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Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press

Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 412-417页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera Masahiro Kitamura yoshiteru takahashi Kohei Tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University1-25-4Daigaku-NishiGifu501-1196Japan Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd12-34HiroshibachoSuita-ShiOsaka564-0052Japan

We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on punches.We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.

关键词： Tableting Formulation design Lubricant Punch shape Single-punch tablet press Losartan potassium

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Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 113-119页

作者： Takashi Osamura Yoshiko Takeuchi Risako Onodera Masahiro Kitamura yoshiteru takahashi Kohei Tahara Hirofumi Takeuchi Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University Pharmaceutical Technology Department Sawai Pharmaceutical Co.Ltd

We previously determined "Tableting properties" by using a multi-functional single-punch tablet press(GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability"on the y-axis to allow visual evaluation of "Tableting properties". Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. We used the GTP-1 to measure "Tableting properties" with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures(capping and binding in particular) occurred when samples that had been evaluated as having poor "Compactability" or"Manufacturability" on the GTP-1 were compressed on the rotary tableting machine. Thus,our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production.

关键词： tableting formulation design wet granulation capping binding single-punch tablet press

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SNOM Observations of Surface Plasmon Polaritons on Metal Heterostructures

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Chinese Physics Letters 2007年第10期24卷 2827-2829页

作者： KITAZAWA Tazuko MIYANISHI Shintaro MURAKAMI yoshiteru KOJIMA Kunio takahashi Akira Advanced Technology Research Laboratories SHARP CORPORATION 2613-1 Ichinomoto-cho Tenri Nara Japan

我们与一台散布类型的扫描近地的光显微镜(SNOM ) 在一件 metalheterostructured 样品上观察表面电浆子电磁声子(SPP ) 折射。Thesample 由其边界与合适的蚀刻的时间足够光滑的艾尔和 Au 在里面飞机组成。到边界和 SPP 的部分的艾尔电... 详细信息

我们与一台散布类型的扫描近地的光显微镜(SNOM ) 在一件 metalheterostructured 样品上观察表面电浆子电磁声子(SPP ) 折射。Thesample 由其边界与合适的蚀刻的时间足够光滑的艾尔和 Au 在里面飞机组成。到边界和 SPP 的部分的艾尔电影旅行上的 SPPsexcited 宣传进 Au 电影。Inaddition，干扰穗在边界出现在 SNOM 图象偏好。结果与有效索引方法被分析，测定角度被解释由敏捷的法律。

关键词：金属异质结构表面结构分子构成物理分析

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Three-Dimensional Computed Tomography Assessment and Planning for Severe Lower Limb Deformities: A Case Report of Bilateral Fibular Hemimelia

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Open Journal of Orthopedics 2013年第3期3卷 167-171页

作者： yoshiteru Kawasaki Mitsuhiko takahashi Natsuo Yasui Department of Orthopedics Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan.

To correct a lower limb deformity, orthopedic surgeons must have an exact understanding of the deformity. In general, preoperative planning is carried out using anterior-posterior (AP) and lateral radiographs. However, for severe cases with a combination of angular and rotational deformities of the lower limb, obtaining true AP and lateral radiographs is difficult and accurate calculation of the rotational deformity from radiographs is impossible. In this report, we propose to focus on preoperative assessment using three-dimensional (3D) reconstruction images of computed tomography (CT) scans for severe lower limb deformity in a patient with bilateral fibular hemimelia type II according to the Achterman- Kalamchi classification. She underwent bifocal deformity corrections of the bilateral tibiae using Taylor spatial frames in combination with the Ilizarov external fixator. Complete bony union was achieved, without angular deformity or limb length discrepancy.

关键词： Deformity Correction Preoperative Planning Three-Dimensional Computed Tomography Fibular Hemimelia Taylor Spatial Frame

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