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Differential expression of hepatic apurinic/apyrimidinic endonuclease 1,a DNA repair enzyme,in chronic hepatitis

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World Journal of Hepatology 2013年第4期5卷 206-213页

作者： Shinichi Sumiyoshi yoshimasa Kobayashi Kinya Kawamura Kazuhito kawata Hirotoshi Nakamura Second Division Department of Internal MedicineHamamatsu University School of MedicineShizuoka 431-3192Japan

AIM:To determine hepatic expression of apurinic/apyrimidinic endonuclease 1(APE-1)and 8-hydroxydeoxyguanosine(8-OHdG)in patients with chronic hepatitis B and ***:Liver biopsies were obtained from 27 patients with chronic hepatitis B virus(HBV),30 with chronic hepatitis C virus(HCV),6 with autoimmune hepatitis(AIH),and 6 with primary biliary cirrhosis(PBC).Normal liver tissue was obtained from surgical resection specimens of four *** APE-1 protein and mRNA expression were assayed by Western blot and by real-time polymerase chain reaction,*** APE-1 and 8-OHdG expression were determined by ***:The staining intensity of hepatocellular nuclear APE-1 was lower in the HBV group than in the other groups(P < 0.05).Hepatic APE-1 protein levels were reduced in the HBV group relative to the other *** APE-1 mRNA levels were also lower in the HBV *** proportion of hepatocytes with 8-OHdG-positive nuclei was increased in the HCV,AIH and PBC groups(P < 0.05),but not in the HBV *** nuclear APE-1 levels were positively correlated with hepatocellular 8-OHdG levels in both the HBV and HCV groups(HBV,r = 0.34,P < 0.05;HCV,r = 0.54,P < 0.01).CONCLUSION:An imbalance between oxidative DNA damage and APE-1 expression may contribute to hepatocarcinogenesis in chronic viral hepatitis.

关键词： Apurinic/apyrimidinic endonuclease 1 8-hydroxydeoxyguanosine Oxidative stress Viral hepatitis

Numerical simulation of a possible origin of the positive radial metallicity gradient of the thick disk

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Research in Astronomy and Astrophysics 2014年第11期14卷 1406-1414页

作者： Awat Rahimi Kenneth Carrell Daisuke kawata National Astronomical Observatories Chinese Academy of Sciences Mullard Space Science Laboratory University College London Holmbury St.Mary DorkingSurrey RH5 6NT UK

We analyze the radial and vertical metallicity and [α/Fe] gradients of the disk stars of a disk galaxy simulated in a fully cosmological setting with the chemo- dynamical galaxy evolution code GCD＋. We study how the radial abundance gradients vary as a function of height above the plane and find that the metallicity （[α/Fe]） gra- dient becomes more positive （negative） with increasing height, changing sign around 1.5 kpc above the plane. At the largest vertical height （2 〈丨z丨〈 3 kpc）, our simulated galaxy shows a positive radial metallicity gradient. We find that the positive metallicity gradient is caused by the age-metallicity and age-velocity dispersion relation, where younger stars have higher metallicity and lower velocity dispersion. Due to the age- velocity dispersion relation, a greater fraction of younger stars reaches 丨z丨〉 2 kpc at the outer region, because of the lower gravitational restoring force of the disk, i.e. flaring. As a result, the fraction of younger stars with higher metallicity due to the age-metallicity relation becomes higher at the outer radii, which makes the median metallicity higher at the outer radii. Combining this result with the recently observed age-metallicity and age-velocity dispersion relation for the Milky Way thick disk stars suggested by Haywood et al., we argue that the observed （small） positive radial metal- licity gradient at large heights of the Milky Way disk stars can be explained by flaring of the younger thick and/or thin disk stars.

