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Cellular physiological approach for treatment of gastric cancer

World Journal of Gastroenterology 2014年第33期20卷 11560-11566页

作者： Atsushi Shiozaki Daisuke Ichikawa Eigo Otsuji yoshinori Marunaka Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Departments of Molecular Cell Physiology and Bio-Ionomics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Japan Institute for Food Education and Health St. Agnes’ University Kyoto 602-8013 Japan

Recent studies show that ion channels/transporters play important roles in fundamental cellular functions that would be involved in the cancer process. We review the evidence for their expression and functioning in human gastric cancer (GC), and evaluate the potential of cellular physiological approach in clinical management. Various types of ion channels, such as voltage-gated K+ channels, intracellular Cl- channels and transient receptor potential channels have been found to express in GC cells and tissues, and to control cell cycles. With regard to water channels, aquaporin 3 and 5 play an important role in the progression of GC. Regulators of intracellular pH, such as anion exchanger, sodium-hydrogen exchanger, vacuolar H+-ATPases and carbonic anhydrases are also involved in tumorigenesis of GC. Their pharmacological manipulation and gene silencing affect cellular behaviours, suggesting their potential as therapeutic targets for GC. Our studies indicate the intracellular Cl- concentration could act as a mediator of cellular signaling and control cell cycle progression in GC cells. Further, we demonstrate the cytocidal effects of hypotonic shock on GC cells, and indicate that the blockade of Cl- channels/transporters enhances these effects by inhibiting regulatory volume decrease. A deeper understanding of molecular mechanisms may lead to the discovery of these cellular physiological approaches as a novel therapeutic strategy for GC.

关键词： Gastric cancer Ion channels Water chan-nels Intracellular pH Intracellular chloride Osmolality

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Visual simulation of clouds

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Visual Informatics 2017年第1期1卷 1-8页

作者： yoshinori Dobashi Kei Iwasaki Yonghao Yue Tomoyuki Nishita Hokkaido University/UEI Research Japan Wakayama University/UEI Research Japan The University of Tokyo Japan UEI Research/Hiroshima Shudo University Japan

Clouds play an important role when synthesizing realistic images of outdoor *** realistic display of clouds is therefore one of the important research topics in computer *** order to display realistic clouds,we need methods for modeling,rendering,and animating clouds *** is also important to control the shapes and appearances of clouds to create certain visual *** this paper,we explain our efforts and research results to meet such requirements,together with related researches on the visual simulation of clouds.

关键词： Clouds Procedural modeling image-based modeling Fluid simulation Feedback control Genetic algorithms

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Deformation behavior and acting earth pressure of three-hinge precast arch culvert in construction process

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Underground Space 2019年第3期4卷 251-260页

作者： Yasuo Sawamura Hiroyuki Ishihara yoshinori Otani Kiyoshi Kishida Makoto Kimura Department of Civil and Earth Resources Engineering Kyoto UniversityJapan Hokkaido Branch Kajima CorporationJapan Hirose Hokyodo&Co. Ltd.Japan Department of Urban Management Kyoto UniversityJapan

The three-hinge precast arch culvert consists of two segmental precast units and three hinge *** harnesses the passive resistance of an embankment by permitting deflection,resulting in a mechanically stable ***,the design of the three-hinge precast arch culvert differs from that of a conventional culvert,prompting the mechanical behavior of the culvert to become an important *** this study,therefore,1/5 scale model tests were conducted on a three-hinge precast arch culvert to measure the changes in the inside width and earth pressure acting on the culvert at each step in order to investigate the culvert’s mechanical behavior at each construction ***,the deflection measurement of the culvert was obtained at the in-situ construction *** results indicate that the arch members were displaced according to the embankment depth in a similar manner to the design ***,the horizontal earth pressure,which was larger than the earth pressure at rest,acted on the culvert at the end of its construction.

关键词： Precast arch culvert Construction process Coefficient of earth pressure Inside width

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Influence of synovia constituents on tribological behaviors of articular cartilage

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Friction 2013年第2期1卷 150-162页

作者： Teruo MURAKAMI Seido YARIMITSU Kazuhiro NAKASHima yoshinori SAWAE Nobuo SAKAI Research Center for Advanced Biomechanics Kyushu University744 MotookaNishi-kuFukuoka819-0395Japan Department of Mechanical Engineering Faculty of EngineeringKyushu University744 MotookaNishi-kuFukuoka819-0395Japan Department of Applied Science for Integrated System Engineering Graduate School of EngineeringKyushu Institute of Technology1-1SensuichoTobata-kuKitakyushu804-8550Japan

The extremely low friction and minimal wear in natural synovial joints appear to be established by effective lubrication mechanisms based on appropriate combination of articular cartilage and synovial *** complex structure of cartilage composed of collagen and proteoglycan with high water content contributes to high load-carrying capacity as biphasic materials and the various constituents of synovial fluid play important roles in various lubrication ***,the detailed differences in functions of the intact and damaged cartilage tissues,and the interaction or synergistic action of synovia constituents with articular cartilage have not yet been *** this study,to examine the roles of synovia constituents and the importance of cartilage surface conditions,the changes in friction were observed in the reciprocating tests of intact and damaged articular cartilage specimens against glass plate lubricated with lubricants containing phospholipid,protein and/or hyaluronic acid as main constituents in synovial *** effectiveness of lubricant constituents and the influence of cartilage surface conditions on friction are *** addition,the protectiveness by synovia constituents for intact articular cartilage surfaces is evaluated.

