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A Case with XXXX Syndrome Who Was Incidentally Diagnosed during Examination for Suspected Post-Human Papillomavirus Vaccination Syndrome

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Case Reports in Clinical Medicine 2019年第9期8卷 239-244页

作者： Akiyo Hineno Tomoki Kosho Hiroyuki Kato yoshiki Sekijima Shu-ichi Ikeda Intractable Disease Care Center Shinshu University Hospital Matsumoto Japan Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine Matsumoto Japan Department of Medical Genetics Shinshu University Hospital Matsumoto Japan Department of Orthopaedic Surgery Shinshu University School of Medicine Matsumoto Japan

A 19-year-old Japanese woman was referred to us with the complaints of arthralgia and meralgia following human papillomavirus (HPV) vaccination. She received HPV vaccination at the age of 15 years and three years later, she developed intermittent arthralgia, meralgia, and numbness in limbs. There were no orthostatic dysregulation symptoms. She had hypertelorism, and brachydactyly in both the hands, and revealed mild cubitus varus deformity with lateral instability. X-ray examination disclosed hypoplasia of the humeral capitellum and trochlea in elbow joints. G-banded chromosomes were shown to be composed of 48, XXXX. She was, therefore, diagnosed with XXXX syndrome, which explained the reason for her limb symptoms. Although some girls with HPV vaccination complain of various symptoms including limb pain and numbness, exact underlying cause of these symptoms needs to be ascertained carefully for reaching a final diagnosis.

关键词： XXXX Syndrome Tetrasomy X Human Papillomavirus Vaccine Arthralgia Complex Regional Pain Syndrome

Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry

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World Journal of Gastroenterology 2016年第40期22卷 8949-8955页

作者： Nobuhiro Fujita Akihiro Nishie yoshiki Asayama Kousei Ishigami Yasuhiro Ushijima Yukihisa Takayama Daisuke Okamoto Ken Shirabe Tomoharu Yoshizumi Kazuhiro Kotoh Norihiro Furusyo Tomoyuki Hida Yoshinao Oda Taisuke Fujioka Hiroshi Honda Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Department of Advanced Imaging and Interventional Radiology Graduate School of Medical Sciences Kyushu University Department of Radiology Informatics and Network Graduate School of Medical Sciences Kyushu University Department of Surgery and Sciences Graduate School of Medical Sciences Kyushu University Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Department of General Internal Medicine Graduate School of Medical Sciences Kyushu University Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University CT Application Philips Electronics Japan Medical Systems

AIM To evaluate the diagnostic performance of computed tomography(CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease(NAFLD).METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment(LLS), left medial segment, caudate lobe, and right lobe(RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic(ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis *** The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage(r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage(r =-0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis(F3-F4) was 4.789%, 85.7% sensitivity and 94.1% *** The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.

关键词：不含酒精的脂肪肝疾病计算断层摄影术容量测定纤维变性舞台不含酒精的 steatohepatitis

Gastric submucosa-invasive carcinoma associated with EpsteinBarr virus and endoscopic submucosal dissection: A case report

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 925-932页

作者： Yu Kobayashi Takehito Kunogi Hiroki Tanabe Yuki Murakami Takuya Iwama Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando yoshiki Nomura Nobuhiro Ueno Shin Kashima Kentaro Moriichi Hidehiro Takei Mikihiro Fujiya Toshikatsu Okumura Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medical UniversityAsahikawa 078-8510Japan Pathological Department of Asahikawa Medical University Hospital Asahikawa Medical UniversityAsahikawa 078-8510Japan

BACKGROUND Epstein-Barr virus(EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma(GCLS).Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric *** previous cases of early gastric cancer associated with EBV had been diagnosed by endoscopic *** SUMMARY We present two GCLS cases subjected to endoscopic submucosal dissection(ESD)for a definitive diagnosis.A protruded gastric lesion was identified by routine endoscopic examination,but forceps biopsy showed no atypical cells before *** resected specimen showed a poorly differentiated adenocarcinoma with lymphoid cells involving the mucosa and *** final diagnosis was submucosa-invasive poorly differentiated gastric ***,additional gastrectomy was recommended to obtain a complete *** patient underwent additional distal gastrectomy with lymph node dissection,but the other was refused because of cardiovascular *** patients remained in remission for more than half a *** positivity was determined by EBV-encoded RNA in situ *** also conducted a literature review of cases of early gastric cancer associated with EBV that had been diagnosed by *** Submucosa-invasive GCLS could be dissected using ESD,and EBV positivity should be subsequently assessed to determine whether or not any additional curative surgery is *** prospective investigations on the prevalence of lymph node metastasis in EBV-associated carcinoma should be performed to expand the indications for endoscopic resection.