关键词： Galaxy disk -- Galaxy kinematics and dynamics -- galaxies interac-tions- galaxies formation- galaxies evolution- galaxies abundances

Study and evaluation of a plant form modeling system based on the Lindenmayer system

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 107-114页

作者： Taiyo Maeda Yasuhiko Manabe Shigeo kawata Department of System Engineering Graduate School of Engineering Saitama Institute of Technology 1690 Fusaiji FukayaSaitama 369-0293Japan Department of Electrical and Electronics Engineering National Institute of Technology Numazu CollegeJapan Department of Electrical and Electronic Engineering Graduate School of Engineering Utsunomiya UniversityJapan

In order to evaluate and recognize plant growth automatically based on photos of plants in plant science and engineering,we propose a diagnostic system for plant growth in which simulated plant growth is used as a reference for real growing *** our diagnostic system,we employ the Lindenmayer system[Lecture Notes in Computer Science,15,53–68,1974]to model healthy growing *** the Lindenmayer system plant growth is expressed by string expressions designed as a numerical model for the *** proposal system provides users the string expressions by using image *** users compare with two strings such as DNA sequence genetic code,users obtain developmental change of plat *** results show that our automatic plant diagnostic system is effective in checking actual healthy plant growth,and suggest that the diagnostic system should be useful in large-scale plant factories.

关键词： Plant growth Lindenmayer system string expression for plant modeling

Dynamic stabilization of plasma instability

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High Power Laser Science and Engineering 2019年第1期7卷 17-26页

作者： S.kawata T.Karino Y.J.Gu Graduate School of Engineering Utsunomiya University Institute of Physics of the ASCR ELI-Beamlines Institute of Plasma Physics of the CAS

The paper presents a review of dynamic stabilization mechanisms for plasma instabilities. One of the dynamic stabilization mechanisms for plasma instability was proposed in the paper [kawata, Phys. Plasmas 19, 024503(2012)],based on a perturbation phase control. In general, instabilities emerge from the perturbations. Normally the perturbation phase is unknown, and so the instability growth rate is discussed. However, if the perturbation phase is known, the instability growth can be controlled by a superimposition of perturbations imposed actively. Based on this mechanism we present the application results of the dynamic stabilization mechanism to the Rayleigh–Taylor instability(RTI) and to the filamentation instability as typical examples in this paper. On the other hand, in the paper [Boris, Comments Plasma Phys. Control. Fusion 3, 1(1977)] another mechanism was proposed to stabilize RTI, and was realized by the pulse train or the laser intensity modulation in laser inertial fusion [Betti et al., Phys. Rev. Lett. 71, 3131(1993)]. In this latter mechanism, an oscillating strong force is applied to modify the basic equation, and consequently the new stabilization window is created. Originally the latter was proposed by Kapitza. We review the two stabilization mechanisms, and present the application results of the former dynamic stabilization mechanism.

关键词： dynamic instability stabilization filamentation instability plasma instability Rayleigh-Taylor instability stabilization of instability

On the calibration of the parameters governing the PWRI distributed hydrological model for flood prediction

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Journal of Safety Science and Resilience 2020年第2期1卷 80-90页

作者： Amaly Fong Lee Adan Vega Saenz Yoshiaki kawata Zoartech Consulting INC Panama CityPanama Panama Maritime Authority Panama CityPanama Kansai University OsakaJapan

The Public Works Research Institute Distributed Hydrological(PWRI-DH)for flood modeling is a combination of the tank model and the kinematic wave *** the PWRI-DH model,fitting the required parameters plays a fundamental *** developers of the PWRI-DH model have introduced the capability of obtaining parameters automatically using the baseline parameters;however,the results are not always the expected results because they depend on several factors and must be calibrated *** last issue has limited the interest of researchers regarding in the usage of the PWRI-DH *** this paper,we present a methodology to obtain the parameters required for the PWRI-DH model that enables to focusing only on the key ***,a parametric study is performed by identifying the influence of each parameter in the *** this study,we found that only four parameters play a fundamental role in the flood modeling using the PWRI-DH *** flood events in the Upper Aikawa River basin are used to calibrate the *** results showed that the proposed methodology is suitable and improve the efficient on the flood simulation of Aikawa River and similar rivers,when using the PWRI-DH model.

关键词： Flood prediction PWRI-DH model Discharge modeling Parameters Calibration

Sensitivity Dependence of Surface Plasmon Resonance Based Sensors on Prism Refractive Index

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Wuhan University Journal of Natural Sciences 2002年第1期7卷 47-50页

作者： Wang Guo-ping Sugiura Tadao kawata Satoshi School of Physics and Technology Wuhan University Wuhan 430072 Hubei China

We theoretically and experimentally demonstrate that refractive index of the prism used to load metal film has significant influence on sensitivity of surface plasmon resonance based sensors. The prism with lower refractive index gives the sensors a higher sensitivity in detecting refractive index variations of a sample. We attribute this effect to the fact that a prism with low refractive index will increase coupling distance between surface plasmons and the medium under investigation.

