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Effect of phosphorus fluctuation caused by river water dilution in eutrophic lake on competition between blue-green alga Microcystis aeruginosa and diatom Cyclotella sp.

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Journal of Environmental Sciences 2010年第11期22卷 1666-1673页

作者： yoshimasa amano Yusuke Sakai Takumi Sekiya Kimitaka Takeya Kazuo Taki Motoi Machida Graduate School of Engineering Chiba University Safety and Health Organization Chiba University Faculty of Engineering Chiba Institute of Technology

Tega-numa （Lake Tega） is one of the eutrophic lakes in Japan. For the improvement of water quality in Lake Tega, the North- chiba Water Conveyance Channel was constructed in 2000, which transfer water from Tone River into the lake. After 2000, the dominant species of diatoms, mainly Cyclotella sp., have been replacing blue-green algae, mainly Microcystis aeruginosa in Lake Tega. This transition of dominant species would be due to the dilution, but the detail mechanism has not been understood yet. This study examined the relationship between phosphorus fluctuation caused by river water dilution to Lake Tega and dominance of algal species, M. aeruginosa or Cyclotella sp. based on the single-species and the mixed-species culture experiments. The single-species culture experiment showed that the half-saturation constant and uptake rate of phosphorus were one order lower and seven times higher for M. aeruginosa than those for Cyclotella sp. These findings implied that M. aeruginosa would possess a potential for the growth and survival over Cyclotella sp. in the phosphorus limited condition. The superiority of M. aeruginosa was reflected in the outcome of the mixed-species culture experiment, i.e., dominance of M. aeruginosa, even phosphorus concentration was lowered to 0.01 mg-P/L. Therefore, it could be concluded that the decrease in phosphorus concentration due to the river water dilution to Lake Tega would be interpreted as a minor factor for the transition of dominant species from M. aeruginosa to Cyclotella sp.

关键词： eutrophic lake water quality improvement water blooms Microcystis aeruginosa Cyclotella sp.

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Enhancing Erectile Function and Alleviating Andropause Symptoms: Clinical Efficacy of a Human Stem Cell Conditioned Medium Cream

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Health 2024年第7期16卷 626-634页

作者： Hoichi amano eHealth Clinic Shinjuku Tokyo Japan Graduate School of Public Health Teikyo University Tokyo Japan

Erectile dysfunction (ED) is increasingly prevalent in Japan, exceeding 30%, and increasing with age. Unhealthy lifestyle habits, obesity, insufficient exercise, and smoking have been implicated in its pathogenesis, along with endothelial dysfunction of the corpora cavernosa and impaired blood flow to the penis considered underlying factors. However, the current treatments are limited to Phosphodiesterase-5 (PDE5) inhibitors. ED is the primary symptom of andropathy. This study reports the clinical efficacy of human stem cell-conditioned medium cream for ED treatment. Ten men without underlying diseases suspected of andropause with ED (mean age 43.2 ± 4.4 y, Hb 15.2 ± 0.6 gm/dL, AST/ALT 30.2/37.9 ± 12.4/14.0, eGFR 82.7 ± 12.4 mL/min/1.73 m2) were targeted. The cream was applied twice daily to the genital and scrotal areas. The erectile hardness score (EHS), International Index of Erectile Function-5 (IIEF-5), and Aging Male Symptoms (AMS) scale were used to evaluate the participants before and 30 days after use, and the results were compared using paired t-tests. The post-use qualitative opinions were collected through interviews. Significant improvements were observed compared to baseline in the IIEF-5 (11.8 ± 4.6→17.2 ± 5.1, P < 0.001), and AMS (46.3 ± 6.7→37.6 ± 5.3, P < 0.001) scores post cream use. EHS did not show a statistically significant difference, but a trend towards improvement was observed. Qualitative feedback included increased morning erection, improved maintenance of erection during intercourse, and reduced post work fatigue. Human stem cell-conditioned medium contains endothelial growth factors that potentially contribute to the improvement of ED and andropause by enhancing corporal endothelial function. Future studies should include control groups to further investigate the efficacy of these treatments.