关键词： Herpesvirus 4 Human Stomach neoplasms Gastric carcinoma with lymphoid stroma Epstein-Barr virus-associated gastric carcinoma Case report

Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

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World Journal of Gastroenterology 2020年第42期26卷 6669-6678页

作者： yoshiki Niwa Masanao Nakamura Hiroki Kawashima Takeshi Yamamura Keiko Maeda Tsunaki Sawada Yasuyuki Mizutani Eri Ishikawa Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo Ohno Takashi Honda Masatoshi Ishigami Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya 466-8560Japan Department of Endoscopy Nagoya University HospitalNagoya 466-8560Japan

BACKGROUND Retrograde cholangiopancreatography using double-balloon endoscopic retrograde cholangiography(DBERC)is a valuable technique to treat biliary stone and jejunobiliary anastomotic stenosis in patients with altered gastrointestinal *** accurate selection of the route at the anastomosis branch is one of the most important factors in reaching the target in a timely *** To determine the accuracy of carbon dioxide insufflation enterography(CDE)at the branch for selecting the correct route during *** We enrolled 52 consecutive patients scheduled for DBERC at our institution from June 2015 to November *** selection via two methods(visual observation and CDE)was performed in each *** determined the correct rate of route selection using *** Thirty-three patients had a jejunojejunal anastomosis and 19 patients had a gastrojejunal *** therapeutic target region was reached in 50 *** mean procedure times from the teeth to the target(total insertion time),from the teeth to the branch,and from the branch to the target,and the mean total examination time were 15.2,5.0,8.2,and 60.3 min,*** rate of correct route selection using visual observation and CDE were 36/52(69.2%)and 48/52(92.3%),respectively(P=0.002).The rate of correct route selection using CDE in patients with a jejunojejunal anastomosis was 29/33(87.8%),and the rate in patients with a gastrojejunal anastomosis was 19/19(100%).CONCLUSION CDE is helpful in selecting the route at the branch in the anastomosis for more timely access to the target in patients with altered gastrointestinal anatomy undergoing DBERC.

关键词： Retrograde cholangiopancreatography Double-balloon endoscopy Carbon dioxide insufflation Anastomosis Accuracy Prospective study

Study on feasibility of cervical lymph node metastases in squamous cell carcinoma of the tongue evaluated by morphometric analyses

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中国口腔颌面外科杂志 2008年第B5期6卷 89-90页

作者： Masaaki Karino Hiroaki Ishibashi yoshiki Nariai Seiji Kondou Jouji Sekine Department of Oral and Maxillofacial Surgery ShimaneUniversity Faculty of Medicine Japan

Purpose:This study was undertaken to confirm the feasibility of nuclear morphometric analyses of lymph node metastases of squamous cell carcinoma of the tongue。Methods: Forty-five cases of squamous cell carcinoma treated including tumorectomy as well as neck dissection at Department of Oral and Maxillofacial Surgery (22 node-positive and 23 node-negative cases) were examined。Using computerized image system, the mean nuclear area, the nuclear perimeter, the circular rate, the largest to the smallest dimension ratio (LS ratio) of the nuclei, and the coefficient of variation of the nuclear area (NACV) were measured。Results: The nuclear area and perimeter were significantly higher in cases with metastasized lymph node than in node-negative cases。Conclusion: Preoperative quantitative estimations of nuclear features can provide a feasible criterion for the prediction of lymph node metastases in squamous cell carcinoma of the tongue。

关键词：舌肿瘤淋巴结鳞状细胞癌治疗方法

In vivo histological diagnosis for gastric cancer using endocytoscopy

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World Journal of Gastroenterology 2017年第37期23卷 6894-6901页

作者： Issei Tsurudome Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Masanobu Matsushita Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Osamu Watanabe Masato Nakaguro Akira Satou yoshiki Hirooka Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine Department of Endoscopy Nagoya University Hospital Department of Pathology and Laboratory Medicine Nagoya University Hospital Department of Surgical Pathology Aichi Medical University Hospital

AIM To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric *** Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas(including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were *** The endocytoscopic images of the cancerous area were assessed as evaluable in 25(83.3%) and 27(90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28(93.3%) and 23(76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specificity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement(κ-value) for endocytoscopic diagnosis was 0.745. CONCLUSION Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy.

