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Chinese Science Bulletin 1997年第2期42卷 147-151页

作者： Seiko Kawano yoshiyuki hirayama Masayasu Hiraoka Akihiko Kuniyasu Hitoshi Nakayama Department of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the Ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

Nondestructive and active interrogation system for special nuclear material:proof of principle and initial results

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Nuclear Science and Techniques 2024年第5期35卷 216-225页

作者： Mahmoud Bakr Kai Masuda yoshiyuki Takahashi Tsuyoshi Misawa Norio Yamakawa Tomas Scott Institute of Advanced Energy Kyoto UniversityGokashoUjiKyoto 611‑0011Japan School of Physics University of BristolBs81TL Tyndall AvenueBristolUK Physics Department Faculty of ScienceAssiut UniversityAssiut 71516Egypt Research Reactor Institute Kyoto University2 Asashiro‑NishiKumatoriOsaka 590‑0494Japan Pony Industry Co.Ltd. 2‑3‑6 Kitakyuhoji‑MachiChuo‑KuOsaka 541‑0057Japan Astral Neutronics LTD Unit H5HallenBristol BS107SBUK

Herein,we employ the threshold energy neutron analysis(TENA)technique to introduce the world's first active interrogation system to detect special nuclear materials(SNMs),including U-235 and *** system utilizes a DD neutron generator based on inertial electrostatic confinement(IEC)to interrogate suspicious *** detect secondary neutrons produced during fission reactions induced in SNMs,a tensioned metastable fluid detector(TMFD)is *** current status of the system's development is reported in this paper,accompanied by the results from experiments conducted to detect 10 g of highly enriched uranium(HEU).Notably,the experimental findings demonstrate a distinct difference in the count rates of measurements with and without *** difference in count rates surpasses two times the standard deviation,indicating a confidence level of more than 96% for identifying the presence of *** paper presents and extensively discusses the proof-of-principle experimental results,along with the system's planned trajectory.

关键词： Special nuclear materials Uranium detection Inertial electrostatic confinement fusion TENA HEU CTMFD

A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer

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Asian Journal of Urology 2024年第2期11卷 286-293页

作者： Tairo Kashihara Yuka Urago Hiroyuki Okamoto Mihiro Takemori Hiroki Nakayama Shohei Mikasa Tetsu Nakaichi Kotaro Iijima Takahito Chiba Junichi Kuwahara Satoshi Nakamura Weishan Chang yoshiyuki Matsui Hiroshi Igaki Department of Radiation Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Radiation Safety and Quality Assurance Division National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Radiological Sciences Graduate School of Human Health SciencesTokyo Metropolitan University7-2-10 Higashi-OguArakawa-kuTokyoJapan Department of Radiological Technology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan Department of Urological Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyoJapan

Objectives: Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate ***: HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were ***: The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (p<0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (p<0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than ***: The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.

关键词： Brachytherapy Hyaluronicacid Hydrogel Prostaticneoplasm Radiotherapy

High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

Development of a Method for Assessing Country-Based Flood Risk at the Global Scale

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International Journal of Disaster Risk Science 2022年第1期13卷 87-99页

作者： yoshiyuki Imamura Department of Civil and Environmental Engineering Tokyo Metropolitan University192-0397 HachiojiTokyoJapan

International frameworks such as the Sustainable Development Goals and the Sendai Framework for Disaster Risk Reduction 2015-2030 require the quantification of country-based flood ***,few approaches at the global scale include the three necessary components(hazard,exposure,and vulnerability)for determining disaster risk and are country-based assessments,owing to major challenges such as limited data availability and vulnerability proxy ***,in this study,a method was developed with the following features:Incorporating the hazard,exposure,and vulnerability components;Applicable to the vast majority of countries in the world;Visualizing priority countries and illustrating effective measures and strategies;Clear and easy to understand by leaders and decision makers of international organizations,governments,and other stakeholders;Identifying each country’s challenges and providing guidance on specific issues for more detailed investigation and policy creation;Including more extensive factors compared with past *** Asia and the Pacific,the Flood Risk Index computed by the developed method is compared with the fatality ratio,and the results show that improving flood resilience secures people and society regardless of the magnitude and frequency of *** at the global scale visualizes regional tendencies and indicates that countries closer to the equator have higher flood *** of country-based flood risk based on five indicators demonstrates that the developed method can assist international organizations,governments,and other stakeholders to further examine country-specific conditions and establish and implement policies and strategies toward building a resilient society and achieving international targets.

