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World Journal of Stem Cells 2017年第10期9卷 179-186页

作者： Harumichi itoh Shimpei Nishikawa Tomoya Haraguchi Yu Arikawa Shotaro Eto Masato Hiyama Toshie Iseri Yoshiki Itoh Munekazu Nakaichi Yusuke Sakai Kenji Tani Yasuho Taura Kazuhito Itamoto Department of Small Animal Clinical Science Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Radiology Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Pathology Joint Faculty of Veterinary Medicine Yamaguchi University

AIM To identify and characterize functionally distinct subpopulation of adipose-derived stem cells(ADSCs).METHODS ADSCs cultured from mouse subcutaneous adipose tissue were sorted fluorescence-activated cell sorter based on aldehyde dehydrogenase(ALDH) activity, a widely used stem cell marker. Differentiation potentials were analyzed by utilizing immunocytofluorescece and its quantitative analysis.RESULTS Approximately 15% of bulk ADSCs showed high ALDH activity in flow cytometric analysis. Although significant difference was not seen in proliferation capacity, the adipogenic and osteogenic differentiation capacity was higher in ALDHHi subpopulations than in ALDHLo. Gene set enrichment analysis revealed that ribosome-related gene sets were enriched in the ALDHHi subpopulation. CONCLUSION High ALDH activity is a useful marker for identifying functionally different subpopulations in murine ADSCs. Additionally, we suggested the importance of ribosome for differentiation of ADSCs by gene set enrichment analysis.

关键词：脂肪质导出 stem/stromal 房间醛脱氢酶活动流动 cytometry Subpopulation 核糖体

Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis

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世界胃肠病学杂志：英文版 2012年第29期18卷 3883-3888页

作者： Takuya Ishikawa Akihiro itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto yoshiki Hirooka Department of Gastroenterology Nagoya University Graduate School of Medicine65 Tsuruma-choShowa-kuNagoya 466-8550Japan Department of Endoscopy Nagoya University Hospital65 Tsuruma-choShowa-kuNagoya 466-8550Japan

AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic criteria.On 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for EUS-FNA.RESULTS:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent EUSFNA.EUS-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic body-tail.Nine of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of LPSP.No one met level 1 findings of IDCP,but 3 patients met level 2 findings of IDCP.Of 10 seronegative cases,2 cases were diagnosed with "definitive type 1 AIP",and 3 cases were diagnosed with "probable type 2 AIP" when considering both the level 2 histological findings and response to steroids.CONCLUSION:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases.

关键词：自身免疫性组织分化胰腺炎 2型穿刺引导超声内镜

Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum

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World Journal of Gastroenterology 2009年第9期15卷 1138-1140页

作者： Akira Kanamori Takashi Kumada Seiki Kiriyama Yasuhiro Sone Makoto Tanikawa Yasuhiro Hisanaga Hidenori Toyoda Hiroki Kawashima Akihiro itoh yoshiki Hirooka Hidemi Goto Department of Gastroenterology Ogaki Municipal HospitalOgaki 503-8502Japan Department of Gastroenterology Nagoya University Graduate School ofMedicineNagoya 466-8560Japan Department of Gastroenterology Nagoya University Graduate School of MedicineNagoya 466-8560Japan Department of Endoscopy Nagoya University HospitalNagoya 466-8560Japan

Tumors of the minor papilla of the duodenum are quite rare.We successfully and safely treated an 18-mm adenoma of the minor papilla associated with pancreas divisum using endoscopic papillectomy.A 64-year-old man was admitted to our hospital for treatment of an asymptomatic mass in the minor papilla detected by upper gastrointestinal endoscopy.Endscopic analysis showed an 18-mm,whitish,sessile mass,located in the duodenum proximal to a normal-appearing major papilla.Endoscopic retrograde pancreatography did not reveal the pancreatic duct.Magnetic resonance cholangiopancreatography showed a lack of the ventral pancreatic duct.We suspected this case was associated with pancreatic divisum;therefore,we performed endoscopic papillectomy of the minor papilla tumor.Subsequently,endoscopic pancreatic stent placement in the minor papilla was done to prevent drainage disturbance.The patient has been asymptomatic without recurrence of tumor or stenosis of the Santorini orifice upon endoscopic examination for the past 2 years.

关键词：胰腺分裂症内镜逆行腺瘤消化道内窥镜磁共振胰胆管十二指肠未成年人复发肿瘤

Crosstalk Suppression in Header Recognition Unit Using Time-Space Conversion

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光学学报 2003年第S1期23卷 633-634页

作者： Hideaki Furukawa Tsuyoshi Konishi Yoshinori Oshita Kazuyoshi itoh yoshiki Ichioka Department of Material and Life Science Osaka University Japan.Department of Material and Life Science Osaka University Japan.Department of Material and Life Science Osaka University Japan.Department of Material and Life Science Osaka University Japan.Department of Material and Life Science Osaka University Japan.

We demonstrate a suppression effect of a crosstalk among a target and similar header signals using the header recognition filter designed by a design technique of the multiple-object discriminant filter.

