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Relationship between wear behaviour of ultra-high-molecular-weight polyethylene and surface profile of Co–Cr–Mo alloy in artificial joint

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Biosurface and Biotribology 2019年第1期5卷 1-7页

作者： Nana Motojima Yuta Nakashima Yukio Fujiwara Yoshihiro Komohara Motohiro Takeya Hiromasa Miura Kazunori Hino Hidehiko Higaki Hidehiro Hata yoshitaka nakanishi Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiCyuo-kuKumamoto 860-8555Japan Faculty of Advanced Science and Technology Kumamoto UniversityKumamotoJapan Faculty of Life Science and Technology Kumamoto UniversityKumamotoJapan Graduate School of Medicine Ehime UniversityEhimeJapan Faculty of Life Science Kyushu Sangyo UniversityFukuokaJapan

The relationship between the wear behaviour of an ultra-high-molecular-weight polyethylene(GUR1050)pin and surface profile of a Co-28Cr-6Mo alloy(ASTM F-75)disc was investigated.Tribological tests have been performed by pin-on-disc wear testing machine with multi-directional pathways,obtaining the influence of micro slurry-jet erosion(MSE)processed Co–Cr–Mo alloy.The specific wear and the wear particles have been investigated.It was elucidated that the Co–Cr–Mo alloy surface processed by MSE influenced the specific wear rate of polyethylene;however,the morphological aspect of polyethylene wear particles was not drastically changed.The wear particles isolated from the lubricating liquid were added to a culture medium,and human monocyte-derived macrophages were incubated by using an upright/inverted method.The production of TNF-α and IL-6 seemed to have a correlation with the amount of wear particles added,however,the influence of particle size on the production of TNF-α and IL-6 was not obvious.This means that the improvements for the incubation method,i.***.upright/inverted method,need further investigation for the accurate analysis.

关键词： wear alloy behaviour

Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

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Nano Research 2022年第5期15卷 4201-4211页

作者： Tsukasa Akasaka Miho Tamai yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi Miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko nakanishi Yasuhiro Yoshida Department of Biomaterials and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune Signal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Support Section for Education and Research Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Prosthodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The surface topography of a material can influence osteoclast activity.However,the surface structural factors that promote osteoclast activity have not yet been investigated in detail.Therefore,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and shapes.The systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ratio.RAW264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥hole.The two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast formation.The optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in height.Furthermore,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and height.Furthermore,resorption pits were observed mainly on the top of calcium phosphate-coated pillars.Thus,osteoclasts prefer convex shapes,such as pillars for differentiation and resorption.Our results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 osteoclast actin structure resorption pit

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稻鸭共生对鸭肉品质和屠宰性能的影响

中国家禽 2009年第5期31卷 20-22页

作者：卢跃红戴志明张曦魏红江万田正治中西良孝韩自鸿大理学院云南大理671003 云南农业大学云南省动物营养与饲料重点实验室云南昆明650201 鹿儿岛大学陆良县农牧局云南陆良655600

以云南麻鸭为试验材料,分别在稻鸭共生(稻鸭组)和常规网上平养(常规组)两种饲养模式下饲养至体重达1.8kg,测定其常规肉品质和部分屠宰性能。结果表明:①两组间鸭肉失水率、嫩度、熟肉率、肉色亮度值和红度值无显著差异(P>0.05);稻鸭组... 详细信息

以云南麻鸭为试验材料,分别在稻鸭共生(稻鸭组)和常规网上平养(常规组)两种饲养模式下饲养至体重达1.8kg,测定其常规肉品质和部分屠宰性能。结果表明:①两组间鸭肉失水率、嫩度、熟肉率、肉色亮度值和红度值无显著差异(P>0.05);稻鸭组的pH值显著高于常规组(P0.05);稻鸭组的皮脂厚、腹脂率比常规组分别降低了18.52%、11.76%(P<0.05);腿肉率提高了11.40%(P<0.05)。③稻鸭组的生长速度明显慢于常规组。

关键词：稻鸭共生饲养模式麻鸭肉品质屠宰性能

Erratum to: Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure

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Nano Research 2022年第5期15卷 4773-4773页

The article“Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure”,written by Tsukasa Akasaka,Miho Tamai,yoshitaka Yoshimura,Natsumi Ushijima,Shinichiro Numamoto,Atsuro Yokoyama,Hirofumi Miyaji,Ryo Takata,Shuichi Yamagata,Yoshiaki Sato,Ko nakanishi,and Yasuhiro Yoshida,was originally published electronically on the publisher’s internet portal on January 17,2022 without open access.

关键词： internet portal Nat