关键词： articular cartilage synovial fluid synovial joint lubrication biotribology

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New ‘multi-omics' approach and its contribution to hepatocellular carcinoma in China

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Chinese Journal of Cancer Research 2014年第6期26卷 639-640页

作者： yoshinori Inagaki Peipei Song Norihiro Kokudo Wei Tang Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo 113-8655 Japan

Hepatocellular carcinoma（HCC）is one of the most common liver neoplasms worldwide,and 70-80%cases are accounted in Asian countries（1）.Etiological background of HCC patients is different in each country or *** China,infection of hepatitis B virus （HBV） is a main etiological factor of increased incidence of HCC. In fact, 93 million HBV carriers are Chinese, accounting for 2/3 of such patients worldwide, and about 20 million of these people have chronic HBV infection （2）. Chronic HBV infection is a high risk factor for development of HCC. Therefore, the follow-up of those chronic viral hepatitis type B patients and the early-detection of HCC in those patients are pressing tasks to reduce the incidence of HCC in China （3）.

关键词： neoplasms accounted recurrence fetoprotein New multi-omics multifocal physiological incidence metastatic

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Studies on numerical site calibration over complex terrain for wind turbines

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Science China(Technological Sciences) 2010年第1期53卷 8-12页

作者： Daisuke MATSUSHITA Hikaru MATSUMIYA yoshinori HARA Satoshi WATANABE Akinori FURUKAWA Department of Mechanical Engineering Science Kyushu University Hikaruwind Lab 5234 Seijo Setagaya-kuTokyoJapan

The estimation of wind turbine performance over complex terrain is very difficult because of the document of standard IEC61400-12 is adapted for flat or slightly complex *** the cost of constructing a meteorological mast is higher with scaling wind turbine *** have proposed a numerical site calibration(NSC) technique in order to estimate the inflow velocity at the position of wind turbine by using CFD tool to calculate the flow field around the *** present paper shows the problems for the procedure of NSC in which a commercial nonlinear CFD tool and the improvement method are used to gain a more accurate *** is clarified that the wind turbine performance which is estimated by using the wind speed on the meteorological mast has a good result for annual energy production.

关键词： wind turbine site calibration complex terrain wind turbine performance

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Ultra-Thin Double-Walled Carbon Nanotubes： A Novel Nanocontainer for Preparing Atomic Wires

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Nano Research 2011年第8期4卷 759-766页

作者： Lei Shi Leimei Sheng Liming Yu Kang An yoshinori Ando Xinluo Zhao Department of Physics and Institute of Low-Dimensional Carbons and Device Physics Shanghai University Shanghai 200444 China Department of Materials Science and Engineering Meijo University Nagoya 468-8502 Japan

Double-walled carbon nanotubes （DWCNTs） with high graphitization have been synthesized by hydrogen arc discharge. The obtained DWCNTs have a narrow distribution of diameters of both the inner and outer tubes, and more than half of the DWCNTs have inner diameters in the range 0.6-1.0 nm. Field electron emission from a DWCNT cathode to an anode has been measured, and the emission current density of DWCNTs reached 1 A/cm2 at an applied field of about 4.3 V/~tm. After high-temperature treatment of DWCNTs, long linear carbon chains （C-chains） can be grown inside the ultra-thin DWCNTs to form a novel C-chain@DWCNT nanostructure, showing that these ultra-thin DWCNTs are an appropriate nanocontainer for preparing truly one-dimensional nanostructures with one-atom-diameter.

关键词： Arc discharge carbon chains double-walled carbon nanotubes field electron emission nanocontainer nanowires

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Evaluation of sorafenib for hepatocellular carcinoma by contrast-enhanced ultrasonography:A pilot study

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World Journal of Gastroenterology 2012年第40期18卷 5753-5758页

作者： Kazue Shiozawa Manabu Watanabe yoshinori Kikuchi Takahide Kudo Kenichi Maruyama Yasukiyo Sumino Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Medical CenterOmori HospitalTokyo 143-8541Japan Department of Clinical Functional Physiology Toho University Medical CenterOmori HospitalTokyo 143-8541Japan