关键词： Erectile Dysfunction Andropause Human Stem Cell Conditioned Medium Cream Stem Cell

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Evaluation of mitral chordae tendineae length using four-dimensional computed

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World Journal of Cardiology 2024年第5期16卷 274-281页

作者： Takuya Mori Satoshi Matsushita Terumasa Morita Abulaiti Abudurezake Junji Mochizuki Atsushi amano Department of Cardiovascular Surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of Cardiovascular Surgery JACCT Japan Animal Cardiovascular Care TeamOsaka 533-0033Japan Department of Radiology Minamino Cardiovascular HospitalTokyo 192-0918Japan

BACKGROUND Mitral valvuloplasty using artificial chordae tendineae represents an effective surgical approach for treating mitral *** precise measurements of artificial chordae tendineae length(CL)is an important factor in the procedure;however,no objective index currently exists to facilitate this ***,preoperative assessment of CL is critical for surgical planning and ***-dimensional x-ray micro-computed tomography(4D-CT)may be useful for accurate CL measurement considering that it allows for dynamic three-dimensional(3D)evaluation compared to that with transthoracic echocardiography,a conventional inspection *** To investigate the behavior and length of mitral chordae tendineae during systole using *** Eleven adults aged>70 years without mitral valve disease were evaluated.A 64-slice CT scanner was used to capture 20 phases in the cardiac cycle in electrocardiographic *** length of the primary chordae tendineae was measured from early systole to early diastole using the 3D *** primary chordae tendineae originating from the anterior papillary muscle and attached to the A1-2 region and those from the posterior papillary muscle and attached to the A2-3 region were designated as cA and cP,*** behavior and maximum lengths[cA(ma),cP(max)]were compared,and the correlation with body surface area(BSA)was *** In all cases,the mitral anterior leaflet chordae tendineae could be *** most cases,the cA and cP chordae tendineae could be measured *** mean cA(max)and cP(max)were 20.2 mm±1.95 mm and 23.5 mm±4.06 mm,***(max)was significantly *** correlation coefficients(r)with BSA were 0.60 and 0.78 for cA(max)and cP(max),*** cA and cP exhibited constant variation in CL during systole,with a maximum 1.16-fold increase in cA and a 1.23-fold increase in cP from early to *** cP,CL reached a plateau at 15%and remaine

关键词： Mitral valve Chordae tendineae Computed tomography Four-dimensional Cardiac cycle

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Rare earth application for heat-resisting alloys

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Journal of Rare Earths 2010年第S1期28卷 12-21页

作者： Tadaaki amano Department of Materials Science and Engineering Shonan Institute of Technology

High-temperature oxidation resistance of Al2O3-and Cr2O3-forming heat-resisting alloys with rare earths(yttrium-implanted FeCrAl,-added FeCrAl,-added FeCrAlPt alloys,Y2O3-or CeO2-coated NiCrSi,yttrium-or lutetium-added NiCr and NiCrSi) was studied in oxygen at high temperatures,by mass gain measurements,mass change measurements,amount of spalled oxide,observation of surface appearance,X-ray diffraction(XRD),scanning electron microscopy(SEM),electron probe X-ray microanalysis(EPMA) and transmission electron microscopy(TEM).After oxidation at 1573 K for 18 ks in oxygen,oxide scale on FeCrAl alloy spalled from the entire surface,however,yttrium-implanted FeCrAl alloys showed good oxide *** oxidation at 1473 K for 18 ks in oxygen,mass gain of FeCrAlY alloys decreased with increasing yttrium of up to 0.1 wt.% follwed by an increase with the yttrium content,and the mass gain of FeCrAl0.005Pt0.05Y alloy with appropriate additions of platinum and yttrium was lower than that of FeCrAl0.1Y ***-added FeCrAl alloys showed good oxide *** analysis revealed that the alumina/alloy interface of FeCrAl0.005Pt0.05Y alloy showed good *** scale surface of FeCrAl alloy was rough,however,those of FeCrAlY and FeCrAlPtY alloys were *** oxidation of NiCrSi,Y2O3-or CeO2-coated NiCrSi alloys was studied up to 10 cycles(1 cycle:300 s) at 1523 K in *** change of NiCrSi alloy increased up to 3 cycles and then decreased up to 10 cycles because of oxide spallation during *** the other hand,mass change of Y2O3-or CeO2-coated NiCrSi alloy increased up to 10 cycles,and these alloys showed good oxide *** Cr2O3 particles on Y2O3-coated NiCrSi alloy were in size smaller than these on CeO2-coated NiCrSi *** result suggested that oxidation rate of Y2O3-coated NiCrSi alloy was lower than that of CeO2-coated NiCrSi *** oxidation at 1473 and 1573 K for 18 ks in oxygen,mass gain of yttrium-or lutetium-added NiCr an

关键词： alumina chromia oxide adherence high-temperature oxidation rare earths

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Who are the fair candidates for testosterone replacement therapy in patients with late-onset hypogonadism symptoms?

