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Solid-state NMR of the retinal protonated Schiff base in microbial rhodopsins

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Magnetic Resonance Letters 2024年第3期4卷 11-18页

作者： Sari Kumagai Izuru kawamura Graduate School of Engineering Science Yokohama National UniversityYokohama240-8501Japan

Rhodopsin is a seven-helical transmembrane protein with a retinal chromophore covalently bound to a conserved lysine in helix G via a retinal protonated Schiff base(RPSB).Microbial rhodopsins absorb light through chromophore and play a fundamental role in *** microbial rhodopsins have been discovered,contributing to diverse functions and ***-state NMR spectroscopy has been instrumental in elucidating the conformation of chromophores and the three-dimensional structure of microbial *** review focuses on the 15N chemical shift values of RPSB and summarizes recent progress in the *** displayed the correlation between the 15N isotropic chemical shift values of RPSB and the maximum absorption wavelength of rhodopsin using solid-state NMR spectroscopy.

关键词： Membrane proteins Microbial rhodopsin Retinal Solid-state NMR Protonated Schiff base

Oxidation behavior and improvement in nonflammability of LPSO-type Mg–Zn–Y–Sr alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 742-749页

作者： Shin-ichi Inoue Kazumasa Iwanaga Yoshihito kawamura Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Materials Science Graduate School of Science and TechnologyKumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg_(97)Zn_(1)Y_(2)alloys with high ignition temperatures were developed by adding *** addition of Sr resulted in the formation of a uniform and thin Y_(2)O_(3)***–Zn–Y alloys containing at least 0.25 at.%Sr exhibited ignition temperatures of 1270–1320 *** a result of EDS measurement,Sr was found to be concentrated in the Y_(2)O_(3)*** addition,a mixed film of MgO and Sr O formed on the outer layer in the 1.5 at.%Sr-containing Mg_(97)Zn_(1)Y_(2)*** findings suggest that the uniform and thin Y_(2)O_(3)film that maintains high soundness at high temperatures was formed owing to valence control and the formation of a protective outer oxide film.

关键词： Magnesium alloy Yttrium Strontium High-temperature oxidation Nonflammability

Droplet morphology analysis of drop-on-demand inkjet printing

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China Foundry 2024年第1期21卷 20-28页

作者： Hu-xiang Xia Takechi Kensuke Tajima Shin kawamura Yoshiumi Qing-yan Xu Key Laboratory for Advanced Materials Processing Technology(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Toyota Central R&D Labs. Inc.41-1 Yokomichi NagakuteAichi 480-1192Japan Frontier Research Center Toyota Motor Corporation1 Toyota-ChoToyotaAichi 471-8572Japan

As an accurate 2D/3D fabrication tool,inkjet printing technology has great potential in preparation of micro electronic *** morphology of droplets produced by the inkjet printer has a great impact on the accuracy of *** this study,the drop-on-demand(DoD)inkjet simulation model was established,and the accuracy of the simulation model was verified by corresponding *** simulation result shows that the velocity of the droplet front and tail,as well as the time to disconnect from the nozzle is mainly affected by density(ρ),viscosity(μ)and surface tension(σ)of *** the liquid filament is about to disconnect from the nozzle,the filament length and filament front velocity are found to have a linear correlation withσ/ρμand ln(ρ/(μσ1/2)).

关键词： microdevice fabrication inkjet printing droplet morphology modeling and simulation

In-situ study of the microstructure evolution during tension of a Mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

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Journal of Magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián Máthis Péter Nagy Péter Jenei Zoltán Hegedus Andrea Farkas Jozef Vesely Shin-ichi Inoue Daria Drozdenko Yoshihito kawamura Department of Materials Physics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation(RSRC)technique exhibit an exceptional mechanical performance indicating promising application *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanoplates(CANaPs),or complete long period stacking ordered(LPSO)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in Mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial microstructure on the mechanical performance,additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation of the mechanical *** maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction profile analysis indicated that most dislocations formed during tension were of non-basal and pyramidal types,what was also in agreement with the Schmid factor values revealed independently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value,which was explained by a model of the interaction between prismatic dislocations and CANaPs/LPSO plates.

