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Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening

World Journal of Gastroenterology 2015年第9期21卷 2793-2799页

作者： Yasushi Yamasaki Ryuta Takenaka Keisuke Hori Koji Takemoto Seiji Kawano yoshiro kawahara Hiroyuki Okada Shigeatsu Fujiki Kazuhide Yamamoto Department of Gastroenterology Tsuyama Chuo HospitalTsuyamaOkayama 708-0841Japan 2nd Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Division of Endoscopy Okayama University HospitalOkayama 700-8558Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

AIM:To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol ***:We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal *** patients were divided into two groups:a magnifying narrow band imaging group,and a lugol chromoendoscopy group,for comparison of adverse *** cancer screening was performed on withdrawal of the *** primary endpoint was a score on a visual analogue scale for heartburn after the *** secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations,change in vital signs,total procedure time,and esophageal observation ***:The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group(P =0.004,0.024,respectively,ANOVA for repeated measures).The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy *** was no significant difference between the two groups with respect to othervital *** total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group(450 ± 116 vs 565 ± 174,P =0.004,44 ± 26 vs 151 ± 72,P < 0.001,respectively).CONCLUSION:Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol *** band imaging endoscopy is useful and suitable for esophageal cancer screening periodically.

关键词： Narrow band imaging Lugol Adverse symptoms Visual

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Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture

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World Journal of Gastroenterology 2014年第17期20卷 5092-5097页

作者： Yoshiyasu Kono Ryuta Takenaka yoshiro kawahara Hiroyuki Okada Keisuke Hori Seiji Kawano Yasushi Yamasaki Koji Takemoto Takayoshi Miyake Shigeatsu Fujiki Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan 2~(nd) Department of Internal Medicine Tsuyama Chuo HospitalOkayama 708-0841Japan Department of Internal Medicine Tsuyama Chuo HospitalOkayama 708-0841Japan Department of Endoscopy Okayama University HospitalOkayama 700-8558Japan Department of Pathology Tsuyama Chuo HospitalOkayama 708-0841Japan

AIM: To investigate the usefulness of chromoendoscopy, using an acetic acid indigocarmine mixture (AIM), for gastric adenoma diagnosed by forceps biopsy.

关键词： Acetic acid indigocarmine mixture Early gastric cancer Gastric adenoma Reddish change Endoscopic submucosal dissection

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Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement

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World Journal of Gastroenterology 2010年第37期16卷 4661-4669页

作者： Masaya Iwamuro Hiroyuki Okada yoshiro kawahara Katsuji Shinagawa Toshiaki Morito Tadashi Yoshino Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Department of Hematology and Oncology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Department of Pathology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL). METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those ***: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7%), 26 (74.3%), and 12 (34.3%) patients, respectively. Twenty-one of the 35 patients underwent colonoscopy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6%), 3 (14.3%), 12 (57.1%), and 10 (47.6%), respectively. Various lesions, such as superficial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3% vs 46.4%, P < 0.01) and better EFS (3-year rate, 66.7% vs 33.8%, P < 0.05) than the remaining 23 patients who were not treated with this regimen. CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients.

关键词： Chemotherapy Gastrointestinal lymphoma Mantle cell lymphoma Multiple lymphomatous polyposis Non-Hodgkin’s lymphoma

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Review of oral and pharyngolaryngeal benign lesions detected during esophagogastroduodenoscopy

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World Journal of Gastrointestinal Endoscopy 2023年第7期15卷 496-509页

作者： Masaya Iwamuro Kenta Hamada Seiji Kawano yoshiro kawahara Motoyuki Otsuka Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

Recent advancements in endoscopy equipment have facilitated endoscopists’detection of neoplasms in the oral cavity and pharyngolaryngeal *** particular,image-enhanced endoscopy using narrow band imaging or blue laser imaging play an integral role in the endoscopic diagnosis of oral and pharyngolaryngeal *** these advancements,limited studies have focused on benign lesions that can be observed during esophagogastroduodenoscopy in the oral and pharyngolaryngeal ***,this mini-review aimed to provide essential information on such benign lesions,along with representative endoscopic images of dental caries,cleft palate,palatal torus,bifid uvula,compression by cervical osteophytes,tonsil hyperplasia,black hairy tongue,oral candidiasis,oral and pharyngolaryngeal ulcers,pharyngeal melanosis,oral tattoos associated with dental alloys,retention cysts,papilloma,radiation-induced changes,skin flaps,vocal cord paresis,and vocal fold *** it is imperative to seek consultation from otolaryngologists or dentists in instances where the diagnosis cannot be definitively ascertained by endoscopists,the merits of attaining foundational expertise pertaining to oral and pharyngolaryngeal lesions are *** article will be a valuable resource for endoscopists seeking to enhance their understanding of oral and pharyngolaryngeal lesions.