关键词： in it et of that with As be

Use of color Doppler ultrasonography in the diagnosis of anomalous connection in pancreatobiliary disease

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World Journal of Gastroenterology 2005年第7期11卷 1018-1022页

作者： Hiroki Kawashima yoshiki Hirooka Akihiro itoh Senju Hashimoto Terutomo itoh Kazuo Hara Akira Kanamori Naoki Ohmiya Yasumasa Niwa Hidemi Goto Department of Gastroenterology Department of Endoscopy

AIM: To estimate the detectability of anomalous connection in pancreatobiliary disease (ACPBD) cases, measuring gallbladder wall blood flow (GWBF).METHODS: In the retrospective study, we enrolled 42subjects with gallbladder wall thickening. GWBF velocity was determined as an average value of the peak velocity of color signals on the gallbladder wall, three times in each case. Based on the findings on endoscopic ultrasonography (EUS) or endoscopic retrograde cholangiopancreatography (ERCP), the 42 subjects were divided into 11 cases with ACPBD and 31 cases without ACPBD. In the prospective study, the subjects were 92 cases with gallbladder wall thickening. Using the cut-off level of the flow velocity obtained in the retrospective study, the usefulness of measuring GWBF velocity in diagnosing ACPBD was evaluated.RESULTS: In the retrospective study, imaging of GWBF was obtained in 40 of the 42 subjects. The mean GWBF velocity of the ACPBD cases was 29.4±3.9 cm/s(mean±SD), which was significantly different (P＜0.0001;95% CI 5.48-13.2) from that of the without ACPBD cases(20.1±5.9 cm/s). Based on this result, we prepared a receiver operating characteristic curve, and the cut-off level appropriate for diagnosing ACPBD was estimated to be 25 cm/s. In the prospective study, GWBF was detected in 86 of the 92 subjects. Based on the EUS or ERCP findings, the 92 subjects were divided into 15 cases with ACPBD and 77 cases without ACPBD. When a cut-off level of 25 cm/s was employed, ACPBD could be diagnosed with a sensitivity of 87.0% (13/15) and a specificity of87.3% (62/71).CONCLUSION: Measurement of GWBF velocity, which is less invasive and provides objective values, is very useful for diagnosing ACPBD prior to the development of malignant tumors in cases with gallbladder wall thickening.

关键词：彩色多普勒超声胰腺疾病超声诊断胆囊壁血液流动学

Pancreatic involvement in chronic viral hepatitis

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World Journal of Gastroenterology 2005年第23期11卷 3508-3513页

作者： yoshiki Katakura Hiroshi Yotsuyanagi Kiyoe Hashizume Chiaki Okuse Noriaki Okuse Kohji Nishikawa Michihiro Suzuki Shiro Iino Fumio itoh Division of Gastroenterology and Hepatology

AIM: To elucidate the frequency and characteristics of pancreatic disorders in the course of chronic viral hepatitis. METHODS: We prospectively assessed the serum pancreatic enzyme levels and imaging findings in patients with chronic viral hepatitis and healthy control subjects. RESULTS: Serum amylase (t-Amy), salivary amylase (s-Amy), pancreatic amylase (p-Amy) and serum lipase levels were higher in hepatitis patients in comparison to control subjects. However, in asymptomatic viral carriers, only the serum t-Amy levels were higher than those of the controls. The levels of each enzyme rose with the progression of liver disease in patients with hepatitis B or C; whereas the levels of each enzyme within the same clinical stage of the disease did not differ between patients diagnosed with either hepatitis B or hepatitis C virus. Imaging findings demonstrated chronic pancreatitis in only 1 out of 202 patients (0.5%).CONCLUSION: Our data suggest that serum levels of pancreatic enzymes increase with the progression of liver disease in patients diagnosed with viral hepatitis. Pancreatic disease, asymptomatic in most cases, may represent an extrahepatic manifestation of chronic viral hepatitis.

关键词：慢性病毒肝炎胰腺损伤病理机制临床表现

Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura:A case report

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World Journal of Gastroenterology 2006年第30期12卷 4922-4926页

作者： Norie Yamada Chiaki Okuse Masahito Nomoto Mayu Orita yoshiki Katakura Toshiya Ishii Takuo Shinmyo Hiroaki Osada Ichiro Maeda Hiroshi Yotsuyanagi Michihiro Suzuki Fumio itoh Division of Gastroenterology and Hepatology Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Department of Chest Surgery St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Department of Diagnostic Pathology St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki 216-8511 Japan Division of Infectious Diseases Department of Internal Medicine University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan

对胸膜的恶意的独居的含纤维的肿瘤的手术后的双边的多重肺转移的全身的化疗上的一个 77 岁的人受不了瘙痒和黄疸。血检查显示出肝胆管酶的提高的层次。腹的计算断层摄影术在胰腺的头与外部改进显示出一个肿瘤，与 intra 肝、额外肝的... 详细信息

