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Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors

第十次中国生物物理学术大会

作者： Y.Furusawa M.Kanazawa A.kitagawa National Institute of Radiological Sciences Chiba 263-8555Japan National Institute of Radiological Sciences Chiba 263-8555Japan National Institute of Radiological Sciences Chiba 263-8555Japan

＜正＞To evaluate the potential importance of a radioactive 9C-ion beam, representing a double radiation source coming from the external beam itself and the delayed particles emitted internally, in cancer therapy, radiobiological experiments using human salivary gland cells （HSG） were performed in the secondary beam line （SBL） at the Heavy Ion Medical Accelerator in Chiba （HIMAC）, Japan, where HSG cell surviving fractions were measured with standard clonogenic assay. An enhanced cell-killing effect at the penetration depths around the Bragg peak of the β-delayed particle decay 9C-ion beam has been observed in comparison with a therapeutic C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by a factor of up to 1.87. This means that radioactive 9C-ion beam has a significant advantage, killing cancerous cells more efficiently, in tumor therapy once its intensity meets the requirement of radiotherapy.

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 918-930页

作者： Mitsuru Esaki Kazuhiro Haraguchi Kazuya Akahoshi Naru Tomoeda Akira Aso Soichi Itaba Haruei Ogino Yusuke kitagawa Hiroyuki Fujii Kazuhiko Nakamura Masaru Kubokawa Naohiko Harada Yosuke Minoda Sho Suzuki Eikichi Ihara Yoshihiro Ogawa Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 8128582Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of MedicineTokyo 1738610Japan Department of Gastroenterology Hara-Sanshin HospitalFukuoka 8120033Japan Department of Gastroenterology Aso Iizuka HospitalIizuka 8208502Japan Department of Gastroenterology Clinical Research InstituteNational Hospital Organization Kyushu Medical CenterFukuoka 8108564Japan Department of Gastroenterology Kitakyushu Municipal Medical CenterKitakyushu 8020077Japan Department of Gastroenterology Kyushu Rosai HospitalKitakyushu 8000296Japan Department of Internal Medicine Saiseikai Fukuoka General HospitalFukuoka 8100001Japan Department of Gastroenterology and Hepatology National Hospital Organization Fukuokahigashi Medical CenterKoga 81103195Japan Department of Gastroenterology and Metabolism Graduate School of Medicine SciencesKyushu UniversityFukuoka 8128582Japan

BACKGROUND The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors(SNADETs)is *** To compare the efficacy and safety of endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)for *** We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs,which included eight hospitals in Fukuoka,Japan,between April 2001 and October 2017.A total of 142 patients with SNADETs treated with EMR or ESD were *** score matching was performed to adjust for the differences in the patient characteristics between the two *** analyzed the treatment outcomes,including the rates of en bloc/complete resection,procedure time,adverse event rate,hospital stay,and local or metastatic *** Twenty-eight pairs of patients were *** characteristics of patients between the two groups were similar after *** EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group[median procedure time(interquartile range):6(3-10.75)min vs 87.5(68.5-136.5)min,P<0.001,hospital stay:8(6-10.75)d vs 11(8.25-14.75)d,P=0.006].Other outcomes were not significantly different between the two groups(en bloc resection rate:82.1%vs 92.9%,P=0.42;complete resection rate:71.4%vs 89.3%,P=0.18;and adverse event rate:3.6%vs 17.9%,P=0.19,local recurrence rate:3.6%vs 0%,P=1;metastatic recurrence rate:0%in both).Only one patient in the ESD group underwent emergency surgery owing to intraoperative *** EMR has significantly shorter procedure time and hospital stay than ESD,and provides acceptable curability and safety compared to ***,EMR for SNADETs is associated with lower medical costs.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Superficial non-ampullary duodenal epithelial tumor Short-term Outcome Propensity score matching

First successful perinatal management of pregnancy after ABO-incompatible liver transplantation