AIM:To determine the usefulness of arrival time parametric imaging(AtPI) using contrast-enhanced ultrasonography(CEUS) with Sonazoid in evaluating early response to sorafenib for hepatocellular carcinoma(HCC).METHODS:Fourteen advanced HCC patients who received sorafenib 400/800 mg/d for at least 4 wk and were followed up by CEUS were enrolled in this *** was performed before treatment and 2 and 4 wk after treatment,and images of the target lesion in the arterial phase were recorded for each *** images were analyzed by *** mapping(CM) images obtained by AtPI were compared before and after the *** these CM images,the mean arrival time of the contrast agent in the region of interest from the starting point [mean time(MT)] was *** each patient,differences between MT before and MT 2 and 4 wk after the treatment were compared with responses evaluated 4-8 wk after the treatment by dynamic computed tomography(CT),and statistical analysis was *** response evaluation criteria in solid tumors was used for the response ***:In CM images both 2 and 4 wk after the treatment,delays in the arrival time of the contrast agent were noted in 8 of the 14 *** the other 6 patients,no color changes were observed in the tumor,or red and/or yellow increase,suggesting a decrease in blood flow velocity between images 2 and 4 wk after the treatment and those before the *** CT could be performed 4-8 wk after the treatment in 13 of the 14 *** differences in the MT were 1.13 s and 1.015 s,2 and 4 wk after the treatment,respectively,in the 8 patients who showed stable disease(SD)/partial response(PR) on dynamic *** differences in the MT were-0.39 s and-0.95 s,2 and 4 wk after the treatment,respectively,in the 5 patients who showed progressive disease(PD).Differences in the median MT between SD/PR and PD groups were significant 2 and 4 wk after the treatment with P = 0.019 and P = 0.028,resp

关键词： Sorafenib Sonazoid Contrast-enhanced ul-trasonography Hepatocellular carcinoma Therapeutic response

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Kiwifruit recognition at nighttime using artificial lighting based on machine vision

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International Journal of Agricultural and Biological Engineering 2015年第4期8卷 52-59页

作者： Fu Longsheng Wang Bin Cui Yongjie Su Shuai yoshinori Gejima Taiichi Kobayashi College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100China Beijing Research Center of Intelligent Equipment for Agriculture Beijing 100089China Faculty of Agriculture University of MiyazakiMiyazaki 889-2192Japan

Most researches involved so far in kiwifruit harvesting robot suggest the scenario of harvesting in daytime for taking advantage of sunlight.A robot operating at nighttime can overcome the problem of low work efficiency and would help to minimize fruit *** addition,artificial lights can be used to ensure constant illumination instead of the variable natural sunlight for image *** paper aims to study the kiwifruit recognition at nighttime using artificial lighting based on machine ***,an RGB camera was placed underneath the canopy so that clusters of kiwifruits could be included in the ***,the images were segmented using an R-G color ***,a group of image processing conventional methods,such as Canny operator were applied to detect the *** image processing results showed that this capturing method could reduce the background noise and overcome any target *** experimental results showed that the optimal artificial lighting ranged approximately between 30-50 *** developed algorithm detected 88.3%of the fruits successfully.

关键词： Elliptic Hough transform image capturing method Kiwifruit minimal bounding rectangle optimal illumination intensity

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Effects of Integrated Organic and Inorganic Fertilizers on Yield and Growth Parameters of Rice Varieties

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Rice science 2019年第5期26卷 309-318页

作者： Kyi MOE Seinn Moh MOH Aung Zaw HTWE yoshinori KAJIHARA Takeo YAMAKAWA Plant Nutrition Laboratory Graduate School of Bioresource and Bioenvironmental SciencesFaculty of AgricultureKyushu University6-10-1 HakozakiHigashi-kuFukuoka 812-8581Japan Department of Agronomy Yezin Agricultural UniversityYezinNay Pyi Taw 15013Myanmar University Farm School of AgricultureKyushu UniversityFukuoka 812-8581Japan Plant Nutrition Laboratory Division of Molecular BiosciencesDepartment of Biosciences and BiotechnologyFaculty of AgricultureKyushu University6-10-1 HakozakiHigashi-kuFukuoka 812-8581Japan

We investigated the effects of integrated organic and inorganic fertilizers on the growth and yield of indica rice variety Manawthukha and japonica rice variety *** a split-plot design,the two rice varieties were assigned as main plot factors,and the integrated treatments were the subplot factors,including no-N fertilizer(N0),50%chemical fertilizer(CF)(CF50),100%CF(CF100),50%CF+50%poultry manure(PM)(CF50PM50),50%CF+50%cow manure(CM)(CF50CM50),and 50%CF+50%compost(CP)(CF50CP50).CF100 was equivalent to N at 85 kg/*** was applied based on the estimated mineralizable nitrogen(EMN)level,which is dependent on total N(%)of each manure *** rice plants were taller with higher tiller number and dry matter ***,higher soil-plant analysis development(SPAD)values were measured in Genkitsukushi throughout the crop growth period,resulting in higher seed-setting rate(%)and greater *** the same N level,CF50PM50 application in both rice varieties resulted in higher SPAD values,plant height and tiller number than ***50PM50 containing total N more than 4%supplied synchronized N for the demands of the rice plants,resulting in maximum dry matter,yield and yield ***50CM50 and CF50CP50 treatments containing total N less than 4%resulted in lower yields which were similar to *** results indicated that integrating organic and inorganic fertilizers enhanced growth parameters and yields of Manawthukha and Genkitsukushi,while reducing the dose of chemical fertilizer.

关键词： estimated mineralizable nitrogen growth parameter inorganic fertilizer organic manure rice yield

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