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Natural history of asymptomatic gallbladder stones in clinic without beds:A long-term prognosis over 10 years

World Journal of Clinical Cases 2024年第1期12卷 42-50页

作者： Yuji Sakai Toshio Tsuyuguchi Hiroshi Ohyama Junichiro Kumagai Takashi Kaiho Masayuki Ohtsuka Naoya kato Tadao Sakai Department of Gastroenterology Sakai ClinicKimistu 299-1162Japan Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Department of Gastroenterology Kimitsu Central HospitalKisarazu 292-8535Japan Department of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

BACKGROUND Several studies have explored the long-term prognosis of patients with asymp-tomatic gallbladder *** reports were primarily conducted in facilities equipped with beds for addressing symptomatic *** To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed *** We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October *** symptoms developed,patients were transferred to hospitals where appropriate treatment was *** investigated the asymptomatic and survival periods during the *** Among the 237 patients,214(90.3%)remained asymptomatic,with a mean asymptomatic period of 3898.9279±46.871 d(50-4111 d,10.7 years on average).Biliary complications developed in 23 patients(9.7%),with a mean survival period of 4010.0285±31.2788 d(53-4112 d,10.9 years on average).No patient died of biliary *** The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was *** the condition became symptomatic,the patients were transferred to hospitals with beds that could address it;thus,no deaths related to biliary complications were *** finding suggests that follow-up care in clinics without beds is possible.

关键词： Gallbladder stone Acute cholangitis Acute cholecystitis Asymptomatic gallbladder stone Symptomatic gallbladder stone

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： Teruhiko Yoshida Yasushi Yatabe Ken kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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No-touch isolation technique in emergency pancreaticoduodenectomy for neoplastic hemorrhage: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： Akihiro Cho Satoshi Katagiri Masao Ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa Takeshi Ishita Toshihiko Mouri Akita kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

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PdPtCuNiP高熵非晶合金蠕变机理研究

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力学学报 2024年

作者：段亚娟徐宗睿郝奇 H.kato 乔吉超西北工业大学力学与土木建筑学院加泰罗尼亚理工大学能源技术研究所物理系日本东北大学材料研究所

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研... 详细信息

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研究结果表明，该合金的蠕变行为明显依赖于温度和应力，低温及低应力环境下合金表现出较好的抗蠕变性能，主要以弹性变形为主.随着温度增加，合金抗蠕变能力减弱，粘弹性（粘塑性）变形成为主导.循环应力在低温下对蠕变变形影响较小，而在高温下其影响显著，表明循环载荷能加剧蠕变行为，导致准稳态蠕变速率上升.回复时间对合金的瞬时弹性变形和滞弹性变形有显著影响，但对粘塑性变形的调节作用有限.卸载后合金变形能力逐渐增强，蠕变抑制得到缓解.此外，变形单元弛豫时间的广泛分布和对循环应力的敏感反应，揭示了蠕变机制的复杂性和多时间尺度的结构演化.本研究通过系统的实验和分析，深化了对高熵非晶合金蠕变行为及其调控机制的理解.为高性能高熵非晶合金的设计和应用提供了重要的理论依据和实践指导，对未来开发更具抗蠕变能力的先进材料具有一定意义.

关键词：高熵非晶合金蠕变滞弹性变形动力学微观结构非均匀性

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Functional Confirmation Using a Medical X-Ray System of a Semiconductor Survey Meter

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Open Journal of Radiology 2024年第1期14卷 1-13页

作者： Katsunao Suzuki Toru Negishi Yoh kato Yasuhisa Kono Michiharu Sekimoto Department of Radiological Technology Kariya Toyota General Hospital Kariya Japan Department of Radiological Sciences Graduate School of Human Health Science Tokyo Metropolitan University Tokyo Japan Department of Radiological Technology Faculty of Medical Technology Niigata University of Health and Welfare Niigata Japan

In recent years, semiconductor survey meters have been developed and are in increasing demand worldwide. This study determined if it is possible to use the X-ray system installed in each medical facility to calculate the time constant of a semiconductor survey meter and confirm the meter’s function. An additional filter was attached to the medical X-ray system to satisfy the standards of N-60 to N-120, more copper plates were added as needed, and the first and second half-value layers were calculated to enable comparisons of the facility’s X-ray system quality with the N-60 to N-120 quality values. Next, we used a medical X-ray system to measure the leakage dose and calculate the time constant of the survey meter. The functionality of the meter was then checked and compared with the energy characteristics of the meter. The experimental results showed that it was possible to use a medical X-ray system to reproduce the N-60 to N-120 radiation quality values and to calculate the time constant from the measured results, assuming actual leakage dosimetry for that radiation quality. We also found that the calibration factor was equivalent to that of the energy characteristics of the survey meter.