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World Journal of Gastroenterology 2017年第3期23卷 547-550页

作者： Hisanobu Higashi Hideaki Obara Kei Miyakoshi Masahiro Shinoda Minoru Kitago Naoki Shimojima Yuta Abe Taizo Hibi Hiroshi Yagi Kentaro Matsubara Yohei Yamada Osamu Itano Ken Hoshino Tatsuo Kuroda Yuko kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan

Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABOincompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge. She was discharged uneventfully on postoperative day 38 without any rejection episodes. At 1 year and 6 mo after transplantation, she indicated a wish to become pregnant. Therefore, treatment with mycophenolate mofetil was interrupted at that time. After two miscarriages, she finally became pregnant and delivered transvaginally 3 years after the transplantation. All of the pregnancies were conceived naturally. The newborn was female with a birth weight of 3146 g; the Apgar scores were 9 and 10. Delivery was performed smoothly, and the newborn exhibited no malformations. The mother and the newborn were discharged uneventfully. We suggest that pregnancy is possible for recipients after ABO-incompatible liver transplantation.

关键词： Pregnancy Liver transplantation Delivery Fulminant hepatic failure ABO-incompatible Living donor

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生态的和经济的钢铁冶金过程-DIOS

钢铁 2003年第Z1期38卷 148-151页

作者： Toro kitagawa O. Kojima T. Sekiguchi M. Watanabe 日本制钢公司炼铁厂日本制钢公司炼铁厂日本制钢公司炼铁厂日本制钢公司炼铁厂

在日本国家发展课题DIOS基础上,双联-DIOS过程实现了工程化,并已在综合的和小钢铁厂生产应用.双联-DIOS中,采用了转底炉(RHF),多床炉(MHF)或其他采用煤的直接还原设备作为预还原装置,而不采用流化床型预还原炉,它只用于开始的DIOS中.周... 详细信息

在日本国家发展课题DIOS基础上,双联-DIOS过程实现了工程化,并已在综合的和小钢铁厂生产应用.双联-DIOS中,采用了转底炉(RHF),多床炉(MHF)或其他采用煤的直接还原设备作为预还原装置,而不采用流化床型预还原炉,它只用于开始的DIOS中.周期加入DIOS的熔炼炉SRF中的预还原铁矿石,其还原度(50%～70%)要比开始DIOS中加入的还原度(小于30%)高得多.因而,双联-DIOS的生产率显著高于开始的DIOS.考虑到预还原特点,材料的品级和钢铁厂的能量平衡等方面的优点,本课题的目标才得以实现.

关键词：用煤炼铁熔池型熔炼 DIOS 双联-DIOS RHF MHF 熔融还原

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成型冶金灰脱硫剂对烟气脱硫及其再生的研究

钢铁 2003年第Z1期38卷 139-142页

作者： Shufeng YE Kuniyuki kitagawa Yusheng XIE Rongfang ZHAO Zhancheng GUO Yunfa CHEN 名古屋大学名古屋大学名古屋大学中国科学院过程工程研究院中国科学院过程工程研究院中国科学院过程工程研究院

冶金灰(MD)因含大量的金属氧化物而有很强的脱硫能力.但是,MD颗粒细小,易被气流吹走,不能直接应用.必须将MD成型为有一定尺寸和足够机械强度后才能采用.研究了成型冶金灰脱硫剂(DSMD)的成型、脱硫和再生.实验结果指出,首先将诸如粘土,... 详细信息

冶金灰(MD)因含大量的金属氧化物而有很强的脱硫能力.但是,MD颗粒细小,易被气流吹走,不能直接应用.必须将MD成型为有一定尺寸和足够机械强度后才能采用.研究了成型冶金灰脱硫剂(DSMD)的成型、脱硫和再生.实验结果指出,首先将诸如粘土,水玻璃,聚磷酸钠等粘结剂,水和MD混合,混合质量比MD:粘土:水玻璃:聚磷酸钠:水为100:3.3:3.3:3.3:5.0,然后将混合粉末压制成圆柱状块体,最后在973 K时结烧3 ***在烟气脱硫(FGD)过程中的脱硫率和MD相近,而且经过几次连续的脱硫-再生循环后,脱硫率仍保持稳定.此外,当DSMD未被贯透和DSMD的硫容量到达约5～6 mol/kg(＞773 K)之前,烟气出口处的H2S浓度可保持在小于10 mg/m3的水平.