关键词： Benign diseases Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Oral lesions Pharyngolaryngeal lesions

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Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer:A multicenter retrospective study

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World Journal of Gastroenterology 2021年第11期27卷 1043-1054页

作者： Takuya Satomi Seiji Kawano Tomoki Inaba Masahiro Nakagawa Hirokazu Mouri Masao Yoshioka Shoichi Tanaka Tatsuya Toyokawa Sayo Kobayashi Takehiro Tanaka Hiromitsu Kanzaki Masaya Iwamuro yoshiro kawahara Hiroyuki OkadaDepartment of Gastroenterology and Hepatology Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558OkayamaJapan Department of Gastroenterology Kagawa Prefectural Central HospitalTakamatsu 760-8557KagawaJapan Department of Endoscopy Hiroshima City Hiroshima Citizens HospitalHiroshima 730-8518HiroshimaJapan Department of Gastroenterology and Hepatology Kurashiki Central HospitalKurashiki 710-8602OkayamaJapan Department of Gastroenterology and Hepatology Okayama Saiseikai General HospitalOkayama 700-8511OkayamaJapan Department of Gastroenterology National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan Department of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 720-8521HiroshimaJapan Department of Internal Medicine Fukuyama City HospitalFukuyama 721-8511HiroshimaJapan Department of Pathology Okayama University HospitalOkayama 700-8558OkayamaJapan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558OkayamaJapan

BACKGROUND Recent improvements in the prognosis of patients with esophageal cancer have led to the increased occurrence of gastric tube cancer(GTC)in the reconstructed gastric ***,there are few reports on the treatment results of endoscopic submucosal dissection(ESD)for *** To evaluate the efficacy and safety of ESD for GTC after esophagectomy in a multicenter *** We retrospectively investigated 48 GTC lesions in 38 consecutive patients with GTC in the reconstructed gastric tube after esophagectomy who had undergone ESD between January 2005 and December 2019 at 8 institutions participating in the Okayama Gut Study *** clinical indications of ESD for early gastric cancer were similarly applied for GTC after *** specimens were evaluated in 2-mm slices according to the Japanese Classification of Gastric Carcinoma with curability assessments divided into curative and non-curative resection based on the Gastric Cancer Treatment *** characteristics,treatment results,clinical course,and treatment outcomes were *** The median age of patients was 71.5 years(range,57-84years),and there were 34 men and 4 *** median observation period after ESD was 884 d(range,8-4040 d).The median procedure time was 81 min(range,29-334 min),the en bloc resection rate was 91.7%(44/48),and the curative resection rate was 79%(38/48).Complications during ESD were seen in 4%(2/48)of case,and those after ESD were seen in 10%(5/48)of *** survival rate at 5 years was 59.5%.During the observation period after ESD,10 patients died of other *** there were differences in the procedure time between institutions,a multivariate analysis showed that tumor size was the only factor associated with prolonged procedure *** ESD for GTC after esophagectomy was shown to be safe and effective.

关键词： Endoscopic submucosal dissection Gastric tube Gastric cancer Esophagectomy Multicenter study Retrospective study

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Proton pump inhibitor step-down therapy for GERD:A multi-center study in Japan

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World Journal of Gastroenterology 2011年第11期17卷 1480-1487页

作者： Takao Tsuzuki Hiroyuki Okada yoshiro kawahara Ryuta Takenaka Junichiro Nasu Hidehiko Ishioka Akiko Fujiwara Fumiya Yoshinaga Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Internal Medicine Tsuyama Central HospitalOkayama 708-0841Japan Ishioka clinic Hiroshima 721-0926Japan Department of Internal Medicine Okayama Saiseikai General HospitalOkayama 700-8511Japan Deparment of Internal Medicine Mihara Red Cross HospitalHiroshima 723-8512Japan