关键词： Mg-Zn-Y-Al alloy Long period stacking ordered(LPSO)phase Cluster arranged nanoplates(CANaPs) Annealing Tension Dislocation density Hardening

Usefulness of Newly Devised Clomiphene Citrate Administration Method Compared with the Conventional Method in Ovulation and Pregnancy

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 637-649页

作者： Makoto kawamura Misaki Akiyama Remi Nakajima Eri Satoi Yoko Ogaki Rieko Kanda Department of Obstetrics and Gynecology Kohseichuo General Hospital Tokyo Japan

Objective: Since not all women wish to conceive a child through aggressive treatment, we investigated the usefulness of modified repeated intracyclic clomiphene citrate (CC) therapy (repeated CC therapy) as a newly devised administration method. Methods: We evaluated the effects of CC administration on menstrual cycle length and retrospectively compared ovulation and pregnancy in 220 women who received CC at our hospital. Patients in the conventional method group received 50 mg per day for five days, starting on the fifth day of menstruation (withdrawal bleeding). Groups with and without menstrual cycle shortening after conventional CC administration were compared. The repeated CC therapy group was also compared with the non-shortened group. Repeated CC therapy was administered for the first five days as in the conventional method, and a second five-day repeat treatment was administered after an interval of five to seven days. Pregnancy rates, including indirect pregnancies, were evaluated by three different methods. Results: Ovulation and pregnancy rates were significantly better in the shortened group than in the non-shortened group (P < 0.001 and P = 0.010, respectively). Even in the non-shortened group, ovulation and pregnancy rates including indirect pregnancies were significantly improved when ovulation was observed with repeated CC therapy (P < 0.001 and P = 0.022, respectively). Conclusions: For patients whose menstrual cycle was not improved or shortened, repeated CC therapy as the newly devised CC administration method is useful as the next step after the conventional CC administration method.

关键词： Clomiphene Citrate Infertility Menstrual Cycle Ovulation Induction

Adult-Type Granulosa Cell Tumor with Similar Clinical Findings Seen during Ovarian Cystectomy Performed at the Same Time as Laparoscopic Ovarian Drilling for Polycystic Ovarian Syndrome: An Extremely Rare Case

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1197-1206页

作者： Remi Nakajima Risa Kobayashi Marie Kawai Eriko Sakamoto Miho Matsuda Rieko Kanda Makoto kawamura Department of Obstetrics and Gynecology Kohseichuo General Hospital. Tokyo Japan

Polycystic ovary syndrome (PCOS) is a major cause of anovulatory infertility. Laparoscopic ovarian drilling (LOD) is a treatment for PCOS that allows the laparoscopic identification of other intra-abdominal lesions and the provision of diagnostic treatment. This study reports a case of PCOS with an ovarian mass in which LOD was aggressively used and a granulosa cell tumor (GCT) was found. A 34-year-old woman with secondary amenorrhea and irregular menstrual cycles presented to the emergency department with abdominal pain of unknown etiology. Imaging studies revealed a 6-cm left ovarian mass with an internal appearance suggestive of a hemorrhage. The patient’s secondary amenorrhea was subsequently diagnosed as PCOS, and LOD was performed to preserve her fertility. Simultaneously, a cystectomy was performed to evaluate the tumor in the left ovary;the diagnosis was adult-type GCT. Although concomitant GCT and PCOS are extremely rare, the two conditions have similar clinical manifestations. In women of reproductive age, the impact of surgery on future fertility should be considered, and the initial surgical technique should be chosen carefully.