关键词：成型冶金灰脱硫剂(DSMD) 脱硫再生

Aqueous Components of Tomato Accelerate Alcohol Metabolism by Increasing Pyruvate Level

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Food and Nutrition Sciences 2014年第10期5卷 870-879页

作者： Yusuke Ushida Shunji Oshima Koichi Aizawa Hiroyuki Suganuma Akihiro Nemoto Hiroko Ishikiriyama Yasushi kitagawa Research & Development Division Kagome Co. Ltd. Tochigi Japan Research Laboratories for Fundamental Technology of Food Asahi Group Holdings Ltd. Ibaraki Japan

Consumption of food while drinking alcohol has been suggested to play important roles in alleviating the physiological and pharmacological influences of alcohol. Vegetables are believed to provide health benefits, but there is little evidence for their influence on the effects of alcohol consumption. The present study aimed to investigate the effect of a common vegetable, tomato, on alcohol metabolism. In a randomized, controlled, crossover study with12 Japanese healthy men aged between 24 and 56 years, drinking tomato juice containing 5% (v/v) alcohol (TJAlc) significantly attenuated the elevation of blood ethanol level and subsequently increased the level of acetate compared with a water-based alcoholic beverage with an equal dose of alcohol (0.4 g/kg body weight). Significantly higher levels of blood pyruvate and lactate were also observed in subjects who had consumed TJAlc compared with those consuming the water-based beverage. Additionally, a biphasic alcohol effects scale method showed that subjective feelings for alcohol-induced stimulant effects were significantly enhanced by drinking TJAlc. Animal experiments using male Sprague Dawleyrats suggested that the effect on blood biomarkers was attributable to the serum fraction of tomato (TS), which largely consisted of aqueous compounds, but not lipophilic compounds such as the carotenoid lycopene. Furthermore, it was suggested the TS possibly included potent compound(s) in addition to alanine, glutamine, and citric acid, all of which have previously been reported to affect alcohol metabolism. Administration of TS clearly increased the activity of NAD (H)-dependent enzymes such as lactate-(LDH), alcohol-, and aldehyde-dehydrogenase in rat liver cytosols. These findings suggest that aqueous compound(s) in tomato promote alcohol metabolism, probably through increasing pyruvate level, enhancing LDH activity, and improving the ratio of NAD to NADH.

关键词： Tomato Blood Ethanol Level Pyruvate Lactate Dehydrogenase Alcohol Metabolism

Peritoneal dissemination of pancreatic cancer caused by endoscopic ultrasound-guided fine needle aspiration:A case report and literature review

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World Journal of Gastroenterology 2021年第3期27卷 294-304页

