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International Journal of Disaster Risk Science 2012年第1期3卷 56-65页

作者： Elizabeth Maly yoshimitsu shiozaki Department of Engineering Kobe UniversityKobe 657-8501Japan

The goal of disaster recovery is for survivors to regain stability in their lives,livelihoods,and housing. A people-centered housing recovery requires that residents are empowered to make decisions about their housing reconstruction,and that policies create housing options that support the ability of all residents to reconstruct their homes and lives. The 1995 Hanshin-Awaji Earthquake caused the largest amount of damage in Japan since World War II,and the subsequent recovery is a starting point for understanding contemporary post-disaster housing reconstruction policies in Japan. Beyond an overview of housing reconstruction programs,we can understand the impact these policies had on Kobe residents’ housing and community recovery. In many cases,housing policies implemented after the Kobe earthquake fragmented communities and caused further damage and disruption in the lives of the survivors. A single-track approach failed to support the entire population of the disaster-stricken area. In subsequent years,Japanese disaster reconstruction laws and policies have seen modifications and improvements. Some of these changes can be seen in cases of recovery after more recent disasters,notably after the 2004 Chuetsu Earthquake in Niigata Prefecture. In the context of these past examples,we can consider what is needed for a people-centered recovery in the Tohoku area after the 2011 Great East Japan Earthquake and Tsunami.

关键词： disaster Earthquake subsequent

Cellular physiological approach for treatment of gastric cancer

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World Journal of Gastroenterology 2014年第33期20卷 11560-11566页

作者： Atsushi shiozaki Daisuke Ichikawa Eigo Otsuji Yoshinori Marunaka Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Departments of Molecular Cell Physiology and Bio-Ionomics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Japan Institute for Food Education and Health St. Agnes’ University Kyoto 602-8013 Japan

Recent studies show that ion channels/transporters play important roles in fundamental cellular functions that would be involved in the cancer process. We review the evidence for their expression and functioning in human gastric cancer (GC), and evaluate the potential of cellular physiological approach in clinical management. Various types of ion channels, such as voltage-gated K+ channels, intracellular Cl- channels and transient receptor potential channels have been found to express in GC cells and tissues, and to control cell cycles. With regard to water channels, aquaporin 3 and 5 play an important role in the progression of GC. Regulators of intracellular pH, such as anion exchanger, sodium-hydrogen exchanger, vacuolar H+-ATPases and carbonic anhydrases are also involved in tumorigenesis of GC. Their pharmacological manipulation and gene silencing affect cellular behaviours, suggesting their potential as therapeutic targets for GC. Our studies indicate the intracellular Cl- concentration could act as a mediator of cellular signaling and control cell cycle progression in GC cells. Further, we demonstrate the cytocidal effects of hypotonic shock on GC cells, and indicate that the blockade of Cl- channels/transporters enhances these effects by inhibiting regulatory volume decrease. A deeper understanding of molecular mechanisms may lead to the discovery of these cellular physiological approaches as a novel therapeutic strategy for GC.

关键词： Gastric cancer Ion channels Water chan-nels Intracellular pH Intracellular chloride Osmolality

Liquid biopsy of gastric cancer patients:Circulating tumor cells and cell-free nucleic acids

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World Journal of Gastroenterology 2014年第12期20卷 3265-3286页

作者： Masahiro Tsujiura Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Atsushi shiozaki Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of Medicine

To improve the clinical outcomes of cancer patients, early detection and accurate monitoring of diseases are necessary. Numerous genetic and epigenetic alterations contribute to oncogenesis and cancer progression, and analyses of these changes have been increasingly utilized for diagnostic, prognostic and therapeutic purposes in malignant diseases including gastric cancer (GC). Surgical and/or biopsy specimens are generally used to understand the tumor-associated alterations; however, those approaches cannot always be performed because of their invasive characteristics and may fail to reflect current tumor dynamics and drug sensitivities, which may change during the therapeutic process. Therefore, the importance of developing a non-invasive biomarker with the ability to monitor real-time tumor dynamics should be emphasized. This concept, so called “liquid biopsy”, would provide an ideal therapeutic strategy for an individual cancer patient and would facilitate the development of “tailor-made” cancer management programs. In the blood of cancer patients, the presence and potent utilities of circulating tumor cells (CTCs) and cell-free nucleic acids (cfNAs) such as DNA, mRNA and microRNA have been recognized, and their clinical relevance is attracting considerable attention. In this review, we discuss recent developments in this research field as well as the relevance and future perspectives of CTCs and cfNAs in cancer patients, especially focusing on GC.