关键词： surface plasmon resonance sensors sensitivity prism propagation length

Quasi-monoenergetic Tens-of-MeV Proton Beams by a Laser-Illuminated Funnel-Like Target

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Chinese Physics Letters 2012年第3期29卷 142-145页

作者： BAN Hong-Ye GU Yan-Jun KONG Qing LI Ying-Ying ZHU Zhen S.kawata Applied Ion Beam Physics Laboratory Key Laboratory of the Ministry of EducationInstitute of Modern PhysicsFudan UniversityShanghai 200433 Department of Interdisciplinary Sciences Utsunomiya UniversityYohtoh 712Utsunomiya 3218585Japan

From numerical simulations,we study the generation of quasi-monoenergetic MeV proton beams from a laserilluminated funnel-like *** show that,when passing through such a target,the laser beam can be focused and constricted within a cylindrical bore at the funnel apex from which proton beams are *** by a much-enhanced laser intensity,the proton beams experience more acceleration time than with normal funnel *** from the cylinder bore,combined with an enhancement of a separated charge field from Al electrons,protons can attain higher energies up to several tens of *** the same time,strong suppression of the transverse divergence of the laser and proton beams yields a localized,collimated,mono-energetic proton beam.

关键词： strict cylindrical cylinder

Silver hierarchical structures grown on microstructured silicon in chip for microfluidic integrated catalyst and SERS detector

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Chinese Optics Letters 2015年第10期13卷 86-90页

作者：闫兆旭李春昊骆杨赵纪红杨海 Prabhat Verma Satoshi kawata State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin University Department of Applied Physics Osaka University Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences General Research Institute for Nonferrous Metals

In this Letter, silver（Ag） hierarchical nanostructures grown on black silicon（BS） are used as the catalyst and a surface-enhanced Raman scattering（SERS） detector integrated in a microfluid. The BS is fabricated via femtosecond laser ablation in an atmosphere of sulfur hexafluoride, and then hydrogenated with hydrofluoric acid. As formed, the BS substrate directly acts as a reducing template to grow silver hierarchical ***, Ag-BS composite micro/nano-structures can be in-situ constructed in silicon-based *** structures simultaneously serve as integrated catalytic reactors and a SERS substrate for sensing. The sensitivity is tested to be as low as 10-8mol∕L using Rhodamine 6G.

关键词： SERS hierarchical silver microfluid template ablation utilized Silver fabrication instance

Acceleration of Protons from a Double-Layer or Multi-Ion-Mixed Foil Irradiated by Ultraintense Lasers

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Plasma Science and Technology 2010年第3期12卷 277-283页

作者：王伟民盛政明於陆勒李玉同 kawata Shigeo 张杰 Beijing National Laboratory of Condensed Matter Physics Institute of PhysicsCAS Graduate School of Engineering Utsunomiya University Department of Physics Shanghai Jiao Tong University

Acceleration of protons by the radiation pressure of a circularly polarized laser pulse with the intensity up to 1021 W/cm^2 from a double-layer or multi-ion-mixed thin foil is investigated by two-dimensional particle-in-cell simulations. The double-layer foil is composed of a heavy ion layer and a proton layer. It is found that the radiation pressure acceleration can be classified into three regimes according to the laser intensity due to the different critical intensities for laser transparency with different ion species. When the laser intensity is moderately high, the laser pushes the electrons neither so slowly nor so quickly that the protons can catch up with the electrons, while the heavy ions cannot. Therefore, the protons can be accelerated efficiently. The proton beam generated from the double-layer foil is of better quality and higher energy than that from a pure proton foil with the same areal electron density. When the laser intensity is relatively low, both the protons and heavy ions are accelerated together, which is not favorable to the proton acceleration. When the laser intensity is relatively high, neither the heavy ions nor the protons can be accelerated efficiently due to the laser transparency through the target.

关键词： ion acceleration radiation pressure acceleration intense laser foil interaction particle-in-cell simulation