关键词： Asia and the Pacific Country-based analysis Flood risk index Global scale Vulnerability proxy

A combination of tides and nontidal variations in ocean bottom pressure may generate interannual slip fluctuations in the transition zone along a subduction plate interface

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Geodesy and Geodynamics 2023年第1期14卷 43-51页

作者： yoshiyuki Tanaka Hiromu Sakaue Masayuki Kano Suguru Yabe Department of Earth and Planetary Science The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Graduate School of Science Tohoku University6-3Aramaki-aza-aobaAoba-kuSendai980-8578Japan Geological Survey of Japan National Institute of Advanced Industrial Science and Technology(AIST)Tsukuba Central 71-1-1 HigashiTsukubaIbaraki 305-8567Japan

The tidal triggering of earthquakes has been studied for many *** discovery of slow earthquakes in the early 2000s,including slow slip,has urged scientists to investigate the tidal responses of these earthquakes due to their sensitivity to weak stress *** studies have shown that slow earthquakes correlate with diurnal and semidiurnal tides and seasonal variations in surface loads more clearly than ordinary ***,little is known about long-term responses to external *** this paper,based on a widely accepted frictional law for faults,a mechanism is proposed by which nontidal variations in ocean bottom pressure,when combined with tides,pro mote the occurrence of slow *** slow earthquakes accompany a slip on the plate interface,this mechanism allows one to estimate slip modulations.A one-degree-of-freedom slip model is constructed and applied to Ise Bay in the Tonankai region of southwestern Japan,where large-scale ocean mass redistributions have *** model calculated with parameters determined from the observation of tectonic tremors is quantitatively consistent with the slip during 1997-2013 inferred from GNSS data,suggesting that the decrease in the sea-level change in approximately 2006 could cause the accele ration of a slip observed after *** result implies that the decreases in sea level in approximately 1996 and 2014 could also cause subsequent slip *** three slip acceleration periods temporally coincide with the increases in background seismicity in a shallower portion of the plate *** changes in seismicity are common to shallow earthquakes in the Tokai area,and a similar model can reproduce *** studies are expected to reveal causality between shallow earthquakes and long-term slip fluctuations based on modeling that considers changes in the frictional property along the plate interface.

关键词： Tides Ocean bottom pressure Slow earthquake Seismicity Kuroshio current

Nanotwin-assisted nitridation of quenched FeNi alloy nanopowders for rare-earth-free magnets

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Journal of Materials Science & Technology 2023年第34期165卷 244-252页

作者： Jian Wang Yusuke hirayama Kazuyuki Suzuki Kwangjae Park Zheng Liu Kenta Takagi Kimihiro Ozaki Innovative Functional Materials Research Institute National Institute of Advanced Industrial Science and Technology4-205SakurazakaMoriyamaNagoya463-8560Japan

L1_(0)-ordered FeNi alloy with a high uniaxial magnetic anisotropy and large magnetic moment is a promising candidate for rare-earth-free permanent magnets ***,the synthesis of this chemically ordered phase remains a longstanding challenge because of its low chemical order-disorder transition temperature(200-320℃).Although a non-equilibrium synthetic route based on a nitrogen topotactic reaction has been proposed as a valid approach,the volume fraction and degree of chemical ordering of the product phase are ***,we propose a promising approach that promotes the efficient formation of L1_(0)-ordered nitride phase in FeNi nanopowders by introducing a quenching treatment during a low-oxygen induction thermal plasma *** quenched FeNi nanopowders possessed much smaller powder sizes(40.4 vs 74.0 nm),exhibited higher number densities of nanotwins(39.8%vs 24.1%)and formed much larger volume fraction(33.6 wt.%vs 0.6 wt.%)of ordered phase than the unquenched ***,quenching-induced high-density nanotwins led to the dominant coverage of serrated{001}crystal facets over the surfaces of the FeNi *** unique features substantially accelerated the formation of the L1_(0)-ordered nitride phase in the FeNi nanopowders because the{001}crystallographic orientation had the highest nitrogen *** work provides not only a valid synthetic approach for mass production of the L10-ordered nitride phase in FeNi nanopowders but also novel insights into the crystal-defect-assisted nitridation of nanomaterials.