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Asian Journal of Andrology 2023年第5期25卷 647-647页

作者： Toshiyasu amano Department of Urology Nagano Red Cross HospitalWakasato 5-22-1Nagano 380-8582Japan

The main cause of late-onset hypogonadism(LOH)symptoms is decline of testosterone according to *** with LOH suffer from various signs including physical-,psychological-,and sexualrelated *** is obvious that the basic treatment for LOH is testosterone replacement therapy(TRT).However,TRT is not effective for a few patients in clinical practice,and it is so important to find out the fair candidates for TRT in patients with LOH symptoms.

关键词： testosterone symptoms patients

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An Optimal Framework for SDN Based on Deep Neural Network

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Computers, Materials & Continua 2022年第10期73卷 1125-1140页

作者： Abdallah Abdallah Mohamad Khairi Ishak Nor Samsiah Sani Imran Khan Fahad RAlbogamy Hirofumi amano Samih M.Mostafa Department of Industrial Engineering School of Applied Technical Sciences German Jordanian UniversityAmman35247Jordan School of Electrical and Electronic Engineering Universiti Sains MalaysiaNibong Tebal14300Malaysia Center for Artificial Intelligence Technology Faculty of Information Science and TechnologyThe National University of Malaysia(UKM)Bangi43600SelangorMalaysia Department of Electrical Engineering University of Engineering and TechnologyPeshawar814Pakistan Turabah University College Computer Sciences ProgramTaif UniversityTaif21944Saudi Arabia Research Institute for Information Technology Kyushu UniversityFukuoka819-0395Japan Computer Science-Mathematics Department Faculty of ScienceSouth Valley UniversityQena83523Egypt

Software-defined networking(SDN)is a new paradigm that promises to change by breaking vertical integration,decoupling network control logic from the underlying routers and switches,promoting(logical)network control centralization,and introducing network ***,the controller is similarly vulnerable to a“single point of failure”,an attacker can execute a distributed denial of service(DDoS)attack that invalidates the controller and compromises the network security in *** address the problem of DDoS traffic detection in SDN,a novel detection approach based on information entropy and deep neural network(DNN)is *** approach contains a DNN-based DDoS traffic detection module and an information-based entropy initial inspection *** initial inspection module detects the suspicious network traffic by computing the information entropy value of the data packet’s source and destination Internet Protocol(IP)addresses,and then identifies it using the DDoS detection module based on *** assaults were found when suspected irregular traffic was *** reveal that the algorithm recognizes DDoS activity at a rate of more than 99%,with a much better accuracy *** false alarm rate(FAR)is much lower than that of the information entropy-based detection ***,the proposed framework can shorten the detection time and improve the resource utilization efficiency.

关键词： Deep neural network computer networks data security optimization

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An ever-increasing metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma:what are problems and countermeasures?

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 941-944页

作者： Shigeo Shimose Tsubasa Tsutsumi Dan Nakano Tomoya Sano Keisuke amano Takumi Kawaguchi Division of Gastroenterology Department of MedicineKurume University School of MedicineKurumeJapan

Hepatocellular carcinoma(HCC)is the third leading cause of cancer deaths worldwide(1).HCC has been classified into viral or non-viral HCC according to the etiology and the incidence of viral HCC is *** contrast,the incidence of non-viral HCC is increasing and fatty liver is becoming a major etiology for the *** 2020,a new concept of fatty liver disease,metabolic dysfunction-associated fatty liver disease(MAFLD).