关键词： Semiconductor Survey Meter Functional Confirmation Medical X-Ray System Calibration Factor Time Constant

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4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

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Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei kato Daisuke Nishizaki Hirotaka Miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

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Which characteristics are associated with changes in medication status for lower urinary tract symptoms among patients with prostate cancer receiving external beam radiotherapy?

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Current Urology 2024年第2期18卷 122-127页

作者： Yuki Kyoda Kohei Hashimoto Atsushi Takahashi TakeshiMaehana Kimihito Tachikawa Takashi Muranaka Shuichi kato Tomoyo Kurisug Fumimasa Fukuta Takahiro Kirisawa Manabu Okada Ko Kobayashi Toshiaki Tanaka Shiro Hinotsu Naoya Masumoria Department of Urology SapporoMedical University School of MedicineSapporoJapan Department of Urology Hakodate Goryoukaku HospitalHakodateJapan Department of Urology Muroran City General HospitalMuroranJapan Department of Urology NTT-East Sapporo HospitalSapporoJapan Department of Urology Sunagawa City Medical CenterSunagawaJapan Department of Urology Oji General HospitalTomakomaiJapan Department of Urology Steel Memorial Muroran HospitalMuroranJapan Department of Urology Obihiro Kyokai HospitalObihiroJapan Department of Medical Statistics Sapporo Medical University School of MedicineSapporoJapan

Background:We clarified the predictive factors for changes in the status ofmedications for lower urinary tract symptoms(LUTS)2 years after local radiotherapy for nonmetastatic prostate *** and methods:We retrospectively included patients who underwent local external radiotherapy for nonmetastatic prostate cancer in 8 institutions between April 2001 and March *** were divided into themedication and no-medication group based on the use of drugs for LUTS before *** defined improvement of LUTS as when the patient did not require medication for LUTS at 24 months after radiotherapy in the medication group and as deterioration whenmedication was required in the no-medication *** regression analysis was used to evaluate predictive factors for changes in medication ***:Altogether,505 patients were divided into a no-medication group(n=352)and a medication group(n=153).The number of patients with deterioration and improvement in LUTS was 49(14%)and 36(23%),*** the multivariate analysis,the predictive variables for deterioration were the International Prostate SymptomScore(≥8;odds ratio[OR],2.21;p=0.014)and the biopsy Gleason score(≤3+4=7;OR,2.430;p=0.008)in the no-medication group,whereas those for improvement were age(<75 years old;OR,5.81;p=0.002),the quality of life score(<3;OR,3.15;p=0.028),and a positive biopsy core rate(≥50%;OR,2.530;p=0.027)in the medication ***:These predictive factors for changes in the status ofmedications for LUTS at 2 years after external radiotherapymay help determine the definitive therapy for nonmetastatic prostate cancer.

关键词： Prostate cancer Radiotherapy Lower urinary tract symptoms Medications

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Japanese herbal medicine, Saiko-keishi-to, prevents gut ischemia/reperfusion-induced liver injury in rats via nitric oxide

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World Journal of Gastroenterology 2004年第15期10卷 2241-2244页

作者： Yoshinori Horie Mikio Kajihara Shuka Mori yoshiyuki Yamagishi Hiroyuki Kimura Hironao Tamai Shinzo kato Hiromasa Ishii Department of Internal Medicine School of MedicineKeio UniversityTokyo 160-8582Japan

AIM:To determine whether Saiko-keishi-to(TJ-10),a Japanese herbal medicine,could protect liver injury induced by gut ischemia/reperfusion(I/R),and to investigate the role of NO. METHODS:Male Wistar rats were exposed to 30-min gut isohemia followed by 60 min of *** microscopy was used to monitor leukocyte *** tumor necrosis factor(TNF)levels and alanine aminotransferase (ALT)activities were ***-10 1 g/(kg.d)was intragastrically administered to rats for 7 d.A NO synthase inhibitor was administered. RESULTS:In control rats,gut I/R elicited increases in the number of stationary leukocytes,and plasma TNF levels and ALT activities were mitigated by pretreatment with *** with the NO synthase inhibitor diminished the protective effects of TJ-10 on leukostasis in the liver,and the increase of plasma TNF levels and ALT *** with TJ-10 increased plasma nitrite/nitrate levels. CONCLUSION:TJ-10 attenuates the gut I/R-induced hepatic microvascular dysfunction and sequential hepatocellular injury via enhancement of NO production.