对胸膜的恶意的独居的含纤维的肿瘤的手术后的双边的多重肺转移的全身的化疗上的一个 77 岁的人受不了瘙痒和黄疸。血检查显示出肝胆管酶的提高的层次。腹的计算断层摄影术在胰腺的头与外部改进显示出一个肿瘤，与 intra 肝、额外肝的胆汁管的膨胀伴随了。他作为把妨碍的黄疸被一个胰腺的头肿瘤引起了被诊断。胰腺的头肿瘤大概作为胸膜的恶意的独居的含纤维的肿瘤的转移被诊断，因为腹的 CT 上的胰腺的头肿瘤上的调查结果类似于胸膜的恶意的独居的含纤维的肿瘤的主要的肺损害上的那些。胰腺的肿瘤在胆总管的劣等的部分在金属性的斯滕特氏印模膏的培植以后很快成长了。病人死于肺的癌性淋巴管炎。尸体揭示了从胰腺的头传播了到肝的核的一个肿瘤。用显微镜，和骨胶原免职展出原子 atypicality 或分割的塑造锭子的房间被观察。Immunohistochemically 胰腺的头肿瘤房间为 alpha 光滑的肌肉肌动朊(alpha-SMA ) 或 CD117 染色是否定的，但是为 vimentin， CD34 和 CD99 积极。这些调查结果与胸膜的恶意的独居的含纤维的肿瘤上的那些一致。我们报导一个第二等的胰腺的肿瘤从胸膜的恶意的独居的含纤维的肿瘤引起的妨碍的黄疸的第一个案例。

关键词：阻塞性黄疸胰腺肿瘤胸膜癌病例报告

Clinical oncology for pancreatic and biliary cancers:Advances and current limitations

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World Journal of Clinical Oncology 2011年第5期2卷 217-224页

作者： yoshiki Hirooka Akihiro itoh Hiroki Kawashima Eizaburo Ohno Takuya Ishikawa Yuya itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Masatoshi Ishigami Yoshiaki Katano Hidemi Goto Department of Endoscopy Nagoya University Hospital65Tsuruma-ChoShowa-KuNagoya CityAichi Prefecture 81-466-8550Japan Department of Gastroenterology Nagoya University Graduate School of Medicine65Tsuruma-ChoShowa-KuNagoya CityAichi Prefecture 81-466-8550Japan

In the early 2000s,the main stream of endoscopic ultrasonography(EUS)changed from a mechanical scanning method to electronic radial or linear scanning methods.Subsequently,useful applications in trans-abdominal ultrasonography came within reach of EUS.In particular,contrast-enhanced EUS(CE-EUS)and EUS-elastography became cutting-edge diagnostic modalities for pancreatic disorders.Each type of pancreatic disorder has characteristic hemodynamics.CE-EUS uses color Doppler flow imaging and harmonic imaging to classify pancreatic lesions.EUS-elastography can assess tissue hardness by measuring its elasticity.This parameter appears to correlate with the malignant potential of the lesions.Tissue elasticity studies can provide information on both its pattern and distribution.The former is the conventional method of morphological diagnosis,but it is restricted to observations made in a region of interest(ROI).The latter is an unbiased analysis that can be performed by image analysis software and is theoretically constant,regardless of the ROI.Though EUSfine needle aspiration(FNA)is also a very useful diagnostic tool,there are several limitations.Diagnostic EUS-FNA of pancreatic cystic lesions has marginal utility mainly due to low sensitivity.Therefore,in particular,endoscopists should keep this limitation in mind.

关键词： Contrast-enhanced endoscopic ultrasonography Endoscopic ultrasonography-elastography Endoscopic ultrasonography-fine needle aspiration Pancreatic cystic lesions Dissemination Track seeding Marginal utility for pancreatic cystic lesions of endoscopic ultrasonography-fine needle aspiration

棕榈叶鞘维管束纤维的结构及其生长变化(英文)

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南京林业大学学报（自然科学版） 2014年第1期38卷 90-96页

作者：翟胜丞潘彪堀川祥生李大纲伊东隆夫杉山淳司南京林业大学材料科学与工程学院江苏南京210037 京都大学生存圈研究所京都府宇治市〒6110011 独立行政法人国立文化财机构奈良文化财研究所奈良县奈良市〒6308577

利用光学显微镜、傅里叶变换红外光谱和扫描电镜对棕榈(Trachycarpus fortunei)叶鞘维管束纤维的结构及其生长变化的研究分析表明:(1)宏观上,叶鞘从叶基部至顶部颜色由白色逐渐变为棕褐色,薄壁细胞逐渐失活;(2)叶鞘自叶基部至顶端的木... 详细信息

利用光学显微镜、傅里叶变换红外光谱和扫描电镜对棕榈(Trachycarpus fortunei)叶鞘维管束纤维的结构及其生长变化的研究分析表明:(1)宏观上,叶鞘从叶基部至顶部颜色由白色逐渐变为棕褐色,薄壁细胞逐渐失活;(2)叶鞘自叶基部至顶端的木素相对含量逐渐增加,而纤维素和半纤维素相对含量则逐渐减少;(3)棕榈植物维管束纤维表面均被硅石颗粒覆盖,这些硅石颗粒的大量存在,对棕榈的耐腐性或起到一定的积极影响。

关键词：棕榈维管束纤维叶鞘 FTIR 硅石