关键词： Rare-earth-free Permanent magnet FeNi Nitridation Nanotwin

Importance of an appropriate number of examined lymph nodes in patients with pancreatic cancer-the more the better?

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 605-607页

作者： Toshiro Ogura Hiroyuki Ishida Amane Takahashi yoshiyuki Kawashima Department of Gastroenterological Surgery Saitama Cancer CenterSaitamaJapan

Pancreatic cancer is a highly aggressive malignant cancer with a 5-year survival rate of approximately 10%.The outcome of patients diagnosed with resectable pancreatic cancer as per the National Comprehensive Cancer Network(NCCN)classification and those who underwent resection was not *** to other abdominal malignant tumors,the stages of pancreatic cancer are defined by local extension,lymph node metastasis,and distant *** presence or absence of lymph node metastasis is diagnosed by pathological examination of the retrieved lymph,the quality of the diagnosis based on lymph node(N)staging depends on the surgical and pathological aspects(1).

关键词： lymph metastasis patients

Non-prosthetic treatment using segmental osteotomy and bone grafting in a patient with cleft lip and palate

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Plastic and Aesthetic Research 2022年第1期9卷 654-660页

作者： Atsuhiro Inoue Michiko Tsuji yoshiyuki Baba Keiji Moriyama Department of Maxillofacial Orthognathics Graduate School of Medical and Dental SciencesTokyo Medical and Dental University1-5-45 YushimaBunkyo-kuTokyo 113-8549Japan Division of Pedodontics and Orthodontics Department of Surgical SpecialtiesNational Center for Child Health and Development2-10-1 OkuraSetagaya-kuTokyo 157-8535Japan

This case report aimed to present the course of surgically combined comprehensive orthodontic treatment of a male adult with cleft lip and palate,showing a left alveolar cleft,lateral deviation of the major segment of the maxilla,and palatal transposition of the lateral ***,the midline of the upper central incisors was shifted by 7.0 mm to the right,the right lateral incisor showed palatal transposition,and the residual alveolar cleft was 6.5 *** Le Fort I osteotomy of the major segment,and simultaneous bone grafting into the extended alveolar bone and former cleft region were performed at 18 years and 4 months of ***,midline correction,alignment of the right lateral incisor,and cleft closure were achieved;no further prosthetic treatment was required.

关键词： Cleft lip and palate palatal transposition segmental Le Fort I osteotomy bone grafting

Atomically precise thiolate-protected gold nanoclusters:Current status of designability of the structure and physicochemical properties

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聚集体(英文)

聚集体(英文) 2023年第2期4卷 1-41页

作者： Sakiat Hossain Daisuke hirayama Ayaka Ikeda Mai Ishimi Sota Funaki Arpan Samanta Tokuhisa Kawawaki Yuichi Negishi Research Institute for Science and Technology Tokyo University of ScienceShinjuku-kuJapan Department of Applied Chemistry Faculty of ScienceTokyo University of ScienceShinjuku-kuJapan

Thiolate(SR)-protected gold nanoclusters(Aun(SR)m NCs)are a rare type of material capable of simultaneously exhibiting multiple physicochemical properties well-suited to specific applications,including photoluminescence,thermocatalysis,electrocatalysis,photocatalysis,magnetism,and optical *** the past several decades,there has been tremendous progress in our understanding of the structure and physicochemical properties of Aun(SR)m NCs,resulting in the ability to fine-tune the characteristics of these *** is therefore helpful to examine the extent to which the properties of Aun(SR)m and related metal NCs can now be adjusted based on *** review presents representative examples of previous studies concerning the geometry,electronic structure,luminescence properties,catalysis,magnetism and optical activity of Aun(SR)m and related metal NCs and discusses the current status of the designability of these NCs to impart specific structural and physicochemical *** information is expected to accelerate the fabrication of highly functional materials based on Aun(SR)m and related metal NCs.

关键词： atomically precise metal nanoclusters gold nanoclusters physicochemical properties structures thiolate