作者： Hideaki Kojima Minoru Kitago Eisuke Iwasaki Yohei Masugi Yohji Matsusaka Hiroshi Yagi Yuta Abe Yasushi Hasegawa Shutaro Hori Masayuki Tanaka Yutaka Nakano Yusuke Takemura Seiichiro Fukuhara Yoshiyuki Ohara Michiie Sakamoto Shigeo Okuda Yuko kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Department of Radiology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)is a biopsy technique widely used to diagnose pancreatic tumors because of its high sensitivity and *** needle-tract seeding caused by EUS-FNA has been recently reported,dissemination of pancreatic cancer cells is generally considered to be a rare complication that does not affect patient ***,the frequency of dissemination and needle-tract seeding appears to have been *** present a case of peritoneal dissemination of pancreatic cancer due to preoperative *** SUMMARY An 81-year-old man was referred to the Department of Surgery of our hospital in Japan owing to the detection of a pancreatic mass on computed tomography during medical ***-gastric EUS-FNA revealed that the mass was an adenocarcinoma;hence laparoscopic distal pancreatectomy with lymphadenectomy was *** intraoperative peritoneal dissemination and liver metastasis were visually detected,and pelvic lavage cytology was negative for carcinoma *** postoperative surgical specimen was negative for carcinoma cells at the dissected margin and the cut end margin;however,pathological findings revealed adenocarcinoma cells on the peritoneal surface proximal to the needle puncture site,and the cells were suspected to be disseminated via ***,the patient received adjuvant therapy with S-1(tegafur,gimeracil,and oteracil potassium);however,computed tomography performed 5 mo after surgery revealed liver metastasis and cancerous *** patient received palliative therapy and died 8 mo after the *** The indications of EUS-FNA should be carefully considered to avoid iatrogenic dissemination,especially for cancers in the pancreatic body or tail.

关键词： Case report Pancreatic carcinoma Endoscopic ultrasound-guided fine needle aspiration Peritoneal dissemination Cancerous peritonitis Biopsy

A square lattice topology coordination network that exhibits highly selectiveC_(2)H_(2)/CO_(2)separation performance

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SmartMat 2020年第1期1卷 48-55页

作者： Naveen Kumar Soumya Mukherjee Andrey A.Bezrukov Matthias Vandichel Mohana Shivanna Debobroto Sensharma Alankriti Bajpai Victoria Gascón Ken‐ichi Otake Susumu kitagawa Michael J.Zaworotko Department of Chemical Sciences Bernal InstituteUniversity of LimerickLimerickRepublic of Ireland Institute for Integrated Cell‐Material Sciences(iCeMS) Kyoto University(KUIAS)Yoshida UshinomiyachoKyotoJapan

C_(2)H_(2)/CO_(2)separation is an industrially important process that remains challenging because of the similar physicochemical properties of C_(2)H_(2)and CO_(2).We herein report that the new square lattice(sql)coordination network[Cu(bipy‐xylene)2(NO3)2]n,sql‐16‐Cu‐NO3,16=bipy‐xylene=4,4′‐(2,5‐dimethyl‐1,4‐phenylene)dipyridine,exists in at least three forms,as‐synthesised(α),activated(α′)and hydrated(β).The activated phase,sql‐16‐Cu‐NO3‐α′,is an ultramicroporous material that exhibits high selectivity towards C_(2)H_(2)over CO_(2)as revealed by dynamic gas breakthrough experiments(1:1,C_(2)H_(2)/CO_(2))that afforded 99.87%pure CO_(2)in the effluent *** separation selectivity at 298 K and 1 bar,78,is the third best value yet reported for C_(2)H_(2)selective physisorbents whereas the mid‐loading performance sets a new *** performance of sql‐16‐Cu‐NO3‐α′is attributed to a new type of C_(2)H_(2)binding site in which CH···ONO2 interactions enable moderately strong sorbent‐sorbate binding(Qst(C_(2)H_(2))=38.6 kJ/mol)at low ***,weak CO_(2)binding(Qst(CO_(2))=25.6 kJ/mol)at low loading means that(ΔQst)AC[Qst(C_(2)H_(2))–Qst(CO_(2))]is 13 kJ/mol at low coverage and 11.4 kJ/mol at mid‐*** of in situ powder X‐ray diffraction and modelling experiments provide insight into the sorption properties and high C_(2)H_(2)/CO_(2)separation performance of sql‐16‐Cu‐NO3‐α′.

关键词： acetylene adsorption coordination networks crystal engineering ultramicroporosity

EFFECTS OF MOLECULE ORIENTATION ON MECHANICAL PROPERTIES OF PC/LCP BLENDS

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EFFECTS OF MOLECULE ORIENTATION ON MECHANICAL PROPERTIES OF ...