关键词： Hepatoma hepatic steatosis metabolic syndrome viral hepatitis lenvatinib(LEN)

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Fragmented QRS complex with an additional R-wave attenuated by short RR interval in a patient with acute pulmonary embolism and cardiogenic shock

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Journal of Geriatric Cardiology 2022年第12期19卷 995-1000页

作者： Koji Takahashi Hiromasa Nakahara Eiji Arimitsu Satoshi Imamine Yoshiyasu Obata Kimio Nakanishi Yoshiyasu Taniguchi Maiko amano Chika Omori Takafumi Okura Department of Community Emergency Medicine Ehime University Graduate School of MedicineEhimeJapan Department of Cardiology Yawatahama City General HospitalEhimeJapan Department of Internal Medicine Oozu City HospitalEhimeJapan Department of Clinical Laboratory Oozu City HospitalEhimeJapan

Registries and hospital discharge datasets of unselected patients with pulmonary embolism show 30-day all-cause mortality rates of approximately 10%.[1]Clinical findings from histories and physical examinations,such as age,systemic blood pressure,and respiratory rate at presentation,classify patients into risk classes of increasing risk of death and other adverse medical outcomes.

关键词： mortality patients Clinical

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An Adjustable Variant of Round Robin Algorithm Based on Clustering Technique

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Computers, Materials & Continua 2021年第3期66卷 3253-3270页

作者： Samih M.Mostafa Hirofumi amano Faculty of Computers and Information South Valley UniversityQena83523Egypt Research Institute for Information Technology Kyushu UniversityFukuoka819-0395Japan

CPU scheduling is the basic task within any time-shared operating *** of the main goals of the researchers interested in CPU scheduling is minimizing time *** between CPU scheduling algorithms is subject to some scheduling criteria(e.g.,turnaround time,waiting time and number of context switches(NCS)).Scheduling policy is divided into preemptive and *** Robin(RR)algorithm is the most common preemptive scheduling algorithm used in the time-shared operating *** this paper,the authors proposed a modified version of the RR algorithm,called dynamic time slice(DTS),to combine the advantageous of the low scheduling overhead of the RR and favor short process for the sake of minimizing time *** process has a weight proportional to the weights of all *** process’s weight determines its time slice within the current *** authors benefit from the clustering technique in grouping the processes that are similar in their attributes(e.g.,CPU service time,weight,allowed time slice(ATS),proportional burst time(PBT)and NCS).Each process in a cluster is assigned the average of the processes’time slices in this cluster.A comparative study of six popular scheduling algorithms and the proposed approach on nine groups of processes vary in their attributes was performed and the evaluation was measured in terms of waiting and turnaround times,and *** experiments showed that the proposed algorithm gives better results.

关键词： Clustering CPU scheduling round robin turnaround time waiting time

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The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domain

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Cell Research 2005年第3期15卷 150-159页

作者： Tosikazu amano,Olivia KWAK,Anastasia MARSHAK Bethesda MD 20892 USA Laboratory of Gene Regulation and Development National Institute of Child Health and Human Development National Institutesof Health Bethesda MD 20892 USA Laboratory of Gene Regulation and Development National Institute of Child Health and Human Development National Institutesof Health Bethesda MD 20892 USA Laboratory of Gene Regulation and Development National Institute of Child Health and Human Development National Institutesof Health

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has long been implicated to play an important role in extracellular matrix (ECM) remodeling and cell fate determination during normal and pathological processes. However like other MMPs, the molecular basis of ST3 function in vivo remains unclear due to the lack of information on its physiological substrates. Furthermore, ST3 has only weak activities toward all tested ECM proteins. Using thyroid hormone-dependent Xenopus laevis metamorphosis as a model, we demonstrated previously that ST3 is important for apoptosis and tissue morphogenesis during intestinal remodeling. Here, we used yeast two-hybrid screen with mRNAs from metamorphosing tadpoles to identify potential substrate of ST3 during development. We thus isolated the 37 kd laminin receptor precursor (LR). We showed that LR binds to ST3 in vitro and can be cleaved by ST3 at two sites distinct from where other MMPs cleave. Through peptide sequencing, we determined that the two cleavage sites are in the extracellular domain between the transmembrane domain and laminin binding sequence. Furthermore, we demon strated that these cleavage sites are conserved in human LR. These results together with high levels of human LR and ST3 expression in carcinomas suggest that LR is a likely in vivo substrate of ST3 and that its cleavage by ST3 may alter cell-extracellular matrix interaction, thus, playing a role in mediating the effects of ST3 on cell fate and behavior ob- served during development and pathogenesis.

关键词： stromelysin-3 laminin receptor matrix metalloproteinase extracellular matrix Xenopus laevis cell surface substrate.

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