFKFB3通路,破坏肺血管内皮细胞功能,进而加重小鼠肺部炎症反应。

关键词：铜绿假单胞菌肺血管内皮细胞 6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 自噬相关基因5 感染

Coefficients of symmetric square L-functions

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Science China Mathematics 2010年第9期53卷 2317-2328页

作者： LAU Yuk-kam Department of Mathematics The University of Hong Kong

Let λsym2f(n) be the n-th coefficient in the Dirichlet series of the symmetric square L-function associated with a holomorphic primitive cusp form *** prove Ω± results for λsym2f(n) and evaluate the number of posi... 详细信息

关键词： Fourier coefficients of modular forms B-free numbers

An omega result for supremum norms of Hecke-eigenforms in the level aspect

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Science China Mathematics 2010年第1期53卷 223-242页

作者： LAU Yuk-kam Department of Mathematics The University of Hong KongPokfulam RoadHong KongChina

This note is to remark the large supremum norms of some Hecke-eigenforms of large squarefree levels and nebentypus of small conductors,based on the recent prominent progress by Soundararajan on the extreme central val... 详细信息

关键词： Hecke-eigenforms central values of L-functions

Asymptotic Results for Tail Probabilities of Sums of Dependent and Heavy-Tailed Random Variables

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Chinese Annals of Mathematics,Series B 2012年第4期33卷 557-568页

作者： kam Chuen YUEN Chuancun YIN Department of Statistics and Actuarial Science The University of Hong Kong Pokfulam Road HongKong China. Corresponding author. School of Mathematical Sciences Qufu Normal University Qufu 273165 Shan- dong China

Abstract Let X1, X2,... be a sequence of dependent and heavy-tailed random variables with distributions F1, F2,.. on （-∞,∞）, and let T be a nonnegative integer-valued random variable independent of the sequence {Xk, k 〉 1}. In this framework, the asymptotic behavior of the tail probabilities of the quantities Sn = fi Xk and S（n） =∑ k=1 n 〉 1, and their randomized versions ST and S（τ） are studied. Some risk theory are presented. max Sk for 1〈k〈n applications to the

关键词： Asymptotic tail probability Copula Heavy-tailed distribution Partialsum Risk process

Mechanical and hydraulic properties of carbonate rock:The critical role of porosity

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 814-825页

作者： kam Ng J.Carlos Santamarina Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramieWY82071USA Physical Science and Engineering Division King Abdullah University of Science and TechnologyThuwal23955-6900Saudi Arabia

Carbonate rocks are extensively used in civil infrastructure and play a critical role in geoenergy geoengineering,either as hydrocarbon reservoirs or potential repositories for CO_(2)geological *** genesis and diagenetic overprint determine the properties of carbonate *** study combines recent data gathered from Madison Limestone and an extensive dataset compiled from published sources to analyze the hydraulic and mechanical properties of limestone carbonate *** models and data analyses recognize the inherently granular genesis of carbonate rocks and explain the strong dependency of physical properties on *** asymptotically-correct power model in terms of(1-Ф/Ф*)a is a good approximation to global trends of unconfined stiffness E and unconfined compressive strength UCS,cohesive intercept in Mohr-Coulomb failure envelopes,and the brittle-toductile transition *** power model is the analytical solution for the mechanical properties of percolating granular *** adopted a limiting granular porosityФ*=0.5 for all models,which was consistent with the loosest packing of monosize *** fitted power model has exponent(α=2)in agreement with percolation theory and highlights the sensitivity of mechanical properties to *** and models confirm a porosity-independent ratio between unconfined stiffness and strength,and the ratio follows a log-normal distribution with mean(E/UCS)≈*** high angle of internal shear strength measured for carbonate rocks reflects delayed contact failure with increased confinement,and it is not sensitive to *** spans more than six orders of *** size controls pore size and determines the reference permeability k^(*)at the limiting porosityФ*=*** a given grain size from fine to coarse-grained dominant carbonates,permeability is very sensitive to changes in porosity,suggesting preferential changes in the internal pore network during compaction.

关键词： Rock porosity Carbonate permeability Rock unconfined stiffness Unconfined compressive strength(UCS)

Are chaos and catastrophe theories relevant to environmental sciences?

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Journal of Environmental Sciences 1992年第1期4卷 39-42页

作者： John Kaihong kam Morrison Hill P. O. Box 47478 Hong Kong

Data acquired in the area of Environmental Sciences are by their very nature often discontinuous and abrupt. As such, the mathematical theories of catastrophe and chaos may be of use in analyzing such scientific data ... 详细信息

关键词： chaos catastrophe environment.