关键词： Gastric cancer Biomarker Liquid biopsy Circulating tumor cells Cell-free nucleic acids MicroRNA

Water-resistant organic thermoelectric generator with >10μW output

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Carbon Energy 2023年第4期5卷 55-67页

作者： Shinichi Hata Kanto Maeshiro Misaki Shiraishi Soichiro Yasuda Yuta shiozaki Koudai Kametani Yukou Du Yukihide Shiraishi Naoki Toshima Department of Applied Chemistry Faculty of EngineeringSanyo‐Onoda City UniversityYamaguchiJapan Graduate School of Engineering Sanyo‐Onoda City UniversityYamaguchiJapan College of Chemistry Chemical Engineeringand Materials ScienceSoochow UniversitySuzhouPeople's Republic of China

Flexible p–n thermoelectric generator(TEG)technology has rapidly advanced with power enhancement and size *** achieve a stable power supply and highly efficient energy conversion,absolute chemical stability of n-type materials is essential to ensuring large temperature differences between device terminals and ambient *** the aim of improving the long-term stability of the n-type operation of carbon nanotubes(CNTs)in air and water,this study uses cationic surfactants,such as octylene-1,8-bis(dimethyldodecylammonium bromide)(12-8-12),a gemini surfactant,to stabilize the nanotubes in a coating,which retains the n-doped state for more than 28 days after exposure to air and water in *** with 10 p-n units of 12-8-12/CNT(n-type)and sodium dodecylbenzene sulfonate/CNT(p-type)layers are manufactured,and their water stability is *** initial maximum output of 16.1μW(75 K temperature difference)is retained after water immersion for 40 days without using a sealant to prevent TEG module *** excellent stability of these CNT-based TEGs makes them suitable for underwater applications,such as battery-free health monitoring and information gathering systems,and facilitates the development of soft electronics.

关键词： gemini surfactant n-type carbon nanotube surfactant doping thermoelectric properties water-resistant generators water stability

Flavonoid Profiles of Wild Grapes Native to Japan: Vitis coignetiae Pulliat andVitis ficifolia Bunge var. ganebuHatusima

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Agricultural Sciences 2017年第3期8卷 239-252页

作者： Shuji shiozaki Kazunori Murakami Osaka Prefecture University Graduate School of Life & Environmental Sciences Sakai Japan saka Prefecture University Graduate School of Life & Environmental Sciences Sakai Japan

Flavonoids are a group of natural compounds in plants with versatile health benefits for humans. Grapes are a dietary source of flavonoids and the flavonoid components in grape berries can depend on the grape species and cultivar. In this experiment, proanthocyanidins, flavonols, and anthocyanins were analyzed in Vitis coignetiae and V. ficifolia var. ganebu, wild grapes native to Japan, and compared with those in V. labruscana cv. Muscat Bailey A, to evaluate the potential of the wild grapes as a grape resource. Proanthocyanidin contents in seeds were lower in the two wild grapes than in Muscat Bailey A. However, the skin of V. ficifolia var. ganebu was the richest source of proanthocyanidins. Flavonol levels in the skins of the two wild grapes were lower than that in the skin of Muscat Bailey A. Colorimetry determined that the total anthocyanin content in the skin of V. ficifolia var. ganebu was 6 times and 7 times higher, respectively, than those of V. coignetiae and Muscat Bailey A. Although monoglucoside anthocyanin levels analyzed by high-pressure liquid chromatography (HPLC) were in the order Muscat Bailey A > V. ficifolia var. ganebu > V. coignetiae, most of the diglucoside and acylated monoglucoside and diglucoside anthocyanin levels identified by HPLC-mass spectrometry were highest in V. ficifolia var. ganebu. These data suggest that V. ficifolia var. ganebu might be a novel source of flavonoids and superior to V. coignetiae as a source of flavonoids.

关键词： Anthocyanin Flavonol Proanthocyanidin Wild Grapes

Evolution of gastric surgery techniques and outcomes

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Chinese Journal of Cancer 2016年第8期35卷 410-415页

作者： Hironori shiozaki Yusuke Shimodaira Elena Elimova Roopma Wadhwa Kazuki Sudo Kazuto Harada Jeannelyn S.Estrella Prajnan Das Brian Badgwell Jaffer A.Ajani Department of Gastrointestinal Medical Oncology Unit 426The University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTX 77030USA National Cancer Center Hospital Tokyo 104-0045Japan Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Surgical management of gastric cancer improves ***,for some time,surgeons have had diverse opinions about the extent of *** have conducted many clinical studies,making slow but steady progress in determining the optimal surgical *** extent of lymph node dissection has been one of the major issues in surgery for gastric *** trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 ***,long-term outcomes demonstrated that D2 dissection resulted in longer survival than D1 *** 2004,the Japan Clinical Oncology Group reported a pivotal trial which was performed to determine whether para-aortic lymph node dissection combined with D2 dissection was superior to D2 dissection alone and found no benefit of the additional *** with pancreatectomy,splenectomy,and bursectomy was initially recommended as part of the D2 ***,pancreas-preserving total gastrectomy with D2 dissection is standard,and ongoing trials are addressing the role of ***,the feasibility and safety of laparoscopic gastrectomy are well *** and quality of life are increasingly recognized as the most important *** this review,we present perspectives on surgical techniques and important trials of these techniques in gastric cancer patients.