关键词： Polycystic Ovary Syndrome Laparoscopic Ovarian Drilling Granulosa Cell Tumor

Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience

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World Journal of Pediatrics 2019年第3期15卷 270-275页

作者： Kenji Kishimoto Masashi Kasai Noriko kawamura Yusuke Ito Makiko Yoshida Daiichiro Hasegawa Keiichiro Kawasaki yoshiyuki Kosaka Department of Hematology and Oncology Children’s Cancer CenterKobe Children’s HospitalMinatojima—Minamimachi 1—6-7Chuo—kuKobe 650—0047 Japan Department of Infectious Disease Kobe Children’s Hospital KobeJapan Department of Clinical Laboratory Kobe Children’s HospitalKobeJapan Department of Diagnostic Pathology Kobe Children’s HospitalKobeJapan Department of Pediatrics Kita—Harima Medical Center KobeJapan

Background There is limited information concerning the overall epidemiology of invasive fungal disease (IFD) in *** aim of this study was to clarify the clinical features of IFD in a tertiary pediatric care *** Patients diagnosed with proven or probable IFD at our hospital between 2011 and 2015 were retrospectively *** and probable IFD were defined according to the European Organization for Research and Treatment of Cancer/Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group *** with possible IFD were *** The incidence of proven or probable IFD was 26 of 20,079 hospitalized patients (0.13%).The predominant underlying disease was malignancy (54%) and congenital anomaly (27%).The most common diagnosis was candidemia among the patients with proven IFD (8 of 13,62%).All the isolated pathogens in the candidemia patients were non-albicans Candida *** most common site of infection was the lungs in patients with probable IFD (11 of 13 patients,85%).In probable IFD episodes,positive β-D-glucan and galactomannan were found in 12 of 13 (92%) and 5 of 13 (38%) patients,*** but one patient (96%) received empirical antifungal *** patients underwent surgical resection of residual *** overall mortality was 23% and the attributable mortality of IFD was 12%.Conclusion Our results suggest the emergence of non-albicans Candida species as important pathogens in childhood IFD.

关键词： Children Invasive fungal disease Incidence Mortality

Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis

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World Journal of Gastroenterology 2008年第38期14卷 5880-5886页

作者： Yasuji Arase Fumitaka Suzuki yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada Department of Hepatology Toranomon HospitalTokyo 105-8470 Japan

AIM： To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus （HCV） positive patients. METHODS： We studied 6150 HCV infected patients who were between 40-70 years old （HCV-group）. Another 2050 patients with hepatitis B virus （HBV） were selected as control （HBV-group）. The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis （IPF） in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS： Fifteen patients in HCV-group developed IPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group （P = 0.021）. The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases：（1） patients ≥ 55 years （P 〈 0.001）; （2） patients who had smoking index （package per day x year） of ≥20 （P = 0.002）; （3） patients with liver cirrhosis （P = 0.042）. CONCLUSION： Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients.

关键词： Hepatitis B virus Hepatitis C virus Idiopathic pulmonary fibrosis A retrospective cohort study

Inherited multimodal microstructure evolution of high-fracture-toughness Mg-Zn-Y-Al alloys during extrusion for the consolidation of rapidly solidified ribbons

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Journal of Magnesium and Alloys 2022年第9期10卷 2433-2445页

作者： Soya Nishimoto Michiaki Yamasaki Yoshihito kawamura Department of Materials Science Graduate School of Science and TechnologyKumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

The mechanisms of multimodal microstructure evolution and the effects of microstructural factors on mechanical properties must be elucidated to design new alloys with superior *** this study,high-fracture-toughness and ductile Mg_(96.75)Zn_(0.85)Y_(2.05)Al_(0.35) alloys were developed using rapidly solidified(RS)ribbon-consolidation technique,and the inherited multimodal microstructure evolution during plastic flow consolidation of the RS ribbons was *** use of extrusion for plastic flow consolidation of the heat-treated RS ribbons produced a multimodal microstructure consisting of the worked grains with high Kernel average misorientation(KAM)angles(Group1),the ultrafine dynamically recrystallized(DRXed)grains with intermediate KAM angles(Group 2),and the fine DRXed grains with low KAM angles(Group 3).Groups 1 and 2 contribute to the alloy strengthening,while Group 3 contributes to improving ductility with strainhardening,resulting in enhancement of the fracture *** form the multimodal microstructure,it was necessary to apply plastic flow with equivalent strains of>2.3 to the heat-treated RS ribbons possessing duplex microstructures with different dispersions of the long-period stacking ordered phase.

关键词： Magnesium alloy Long-period stacking ordered phase Multimodal microstructure Rapid solidification Extrusion Dynamic recrystallization