关键词： Endocytoscopy 胃的癌症虚拟活体检视在 vivo 组织病理学说放大内视镜检查法加倍染色水晶紫甲又蓝色

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日本视觉摇滚乐中的图腾崇拜

大舞台 2001年第16期 18-19页

作者： yoshiki

摇滚乐中其实一直存在善对图腾的崇拜,从欧美摇滚歌手热衷于纹身可见一斑。“图腾”一词是我国清代学者严复于1903年译英国学者甄克思的《社会通诠》一书时,将“tatem”一词音译而成的并由此成为中国学术界的通用译名。严复在解释中指出... 详细信息

摇滚乐中其实一直存在善对图腾的崇拜,从欧美摇滚歌手热衷于纹身可见一斑。“图腾”一词是我国清代学者严复于1903年译英国学者甄克思的《社会通诠》一书时,将“tatem”一词音译而成的并由此成为中国学术界的通用译名。严复在解释中指出:图腾是群体的标志,旨在区分群体。而摇滚乐基本上都是反射出对社会上的某些事物与不公正规则的不满情绪和呼声;或者生活的压力所促使的积压精绪的宣泄。这类音乐者选择以“喧闹”的音乐来表达心声,也就是我们所说的摇滚乐。本身受欧美朋克音乐影响较深的日本视觉摇滚的初期理所当然也承袭了朋克乐者的装扮,并且,又有着日本传统的一些文化鼓噪其中,最明显的就是表现在日本的妖怪图腾的化妆上。

关键词：摇滚乐图腾崇拜视觉音乐人日本传统音乐风格重金属自然现象纹身严复

Contrast-Enhanced CT Colonography Features of Rectal Carcinoid Tumors

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Advances in Computed Tomography 2014年第2期3卷 24-30页

作者： Daisuke Tsurumaru Satoshi Kawanami Yusuke Nishimuta Mitsutoshi Miyasaka yoshiki Asayama Hiroshi Honda Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Purpose: The purpose of this study was to retrospectively assess the detectability and enhancement pattern of rectal carcinoid tumors on contrast-enhanced computed tomography colonography (CE-CTC). Methods: The study sample consisted of 12 lesions in nine patients of rectal carcinoid tumors. To evaluate the detectability, two radiologists reviewed axial and 3D images including air enema (AE), virtual endoscopy (VE), and virtual colon dissection (VCD). To determine the contrast enhancement pattern of the tumors, the CT attenuation value of each lesion was measured in three phases. Results: Four of the 12 lesions (33%) were detected on axial images in patients in both the prone and supine positions, the sizes of which were 6 mm or larger. Seven lesions (58%), including the four lesions mentioned above, were detected on 3D images including AE and VE in patients in the prone position, the sizes of which were 5 mm or larger. The ranges of CT attenuation values of the lesions at 40 s, 70 s and 240 s were 112 - 147, 116 - 140 and 82 - 97 HU, respectively. Conclusion: Rectal carcinoid tumors are challenging to detect on CE-CTC. They demonstrated enhancement at the early phase and washout at the delayed phase on CE-CTC.

关键词： Carcinoid Tumors Rectum Contrast Enhancement CT Colonography

Application of Nanofiber Fabricated by Cotton Candy Method to Electric Double-Layer Capacitor

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Open Journal of Composite Materials 2018年第3期8卷 138-144页

作者： Akihiro Tada Tomohiko Adachi yoshiki Tanaka Yoshifumi Aoi Atsushi Yokoyama Hiroyuki Hamada Ohgi Technological Creation Co. Ltd Shiga Japan Industrial Resarch Center of Shiga Prefecture Shiga Japan Ryukoku University Kyoto Japan Kyoto Institute of Technology Kyoto Japan

In recent years, application of carbon-based nano material to electrode material has been paid attention, however, due to its higher cost, it would be difficult to put it into practical use. Then, we have proposed to make nano carbon fiber with lower production cost. The purpose of our research was, to apply our nano carbon fiber to electrical double-layer capacitor electrode. We used cotton candy method to make nano fiber, and applied microwave heating for carbonization. By applying nano carbon fiber to electrical double-layer capacitor electrode, we got results that thicker electrode containing nano carbon fiber leads to lower resistance value, compared with electrode without containing nano carbon fiber. From this result, it was indicated that by containing nano carbon fiber, the electric bypass was formed in the electrode.

关键词： Cotton Candy Method Carbon Nanofiber Electric Double Layer Capacitor