AIM:To investigate the predictors of success in stepdown of proton pump inhibitor and to assess the quality of life(QOL).METHODS:Patients who had heartburn twice a week or more were treated with 20 mg omeprazole(OPZ) once daily for 8 wk as an initial therapy(study 1).Patients whose heartburn decreased to once a week or less at the end of the initial therapy were enrolled in study 2 and treated with 10 mg OPZ as maintenance therapy for an additional 6 mo(study 2).QOL was in-vestigated using the gastrointestinal symptom rating scale(GSRS)before initial therapy,after both 4 and 8 wk of initial therapy,and at 1,2,3,and 6 mo after starting maintenance ***:In study 1,108 patients were *** characteristics were as follows;median age:63(range: 20-88)years,sex:46 women and 62 *** success rate of the initial therapy was 76%.In the patients with successful initial therapy,abdominal pain,indigestion and reflux GSRS scores were *** study 2,83 patients were *** of 83 patients completed the study 2 *** the per-protocol analysis,80%of 70 patients were successful for *** multivariate analysis of baseline demographic data and clinical information,no previous treatment for gastroesophageal reflux disease(GERD)[odds ratio (OR)0.255,95%CI:0.06-0.98]and a lower indigestion score in GSRS at the beginning of step-down therapy(OR 0.214,95%CI:0.06-0.73)were found to be the predictors of successful step-down *** improved GSRS scores by initial therapy were maintained through the step-down ***:OPZ was effective for most GERD ***,those who have had previous treatment for GERD and experience dyspepsia before stepdown require particular monitoring for relapse.

关键词： Gastroesophageal reflux disease Proton pump inhibitor Omeprazole Step-down therapy Gastrointestinal symptom rating scale

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Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement

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World Journal of Gastroenterology 2012年第44期18卷 6427-6436页

作者： Masaya Iwamuro Hiroyuki Okada Katsuyoshi Takata Katsuji Shinagawa Shigeatsu Fujiki Junji Shiode Atsushi Imagawa Masashi Araki Toshiaki Morito Mamoru Nishimura Motowo Mizuno Tomoki Inaba Seiyu Suzuki Yoshinari Kawai Tadashi Yoshino yoshiro kawahara Akinobu Takaki Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Endoscopy Okayama University HospitalOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Hematology and Oncology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Internal Medicine Tsuyama Central HospitalTsuyama 708-0841Japan Department of Internal Medicine Okayama Saiseikai General HospitalOkayama 700-8511Japan Department of Gastroenterology Mitoyo General HospitalKanonji 769-1695Japan Department of Internal Medicine Kagawa Rosai HospitalMarugame 763-8502Japan Department of Anatomic Pathology Kagawa Rosai HospitalMarugame 763-8502Japan Department of Internal Medicine Okayama Citizens' HospitalOkayama 700-8557Japan Department of Internal Medicine Hiroshima City HospitalHiroshima 730-8518Japan Department of Gastroenterology Kagawa Prefectural Central HospitalTakamatsu 760-8557Japan Department of Internal Medicine Sumitomo Besshi HospitalNiihama 792-8543Japan Department of Gastroenterology Onomichi Municipal HospitalOnomichi 722-8503Japan

AIM:To investigate the capacity for 18F-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) to evaluate patients with gastrointestinal lesions of follicular ***:This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten different institutions between November 1996 and October *** for endoscopic,radiological,and biological examinations performed were retrospectively reviewed from clinical records.A semi-quantitative analysis of 18F-FDG uptake was performed for each involved area by calculating the maximum standardized uptake value(SUVmax).Based on the positivity of 18F-FDG uptake in the gastrointestinal lesions analyzed,patients were subdivided into two *** identify potential predictive factors for 18F-FDG positivity,these two groups were compared with respect to gender,age at diagnosis of lymphoma,histopathological grade,pattern of follicular dendritic cells,mitotic rate,clinical stage,soluble interleukin-2 receptor levels detected by 18F-FDG-PET,lactate dehydrogenase(LDH) levels,hemoglobin levels,bone marrow involvement,detectability of gastrointestinal lesions by computed tomography(CT) scanning,and follicular lymphoma international prognostic index(FLIPI) ***:Involvement of follicular lymphoma in the stomach,duodenum,jejunum,ileum,cecum,colon,and rectum was identified in 1,34,6,3,2,3,and 6 patients,*** patient had esophageal *** total,19/41(46.3%) patients exhibited true-positive 18F-FDG uptake in the lesions present in their gastrointestinal *** contrast,false-negative 18F-FDG uptake was detected in 24 patients(58.5%),while false-positive 18F-FDG uptake was detected in 5 patients(12.2%).In the former case,2/19 patients had both 18F-FDG-positive lesions and 18F-FDGnegative lesions in the gastrointestinal *** patients with 18F-FDG avidity,the SUVmax value of the involved gast

关键词： Follicular lymphoma Gastrointestinal endoscopy F-fluorodeoxyglucose positron emission tomography Gastrointestinal lymphoma Duodenal neoplasm

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