关键词： Gastric cancer Gastrectomy Laparoscopic gastrectomy Lymph node dissection

Role of the Na^+/K^+/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2014年第22期20卷 6844-6859页

作者： Atsushi shiozaki Yoshito Nako Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yoshinori Marunaka Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto PrefecturalUniversity of MedicineKyoto 602-8566Japan Departments of Molecular Cell Physiology and Bio-Ionomics Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Japan Institute for Food Education and Health St. Agnes’ UniversityKyoto 602-8013Japan

AIM: To investigate the role of Na+/K+/2Cl- cotransporter 1 (NKCC1) in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell ... 详细信息

关键词： Na+/K+/2Cl- cotransporter 1 Esophageal cancer Cell cycle

Medical management of gastric cancer:A 2014 update

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World Journal of Gastroenterology 2014年第38期20卷 13637-13647页

作者： Elena Elimova Hironori shiozaki Roopma Wadhwa Kazuki Sudo Qiongrong Chen Jeannelyn S Estrella Mariela A Blum Brian Badgwell Prajnan Das Shumei Song Jaffer A Ajani Department of Gastrointestinal Medical Oncology University of TexasAnderson Cancer Center Pathology University of TexasAnderson Cancer Center Surgical Oncology University of TexasAnderson Cancer Center Radiation Oncology University of TexasAnderson Cancer Center

Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy (United States), pre-and post-operative chemotherapy (Europe), and adjuvant chemotherapy after a D2 resection (Asia) can all be regarded as standards of care in the localized gastric cancer management. In metastatic disease the addition of trastuzumab to chemotherapy is standard of care in Her2 positive disease. In the HER2 negative population, the treatments remain limited. In the first line setting, the standard of care is a combination of fluoropyrimidine and platinum containing chemotherapy, with or without epirubicin or docetaxel. The results of targeted therapy trials have by and large been disappointing, but none of these trials looked at an appropriately enriched population. Finally there is a meager overall survival benefit in treating patients with metastatic disease in the second line setting, with either irinotecan, docetaxel or ramucirumab however none of these drugs have been compared head to head in a well-powered randomized controlled trial.

关键词： Chemotherapy Gastric cancer Chemoradiation Metastatic Localized

Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma

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World Journal of Gastroenterology 2018年第8期24卷 949-956页

作者： Shinpei Ogino Hirotaka Konishi Daisuke Ichikawa Junichi Hamada Katsutoshi Shoda Tomohiro Arita Shuhei Komatsu Atsushi shiozaki Kazuma Okamoto Sanae Yamazaki Satoru Yasukawa Eiichi Konishi Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Department of Surgical Pathology Kyoto Prefectural University of Medicine

Synovial sarcoma(SS) is genetically characterized by chromosomal translocation, which generates SYT-SSX fusion transcripts. Although SS can occur in any body part, primary gastric SS is substantially rare. Here we describe a detection of the fusion gene sequence of gastric SS in plasma cell-free DNA(cf DNA). A gastric submucosal tumor was detected in the stomach of a 27-year-old woman and diagnosed as SS. Candidate intronic primers were designed to detect the intronic fusion breakpoint and this fusion sequence was confirmed in intron 10 of SYT and intron 5 of SSX2 by genomic polymerase chain reaction(PCR) and direct sequencing. A locked nucleic acid(LNA) probe specificto the fusion sequence was designed for detecting the fusion sequence in plasma and the fusion sequence was detected in preoperative plasma cfD NA, while not detected in postoperative plasma cfD NA. This technique will be useful for monitoring translocation-derived diseases such as SS.

关键词： Fusion gene Gastric synovial sarcoma Plasma Cell free DNA

Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells

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World Journal of Gastroenterology 2014年第47期20卷 17863-17876页

作者： Atsushi shiozaki Hiroki Shimizu Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Daisuke Iitaka Shingo Nakashima Yoshito Nako Mingyao Liu Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Latner Thoracic Surgery Research Laboratories University Health Network Toronto General Research InstituteToronto M5G 1L7Canada Department of Surgery Faculty of MedicineUniversity of TorontoToronto M5G 1L7Canada

AIM: To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha (TNF-α)-induced gene expression in human gastric adenocarcinoma cells.

关键词： Tumor necrosis factor alpha Claudin 1 Cell migration Microarray Gene expression change