关键词： Liver Circulation Animals Drugs, Chinese Herbal Liver Diseases control Male Nitric Oxide Rats Rats, Wistar Reperfusion Injury Research Support, Non-U.S. Gov't

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Erythropoietin -induced proliferation of gastric mucosal cells

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World Journal of Gastroenterology 2006年第2期12卷 234-239页

作者： Kazuro Itoh Yoshio Sawasaki Kyoko Takeuchi Shingo kato Nobuhiro Imai Yoichiro kato Noriyuki Shibata Makio Kobayashi yoshiyuki Moriguchi Masato Higuchi Fumio Ishihata Yushi Sudoh Soichiro Miura Second Department of Internal Medicine National Defense Medical CollegeTokorozawaSaitamaJapan First Department of Anatomy National Defense Medical CollegeTokorozawaSaitamaJapan Department of Pathology Tokyo Women's Medical CollegeShinjuku-kuTokyoJapan Chugai Pharmaceutical Co. Ltd.GotenbaShizuokaJapan Kisen Hospital Katsushika-kuTokyoJapan

AIM： To analyze the localization of erythropoietin receptor on gastric specimens and characterize the effects of erythropoietin on the normal gastric epithelial proliferation using a porcine gastric epithelial cell culture model. METHODS： Erythropoietin receptor was detected by RT-PCR, Western blotting and immunohistochermistry. Growth stimulation effects of erythropoietin on cultured gastric mucosal cells were determined by ELISA using bromodeoxyuridine （BrdU）. RESULTS： Erythropoietin receptor was detected on cultured porcine gastric mucosal epithelial cells. Erythropoietin receptor was also detected histochemically at the base of gastric mucosal epithelium. BrdU assay demonstrated a dose-dependent increase in growth potential of cultured porcine gastric mucosal epithelial cells by administration of erythropoietin, as well as these effects were inhibited by administration of antierythropoietin antibody （P〈 0.01）. CONCLUSION： These findings indicate that erythropoietin has a potential to proliferate gastric mucosal epithelium via erythropoietin receptor.

关键词： Erythropoietin Erythropoietin receptor Gastric epithelial cell proliferation Porcine gastric mucosal epithelial cells

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Injuries and illness of athletes at the Tokyo 2020 Olympic and Paralympic summer games visiting outside facilities

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Sports Medicine and Health Science 2024年第1期6卷 48-53页

作者： Shuji Sakanashi Hideharu Tanaka Hiroyuki Yokota Yasuhiro Otomo Tomohiko Masuno Kousuke Nakano Junichi Inoue Manabu Sugita Takahiko Tokunaga Nagisa kato Tomoya Kinoshi Hironori Inoue Hiroto Numata Koshi Nakagawa Ryo Sagisaka Shota Tanaka Tetsuya Miyamoto Takao Akama The Tokyo Organising Committee of the Olympic and Paralympic Games TokyoJapan Department of Sports Medicine Kokushikan University TokyoJapan Graduate School of Emergency Medical System Kokushikan UniversityTokyoJapan Research Institute of Disaster Management and EMS Kokushikan University TokyoJapan Graduate School of Health and Medical Science Nippon Sports Science UniversityJapan Tokyo Medical and Dental University Hospital Trauma and Acute Critical Care CenterTokyoJapan Graduate School of Medicine Nippon Medical UniversityTokyoJapan Saitama City Hospital Emergency DepartmentSaitamaJapan Graduate School of Medicine Juntendo UniversityTokyoJapan Emergency Lifesaving Academy Tokyo TokyoJapan Nippon Medical School Musashikosugi Hospital Emergency and Critical Care CenterKnagawaJapan Department of Integrated Science and Engineering for Sustaiable Society Chuo UniversityJapan Faculty of Sport Sciences Waseda UniversitySaitamaJapan National Hospital Organization Disaster Medical Center TokyoJapan

This study aimed to identify the reasons for transferring athletes to local medical facilities during the Olympic and Paralympic *** on 567 injuries and other illnesses of athletes treated at the on-site clinics were collected from the Tokyo 2020 Organizing *** these,84 athletes who required outpatient care during the Games were registered for this *** the Olympic and Paralympic Games,66(8.3/1000)and 18(7.2/1000)athletes,respectively,consulted external medical *** the Olympic Games,the reasons for these visits included 48 cases(72.7%)of injuries,13(19.7%)cases of illnesses,and 5(7.6%)cases of heat stroke illness(HSI).Of these patients,56(84.9%)were treated as outpatients and 10(15.1%)were hospitalized,while three of these patients required hospitalization for>7 *** the other hand,in the Paralympics Games,there were 7(38.8%)cases of injuries,9(50.0%)other illnesses,1(5.6%)case of HSI,and 1(5.6%)other cases,of which 11(61.1%)were treated as outpatients and 7(38.9%)were hospitalized,but none was hospitalized for>7 *** accounted for 70%of the total cases at the 2021 Olympic Games,but only three(0.05%)were severe cases that required hospitalization for more than 1 *** contrast,in the Paralympic Games,other illnesses accounted for approximately half of the total *** study provides details on the extent of injuries and other illnesses that were transferred to outside facilities,which has not been documented in previous games.

关键词： Olympic games Paralympic games Sports injuries Illness Heat-related illness 2020 Tokyo

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